Zhan-Guo Li, Jian-Kang Hu, Xiang-Pei Li, Yue Yang, Xing-Fu Li, Jian-Hua Xu, Xiao Zhang, Jian Xu, Chun-De Bao, Dong-Yi He, Zhi-Jun Li, Guo-Chun Wang, Xiao-Xia Zuo, Yi Liu, Zheng-Yu Xiao, Jin-Wei Chen, Xia-Fei Xin, Jing-Yang Li, Lin-Di Jiang, Meng-Ru Liu, Fei Ji, Chen-Ge Li
INTRODUCTION: Baricitinib is an oral, selective inhibitor of Janus kinase which demonstrates clinical efficacy in patients with rheumatoid arthritis (RA). This report aims to analyze the onset time of baricitinib in Chinese patients with moderately to severely active RA who had an inadequate response to methotrexate. METHODS: This post hoc analysis evaluated clinical improvements of Chinese patients treated with baricitinib 4 mg once daily compared with placebo, based on data from a phase 3 study RA-BALANCE...
November 25, 2020: Advances in Therapy
Yi Guan, Chia-Hsin Cheng, Weifan Chen, Yingqi Zhang, Sophia Koo, Maxine Krengel, Patricia Janulewicz, Rosemary Toomey, Ehwa Yang, Rafeeque Bhadelia, Lea Steele, Jae-Hun Kim, Kimberly Sullivan, Bang-Bon Koo
Gulf War illness (GWI) refers to the multitude of chronic health symptoms, spanning from fatigue, musculoskeletal pain, and neurological complaints to respiratory, gastrointestinal, and dermatologic symptoms experienced by about 250,000 GW veterans who served in the 1991 Gulf War (GW). Longitudinal studies showed that the severity of these symptoms often remain unchanged even years after the GW, and these veterans with GWI continue to have poorer general health and increased chronic medical conditions than their non-deployed counterparts...
November 20, 2020: Brain Sciences
Girija Kaimal, Rebekka Dieterich-Hartwell
Background : Although the Gulf War occurred almost 30 years ago, the chronic symptoms of Gulf War illness (GWI), which include respiratory, gastrointestinal, and skin problems, as well as fatigue, pain, and mood alterations, currently affect over 200,000 veterans. Meanwhile, healthcare providers lack clear guidelines about how to best treat this illness. The objective in this study was to learn about the perceptions and experiences of healthcare providers of GWI veterans in terms of medical symptoms, resources for treatment, and quality of care...
November 19, 2020: International Journal of Environmental Research and Public Health
Joel T Parkinson, Éimear M Foley, Deepak R Jadon, Golam M Khandaker
Depression is a major neuropsychiatric disorder common in patients with rheumatological conditions including spondyloarthritis (SpA). It is associated with higher disease activity, functional impairment, poor treatment response and quality of life in patients with musculoskeletal disorders. Using ankylosing spondylitis (AS) and psoriatic arthritis (PsA) as examples, we have reviewed the evidence regarding the burden, risk factors, potential mechanisms and clinical management of depression in spondyloarthritis...
2020: Therapeutic Advances in Musculoskeletal Disease
Peter J Bayley, R Jay Schulz-Heik, Rachael Cho, Danielle Mathersul, Linda Collery, Kamala Shankar, J Wesson Ashford, Jennifer S Jennings, Julia Tang, Melinda S Wong, Timothy J Avery, Michael Vicente Stanton, Hillary Meyer, Marcelle Friedman, Stephan Kim, Booil Jo, Jarred Younger, Binil Mathews, Matra Majmundar, Louise Mahoney
Many Veterans of the 1990-1991 Gulf War report symptoms of Gulf War Illness, a condition involving numerous chronic symptoms including pain, fatigue, and mood/cognition symptoms. Little is known about this condition's etiology and treatment. This study reports outcomes from a randomized controlled single-blind trial comparing yoga to cognitive behavioral therapy for chronic pain and other symptoms of Gulf War Illness. Participants were Veterans with symptoms of GWI: chronic pain, fatigue and cognition-mood symptoms...
November 11, 2020: Journal of Psychiatric Research
Dora Gašparini, Rudolf Ljubičić, Jasenka Mršić-Pelčić
Chronic pain is a painful condition defined by its duration where pain persists three months or more. Pain is connected with the high price of health care, work inability and disability. Moreover, it has significant consequences for patients and their families, working organizations and the society as a whole. The prevalence of chronic pain can range between 11.0% and 51.3% in general population. Pain is usually coherent with distress and a range of psychological symptoms such as depression, anxiety, altered attention and cognition manifesting as fear...
November 2020: Psychiatria Danubina
Palle Bager, Christian Lodberg Hvas, Charlotte Lock Rud, Jens Frederik Dahlerup
BACKGROUND: Fatigue is a burdensome symptom for patients with inflammatory bowel disease (IBD). Few pharmacological interventions have documented effect on fatigue in patients with IBD. A pilot study indicated a 20-day effect  with high-dose thiamine. AIMS: To investigate the effect and safety of high-dose oral thiamine (600-1800 mg/d) based on gender and weight on chronic fatigue in patients with quiescent IBD. METHODS: This was a randomised, double-blinded, placebo-controlled crossover trial...
