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JOURNAL ARTICLE
Marcos Adriano Garcia Campos, Patrícia da Silva Sousa, Tamires Barradas Cavalcante, Eliana Harumi Morioka Takahasi, Luciana Cavalcante Costa, Marizélia Rodrigues Costa Ribeiro, Elaine de Paula Fiod Costa, Gláucio Andrade Amaral, João Ricardo Nickenig Vissoci, Antônio Augusto Moura da Silva
PURPOSE: This study aimed to identify continuous epileptiform discharges (CEDs) on electroencephalograms (EEG) and to determine their clinical significance in children with congenital Zika syndrome (CZS). METHODS: This prospective cohort study included 75 children diagnosed with CZS born from March 2015 and followed up until September 2018 (age up to 36 months). EEG was performed to detect CEDs up to 24 months old. Data on obstetric, demographic, and clinical signs; cranial computed tomography (CT); ophthalmology examination; anti-seizure medication; growth; and motor development were collected...
April 24, 2024: Seizure: the Journal of the British Epilepsy Association
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JOURNAL ARTICLE
Zhenliang Xiong, Mingxian Bai, Zhongxin Wang, Rongpin Wang, Chong Tian, Lihui Wang, Lisha Nie, Xianchun Zeng
INTRODUCTION: Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with cognitive impairment and physiological complications, necessitating further understanding of its mechanisms. This study investigates the relationship between glymphatic system function, brain network efficiency, and cognitive impairment in OSAHS patients using diffusion tensor image analysis along the perivascular space (DTI-ALPS) and resting-state fMRI. MATERIALS AND METHODS: This study included 31 OSAHS patients and 34 age- and gender-matched healthy controls (HC)...
May 3, 2024: Sleep Medicine
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JOURNAL ARTICLE
Francesca Conca, Valentina Esposito, Eleonora Catricalà, Rosa Manenti, Federica L'Abbate, Davide Quaranta, Guido Maria Giuffrè, Federica Rossetto, Federica Solca, Beatrice Orso, Emanuela Inguscio, Valeria Crepaldi, Maddalena De Matteis, Emanuela Rotondo, Marina Manera, Giulia Caruso, Valentina Catania, Elisa Canu, Francesco Rundo, Matteo Cotta Ramusino, Massimo Filippi, Cira Fundarò, Federica Piras, Andrea Arighi, Pietro Tiraboschi, Michelangelo Stanzani Maserati, Matteo Pardini, Barbara Poletti, Vincenzo Silani, Camillo Marra, Sonia Di Tella, Maria Cotelli, Raffaele Lodi, Fabrizio Tagliavini, Stefano Francesco Cappa
BACKGROUND: The identification and staging of Alzheimer's Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts were dedicated to select and harmonize available neuropsychological instruments. In Italy, the Italian Network of Neuroscience and Neuro-Rehabilitation has promoted the adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB), collecting normative data from 433 healthy controls (HC)...
May 4, 2024: Alzheimer's Research & Therapy
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REVIEW
Endurance Evbayekha, Yetunde Ishola, Ovie Okorare, Assumpta Chike, Sheeba AbrahamMBBS, Adaeze Vivian Aneke, Joshua T Green, Adenuga Ebunoluwa Grace, Cece E Ibeson, Evidence Eseose Ohikhuai Bpharm, Okelue E Okobi, Pius Ouwatosin Akande, Patience Nwafor, Tamunoinemi Bob-Manuel
INTRODUCTION: Hypertensive crisis (HC) encompasses hypertensive emergencies (HE) and urgencies (HU). Recent literature on HC's social determinants (SD) and racial disparities (RD) of the inpatient population is scarce. We aimed to examine these factors. METHODS: A retrospective analysis of the 2016-2020 National Inpatient Sample was conducted, and all hospitalizations for HC were identified with their ICD-10 codes. A probability estimation of outcomes was calculated by performing multivariable logistic regression analysis, which took confounders into account...
