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knee cartilage

Ikufumi Takahashi, Taro Matsuzaki, Hiroshi Kuroki, Masahiro Hoso
OBJECTIVE: The aim of the study was to examine how mechanical unloading affects articular cartilage degeneration in the patellofemoral (PF) and tibiofemoral (TF) joints of a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis (OA). DESIGN: The study involved 60 male rats. Osteoarthritis was induced by intra-articular injecting MIA into both knee joints. All animals were equally divided into two groups: sedentary (SE) and hindlimb unloading (HU) groups...
March 16, 2019: Osteoarthritis and Cartilage
Won-Joon Cho, Jong-Min Kim, Bum-Sik Lee, Hyo-June Kim, Seong-Il Bin
PURPOSE: The relationship between the tear type of discoid lateral meniscus (DLM) and articular cartilage degeneration has not been well studied. METHODS: Data from patients with DLM tears who underwent arthroscopic surgery, between 2008 and 2016, were reviewed retrospectively. Demographic variables were obtained from medical records. The types of DLM and meniscal tear and status of cartilage were assessed using operation records and arthroscopic images. Patients were assigned to horizontal or non-horizontal tear groups according to the types of the tear...
March 19, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Blake A Gibson, Richard E Sobonya
Patients regularly request to take possession of their human tissues after they have become surgical pathology specimens. To date, few formal research studies have examined the prevalence of this practice or the reasoning patients' request that their specimens to be returned to them. This study interviews patients from 2015 to 2017 at one US academic medical center who requested their surgical pathology specimens. Of the 22 eligible patients, 8 patients agreed to be interviewed. Interviews lasted 10 to 30 minutes and included 5 questions...
January 2019: Academic Pathology
Eric T Beck, Allen C Bateman, Darin Maccoux
Introduction: Osteoarthritis (OA) is a common cause of knee pain in older adults. OA is primarily caused by deterioration of cartilage in the knee, which decreases the ability of synovial fluid to absorb shock and increases the opportunity for bones of the joint to rub together. Hylan G-F 20 (Synvisc-One) is a compound that can be injected directly into the knee to help combat the pain associated with OA by lubricating and cushioning the joint. Case presentation: A 92-year-old male reported to his primary care provider with complaints of pain due to OA...
February 2019: JMM Case Reports
Li-Ya Zhu, Lan Li, Zong-An Li, Jian-Ping Shi, Wen-Lai Tang, Ji-Quan Yang, Qing Jiang
BACKGROUND: Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal implants and assess their biomechanical properties. METHODS: Finite element simulations were conducted on eight different cases including intact healthy knees, knee joints with solid meniscal implants, and knee joints with meniscal implants with two types of triply periodic minimal surfaces...
March 18, 2019: Journal of Translational Medicine
Anne-Mari Mustonen, Reijo Käkelä, Mikko A J Finnilä, Andrew Sawatsky, Rami K Korhonen, Simo Saarakkala, Walter Herzog, Tommi Paakkonen, Petteri Nieminen
BACKGROUND: The infrapatellar fat pad (IFP) of the knee joint has received lots of attention recently due to its emerging role in the pathogenesis of osteoarthritis (OA), where it displays an inflammatory phenotype. The aim of the present study was to examine the infrapatellar fatty acid (FA) composition in a rabbit (Oryctolagus cuniculus) model of early OA created by anterior cruciate ligament transection (ACLT). METHODS: OA was induced randomly in the left or right knee joint of skeletally mature New Zealand White rabbits by ACLT, while the contralateral knee was left intact...
March 18, 2019: Lipids in Health and Disease
Qingjia Xu, Xuefeng Zheng, Yang Li, Lei Zhu, Zihai Ding
PURPOSE: With increasing use of the chimeric flap of the descending genicular artery, the authors systematically investigated the anatomy of its branches in cadavers. METHODS: Fifteen fresh cadaveric thighs were studied by anatomical dissection. The branches of the descending genicular arteries were skeletonized along their courses to the femoral arteries. Branches' lengths and diameters were measured to simulate the combined application of the skin, muscle, bone, osteochondral and osteocutaneous flaps with tendon enthesis...
