Moisés Rodríguez-González, Lorena Estepa-Pedregosa, Ana Estalella-Mendoza, Ana Castellano-Martínez, Patricia Rodríguez-Campoy, Jose Carlos Flores-González
BACKGROUND: We aimed to explore and to compare the association between the NT-proBNP and high-sensitivity troponin I (hs-cTnI) at early stages of acute bronchiolitis with echocardiographic alterations, clinical severity and outcomes. METHODS: A single centre, prospective observational study including previously healthy infants aged 1-12 months with bronchiolitis admitted to a tertiary hospital from April 2019 to March 2020. All patients underwent clinical, laboratory and echocardiographic evaluation at the same time point within 12 hours of hospital admission...
April 5, 2021: Clinica Chimica Acta; International Journal of Clinical Chemistry
Yanlin Liu, Xiaoli Duan, Xiaodi Zhao, Wenlong Ding, Yaowei Wang, Yan Xiong
The evolutionarily conserved target-of-rapamycin (TOR) kinase coordinates cellular and organismal growth in all eukaryotes. Amino acids (AAs) are key upstream signals for mammalian TOR activation, but how nitrogen-related nutrients regulate TOR signaling in plants is poorly understood. Here, we discovered that, independent of nitrogen assimilation, nitrate and ammonium function as primary nitrogen signals to activate TOR in the Arabidopsis leaf primordium. We further identified that a total of 15 proteinogenic AAs are also able to activate TOR, and the first AAs generated from plant specific nitrogen assimilation (glutamine), sulfur assimilation (cysteine), and glycolate cycle (glycine), exhibit the highest potency...
March 31, 2021: Developmental Cell
Minghui Wang, Nicholas B Gallo, Yilin Tai, Bo Li, Linda Van Aelst
Ample evidence indicates that individuals with intellectual disability (ID) are at increased risk of developing stress-related behavioral problems and mood disorders, yet a mechanistic explanation for such a link remains largely elusive. Here, we focused on characterizing the syndromic ID gene oligophrenin-1 (OPHN1). We find that Ophn1 deficiency in mice markedly enhances helpless/depressive-like behavior in the face of repeated/uncontrollable stress. Strikingly, Ophn1 deletion exclusively in parvalbumin (PV) interneurons in the prelimbic medial prefrontal cortex (PL-mPFC) is sufficient to induce helplessness...
April 1, 2021: Neuron
Hiroe Konishi McKee, Chiaki Kajiwara, Tetsuo Yamaguchi, Yoshikazu Ishii, Norikazu Shimizu, Akira Ohara, Kazuhiro Tateda
Introduction. Clostridioides difficile infection (CDI) causes toxin-mediated enteropathy, such as antibiotic-associated diarrhoea and pseudomembranous colitis. Rho-glucosylating toxin A (TcdA) and toxin B (TcdB) have been clearly implicated in pathogenesis, whereas the virulence of binary toxin (CDT) is still debated. Hypothesis statement. We hypothesized that CDT is involved in the host immune response and plays a pivotal role in establishing virulence by modulating pro-inflammatory cytokine production; this is achieved through the integral Toll-like receptor (TLR) signalling pathways...
April 2021: Journal of Medical Microbiology
Ivo Bozovic, Marina Peric, Ana Arsic Azanjac, Aleksa Palibrk, Ivana Bulatovic, Dejan Aleksic, Stojan Peric, Ivana Basta
PURPOSE: Even treated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) continues to pose a significant burden in patients' everyday functioning and may continuously affect their quality of life (QoL). The aims of our prospective study were to analyze health-related QoL in CIDP patients during a 1-year follow-up period in real-life settings and to compare QoL changes with changes in disability and with patient impression of change. METHODS: The study comprised 59 patients diagnosed with CIDP...
April 8, 2021: Quality of Life Research
Thais Regina de Mattos Lourenço, Vasilis Pergialiotis, Constantin M Durnea, Abdullatif Elfituri, Jorge Milhem Haddad, Cornelia Betschart, Gabriele Falconi, Christiana Campani Nygaard, Stergios K Doumouchtsis
INTRODUCTION AND HYPOTHESIS: Variations in outcome measures and reporting of outcomes in trials on surgery for pelvic organ prolapse (POP) using synthetic mesh have been evaluated and reported. However, the quality of outcome reporting, methodology of trials and their publication parameters are important considerations in the process of development of Core Outcome Sets. We aimed to evaluate these characteristics in randomized controlled trials on surgery for POP using mesh. METHODS: Secondary analysis of randomized controlled trials on surgical treatments using synthetic mesh for POP previously included in a systematic review developing an inventory of reported outcomes and outcome measures...