November 18, 2020: Alimentary Pharmacology & Therapeutics
Sami O Simons, Adrian Elliott, Manuel Sastry, Jeroen M Hendriks, Michael Arzt, Michiel Rienstra, Jonathan M Kalman, Hein Heidbuchel, Stanley Nattel, Geertjan Wesseling, Ulrich Schotten, Isabelle C van Gelder, Frits M E Franssen, Prashanthan Sanders, Harry J G M Crijns, Dominik Linz
Chronic obstructive pulmonary disease (COPD) is highly prevalent among patients with atrial fibrillation (AF), shares common risk factors, and adds to the overall morbidity and mortality in this population. Additionally, it may promote AF and impair treatment efficacy. The prevalence of COPD in AF patients is high and is estimated to be ∼25%. Diagnosis and treatment of COPD in AF patients requires a close interdisciplinary collaboration between the electrophysiologist/cardiologist and pulmonologist. Differential diagnosis may be challenging, especially in elderly and smoking patients complaining of unspecific symptoms such as dyspnoea and fatigue...
November 18, 2020: European Heart Journal
Toshimori Kitami, Sanae Fukuda, Tamotsu Kato, Kouzi Yamaguti, Yasuhito Nakatomi, Emi Yamano, Yosky Kataoka, Kei Mizuno, Yuuri Tsuboi, Yasushi Kogo, Harukazu Suzuki, Masayoshi Itoh, Masaki Suimye Morioka, Hideya Kawaji, Haruhiko Koseki, Jun Kikuchi, Yoshihide Hayashizaki, Hiroshi Ohno, Hirohiko Kuratsune, Yasuyoshi Watanabe
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with no molecular diagnostics and no treatment options. To identify potential markers of this illness, we profiled 48 patients and 52 controls for standard laboratory tests, plasma metabolomics, blood immuno-phenotyping and transcriptomics, and fecal microbiome analysis. Here, we identified a set of 26 potential molecular markers that distinguished ME/CFS patients from healthy controls. Monocyte number, microbiome abundance, and lipoprotein profiles appeared to be the most informative markers...
November 16, 2020: Scientific Reports
Aditi Kumar, Matthew J Brookes
The most common complication seen in inflammatory bowel disease (IBD) patients is iron deficiency anaemia (IDA). Symptoms such as chronic fatigue can be as debilitating to IBD patients as pathological symptoms of abdominal pain and diarrhoea. Recognising and correcting anaemia may be as important as managing IBD symptoms and improving overall quality of life. Thus, iron replacement should be commenced the moment IDA is identified. Although intravenous iron is now considered standard treatment for IBD patients in Europe, oral iron still appears to be the preferred option...
November 12, 2020: Nutrients
Lindsey M Knowles, Anne Arewasikporn, Anna L Kratz, Aaron P Turner, Kevin N Alschuler, Dawn M Ehde
BACKGROUND: Depression, fatigue, and pain commonly co-occur in multiple sclerosis (MS) and are positively associated with one another. However, it is unclear whether treatment-related improvement in one of these symptoms is associated with improvements in the other two symptoms. PURPOSE: This study examined whether early improvements in depressive symptoms, fatigue impact, and pain interference during a multisymptom intervention in persons with MS were associated with overall improvements in the other two symptoms...
November 16, 2020: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Younghoon Jeon
Fibromyalgia is a syndrome characterized by chronic pain in the skeletal system accompanied by stiffness, sleep disturbance, fatigue, and psychiatric problems, such as anxiety and depression. Fibromyalgia commonly affects orofacial health, presenting with a variety of oral manifestations, including temporomandibular disorder, xerostomia, glossodynia, and dysgeusia. Therefore, oral healthcare providers need to be aware of this clinical entity to effectively manage oral symptoms and provide proper oral self-care modification and education on the nature of fibromyalgia...
October 2020: Journal of Dental Anesthesia and Pain Medicine
Yong-Yu Mei, You-Ming Chen, Yuan-Kai Wu, Xiao-Hong Zhang, Wen-Xiong Xu
Aims: The aim is to evaluate the efficacy and safety of Sofosbuvir- (SOF-) based direct-acting antiviral agents (DAAs) treatment for patients with genotype (GT) 3/6 hepatitis C virus (HCV) infection. Methods: Patients infected with GT 3/6 HCV and treated with SOF-based DAAs were enrolled in this prospective, open, single-center, and real-world study. Drugs included Sofosbuvir (SOF), Velpatasvir (VEL), Daclatasvir (DCV), and Ribavirin (RBV). The treatment regimens included SOF + RBV for 24 weeks, SOF + DCV ± RBV for 12/24 weeks, and SOF/VEL ± RBV for 12 weeks...
