keyword
https://read.qxmd.com/read/38546884/an-updated-systematic-review-of-neuroprotective-agents-in-the-treatment-of-spinal-cord-injury
#1
REVIEW
Ibrahim Serag, Mohamed Abouzid, Ahmed Elmoghazy, Khalid Sarhan, Saad Ashraf Alsaad, Rashad G Mohamed
This systematic review aims to summarize the findings from all clinical randomized trials assessing the efficacy of potential neuroprotective agents in influencing the outcomes of acute spinal cord injuries (SCI). Following the PRISMA guidelines, we conducted comprehensive searches in four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) up to September 5th, 2023. Our analysis included a total of 30 studies. We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration...
March 28, 2024: Neurosurgical Review
https://read.qxmd.com/read/38546802/trends-in-burdens-of-disease-by-transmission-source-usa-2005-2020-and-hazard-identification-for-foods-focus-on-milkborne-disease
#2
JOURNAL ARTICLE
Michele M Stephenson, Margaret E Coleman, Nicholas A Azzolina
BACKGROUND: Robust solutions to global, national, and regional burdens of communicable and non-communicable diseases, particularly related to diet, demand interdisciplinary or transdisciplinary collaborations to effectively inform risk analysis and policy decisions. OBJECTIVE: U.S. outbreak data for 2005-2020 from all transmission sources were analyzed for trends in the burden of infectious disease and foodborne outbreaks. METHODS: Outbreak data from 58 Microsoft Access® data tables were structured using systematic queries and pivot tables for analysis by transmission source, pathogen, and date...
March 28, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38544753/combined-effects-of-rhodiola-rosea-and-caffeine-supplementation-on-aerobic-endurance-and-muscle-explosiveness-a-synergistic-approach
#3
JOURNAL ARTICLE
Hezhang Yun, Bin Lu, Wenbo Su, Junjie Wang, Jing Zheng, Jing Wang, Zhaolong Wang, Yi Li, Yaowei Sun, Chang Liu
This study examined the synergistic effects of combining Rhodiola rosea (RHO) and caffeine (CAF) supplementation on muscle endurance and explosiveness in SD rats and human subjects, encompassing individuals without prior exercise training experience and seasoned aerobic athletes. Male SD rats and healthy human volunteers were randomly divided into four groups: CAF, RHO, CAF + RHO, and a control group (CTR). Nutritional supplements were administered throughout the training period, and pre-and post-measurement data were collected...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38543873/igg-serum-antibodies-to-shigella-sonnei-lipopolysaccharide-are-inversely-associated-with-the-incidence-of-culture-proven-s-sonnei-shigellosis-in-israeli-children-and-adolescents
#4
JOURNAL ARTICLE
Valeria Asato, Ravit Bassal, Shiri Meron-Sudai, Sophy Goren, Lital Keinan-Boker, Calman A MacLennan, Dani Cohen
BACKGROUND: Shigella is a leading cause of moderate-to-severe diarrhea globally, with young children most affected. The burden of shigellosis drops increasingly with age, inferring the acquisition of natural immunity. We tested the hypothesis that IgG antibodies elicited against Shigella O-specific polysaccharide (O-SP) are correlates of age-acquired immunity. OBJECTIVES: We examined levels and determinants of serum IgG to S. sonnei LPS and the association with the incidence of S...
February 25, 2024: Vaccines
https://read.qxmd.com/read/38543800/understanding-the-impact-of-covid-19-on-roma-vulnerable-communities-in-western-romania-insights-and-predictive-factors-from-a-retrospective-study
#5
JOURNAL ARTICLE
Ionut Dragos Capraru, Catalin Marian, Dan Dumitru Vulcanescu, Sonia Tanasescu, Tiberiu Liviu Dragomir, Teodora Daniela Marti, Casiana Boru, Cecilia Roberta Avram, Monica Susan, Cristian Sebastian Vlad
BACKGROUND: The COVID-19 pandemic disproportionately affected vulnerable populations like Roma patients in Western Romania due to marginalization and limited healthcare access. METHODS: A retrospective study analyzed COVID-19 cases between March 2020 and August 2022 using data from the Directorate of Public Health in Timis county. Demographic, epidemiological, clinical, and laboratory data were assessed, along with risk factors and biomarkers for ICU admission and mortality prediction...
March 12, 2024: Viruses
https://read.qxmd.com/read/38542721/myostatin-and-activin-a-as-biomarkers-of-sarcopenia-in-inflammatory-bowel-disease-patients
#6
JOURNAL ARTICLE
Małgorzata Godala, Ewelina Gaszyńska, Konrad Walczak, Ewa Małecka-Wojciesko
The prevalence of sarcopenia in inflammatory bowel disease patients has received increasing attention. The aim of this study is to assess the usefulness of determining levels of myostatin (MSTN) and activin A (Act A) as potential markers of disease activity and occurrence of sarcopenia in Crohn's disease and ulcerative colitis patients. The case-control study included 82 patients with Inflammatory Bowel Disease. The control group consisted of 25 healthy volunteers. The serum levels of myostatin and activin A were determined by the quantitative sandwich enzyme-linked immunosorbent assay...
