keyword
Keywords endoplasmic reticulum and auto...

endoplasmic reticulum and autophagy

https://read.qxmd.com/read/38470018/role-of-%C3%AE-cell-autophagy-in-%C3%AE-cell-physiology-and-the-development-of-diabetes
#21
REVIEW
Xaviera Riani Yasasilka, Myung-Shik Lee
Elucidating the molecular mechanism of autophagy was a landmark in understanding not only the physiology of cells and tissues, but also the pathogenesis of diverse diseases, including diabetes and metabolic disorders. Autophagy of pancreatic β-cells plays a pivotal role in the maintenance of the mass, structure and function of β-cells, whose dysregulation can lead to abnormal metabolic profiles or diabetes. Modulators of autophagy are being developed to improve metabolic profile and β-cell function through the removal of harmful materials and rejuvenation of organelles, such as mitochondria and endoplasmic reticulum...
March 12, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38469573/-c9orf72-gene-networks-in-the-human-brain-correlate-with-cortical-thickness-in-c9-ftd-and-implicate-vulnerable-cell-types
#22
JOURNAL ARTICLE
Iris J Broce, Daniel W Sirkis, Ryan M Nillo, Luke W Bonham, Suzee E Lee, Bruce L Miller, Patricia A Castruita, Virginia E Sturm, Leo S Sugrue, Rahul S Desikan, Jennifer S Yokoyama
INTRODUCTION: A hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 ( C9orf72 ) is recognized as the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and ALS-FTD. Identifying genes that show similar regional co-expression patterns to C9orf72 may help identify novel gene targets and biological mechanisms that mediate selective vulnerability to ALS and FTD pathogenesis. METHODS: We leveraged mRNA expression data in healthy brain from the Allen Human Brain Atlas to evaluate C9orf72 co-expression patterns...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38463514/machine-learning-based-prediction-of-a-diagnostic-model-using-autophagy-related-genes-based-on-rna-sequencing-for-patients-with-papillary-thyroid-carcinoma
#23
JOURNAL ARTICLE
Lin Chen, Gaofeng Tao, Mei Yang
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and belongs to the category of malignant tumors of the thyroid gland. Autophagy plays an important role in PTC. The purpose of this study is to develop a novel diagnostic model using autophagy-related genes (ARGs) in patients. In this study, RNA sequencing data of PTC samples and normal samples were obtained from GSE33630 and GSE29265. Then, we analyzed GSE33630 datasets and identified 127 DE-ARGs. Functional enrichment analysis suggested that 127 DE-ARGs were mainly enriched in pathways in cancer, protein processing in endoplasmic reticulum, toll-like receptor pathway, MAPK pathway, apoptosis, neurotrophin signaling pathway, and regulation of autophagy...
2024: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38462227/lipid-nanoparticles-of-quercetin-qu-lip-alleviated-pancreatic-microenvironment-in-diabetic-male-rats-the-interplay-between-oxidative-stress-unfolded-protein-response-upr-autophagy-and-their-regulatory-mirna
#24
JOURNAL ARTICLE
Safaa I Khater, Mahran Mohamed Abd El-Emam, Hussein Abdellatif, Mahmoud Mostafa, Tarek Khamis, Rania Hassan Mohamed Soliman, Heba S Ahmed, Sahar K Ali, Heba Mohammed Refat M Selim, Leena S Alqahtani, Doaa Habib, Mohamed M M Metwally, Anwar M Alnakhli, Asmaa Saleh, Amira Mohammed Abdelfattah, Hanim M Abdelnour, Mohamed F Dowidar
BACKGROUND: Autophagy is a well-preserved mechanism essential in minimizing endoplasmic reticulum stress (ER)-related cell death. Defects in β-cell autophagy have been linked to type 1 diabetes, particularly deficits in the secretion of insulin, boosting ER stress sensitivity and possibly promoting pancreatic β-cell death. Quercetin (QU) is a potent antioxidant and anti-diabetic flavonoid with low bioavailability, and the precise mechanism of its anti-diabetic activity is still unknown...
March 8, 2024: Life Sciences
https://read.qxmd.com/read/38458297/an-anti-tumor-protein-pfap-specifically-interacts-with-cholesterol-enriched-membrane-domains-of-a549-cells-and-induces-paraptosis-and-endoplasmic-reticulum-stress
#25
JOURNAL ARTICLE
Meng-Han Liu, Zhao-Kun Liu, Fang Liu
Nowadays, non-small cell lung cancer (NSCLC) is still one of the most life-threatening diseases in the world. In previous studies, a fungal protein PFAP with anti-NSCLC properties was isolated and identified from Pleurotus ferulae lanzi. In this study, the amino acid sequence of PFAP was analyzed and found to be highly homologous to the aegerolysin family. PFAP, like other members of the aegerolysin family, specifically recognizes lipid raft domains rich in cholesterol and sphingomyelin, which is probably its specific anti-tumor mechanism...
