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JOURNAL ARTICLE
Francieli Gesleine Capote-Bonato, Denis Vinicius Bonato, Ilan Munhoz Ayer, Charles Silva de Lima, Larissa Fernandes Magalhães, Cecilia Aparecida Spada, Georgia Modé Magalhães, Ewaldo de Mattos Junior, Pedro Paulo Maia Teixeira, Melyssa Negri, Leandro Zuccolotto Crivellenti, Terezinha Inez Estivalet Svidzinski
The present study evaluated renal infection resulting from the implantation of C. tropicalis in the bladder of immunosuppressed mice. Yeasts were implanted in two manners: planktonic and via preformed biofilm on a small catheter fragment (SCF). Renal histopathology and cultures was performed 72 and 144 h after cystotomy was carried out in mice from three groups: group I contained non-contaminated mice implanted with a sterile SCF; group II mice received a sterile SCF plus a yeast suspension containing 1 × 107 yeasts/mL in a planktonic form; group III mice were implanted with a SCF containing preformed C...
August 8, 2023: Microbial Pathogenesis
#62
JOURNAL ARTICLE
Haitao Yang, Yan Wang, Hui Fan, Feixue Liu, Huimiao Feng, Xueqing Li, Mingyi Chu, Enzhuang Pan, Daoyang Teng, Huizhen Chen, Jingquan Dong
Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory infections, sepsis, osteomyelitis, endocarditis, and urinary tract infections in burned or immunocompromised patients (Azam and Khan, 2019; Chai and Xu, 2020; Voth et al...
August 1, 2023: Journal of Zhejiang University. Science. B
#63
REVIEW
Jaber Hemmati, Mehdi Azizi, Babak Asghari, Mohammad Reza Arabestani
Multidrug-resistant pathogens are one of the common causes of death in burn patients and have a high risk of nosocomial infections, especially pneumonia, urinary tract infections, and cellulitis. The role of prolonged hospitalization and empirical antibiotics administration in developing multidrug-resistant pathogens is undeniable. In the early days of admitting burn patients, Gram-positive bacteria were the dominant isolates with a more sensitive antibiotic pattern. However, the emergence of Gram-negative bacteria that are more resistant later occurs...
2023: Canadian Journal of Infectious Diseases & Medical Microbiology
#64
REVIEW
Lukasz Dobrek
A potential complication of pharmacotherapy for a given patient is the possibility of various side effects of drugs, which are manifested in many ways and constitute iatrogenic causes of diseases. Among the systemic side effects of drugs, there are also those involving the urinary tract, although these are less reported in the literature. The use of numerous drugs-especially of anticholinergics or drugs with anticholinergic potential, opioid analgesics, non-steroidal anti-inflammatory drugs, antidepressants, first-generation antipsychotics (classic neuroleptics) and selected cardiovascular drugs (beta-blockers, thiazides potassium-sparing diuretics, statins), as well as others-may increase the risk of developing urological disorders, such as urinary retention or incontinence, urinary tract infections, urolithiasis, erectile dysfunction in men and retroperitoneal fibrosis...
July 20, 2023: Pharmaceuticals
#65
JOURNAL ARTICLE
Priyanka H Krishnaswamy, Eilidh Middleton, Suzanne Hagen, Karen Lesley Guerrero, Jo Booth
IMPORTANCE: Despite high incidences of urinary tract infections (UTIs), little is known about how bothersome symptoms are and the effects on women's life and sexual activity, leaving a gap in our understanding of the physical and emotional effects of UTIs on women. OBJECTIVES: This initial exploratory and descriptive study analyzes women's experiences of UTI and their perceived impact on quality of life. STUDY DESIGN: Qualitative interviews were undertaken with 23 women who had experienced at least 1 UTI, recruited from different settings-primary care, general gynecology clinics, urogynecology clinics, and online via social media...