March 12, 2024: Nutrients
https://read.qxmd.com/read/38542679/the-sdor-2-6y%C3%A2-is-a-valid-measure-of-nutrition-risk-independent-of-bmi-for-age-z-score-and-household-food-security-status-in-preschool-aged-children
#7
JOURNAL ARTICLE
Elizabeth H Ruder, Barbara Lohse
Parents' feeding practices are a function of child eating behaviors, health, and other factors. Adherence to the Satter Division of Responsibility in Feeding (sDOR) model has not been examined relating to child BMI, household food security, or child eating behavior. This study evaluates the adherence to sDOR in relation to child eating behavior, nutrition risk, BMI-for-age, dietary intake, and food security. Ninety-one parent-child (3 to <6 years) dyads completed a cross-sectional asymmetric survey in August-November 2019; n = 69 parents from the original sample completed additional and retrospective questions in June 2021...
March 7, 2024: Nutrients
https://read.qxmd.com/read/38542539/cooling-performance-prediction-of-particle-based-radiative-cooling-film-considering-particle-size-distribution
#8
JOURNAL ARTICLE
Jaehyun Lim, Junbo Jung, Jinsung Rho, Joong Bae Kim
Here, we present a novel protocol concept for quantifying the cooling performance of particle-based radiative cooling (PBRC). PBRC, known for its high flexibility and scalability, emerges as a promising method for practical applications. The cooling power, one of the cooling performance indexes, is the typical quantitative performance index, representing its cooling capability at the surface. One of the primary obstacles to predicting cooling power is the difficulty of simulating the non-uniform size and shape of micro-nanoparticles in the PBRC film...
February 21, 2024: Micromachines
https://read.qxmd.com/read/38542203/ripasudil-as-a-potential-therapeutic-agent-in-treating-secondary-glaucoma-in-htlv-1-uveitis-an-in-vitro-analysis
#9
JOURNAL ARTICLE
Mingming Yang, Koju Kamoi, Yuan Zong, Jing Zhang, Yaru Zou, Kyoko Ohno-Matsui
Human T-cell leukemia virus type 1 (HTLV-1), a virus that affects 5-10 million people globally, causes several diseases, including adult T-cell leukemia-lymphoma and HTLV-1-associated uveitis (HU). HU is prevalent in Japan and often leads to secondary glaucoma, which is a serious complication. We investigated the efficacy of ripasudil, a Rho-associated coiled coil-forming protein kinase inhibitor, in alleviating changes in human trabecular meshwork cells (hTM cells) infected with HTLV-1. HTLV-1-infected hTM cells were modeled in vitro using MT-2 cells, followed by treatment with varying concentrations of ripasudil...
March 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541970/efficacy-and-safety-of-rho-kinase-inhibitors-vs-beta-blockers-in-primary-open-angle-glaucoma-a-systematic-review-with-meta-analysis
#10
REVIEW
Brenda Nana Wandji, Noélie Bacq, Adèle Ehongo
Background: In order to support the positioning of Rho kinase inhibitors (Rhokis) in the European market for the treatment of glaucoma, scientific evidence comparing the efficacy and safety of Rhokis and beta-blockers (β-βs) in the treatment of open-angle glaucoma after 3 months was assembled through a systematic review and meta-analysis (meta-A) of randomized controlled trials (RCTs). Methods: Relevant articles were searched for on PubMed, EMBASE, and the Cochrane Library. Of the 251 articles found, three met all eligibility criteria...
March 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541945/may-spasticity-related-unpleasant-sensations-interfere-with-daily-activities-in-people-with-stroke-and-traumatic-brain-injury-secondary-analysis-from-the-cortox-study
#11
JOURNAL ARTICLE
Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Franco Molteni, Andrea Santamato
Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation, and overall quality of life, guided by the comprehensive framework of the ICF. Methods: Utilizing a secondary analysis of data from a cohort undergoing Botulinum toxin type-A treatment for spasticity post-stroke or TBI, we developed and administered an ad-hoc questionnaire focusing on ICF domains such as body function, activities and participation, and psychosocial aspects such as mood, relationship, social life, motivation, and sleep quality...