May 2, 2024: Current Problems in Cardiology
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JOURNAL ARTICLE
Maria J Knol, Raymond A Poot, Tavia E Evans, Claudia L Satizabal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra van der Auwera, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C Hostettler, Dianne H K van Dam-Nolen, Sander Lamballais, Mikolaj A Pawlak, Cora E Lewis, Amaia Carrion-Castillo, Theo G M van Erp, Céline S Reinbold, Jean Shin, Markus Scholz, Asta K Håberg, Anders Kämpe, Gloria H Y Li, Reut Avinun, Joshua R Atkins, Fang-Chi Hsu, Alyssa R Amod, Max Lam, Ami Tsuchida, Mariël W A Teunissen, Nil Aygün, Yash Patel, Dan Liang, Alexa S Beiser, Frauke Beyer, Joshua C Bis, Daniel Bos, R Nick Bryan, Robin Bülow, Svenja Caspers, Gwenaëlle Catheline, Charlotte A M Cecil, Shareefa Dalvie, Jean-François Dartigues, Charles DeCarli, Maria Enlund-Cerullo, Judith M Ford, Barbara Franke, Barry I Freedman, Nele Friedrich, Melissa J Green, Simon Haworth, Catherine Helmer, Per Hoffmann, Georg Homuth, M Kamran Ikram, Clifford R Jack, Neda Jahanshad, Christiane Jockwitz, Yoichiro Kamatani, Annchen R Knodt, Shuo Li, Keane Lim, W T Longstreth, Fabio Macciardi, Outi Mäkitie, Bernard Mazoyer, Sarah E Medland, Susumu Miyamoto, Susanne Moebus, Thomas H Mosley, Ryan Muetzel, Thomas W Mühleisen, Manabu Nagata, Soichiro Nakahara, Nicholette D Palmer, Zdenka Pausova, Adrian Preda, Yann Quidé, William R Reay, Gennady V Roshchupkin, Reinhold Schmidt, Pamela J Schreiner, Kazuya Setoh, Chin Yang Shapland, Stephen Sidney, Beate St Pourcain, Jason L Stein, Yasuharu Tabara, Alexander Teumer, Anne Uhlmann, Aad van der Lugt, Meike W Vernooij, David J Werring, B Gwen Windham, A Veronica Witte, Katharina Wittfeld, Qiong Yang, Kazumichi Yoshida, Han G Brunner, Quentin Le Grand, Kang Sim, Dan J Stein, Donald W Bowden, Murray J Cairns, Ahmad R Hariri, Ching-Lung Cheung, Sture Andersson, Arno Villringer, Tomas Paus, Sven Cichon, Vince D Calhoun, Fabrice Crivello, Lenore J Launer, Tonya White, Peter J Koudstaal, Henry Houlden, Myriam Fornage, Fumihiko Matsuda, Hans J Grabe, M Arfan Ikram, Stéphanie Debette, Paul M Thompson, Sudha Seshadri, Hieab H H Adams
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants...
May 3, 2024: Cell reports medicine
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JOURNAL ARTICLE
David Alan Parker, Sid Imes, Gabrielle Ruban, Opal Yates Ousley, Brett Henshey, Nicholas M Massa, Elaine Walker, Joseph F Cubells, Erica Duncan
BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is one of the most robust genetic predictors of psychosis and other psychiatric illnesses. In this study, we examined 22q11DS subjects' acoustic startle responses (ASRs), which putatively index psychosis risk. Latency of the ASR is a presumptive marker of neural processing speed and is prolonged (slower) in schizophrenia. ASR measures correlate with increased psychosis risk, depend on glutamate and dopamine receptor signaling, and could serve as translational biomarkers in interventions for groups at high psychosis risk...
May 3, 2024: Schizophrenia Research
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JOURNAL ARTICLE
Henry H Chill, Aharon Dick, Wajdy Zarka, Naama Vilk Ayalon, Joshua I Rosenbloom, David Shveiky, Gilad Karavani
INTRODUCTION AND HYPOTHESIS: Obstetric anal sphincter injury (OASI) is a major complication associated with vacuum-assisted vaginal delivery (VAVD). The aim of this study was to evaluate risk factors related to vacuum extraction that are associated with OASI. METHODS: This was a case-control study performed at a tertiary university teaching hospital. Included were patients aged 18-45 years who had a singleton pregnancy resulting in a live, term, VAVD. The study group consisted of women diagnosed with OASI following vacuum extraction...
May 4, 2024: International Urogynecology Journal
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JOURNAL ARTICLE
Guanyu Zhang, Jinghong Ma, Piu Chan, Zheng Ye
PURPOSE: Sequential working memory is the ability to maintain and manipulate sequential information at a second time scale. Patients with progressive supranuclear palsy (PSP) or Parkinson's disease (PD) perform poorly in tests that require the flexible arrangement of thoughts or actions. This study investigated whether sequential working memory is differently impaired in patients with PSP versus PD. METHOD: Twenty-nine patients with PSP Richardson's syndrome (PSP-RS), 36 patients with PD, and 36 healthy controls (HC) completed 3 well-established neuropsychological tests, including digit span forward (DST-F), digit span backward (DST-B), and adaptive digit ordering tests (DOT-A)...
