Zhigang Rao, Elena Brunner, Benjamin Giszas, Aishwarya Iyer-Bierhoff, Jana Gerstmeier, Friedemann Börner, Paul M Jordan, Simona Pace, Katharina P L Meyer, Robert K Hofstetter, Daniel Merk, Christian Paulenz, Thorsten Heinzel, Philip C Grunert, Andreas Stallmach, Charles N Serhan, Markus Werner, Oliver Werz
Glucocorticoids (GC) are potent anti-inflammatory agents, broadly used to treat acute and chronic inflammatory diseases, e.g., critically ill COVID-19 patients or patients with chronic inflammatory bowel diseases. GC not only limit inflammation but also promote its resolution although the underlying mechanisms are obscure. Here, we reveal reciprocal regulation of 15-lipoxygenase (LOX) isoform expression in human monocyte/macrophage lineages by GC with respective consequences for the biosynthesis of specialized proresolving mediators (SPM) and their 15-LOX-derived monohydroxylated precursors (mono-15-OH)...
August 29, 2023: Proceedings of the National Academy of Sciences of the United States of America