Judeng Zeng, Chuan Xie, Ziheng Huang, Chi H Cho, Hung Chan, Qing Li, Hassan Ashktorab, Duane T Smoot, Sunny H Wong, Jun Yu, Wei Gong, Cong Liang, Hongzhi Xu, Huarong Chen, Xiaodong Liu, Justin C Y Wu, Margaret Ip, Tony Gin, Lin Zhang, Matthew T V Chan, Wei Hu, William K K Wu
The role of N6 -methyladenosine (m6 A) modification of host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori infection upregulates host m6 A methylases and increases m6 A levels in gastric epithelial cells. Reducing m6 A methylase activity via hemizygotic deletion of methylase-encoding gene Mettl3 in mice, or via small interfering RNAs targeting m6 A methylases, enhances H. pylori colonization. We identify LOX-1 mRNA as a key m6 A-regulated target during H. pylori infection...
January 22, 2024: Nature Communications