March 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541234/changes-in-dickkopf-1-but-not-sclerostin-in-gingival-crevicular-fluid-are-associated-with-peroral-statin-treatment-in-patients-with-periodontitis
#12
JOURNAL ARTICLE
Kristina Duspara, Renata Sikora, Ana Petrovic, Lucija Kuna Roguljic, Anita Matic, Kristina Kralik, Hrvoje Roguljic, Tomislav Kizivat, Mirjana Duspara, Dunja Igrec, Kristina Bojanic, Robert Smolic, Aleksandar Vcev, Magdalena Wyszyńska, George Y Wu, Martina Smolic
Background and Objectives : Periodontitis is marked by the destruction of alveolar bone. Sclerostin (SOST) and dickkopf-1 (DKK-1) act as inhibitors of the Wingless-type (Wnt) signaling pathway, a key regulator of bone metabolism. Recent studies have suggested that statins play a role in bone resorption and formation by influencing Wnt signaling. The aim of this study was to determine the levels of SOST and DKK-1 in periodontal patients with and without peroral statins treatment in their therapy. Materials and Methods: A total of 79 patients with diagnosed periodontitis were divided into two groups: 39 patients on statin therapy (SP group) and 40 patients without statin therapy as a control group (P group)...
March 20, 2024: Medicina
https://read.qxmd.com/read/38540212/rhoa-rock-pathway-is-upregulated-in-experimental-autoimmune-myocarditis-and-is-inhibited-by-simvastatin-at-the-stage-of-myosin-light-chain-phosphorylation
#13
JOURNAL ARTICLE
Monika Skrzypiec-Spring, Maciej Kaczorowski, Alina Rak-Pasikowska, Agnieszka Sapa-Wojciechowska, Krzysztof Kujawa, Agnieszka Żuryń, Iwona Bil-Lula, Agnieszka Hałoń, Adam Szeląg
Many studies have proven the involvement of the RhoA/ROCK pathway in autoimmune and cardiovascular diseases and the beneficial effects of its downregulation. Here, we examined whether the effect of simvastatin on experimental autoimmune myocarditis (EAM) may be through targeting the Ras homolog family member A/Rho-associated coiled-coil containing kinases (RhoA/ROCK) pathway and whether previously shown downregulation of metalloproteinase 9 (MMP-9) could be associated with MLC phosphorylation. Two doses of simvastatin were administered to experimental rats with autoimmune myocarditis by gastric gavage for 3 weeks, at the stage of development of the inflammatory process...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38539373/clinical-symptomatology-of-anxiety-and-family-function-in-adolescents-the-self-esteem-mediator
#14
JOURNAL ARTICLE
Ignatia Farmakopoulou, Maria Lekka, Evgenia Gkintoni
BACKGROUND: Family, the child's first environment, shapes their psycho-emotional balance. The literature links adolescent anxiety to family relationships, interactions, and dynamics. The self-esteem of adolescents appears to protect their mental health. GOAL: This study examines whether family cohesion and adaptability affect adolescent anxiety symptoms. It also examines whether teen self-esteem mediates this relationship. METHOD: This cross-sectional, descriptive study included 166 Attica youth aged 12-18 from schools and educational units...
March 12, 2024: Children
https://read.qxmd.com/read/38538755/bakuchicin-alleviates-ovalbumin-induced-allergic-asthma-by-regulating-m2-macrophage-polarization
#15
JOURNAL ARTICLE
Yeon-Yong Kim, Seungwon Jeong, Seung Woong Lee, Seung-Jae Lee, Mun-Chual Rho, Sang-Hyun Kim, Soyoung Lee
OBJECTIVE: Asthma is an airway inflammatory disease caused by activation of numerous immune cells including macrophages. Bakuchicin (BKC) is known to exhibit anti-inflammatory effects and type 2 T helper (Th2) regulation, but has not been investigated for airway inflammation. This study aimed to evaluate the effects of BKC on airway inflammation and demonstrate the mechanisms of macrophage polarization. METHODS: The anti-inflammatory effects were determined using lipopolysaccharide (LPS)-stimulated macrophages...
March 27, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38538716/rock1-inhibition-improves-wound-healing-in-diabetes-via-ripk4-ampk-pathway
#16
JOURNAL ARTICLE
Tianru Huyan, Lu Fan, Zhong-Yuan Zheng, Jing-Hui Zhao, Zhen-Ru Han, Pin Wu, Qun Ma, Ya-Qin Du, Yun-di Shi, Chun-Yan Gu, Xue-Jun Li, Wen-Hui Wang, Long Zhang, Lu Tie
Refractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound healing and molecular mechanisms...
