Stephanie Ramboarina, Tania Crucitti, Katherine Gill, Linda Gail Bekker, Emma Michele Harding-Esch, Janneke H H M van de Wijgert, Bich-Tram Huynh, Camille Fortas, Aina Harimanana, Théodora Mayouya Gamana, Rindra Vatosoa Randremanana, Reziky Mangahasimbola, Chido Dziva Chikwari, Katharina Kranzer, Constance R S Mackworth-Young, Sarah Bernays, Nicola Thomas, David Anderson, Fatime Ramla Tanko, Monalisa Manhanzva, Micaela Lurie, Fezile Khumalo, Edina Sinanovic, Ayako Honda, Tanya Pidwell, Suzanna C Francis, Lindi Masson, Jo-Anne Passmore
INTRODUCTION: A prototype lateral flow device detecting cytokine biomarkers interleukin (IL)-1α and IL-1β has been developed as a point-of-care test-called the Genital InFlammation Test (GIFT)-for detecting genital inflammation associated with sexually transmitted infections (STIs) and/or bacterial vaginosis (BV) in women. In this paper, we describe the rationale and design for studies that will be conducted in South Africa, Zimbabwe and Madagascar to evaluate the performance of GIFT and how it could be integrated into routine care...
May 1, 2024: BMJ Open