2020: Canadian Journal of Gastroenterology & Hepatology
Ömer Gezginaslan, Gökhan Başar
This study aims to investigate the effect of density and number of sessions extracorporeal shock wave therapy (ESWT) on pain, fatigue, disability, physical function, and quality of life in patients with plantar fasciitis (PF). Between September 2019 and December 2019, a total of 94 patients with the diagnosis of PF were included in the study. All patients were randomly divided into 3 groups. Group 1 (n = 33) received a total of 7 sessions of high-energy flux density (H-ESWT) (0.26 mJ/mm2 ) , group 2 (n = 31) received a total of 3 sessions of H-ESWT (0...
August 7, 2020: Journal of Foot and Ankle Surgery
Diana Zarantonello, Connie M Rhee, Kamyar Kalantar-Zadeh, Giuliano Brunori
PURPOSE OF REVIEW: In advanced chronic kidney disease (CKD) patients with progressive uremia, dialysis has traditionally been the dominant treatment paradigm. However, there is increasing interest in conservative and preservative management of kidney function as alternative patient-centered treatment approaches in this population. RECENT FINDINGS: The primary objectives of conservative nondialytic management include optimization of quality of life and treating symptoms of end-stage renal disease (ESRD)...
November 12, 2020: Current Opinion in Nephrology and Hypertension
Eva M Gonzalez-Soler, Arantxa Blasco-Serra, Gloria M Alfosea-Cuadrado, Marta Igual-Lopez, Jorge Orduna-Valls, Carlos Tornero-Tornero, Alfonso A Valverde-Navarro
BACKGROUND: Anticonvulsants are often prescribed as coanalgesics for pathologies presenting chronic pain, such as chronic neuropathic pain and fibromyalgia. These pathologies are associated with a wide range of comorbidities: chronic fatigue, cognitive impairment, sleep disturbances, and mood disorders. Pregabalin, an anticonvulsant used to treat fibromyalgia syndrome, has been proven to improve pain and fatigue symptoms. However, most studies have not considered the analytic effect of this drug on comorbid depressive-like symptoms in this syndrome...
November 2020: Pain Physician
Evguenia Nepotchatykh, Wesam Elremaly, Iurie Caraus, Christian Godbout, Corinne Leveau, Lynda Chalder, Catherine Beaudin, Emi Kanamaru, Renata Kosovskaia, Shawn Lauzon, Yanick Maillet, Anita Franco, Viorica Lascau-Coman, Saadallah Bouhanik, Yaned Patricia Gaitan, Dawei Li, Alain Moreau
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM...
November 12, 2020: Scientific Reports
Erdal Dilekçi, Kağan Özkuk, Barış Kaki
OBJECTIVE: This study aimed to compare whether there are positive effects of balneotherapy(BT) on pain, quality of life and disability of individuals receiving physical therapy(PT) for chronic low back pain and to examine the effect of body mass index(BMI) on treatment. MATERIALS AND METHOD: This prospective, controlled, single blind study was conducted. Patients were randomized into two groups through a simple randomization in a 1:1 ratio. The clinician and biostatistics expert were blinded...
November 2020: Complementary Therapies in Medicine
Ehab Atallah, Charles A Schiffer, Jerald P Radich, Kevin P Weinfurt, Mei-Jie Zhang, Javier Pinilla-Ibarz, Vamsi Kota, Richard A Larson, Joseph O Moore, Michael J Mauro, Michael W N Deininger, James E Thompson, Vivian G Oehler, Martha Wadleigh, Neil P Shah, Ellen K Ritchie, Richard T Silver, Jorge Cortes, Li Lin, Alexis Visotcky, Arielle Baim, Jill Harrell, Bret Helton, Mary Horowitz, Kathryn E Flynn
Importance: Tyrosine kinase inhibitors (TKIs) have been associated with improved survival of patients with chronic myeloid leukemia (CML) but are also associated with adverse effects, especially fatigue and diarrhea. Discontinuation of TKIs is safe and is associated with the successful achievement of treatment-free remission (TFR) for some patients. Objective: To evaluate molecular recurrence (MRec) and patient-reported outcomes (PROs) after TKI discontinuation for US patients with CML...
November 12, 2020: JAMA Oncology
Amr Elmoheen, Larissa Michael Mishreky, Shadi Albeiruti, Rabab Helmi Elanani, Aftab Azad
A 62-year-old female presented to the emergency department (ED) with fatigue and generalized body weakness for the last three days. Upon arrival, initial ECG showed wide complex tachycardia with sine waves and a heart rate (HR) ranging between 100-170 bpm. She was otherwise vitally stable. The patient had a past medical history of hyperaldosteronism, type 2 diabetes mellitus (DM), chronic kidney disease (CKD) with microalbuminuria, and hypertension. She also had a history of cerebrovascular accident (CVA) and residual left-sided weakness more pronounced in the upper limb...
November 6, 2020: Curēus
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