July 13, 2023: Urogynecology (Phila)
#66
JOURNAL ARTICLE
Anuj Rohatgi, Pratima Gupta
Klebsiella pneumoniae is responsible for a significant proportion of human urinary tract infections, and its biofilm is a major virulence. One potential approach to controlling biofilm-associated infections is targeting the adhesin MrkD1P to disrupt biofilm formation. We employed Schrodinger's Maestro tool with the OPLS 2005 force field to dock compounds with the target protein. Two benzoic acid derivatives, 3-hydroxy benzoic acid and 2,5-dihydroxybenzoic acid, had strong binding free energies (-55.57 and -18...
July 19, 2023: Journal of Bioscience and Bioengineering
#67
JOURNAL ARTICLE
Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I Matter, Lorenz Leitner, Thomas M Kessler, Martin J Loessner, Samuel Kilcher, Matthew Dunne
Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial resistance development. Here, we engineer phages for target-specific effector gene delivery and host-dependent production of colicin-like bacteriocins and cell wall hydrolases. Using urinary tract infection (UTI) as a model, we show how heterologous effector phage therapeutics (HEPTs) suppress resistance and improve uropathogen killing by dual phage- and effector-mediated targeting...
July 20, 2023: Nature Communications
#68
REVIEW
E Bouza, A Asensio, J A García Navarro, P González, M A Costa Benito, J Aguilar, J Barberán, J Cabrera, J Díez-Manglano, C Fernández, M Fernandez-Prada, G Fontán, J M Cisneros, B Lorenzo-Vidal, A Martín Oliveros, P Navas, E Palomo, M Kestler
Nursing homes (NH) conceptually should look as much like a home as possible. However NH have unquestionable similarities with a nosocomium as they are places where many patients with underlying diseases and comorbidities accumulate. There is evidence of transmission of microorganisms between residents and between residents and caregivers. We have not found any recommendations specifically aimed at the prevention of nosocomial infections in NH by the major Public Health Agencies and, therefore, the Health Sciences Foundation (Fundación de Ciencias de la Salud) has convened a series of experts and 14 Spanish scientific societies to discuss recommendations that could guide NH personnel in establishing written programs for the control and reduction of these infections...
July 19, 2023: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
#69
JOURNAL ARTICLE
Vishrut Bharti, Rajesh K Tiwari, Sanjay Gupta, Rohit Upadhyay, Manoj K Singh, Deelip K Singh
BACKGROUND: Although the prevalence of lower urinary tract symptoms (LUTS) is high in the female population, it is even higher in postmenopausal females. The frequency, severity, and etiology of LUTS vary among populations and individuals. This study aimed to define the characteristics of LUTS in postmenopausal women and their underlying etiologies. MATERIAL AND METHODS: Overall, 74 postmenopausal patients presenting with LUTS in the urological outpatient department were included in the study...
September 2023: Current Urology
#70
REVIEW
Yang Zhou, Zuying Zhou, Lin Zheng, Zipeng Gong, Yueting Li, Yang Jin, Yong Huang, Mingyan Chi
Urinary tract infections (UTIs) are common bacterial infections that represent a severe public health problem. They are often caused by Escherichia coli ( E. coli ), Klebsiella pneumoniae ( K. pneumonia ), Proteus mirabilis ( P. mirabilis ), Enterococcus faecalis ( E. faecalis ), and Staphylococcus saprophyticus ( S. saprophyticus ). Among these, uropathogenic E. coli (UPEC) are the most common causative agent in both uncomplicated and complicated UTIs. The adaptive evolution of UPEC has been observed in several ways, including changes in colonization, attachment, invasion, and intracellular replication to invade the urothelium and survive intracellularly...
June 23, 2023: International Journal of Molecular Sciences
#71
REVIEW
K C Coffey, Daniel J Morgan, Kimberly C Claeys
PURPOSE OF REVIEW: The aim of this study was to review recently published diagnostic stewardship studies of common clinical infectious syndromes and the impact on antibiotic prescribing. RECENT FINDINGS: Diagnostic stewardship can be implemented within healthcare systems and tailored to infectious syndromes, including urinary tract, gastrointestinal, respiratory and bloodstream infections. In urinary syndromes, diagnostic stewardship can decrease unnecessary urine culturing and associated antibiotic prescribing...