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38454050/loss-of-wipi4-in-neurodegeneration-causes-autophagy-independent-ferroptosis
#26
JOURNAL ARTICLE
Ye Zhu, Motoki Fujimaki, Louisa Snape, Ana Lopez, Angeleen Fleming, David C Rubinsztein
β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45) gene encoding WIPI4 lead to loss of function in BPAN but the cellular mechanisms of how these trigger pathology are unclear. The prevailing view in the literature is that BPAN is simply the consequence of autophagy deficiency given that WIPI4 functions in this degradation pathway...
March 7, 2024: Nature Cell Biology
https://read.qxmd.com/read/38452695/effectively-%C3%AE-terpineol-suppresses-glioblastoma-aggressive-behavior-and-downregulates-kdelc2-expression
#27
JOURNAL ARTICLE
Jong-Shiaw Jin, Jung-Mao Chou, Wen-Chiuan Tsai, Ying-Chuan Chen, Ying Chen, Jiann-Ruey Ong, Yu-Ling Tsai
BACKGROUND: Glioblastoma (GBM) is notorious for the aggressive behaviors and easily results in chemo-resistance. Studies have shown that the use of herbal medicines as treatments for GBM as limited by the blood-brain barrier (BBB) and glioma stem cells. PURPOSE: The aim of this study was to investigate the relationship between GBM suppression and α-terpineol, the monoterpenoid alcohol derived from Eucalyptus glubulus and Pinus merkusii. STUDY DESIGN: Using serial in-vitro and in-vivo studies to confirm the mechanism of α-terpineol on down-regulating GBM development...
February 23, 2024: Phytomedicine
https://read.qxmd.com/read/38451396/celecoxib-attenuates-hindlimb-unloading-induced-muscle-atrophy-via-suppressing-inflammation-oxidative-stress-and-er-stress-by-inhibiting-stat3
#28
JOURNAL ARTICLE
Yanan Ji, Junfei Lin, Ruiqi Liu, Kexin Wang, Mengyuan Chang, Zihui Gao, Boya Liu, Yuntian Shen, Jianwei Zhu, Xinlei Yao, Lei Qi, Hualin Sun
Improving inflammation may serve as useful therapeutic interventions for the hindlimb unloading-induced disuse muscle atrophy. Celecoxib is a selective non-steroidal anti-inflammatory drug. We aimed to determine the role and mechanism of celecoxib in hindlimb unloading-induced disuse muscle atrophy. Celecoxib significantly attenuated the decrease in soleus muscle mass, hindlimb muscle function and the shift from slow- to fast-twitch muscle fibers caused by hindlimb unloading in rats. Importantly, celecoxib inhibited the increased expression of inflammatory factors, macrophage infiltration in damaged soleus muscle...
March 7, 2024: Inflammopharmacology
https://read.qxmd.com/read/38448202/analysis-of-cantharidin-induced-kidney-injury-and-the-protective-mechanism-of-resveratrol-in-mice-determined-by-liquid-chromatography-mass-spectrometry-based-metabonomics
#29
JOURNAL ARTICLE
Yuanyuan Xiao, Ruxia Liu, Xiaoyue Zhang, Yaofeng Li, Fang Peng, Wenchao Tang
Cantharidin (CTD) is the main active component in the traditional Chinese medicine Mylabris and an effective anti-tumor agent. However, it is relatively toxic and exhibits nephrotoxicity, which limits its clinical use. However, its toxic mechanism is not clear. The toxic effects of CTD exposure on the kidney and the protective effect of resveratrol (RES) were studied in a mouse model, by determination of serum biochemical and renal antioxidant indicators, histopathological and ultrastructural observation, and metabonomics...
March 6, 2024: Journal of Applied Toxicology: JAT
https://read.qxmd.com/read/38446297/mitochondria-associated-endoplasmic-reticulum-membrane-as-a-mediator-of-vanadium-induced-endoplasmic-reticulum-quality-control-in-duck-brains
#30
JOURNAL ARTICLE
Yiqun Lin, Fan Yang, Xueyan Dai, Jiyi Shan, Huabin Cao, Guoliang Hu, Caiying Zhang, Chenghong Xing
Vanadium (V) plays a crucial role in normal cells, but excess V causes multi-organ toxicity, including neurotoxicity. Mitochondria-associated endoplasmic reticulum membrane (MAM) is a dynamic structure between endoplasmic reticulum (ER) and mitochondria that mediates ER quality control (ERQC). To explore the effects of excess V on MAM and ERQC in the brain, 72 ducks were randomly divided into two groups: the control group (basal diet) and the V group (30 mg V/kg basal diet). On days 22 and 44, brain tissues were collected for histomorphological observation and determination of trace element contents...