April 8, 2021: International Urogynecology Journal
Xiaohang Cheng, Bethany W Mwaura, Sophia R Chang Stauffer, Magdalena Bezanilla
Rho of Plants (ROPs) are GTPases that regulate polarity and patterned wall deposition in plants. As these small, globular proteins have many interactors, it has been difficult to ensure that methods to visualize ROP in live cells do not affect ROP function. Here, motivated by work in fission yeast (Schizosaccharomyces pombe), we generated a fluorescent moss (Physcomitrium [Physcomitrella] patens) ROP4 fusion protein by inserting mNeonGreen after Gly-134. Plants harboring tagged ROP4 and no other ROP genes were phenotypically normal...
November 2, 2020: Plant Cell
Inki Kim, Won-Sik Kim, Kwan Kim, Muhammad Afnan Ansari, Muhammad Qasim Mehmood, Trevon Badloe, Yeseul Kim, Junho Gwak, Heon Lee, Young-Ki Kim, Junsuk Rho
The rapid detection of biological and chemical substances in real time is particularly important for public health and environmental monitoring and in the military sector. If the process of substance detection to visual reporting can be implemented into a single miniaturized sensor, there could be a profound impact on practical applications. Here, we propose a compact sensor platform that integrates liquid crystals (LCs) and holographic metasurfaces to autonomously sense the existence of a volatile gas and provide an immediate visual holographic alarm...
April 2021: Science Advances
Marco Monticone, Cristiano Sconza, Igor Portoghese, Tomohiko Nishigami, Benedict M Wand, Gregorio Sorrentino, Giulia Lemorini, Stefano Respizzi, Andrea Giordano, Franco Franchignoni
BACKGROUND AND AIM: Growing attention is being given to utilising physical function measures to better understand and manage knee osteoarthritis (OA). The Fremantle Knee Awareness Questionnaire (FreKAQ), a self-reported measure of body-perception specific to the knee, has never been validated in Italian patients. The aims of this study were to culturally adapt and validate the Italian version of the FreKAQ (FreKAQ-I), to allow for its use with Italian-speaking patients with painful knee OA...
April 7, 2021: Health and Quality of Life Outcomes
Mohammad Kamal, Mohammad Abdulwahab
BACKGROUND: To evaluate the self-confidence of undergraduate dental students in relation to oral and maxillofacial surgery (OMFS) to assess the teaching curriculum at Kuwait University using a validated questionnaire originally developed by the Association of British Academic Oral Maxillofacial Surgeons (ABAOMS). METHODS: A cross-sectional survey of sixth year (n = 20) and seventh year (n = 19) dentistry students was conducted by Kuwait University Faculty of Dentistry between the 1st and 15th of May 2020...
April 7, 2021: BMC Medical Education
Ryan M Burke, Ronald A Dirkx, Pearl Quijada, Janet K Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn Woeller, Richard P Phipps, Jeffrey D Alexis, John Ashton, Eric M Small
Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts, called myofibroblasts. There are currently no therapeutic approaches to blunt the development of pathological fibrosis and ventricle chamber stiffening that ultimately leads to heart failure. Objective: We undertook a high-throughput screen to identify small molecule inhibitors of myofibroblast activation that might limit the progression of heart failure. We evaluated the therapeutic efficacy of the polyether ionophore salinomycin in patient derived cardiac fibroblasts and pre-clinical mouse models of ischemic and non-ischemic heart failure...
April 7, 2021: Circulation Research
Laura Keller, Claudine Tardy, Laetitia Ligat, Julia Gilhodes, Thomas Filleron, Nicolas Bery, Philippe Rochaix, Alexis Aquilina, Sara Bdioui, Thomas Roux, Eric Trinquet, Gilles Favre, Aurélien Olichon
As key regulators of the actin cytoskeleton, RHO GTPase expression and/or activity are deregulated in tumorigenesis and metastatic progression. Nevertheless, the vast majority of experiments supporting this conclusion was conducted on cell lines but not on human tumor samples that were mostly studied at the expression level only. Up to now, the activity of RHO proteins remains poorly investigated in human tumors. In this article, we present the development of a robust nanobody-based ELISA assay, with a high selectivity that allows an accurate quantification of RHO protein GTP-bound state in the nanomolar range (1 nM; 20 μg/L), not only in cell lines after treatment but also in tumor samples...