March 27, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38538220/association-of-retinal-nerve-fiber-layer-thickness-with-brain-microstructural-changes-in-participants-with-white-matter-hyperintensities
#17
JOURNAL ARTICLE
Yucong Wu, Jueyue Yan, Lu Xu, Chunfei Xu, Meiqi Zhao, Zhenxiang Zhan, Yi Lu, Xiaozhen Liu, Yungang Cao, Zhao Han
PURPOSE: White matter hyperintensity (WMH) is suggested to cause stroke and dementia in older adults. Retinal structural thicknesses revealed by optical coherence tomography (OCT) are associated with structural changes in the brain. We aimed to explore the association between the peripapillary retinal nerve fiber layer (RNFL) and cerebral microstructural changes in participants with white matter hyperintensities (WMH). METHODS: Seventy-four participants (37 controls, healthy control (HC), and 37 older adults with WMH) underwent retinal and brain imaging using OCT and magnetic resonance imaging (MRI) respectively...
March 11, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38538093/safety-and-efficacy-of-snk01-autologous-natural-killer-cells-in-combination-with-cytotoxic-chemotherapy-and-or-cetuximab-after-failure-of-prior-tyrosine-kinase-inhibitor-in-non-small-cell-lung-cancer-non-clinical-mouse-model-and-phase-i-iia-clinical-study
#18
JOURNAL ARTICLE
Myeong Geun Choi, Gun Woo Son, Mi Young Choi, Jae Seob Jung, Jin Kyung Rho, Wonjun Ji, Byeong Gon Yoon, Jong-Min Jo, Yong Man Kim, Dae-Hyun Ko, Jae Cheol Lee, Chang-Min Choi
BACKGROUND: Choosing treatments for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) patients with osimertinib resistance is challenging. We evaluated the safety and efficacy of SNK01 (autologous natural killer (NK) cells) in combination with cytotoxic chemotherapy and/or cetuximab (an anti-EGFR monoclonal antibody) in treating EGFR-mutated NSCLC in this non-clinical and phase I/IIa clinical trial. METHODS: We developed a cell line-derived xenograft-humanized mouse model with an osimertinib-resistant lung cancer cell line...
March 27, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38537632/discovery-of-yap1-taz-pathway-inhibitors-through-phenotypic-screening-with-potent-anti-tumor-activity-via-blockade-of-rho-gtpase-signaling
#19
JOURNAL ARTICLE
Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche, Joerg Weiske, Julia Kuehnlenz, Krzysztof Brzezinka, Lisette Potze, Francesca Zanconato, Barbara Nicke, Anna Montebaur, Wilhelm Bone, Sven Golfier, Stefan Kaulfuss, Charlotte Kopitz, Sabine Pilari, Holger Steuber, Sikander Hayat, Atanas Kamburov, Andreas Steffen, Andreas Schlicker, Philipp Buchgraber, Nico Braeuer, Nuria Aiguabella Font, Tobias Heinrich, Lara Kuhnke, Katrin Nowak-Reppel, Carlo Stresemann, Patrick Steigemann, Annette O Walter, Simona Blotta, Matthias Ocker, Ashley Lakner, Franz von Nussbaum, Dominik Mumberg, Knut Eis, Stefano Piccolo, Martin Lange
This study describes the identification and target deconvolution of small molecule inhibitors of oncogenic Yes-associated protein (YAP1)/TAZ activity with potent anti-tumor activity in vivo. A high-throughput screen (HTS) of 3.8 million compounds was conducted using a cellular YAP1/TAZ reporter assay. Target deconvolution studies identified the geranylgeranyltransferase-I (GGTase-I) complex as the direct target of YAP1/TAZ pathway inhibitors. The small molecule inhibitors block the activation of Rho-GTPases, leading to subsequent inactivation of YAP1/TAZ and inhibition of cancer cell proliferation in vitro...
March 19, 2024: Cell Chemical Biology
https://read.qxmd.com/read/38536923/lupus-susceptibility-gene-pbx1-controls-the-development-stability-and-function-of-regulatory-t-cells-via-rtkn2-expression
#20
JOURNAL ARTICLE
Seung-Chul Choi, Yuk Pheel Park, Tracoyia Roach, Damian Jimenez, Amanda Fisher, Mojgan Zadeh, Longhuan Ma, Eric S Sobel, Yong Ge, Mansour Mohamadzadeh, Laurence Morel
The maintenance of regulatory T (Treg ) cells critically prevents autoimmunity. Pre-B cell leukemia transcription factor 1 ( Pbx1 ) variants are associated with lupus susceptibility, particularly through the expression of a dominant negative isoform Pbx1-d in CD4+ T cells. Pbx1-d overexpression impaired Treg cell homeostasis and promoted inflammatory CD4+ T cells. Here, we showed a high expression of Pbx1 in human and murine Treg cells, which is decreased in lupus patients and mice. Pbx1 deficiency or Pbx1-d overexpression reduced the number, stability, and suppressive activity of Treg cells, which increased murine responses to immunization and autoimmune induction...
March 29, 2024: Science Advances
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