March 6, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38441291/endoplasmic-reticulum-stress-in-t-cell-mediated-diseases
#31
REVIEW
Shaodan Chen, Qiulei Wang, Hui Wang, Sheng Xia
T cells synthesize a large number of proteins during their development, activation, and differentiation. The build-up of misfolded and unfolded proteins in the endoplasmic reticulum, however, causes endoplasmic reticulum (ER) stress. Thus, T cells can maintain ER homeostasis via endoplasmic reticulum-associated degradation, unfolded protein response, and autophagy. In T cell-mediated diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, type 1 diabetes and vitiligo, ER stress caused by changes in the internal microenvironment can cause disease progression by affecting T cell homeostasis...
September 2023: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38434710/acute-kidney-injury-exploring-endoplasmic-reticulum-stress-mediated-cell-death
#32
REVIEW
Cong Cheng, Yuan Yuan, Fang Yuan, Xin Li
Acute kidney injury (AKI) is a global health problem, given its substantial morbidity and mortality rates. A better understanding of the mechanisms and factors contributing to AKI has the potential to guide interventions aimed at mitigating the risk of AKI and its subsequent unfavorable outcomes. Endoplasmic reticulum stress (ERS) is an intrinsic protective mechanism against external stressors. ERS occurs when the endoplasmic reticulum (ER) cannot deal with accumulated misfolded proteins completely. Excess ERS can eventually cause pathological reactions, triggering various programmed cell death (autophagy, ferroptosis, apoptosis, pyroptosis)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38434290/eif2%C3%AE-mediated-integrated-stress-response-links-multiple-intracellular-signaling-pathways-to-reprogram-vascular-smooth-muscle-cell-fate-in-carotid-artery-plaque
#33
JOURNAL ARTICLE
Jichang Luo, Xiao Zhang, Wenjing Li, Tao Wang, Shengyan Cui, Tianhua Li, Yilin Wang, Wenlong Xu, Yan Ma, Bin Yang, Yumin Luo, Ge Yang, Ran Xu, Liqun Jiao
BACKGROUND: Carotid arterial atherosclerotic stenosis is a well-recognized pathological basis of ischemic stroke; however, its underlying molecular mechanisms remain unknown. Vascular smooth muscle cells (VSMCs) play fundamental roles in the initiation and progression of atherosclerosis. Organelle dynamics have been reported to affect atherosclerosis development. However, the association between organelle dynamics and various cellular stresses in atherosclerotic progression remain ambiguous...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38432436/norflurazon-causes-cell-death-and-inhibits-implantation-related-genes-in-porcine-trophectoderm-and-uterine-luminal-epithelial-cells
#34
JOURNAL ARTICLE
Taeyeon Hong, Sunwoo Park, Garam An, Fuller W Bazer, Gwonhwa Song, Whasun Lim
Norflurazon, an inhibitor of carotenoid synthesis, is a pre-emergent herbicide that prevents growth of weeds. The norflurazon is known to hamper embryo development in non-mammals. However, specific toxic effects of norflurazon on mammalian maternal and fetal cells have not been elucidated. Thus, the hypothesis of this study is that norflurazon may influence the toxic effects between maternal and fetal cells during early pregnancy in pigs. We aimed to examine the toxic effects of norflurazon in porcine trophectoderm (Tr) and uterine luminal epithelium (LE) cells...
March 1, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38430516/non-canonical-isoforms-of-the-mrna-polyadenylation-factor-wdr33-regulate-sting-mediated-immune-responses
#35
JOURNAL ARTICLE
Lizhi Liu, James L Manley
The human WDR33 gene encodes three major isoforms. The canonical isoform WDR33v1 (V1) is a well-characterized nuclear mRNA polyadenylation factor, while the other two, WDR33v2 (V2) and WDR33v3 (V3), have not been studied. Here, we report that V2 and V3 are generated by alternative polyadenylation, and neither protein contains all seven WD (tryptophan-aspartic acid) repeats that characterize V1. Surprisingly, V2 and V3 are not polyadenylation factors but localize to the endoplasmic reticulum and interact with stimulator of interferon genes (STING), the immune factor that induces the cellular response to cytosolic double-stranded DNA...