August 1, 2023: Current Opinion in Infectious Diseases
#72
JOURNAL ARTICLE
Hakan Erdem, Esra Kocoglu, Handan Ankarali, Rehab El-Sokkary, Atousa Hakamifard, Ridvan Karaali, Sholpan Kulzhanova, Amani El-Kholy, Hamed Azhdari Tehrani, Reham Khedr, Ayşe Kaya-Kalem, Nenad Pandak, Meliha Cagla-Sonmezer, Summiya Nizamuddin, Hande Berk-Cam, Rahmet Guner, Jehan Ali Elkholy, Ferran Llopis, Andrea Marino, Roman Stebel, Balint Gergely Szabo, Maya Belitova, Elias Fadel, Tarkan Yetisyigit, Yasemin Cag, Sevil Alkan, Bircan Kayaaslan, Serkan Oncu, Mehmet Ozdemir, Mesut Yilmaz, Arzu Cennet Isik, Dilşah Başkol, Gulden Sincan, Antonio Cascio, Safak Ozer-Balin, Nesibe Korkmaz, Rezaul Karim Ripon, Salma Abbas, Irina Magdalena Dumitru, Gulden Eser-Karlidag, Massimiliano Lanzafame, Abdur Rafey, Aun Raza, Oguz Resat Sipahi, Ilad Alavi Darazam, Umran Elbahr, Ilknur Erdem, Pinar Ergen, Cemil Bilir, Hulya Caskurlu, Aysegul Erdem, Mateja Jankovic Makek, Mustafa Altindis, Botond Lakatos, Catalina Mihaela Luca, Esmeray Mutlu Yilmaz, Emmanuel Nsutebu, Rumeysa Cakmak, Fatma Sirmatel
OBJECTIVES: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management. METHODS: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021...
September 2023: International Journal of Antimicrobial Agents
#73
REVIEW
Pierre-Marie Roger, Olivia Keïta-Perse, Jean-Luc Mainardi
Diagnostic uncertainty (DU) is frequent in infectious diseases (ID), being recorded in 10% to over 50% of patients. Herein, we show that in several fields of clinical practice, high rates of DU are constant over time. DUs are not taken into account in guidelines, as therapeutic propositions are based on an established diagnosis. Moreover, while other guidelines underline the need for rapid broad-spectrum antibiotic therapy for patients with sepsis, many clinical conditions mimic sepsis and lead to unnecessary antibiotic therapy...
July 6, 2023: Infectious diseases now
#74
JOURNAL ARTICLE
A S Al-Shukri, A V Maksimova, N I Dub, S V Kostyukov, A A Manchenko, I D Mayorov, Yu A Ponomareva, S B Petrov
BACKGROUND: Bladder catheterization is a common medical manipulation that is associated with the risk of complications, including catheter-associated urinary tract infection (CAUTI), which accounts for 80% of all nosocomial infections of the urological profile. AIM: To evaluate the combined use of the biologically active additive Uronext and ceftriaxone in the prevention of the development of CAUTI in the early postoperative period in 120 patients aged 20-80 years with a Foley indwelling catheter...
May 2023: Urologii︠a︡
#75
JOURNAL ARTICLE
Lalitha Maniam, Kumutha Malar Vellasamy, Teng Aik Ong, Cindy Shuan Ju Teh, Kartini Abdul Jabar, Vanitha Mariappan, Vallikkannu Narayanan, Jamuna Vadivelu, Vinod Pallath
BACKGROUND: Uropathogenic Escherichia coli (UPEC) is the predominant agent causing various categories of complicated urinary tract infections (cUTI). Although existing data reveals that UPEC harboured numerous virulence determinants to aid its survival in the urinary tract, the reason behind the occurrence of differences in the clinical severity of uninary tract infections (UTI) demonstrated by the UPEC infection is poorly understood. Therefore, the present study aims to determine the distribution of virulence determinants and antimicrobial resistance among different phylogroups of UPEC isolated from various clinical categories of cUTI and asymptomatic bacteriuria (ASB) E...