May 2024: Brain and Behavior
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JOURNAL ARTICLE
Zi Chen, Yuxue Li, Yao Gao, Xiaoxuan Fan, Xinzhe Du, Xinrong Li, Zhifen Liu, Sha Liu, Xiaohua Cao
BACKGROUND: Early-onset schizophrenia (EOS) is a type of schizophrenia (SCZ) with an age of onset of < 18 years. An abnormal inflammatory immune system may be involved in the occurrence and development of SCZ. We aimed to identify the immune characteristic genes and cells involved in EOS and to further explore the pathogenesis of EOS from the perspective of immunology. METHODS: We obtained microarray data from a whole-genome mRNA expression in peripheral blood mononuclear cells (PBMCs); 19 patients with EOS (age range: 14...
May 3, 2024: BMC Immunology
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JOURNAL ARTICLE
Hua-Shan Gong, Jing-Pei Pan, Fei Guo, Mei-Mei Wu, Li Dong, Yang Li, Wei-Fang Rong
Enteroendocrine cells (EECs) and vagal afferent neurons constitute functional sensory units of the gut, which have been implicated in bottom-up modulation of brain functions. Sodium oligomannate (GV-971) has been shown to improve cognitive functions in murine models of Alzheimer's disease (AD) and recently approved for the treatment of AD patients in China. In this study, we explored whether activation of the EECs-vagal afferent pathways was involved in the therapeutic effects of GV-971. We found that an enteroendocrine cell line RIN-14B displayed spontaneous calcium oscillations due to TRPA1-mediated calcium entry; perfusion of GV-971 (50, 100 mg/L) concentration-dependently enhanced the calcium oscillations in EECs...
May 3, 2024: Acta Pharmacologica Sinica
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JOURNAL ARTICLE
Michele Matarazzo, Alexandra Pérez-Soriano, Nasim Vafai, Elham Shahinfard, Kevin Ju-Chieh Cheng, Jessamyn McKenzie, Nicole Neilson, Qing Miao, Paul Schaffer, Hitoshi Shinotoh, Jeffrey H Kordower, Vesna Sossi, A Jon Stoessl
Parkinson's disease (PD) is associated with aggregation of misfolded α-synuclein and other proteins, including tau. We designed a cross-sectional study to quantify the brain binding of [11 C]PBB3 (a ligand known to bind to misfolded tau and possibly α-synuclein) as a proxy of misfolded protein aggregation in Parkinson's disease (PD) subjects with and without cognitive impairment and healthy controls (HC). In this cross-sectional study, nineteen cognitively normal PD subjects (CN-PD), thirteen cognitively impaired PD subjects (CI-PD) and ten HC underwent [11 C]PBB3 PET...
May 3, 2024: NPJ Parkinson's Disease
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JOURNAL ARTICLE
Weina Chen, Yuanlv Deng, Yan Li, Xinying Huang, Chenglong Ma, Wenxin Huang, Rong Wang, Zhaodian Zheng, Manli Wang, Huidong Zhang
Environmental benzo(a)pyrene (BaP) and itsmetabolite benzo(a)pyrene-7, 8-dihydrodiol-9, 10-epoxide (BPDE), classic endocrine disrupting chemical and persistent organic pollutant, could cause miscarriage. However, the detailed mechanisms are still largely unclear and should be further explored. In this study, we discovered that exposure of trophoblast cells with BPDE could suppressed cell invasion/migration by inhibiting MEST/VIM (Vimentin) pathway. Moreover, BPDE exposure also increased lnc-HZ01 expression level, which further inhibited MEST/VIM pathway and then suppressed invasion/migration...
May 2, 2024: Ecotoxicology and Environmental Safety
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JOURNAL ARTICLE
Shuhui Li, Jie Jiang, Wenli Zhu, Dandan Wang, Chaoqing Dong, Yangying Bu, Juan Zhang, Daiyutong Gao, Xiaowen Hu, Chunling Wan
Cell-free DNA (cfDNA) has been found to be elevated in patients with schizophrenia (SZ), potentially derived from activated apoptosis, but the underlying mechanisms remain unknown. Moreover, whether the concentrations of cfDNA are altered with disease stage has not been investigated, which limits its clinical application as an auxiliary diagnostic marker for SZ. Using an improved fluorescence correlation spectroscopy (FCS) method that does not require DNA extraction, we measured the molar concentrations of cfDNA in plasma samples of 191 patients with SZ, 78 patients with mood disorders (MD) and 65 healthy controls (HC)...