April 7, 2021: Analytical Chemistry
Jiong Zhang, Yuanmeng Yu, Xiaoshuang Liu, Xiong Tang, Feng Xu, Mingchao Zhang, Guotong Xie, Longjiang Zhang, Xiang Li, Zhi-Hong Liu
Background: Renal fibrosis is a key driver of progression in chronic kidney disease (CKD). Recent advances in diagnostic imaging techniques have shown promising results for the noninvasive assessment of renal fibrosis. However, the specificity and accuracy of these techniques are controversial because they indirectly assess renal fibrosis. This limits fibrosis assessment by imaging in CKD for clinical practice. To validate magnetic resonance imaging (MRI) assessment for fibrosis, we derived representative models by mapping histology-proven renal fibrosis and imaging in CKD...
March 2021: Kidney Diseases
Tatsuya Maruhashi, Yukihito Higashi
INTRODUCTION: Survival from aneurysmal subarachnoid hemorrhage has increased in the past few decades. However, functional outcome after subarachnoid hemorrhage is still suboptimal. Delayed cerebral ischemia (DCI) is one of the major causes of morbidity. AREAS COVERED: Mechanisms underlying vasospasm and DCI after aneurysmal subarachnoid hemorrhage and pharmacological treatment are summarized in this review. EXPERT OPINION: Oral nimodine, an L-type dihydropyridine calcium channel blocker, is the only FDA-approved drug for the prevention and treatment of neurological deficits after aneurysmal subarachnoid hemorrhage...
April 6, 2021: Expert Opinion on Pharmacotherapy
Isabelle Fobis-Loisy, Yvon Jaillais
The pollen tube grows inside the pistil, carrying male gametes to the ovule. During this journey, it invades diverse tissues, sensing and adapting to abrupt transitions in mechanical environment. In this issue of Developmental Cell, Zhou et al. identify a receptor-like kinase/Rho-GTPase module that regulates adaptation to such a transition.
April 5, 2021: Developmental Cell
Tansu Birinci, Eylul Pınar Kısa, Buket Akıncı, Goksen Kuran Aslan, Esen Kıyan
The aim of this study was (1) to compare the activities of daily living (ADLs), perceived falling risk and balance in chronic obstructive pulmonary disease (COPD) patients with or without falling history and (2) to investigate the relationship between ADLs and balance. Fourteen patients with COPD with a history of falling whose mean falling frequency was 2.64 ± 0.74 times in the last 12-months (fallers) and 14 age and sex-matched patients with COPD with no history of falling (non-fallers) were included...
April 6, 2021: COPD
Stéphanie Motton, Kelig Vergriete, Luc Nguyen VanPhi, Eric Lambaudie, Audrey Berthoumieu, Jean Pous, Martine Delannes, Julien Piscione, Caroline Cornou, Benoit Bataille, Diane Saxod, Fabien Pillard
PURPOSE: The benefits of regular physical exercise on the tolerability of cancer treatments, quality of life and survival rates post-diagnosis have been demonstrated but all supervised physical activities have been interrupted due to the global health crisis and the need for lockdown to halt the spread of SARS-CoV-2. To reintroduce activities post-lockdown, we wanted to assess the impact of the COVID-19 lockdown on the quality of life and the psychological status of patients who practice an adapted physical activity such as rugby for health...
April 5, 2021: Journal of Cancer Research and Clinical Oncology
Chang Dae Kum, Jung Gi Rho, Hong Kyu Park, Hae Sang Lee, Jin Soon Hwang
PURPOSE: Because small for gestational age (SGA) children who fail to experience catch-up growth have an increased risk of short stature in adulthood, growth hormone (GH) treatment is recommended for effective growth. In this study, we evaluated the effect of GH treatment during the prepubertal period and analyzed for correlation between GH treatment response and clinical factors in SGA children. METHODS: A retrospective, single-center study was conducted from 2014 to 2020...
March 2021: Annals of Pediatric Endocrinology & Metabolism
Raj Chovatiya, Donald Lei, Adnan Ahmed, Rajeev Chavda, Sylvie Gabriel, Jonathan I Silverberg
BACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes. OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity. METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592)...
April 2, 2021: Annals of Allergy, Asthma & Immunology
David Sheyn, Sara Myers, Dominique Tucker, Fred E Hazlett, Xiaolin Li, Britt Conroy, Adonis K Hijaz
INTRODUCTION AND HYPOTHESIS: To investigate differences in urine cholinergic metabolites in women with urinary urgency incontinence (UUI) and responders (R) and non-responders (NR) to anti-cholinergic medications (AC). METHODS: Patients with UUI and age-matched controls were evaluated pre- and post-treatment using OABSS, UDI-6 and IIQ-7. Controls were defined as having a cumulative OABSS of zero. Patients with UUI were treated with AC and followed for 12 weeks...
April 5, 2021: International Urogynecology Journal
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