March 19, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Tetsuro Ushio, Ken Okazaki, Kanji Osaki, Yukihisa Takayama, Koji Sagiyama, Hideki Mizu-Uchi, Satoshi Hamai, Yukio Akasaki, Hiroshi Honda, Yasuharu Nakashima
PURPOSE: Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values. METHODS: Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery...
March 16, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Hanna Schell, Elisabeth Zimpfer, Katharina Schmidt-Bleek, Tobias Jung, Georg N Duda, Leif Ryd
PURPOSE: The treatment of osteochondral defects in joint cartilage remains challenging due to its limited repair capacity. This study presents a metallic osteochondral plug with hydroxyapatite (HA)-coated cap edges for improved implant-tissue contact. The hypothesis was that improved attachment prevents from synovial fluid-influx and thereby avoids osteolysis and resulting implant instability. METHODS: In total, 24 female, adult sheep were randomized into three groups...
March 16, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Yu Wang, Jiaji Yue, Chunxi Yang
Objective: To summarize the current research progress about influence of patellofemoral osteoarthritis on clinical outcome of unicompartmental knee arthroplasty (UKA). Methods: The recent related literature was extensively reviewed and summarized, including pros and cons to regard the patellofemoral osteoarthritis as the contraindication. Results: Previous studies regarded patellofemoral osteoarthritis as the contraindication of UKA. Most of current researches show that the damage to the articular cartilage of the patellofemoral joint to the extent of full-thickness cartilage loss has no influence on outcome of UKA...
March 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Zhi Zhao, Xiu-Song Dai, Zhi-Yan Wang, Zheng-Qi Bao, Jian-Zhong Guan
OBJECTIVE: Inflammation is closely implicated in the process of osteoarthritis (OA) and affects disease progression and pain. Herein, this study explored the effect of microRNA-26a (miR-26a) on the synovial inflammation and cartilage injury in OA, with the involvement with the NF-κB signaling pathway. METHODS: Rat models of OA was established by anterior cruciate ligament transection, which were then treated with miR-26a mimics/inhibitors or BMS-345541 (inhibitor of NF-κB pathway)...
March 14, 2019: Bioscience Reports
Ljiljana Bogunovic, Nathan G Wetters, Akshay Jain, Brian J Cole, Adam B Yanke
PURPOSE: The purpose of the study is to assess the stability of a dehydrated cartilage allograft combined with platelet-rich plasma sealed with fibrin glue within trochlear and medial femoral condyle (MFC) chondral defects in a cadaver knee model. METHODS: Defects were made in the trochlea (20, 25, and 30 mm) and MFC (15, 20, and 25 mm) of 6 cadaver specimens. Allograft was applied utilizing 2 different techniques: (1) proud in which the fibrin level extends beyond surrounding cartilage and (2) recessed in which the fibrin level is even with or below the surrounding cartilage...
March 11, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Leonardo Cavinatto, Betina B Hinkel, Ryan E Tomlinson, Sunny Gupta, Jack Farr, Arthur R Bartolozzi
PURPOSE: To summarize currently available data regarding the use of bone marrow aspirate concentrate (BMAC) for the treatment of focal chondral lesions of the knee in experimental animal models and human clinical studies. METHODS: A systematic review searching for the terms "(bone marrow)" AND "(aspirate OR concentrate)" AND "(cartilage OR chondral OR osteochondral)" was performed in the databases PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar regarding the use of BMAC for the treatment of focal chondral lesions of the knee...
March 11, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Ralph Akoto, Malte Albers, Maurice Balke, Bertil Bouillon, Jürgen Höher
BACKGROUND: The objective of the study was to compare the results of a primary anterior cruciate ligament reconstruction (ACLR) using the press-fit fixation technique for a quadriceps tendon (QT) graft to a standard quadrupled hamstring (HT) graft with interference screw fixation. METHODS: A retrospective cohort study with a 12-month follow up provided data for 92 patients. Exclusion criteria were accompanying ligament injuries and contralateral ACL injury. Patients who suffered a graft failure, which was defined as a side-to-side difference of > 3 mm, or infection were rated 'D' according to the IKDC and excluded from further evaluation...