April 26, 2024: Journal of Psychiatric Research
#54
JOURNAL ARTICLE
Annie Bane, Lorraine Wilson, Jill Jumper, Lindsay Spindler, Pricilla Wyatt, Darryn Willoughby
BACKGROUND: Autonomic dysfunction precedes endothelial dysfunction in Parkinson's disease (PD) and causes blood pressure and circulation abnormalities that are highly disruptive to one's quality of life. While exercise interventions have proven helpful for motor symptoms of PD, improving associated non-motor symptoms is limited. Low-intensity resistance training with blood flow restriction (LIRT-BFR) improves autonomic dysfunction in non-PD patients and high-intensity resistance training (HIRT) is recommended for motor symptom improvements for people with PD (PwPD)...
April 27, 2024: Journal of Parkinson's Disease
#55
JOURNAL ARTICLE
Chih-Ying Lee, Lung Chan, Chaur-Jong Hu, Chien-Tai Hong, Jia-Hung Chen
Vitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta-analysis...
May 2, 2024: Aging
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JOURNAL ARTICLE
Adam Rufa, Gary Brooks, Kyle R Adams, Michelle Dolphin
BACKGROUND: The LBP-related attitudes and beliefs of clinicians may impact the experience of patients by influencing clinician decision-making and by shaping the attitudes, beliefs, and actions of patients. The purpose of this study was to identify the specific LBP-related attitudes and beliefs of US-based physical therapists and determine if those beliefs correlate with clinical decision-making. METHODS: An electronic survey was sent to US-based physical therapists...
May 3, 2024: Journal of Manual & Manipulative Therapy
#57
JOURNAL ARTICLE
Chloe L Johnson, Daniel J Storm, Muhammad Arif Sajjad, Matthew R Gyton, Simon B Duckett, Stuart A Macgregor, Andrew S Weller, Miquel Navarro, Jesus Campos
Using single-crystal to single-crystal solid/gas reactivity the gold(I) acetylene complex [Au(L1)(η2-HC≡CH)][BArF4] is cleanly synthesized by addition of acetylene gas to single crystals of [Au(L1)(CO)][BArF4] [L1 = tris-2-(4,4'-di-tert-butylbiphenyl)phosphine, ArF = 3,5-(CF3)2C6H3]. This simplest gold-alkyne complex has been characterized by single crystal X-ray diffraction, solution and solid-state NMR spectroscopy and periodic DFT. Bonding of HC≡CH with [Au(L1)]+ comprises both σ-donation and π-backdonation with additional dispersion interactions within the cavity-shaped phosphine...
May 3, 2024: Angewandte Chemie
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JOURNAL ARTICLE
Yanfeng Huang, Wanjuan Li, Xiaojian Shi, Wenchao Wang, Chengshuo Xu, Roger David Adams, Jie Lyu, Jia Han, Yaohua He
Background: Knee osteoarthritis (KOA) is a common musculoskeletal condition that affects dynamic balance control and increases the risk of falling during walking. However, the mechanisms underlying this are still unclear. Diminished ankle proprioception during walking has been found to be related to fear of falling in older adults, with a gender difference in incidence of falling. This study aimed to determine 1) whether ankle inversion proprioceptive acuity during walking is impaired in patients with KOA; and 2) whether there is any difference between genders...
2024: Frontiers in Bioengineering and Biotechnology
#59
JOURNAL ARTICLE
Friedhelm Sayk, Susanne Hauswaldt, Johannes K Knobloch, Jan Rupp, Martin Nitschke
Asymptomatic long-term carriers of Shigatoxin producing Escherichia coli (STEC) are regarded as potential source of STEC-transmission. The prevention of outbreaks via onward spread of STEC is a public health priority. Accordingly, health authorities are imposing far-reaching restrictions on asymptomatic STEC carriers in many countries. Various STEC strains may cause severe hemorrhagic colitis complicated by life-threatening hemolytic uremic syndrome (HUS), while many endemic strains have never been associated with HUS...
2024: Frontiers in Public Health
#60
REVIEW
Bing Cai, Yikang Zhu, Dongyang Liu, Yaxi Li, Marlys Bueber, Xuezhi Yang, Guoshuai Luo, Ying Su, Margaux M Grivel, Lawrence H Yang, Min Qian, William S Stone, Michael R Phillips
More than one hundred studies have used the mainland Chinese version of the MATRICS Consensus Cognitive Battery (MCCB) to assess cognition in schizophrenia, but the results of these studies, the quality of the reports, and the strength of the evidence provided in the reports have not been systematically assessed. We identified 114 studies from English-language and Chinese-language databases that used the Chinese MCCB to assess cognition in combined samples of 7394 healthy controls (HC), 392 individuals with clinical high risk for psychosis (CHR-P), 4922 with first-episode schizophrenia (FES), 1549 with chronic schizophrenia (CS), and 2925 with schizophrenia of unspecified duration...
April 2024: The Lancet Regional Health. Western Pacific
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