Marlon J A de Haan, Marleen E Jacobs, Franca M R Witjas, Annemarie M A de Graaf, Elena Sánchez-López, Sarantos Kostidis, Martin Giera, Francisco Calderon Novoa, Tunpang Chu, Markus Selzner, Mehdi Maanaoui, Dorottya K de Vries, Jesper Kers, Ian P J Alwayn, Cees van Kooten, Bram Heijs, Gangqi Wang, Marten A Engelse, Ton J Rabelink
The growing disparity between the demand for transplants and the available donor supply, coupled with an aging donor population and increasing prevalence of chronic diseases, highlights the urgent need for the development of platforms enabling reconditioning, repair, and regeneration of deceased donor organs. This necessitates the ability to preserve metabolically active kidneys ex vivo for days. However, current kidney normothermic machine perfusion (NMP) approaches allow metabolic preservation only for hours...
May 13, 2024: Nature Communications