Feng Shi, Li Shang, Min Zhou, Cong Lv, Yueshuo Li, Cheng Luo, Na Liu, Jingchen Lu, Min Tang, Xiangjian Luo, Jing Xu, Jia Fan, Jian Zhou, Qiang Gao, Weizhong Wu, Weihua Jia, Hailin Wang, Ya Cao
Metabolic reprogramming induced by Epstein-Barr virus (EBV) often mirrors metabolic changes observed in cancer cells. Accumulating evidence suggests that lytic reactivation is crucial in EBV-associated oncogenesis. The aim of this study was to explore the role of metabolite changes in EBV-associated malignancies and viral life cycle control. We first revealed that EBV (LMP1) accelerates the secretion of the oncometabolite D-2HG, and serum D-2HG level is a potential diagnostic biomarker for NPC. EBV (LMP1)-driven metabolite changes disrupts the homeostasis of global DNA methylation and demethylation, which have a significantly inhibitory effect on active DNA demethylation and 5hmC content...
May 2024: Journal of Medical Virology