March 1, 2024: Cell Reports
https://read.qxmd.com/read/38429475/combinatorial-selective-er-phagy-remodels-the-er-during-neurogenesis
#36
JOURNAL ARTICLE
Melissa J Hoyer, Cristina Capitanio, Ian R Smith, Julia C Paoli, Anna Bieber, Yizhi Jiang, Joao A Paulo, Miguel A Gonzalez-Lozano, Wolfgang Baumeister, Florian Wilfling, Brenda A Schulman, J Wade Harper
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in point concerns the process of neurogenesis, where a refined tubular ER network is assembled via ER shaping proteins into the newly formed neuronal projections to create highly polarized dendrites and axons. Previous studies have suggested a role for autophagy in ER remodelling, as autophagy-deficient neurons in vivo display axonal ER accumulation within synaptic boutons, and the membrane-embedded ER-phagy receptor FAM134B has been genetically linked with human sensory and autonomic neuropathy...
March 1, 2024: Nature Cell Biology
https://read.qxmd.com/read/38426093/the-cgas-sting-pathway-in-viral-infections-a-promising-link-between-inflammation-oxidative-stress-and-autophagy
#37
REVIEW
Kunli Zhang, Qiuyan Huang, Xinming Li, Ziqiao Zhao, Chun Hong, Zeyi Sun, Bo Deng, Chunling Li, Jianfeng Zhang, Sutian Wang
The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in the cytoplasm, cyclic GMP-AMP synthase (cGAS) senses and binds virus DNA and subsequently activates stimulator of interferon genes (STING) to trigger a series of intracellular signalling cascades to defend against invading pathogenic microorganisms...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38425451/hepatitis-b-surface-antigen-expression-impairs-endoplasmic-reticulum-stress-related-autophagic-flux-by-decreasing-lamp2
#38
JOURNAL ARTICLE
Yaojie Liang, Xufeng Luo, Stefan Schefczyk, Lorraine T Muungani, Hui Deng, Baoju Wang, Hideo A Baba, Mengji Lu, Heiner Wedemeyer, Hartmut H Schmidt, Ruth Broering
BACKGROUND & AIMS: Hepatitis B surface antigen (HBsAg) drives hepatocarcinogenesis. Factors and mechanisms involved in this progression remain poorly defined, hindering the development of effective therapeutic strategies. Therefore, the mechanisms involved in the HBsAg-induced transformation of normal liver into hepatocellular carcinoma (HCC) were investigated. METHODS: Hemizygous Tg(Alb1HBV)44Bri/J mice were examined for HBsAg-induced carcinogenic events. Gene set-enrichment analysis identified significant signatures in HBsAg-transgenic mice that correlated with endoplasmic reticulum (ER) stress, unfolded protein response, autophagy and proliferation...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38421527/knockdown-of-circ_0044226-promotes-endoplasmic-reticulum-stress-mediated-autophagy-and-apoptosis-in-hepatic-stellate-cells-via-mir-4677-3p-sec61g-axis
#39
JOURNAL ARTICLE
Shanshan Yuan, Jiaming Liu, Li Yang, Xin Zhang, Kun Zhuang, Shuixiang He
Downregulation of circ_0044226 has been demonstrated to reduce pulmonary fibrosis, but the role of circ_0044226 in liver fibrosis remains to be explored. In this work, we found that circ_0044226 expression was upregulated during liver fibrosis. Knockdown of circ_0044226 inhibited proliferation, promoted autophagy and apoptosis of hepatic stellate cell LX-2. Bioinformatic analysis and dual luciferase reporter assays confirmed the interaction between circ_0044226, miR-4677-3p and SEC61G. Mechanistically, knockdown of circ_0044226 suppressed SEC61G expression by releasing miR-4677-3p, thereby enhancing endoplasmic reticulum stress...
February 29, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38420922/%C3%AE-synuclein-multiple-pathogenic-roles-in-trafficking-and-proteostasis-pathways-in-parkinson-s-disease
#40
REVIEW
Annie J Zalon, Drew J Quiriconi, Caleb Pitcairn, Joseph R Mazzulli
Parkinson's disease (PD) is a common age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. A hallmark of both familial and sporadic PD is the presence of Lewy body inclusions composed mainly of aggregated α-synuclein (α-syn), a presynaptic protein encoded by the SNCA gene. The mechanisms driving the relationship between α-syn accumulation and neurodegeneration are not completely understood, although recent evidence indicates that multiple branches of the proteostasis pathway are simultaneously perturbed when α-syn aberrantly accumulates within neurons...
February 29, 2024: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
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