2023: PeerJ
#76
JOURNAL ARTICLE
Stephen M Reingold, Zachi Grossman, Adamos Hadjipanayis, Stefano Del Torso, Arunas Valiulis, Lukasz Dembinski, Shai Ashkenazi
BACKGROUND: Antimicrobial resistance (AMR) is one of the leading causes of morbidity and mortality worldwide. Efforts to promote the judicious use of antibiotics and contain AMR are a priority of several medical organizations, including the WHO. One effective way to achieve this goal is the deployment of antibiotic stewardship programs (ASPs). This study aimed to survey the current situation of pediatric ASPs in European countries and establish a baseline for future attempts to harmonize pediatric ASPs and antibiotic use in Europe...
2023: Frontiers in Pediatrics
#77
JOURNAL ARTICLE
Karim Bariz, Lamia Trabelsi, Souad Lahcene, Mounir M Salem-Bekhit, Gehan M Elossaily, Hayat Ali Alzahrani, Omar O Alharbi, Mohamed Abbaci, Hocine Abbaci, Yacine Benguerba, Karim Houali
Klebsiella pneumoniae producing extended-spectrum β-lactamases (ESBL) continues to pose huge therapeutic challenges in the treatment of infections, primarily urinary infections, due to its multidrug resistance to antibiotics. Therefore, there is a need for research on this topic to investigate ways to reduce the spread of antibiotic resistance, identify novel therapeutic approaches to treat these infections and gain a better understanding of the mechanisms of resistance. In this context, this study aimed to analyze the chemical composition of essential oils (EOs) of Thymus algeriensis, Syzygium aromaticum, and Eucalyptus globulus and assess their activity against K...
March 31, 2023: Cellular and Molecular Biology
#78
JOURNAL ARTICLE
Sanjay Saint, M Todd Greene, Sarah L Krein, Karen E Fowler, Kathleen A Linder, David Ratz, Jennifer Meddings
OBJECTIVE: The ways that device-associated infection prevention practices changed during the coronavirus disease 2019 (COVID-19) pandemic remain unknown. We collected data mid-pandemic to assess the use of several infection prevention practices and for comparison with historical data. DESIGN: Repeated cross-sectional survey. SETTING: US acute-care hospitals. PARTICIPANTS: Infection preventionists. METHODS: We surveyed infection preventionists from a national random sample of 881 US acute-care hospitals in 2021 to estimate the current use of practices to prevent catheter-associated urinary tract infection (CAUTI), central line-associated bloodstream infection (CLABSI), and ventilator-associated events (VAE)...
June 1, 2023: Infection Control and Hospital Epidemiology
#79
JOURNAL ARTICLE
Sarah H Needs, Jeremy Pivetal, Jessica Hayward, Stephen P Kidd, HoYin Lam, Tai Diep, Kiran Gill, Martin Woodward, Nuno M Reis, Alexander D Edwards
Innovation in infection based point-of-care (PoC) diagnostics is vital to avoid unnecessary use of antibiotics and the development of antimicrobial resistance. Several groups including our research team have in recent years successfully miniaturised phenotypic antibiotic susceptibility tests (AST) of isolated bacterial strains, providing validation that miniaturised AST can match conventional microbiological methods. Some studies have also shown the feasibility of direct testing (without isolation or purification), specifically for urinary tract infections, paving the way for direct microfluidic AST systems at PoC...
May 19, 2023: Sens Diagn
#80
REVIEW
Mengqi Gao, Tingting Zhao, Chuanlong Zhang, Ping Li, Jiazhe Wang, Jiatong Han, Ning Zhang, Bo Pang, Shiwei Liu
Uropathogenic Escherichia coli (UPEC) is the main pathogen of recurrent urinary tract infections (RUTIs). Urinary tract infection is a complicated interaction between UPEC and the host. During infection, UPEC can evade the host's immune response and retain in bladder epithelial cells, which requires adequate nutritional support. Iron is the first necessary trace element in life and a key nutritional factor, making it an important part of the competition between UPEC and the host. On the one hand, UPEC grabs iron to satisfy its reproduction, on the other hand, the host relies on iron to build nutritional immunity defenses against UPEC...
May 9, 2023: Biomedicine & Pharmacotherapy
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