March 14, 2019: BMC Musculoskeletal Disorders
Xiaojie Dou, Zhaodong Zhang, Shuai Wang, Xuemei Zhou
BACKGROUND: In this study, the serum levels of miR-338-3p, COMP, and CS-846 were detected in the patients with KOA and healthy controls, to explore the value of miR-338-3p, COMP, and CS-846 in the early diagnosis of KOA. METHODS: Real-time PCR was carried out to evaluate the level of miR-338-3p in KOA patients and healthy controls. Spearman's correlation coefficient was performed to examine the correlation between the expression of miR-338-3p, COMP, and CS-846. Receiver operating characteristic (ROC) curves were carried out to evaluate the diagnostic values of miR-338-3p, COMP, and CS-846 for KOA patients...
March 1, 2019: Clinical Laboratory
Sean S Doyle, Edward D Lemaire, Julie Nantel, Emily H Sinitski
BACKGROUND: Osteoarthritis (OA) is a degenerative disease caused by the wearing of joint cartilage and bone. Literature has established that a prosthesis user's intact limb is at greater risk of developing OA. This study analyzed the effect of commonly encountered surface inclinations on knee joint loading measures in able-bodied and transtibial prosthesis users. METHODS: 12 transtibial prosthesis users and 12 able-bodied participants walked across level ground, up slope, down slope, and cross slope (further divided into top and bottom slope depending on the location of the limb being analyzed)...
March 12, 2019: Journal of Neuroengineering and Rehabilitation
Takanori Kumai, Naoko Yui, Kanaka Yatabe, Chizuko Sasaki, Ryoji Fujii, Mitsuko Takenaga, Hiroto Fujiya, Hisateru Niki, Kazuo Yudoh
Purpose: We previously created a self-assembled cartilage-like complex in vitro from only three cartilage components, hyaluronic acid (HA), aggrecan (AG) and type II collagen, without other materials such as cross-linking agents. Based on this self-organized AG/HA/collagen complex, we have created three novel types of biphasic cartilage and bone-like scaffolds combined with hydroxyapatite (HAP) for osteochondral tissue engineering. These scaffolds have been developed from self-assembled cartilage component molecules and HAP at the nanometer scale by manipulating the intermolecular relations...
2019: International Journal of Nanomedicine
M Zarka, E Hay, A Ostertag, C Marty, C Chappard, F Oudet, K Engelke, J D Laredo, M Cohen-Solal
OBJECTIVES: Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone. METHODS: We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin...
March 9, 2019: Bone
Frauke Wilken, Julia Slotta-Huspenina, Florian Laux, Fabian Blanke, Johannes Schauwecker, Stephan Vogt, Hans Gollwitzer
OBJECTIVE: Cam-type femoroacetabular impingement (FAI) syndrome is one of the most frequent reasons for cartilage damage in the hip. Autologous chondrocyte transplantation has proven high success rates in the treatment of focal chondral defects; however, harvesting of chondrocytes in the hip has been reported but not specifically from the region of femoral cam lesions. Therefore, the goal of this study was to analyze the growth and redifferentiation potential of cartilage samples harvested from the cam deformities in patients with FAI...
March 12, 2019: Cartilage
Yan Li, Kuan Wang, Lejun Wang, Tongbo Chang, Shengnian Zhang, Wenxin Niu
This study aimed to analyze the biomechanical response of the knee cartilage and meniscus to a typical Tai Chi (TC) movement, brush-knee and twist-step (BKTS). Kinematic and kinetic data was recorded while an experienced TC practitioner performed normal walking, jogging and BKTS. The kinetic data were then imported into a validated finite element model of the knee joint to examine the biomechanical response of the articular cartilage and meniscus. Compared with walking and jogging, the BKTS movement showed a greater increase in the range of motion (ROM) of the knee...
January 30, 2019: Mathematical Biosciences and Engineering: MBE
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