Aline Z Schavinski, Natany G Reis, Henrique J N Morgan, Ana Paula Assis, Matheus L Moro, Rafael R Valentim, Ana Carolina Seni-Silva, Ester S Ramos, Isis C Kettelhut, Luiz C C Navegantes
Recent studies have shown that maternal vitamin D deficiency (VDD) causes long-term metabolic changes in offspring. However, little is known about the impact of maternal VDD on offspring endocrine pancreas development and insulin secretion in the adult life of male and female animals. Female rats (Wistar Hannover) were fed either control (1000 IU Vitamin D3/kg), VDD (0 IU Vitamin D3/kg), or a Ca2+ -enriched VDD diet (0 IU Vitamin D3/kg + Ca2+ and P/kg) for 6 weeks and during gestation and lactation. At weaning, VDD status was confirmed based on low serum calcidiol levels in dams and pups...
April 9, 2024: International Journal of Molecular Sciences