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Luis Guilherme de Oliveira Silva, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Mariana Dos Santos Calmon, Gabriel Lima Correa Santos, Gabriel Reis Rocha, Fabrício Freire de Melo
Pancreatic cancer (PC) is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases worldwide. However, due to its complexity, it ranks 7th in the list of the most lethal cancers worldwide. The pathogenesis of PC involves several complex processes, including familial genetic factors associated with risk factors such as obesity, diabetes mellitus, chronic pancreatitis, and smoking. Mutations in genes such as KRAS, TP53 , and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and, consequently, cancer...
April 15, 2024: World Journal of Gastrointestinal Oncology
#2
Gonzalo Nathaniel Cantú-Soriano, Álvaro Lezid Padilla-Rodríguez
Calcifying fibrous tumor (CFT) is a rare benign lesion of mesenchymal origin that may present similar characteristics to other more common tumors. We present the case of a 36-year-old woman with a tumor in the proximal jejunum, initially suspected to be a gastrointestinal stromal tumor (GIST). Surgical resection was performed, revealing a well-demarcated nodule at the anti-mesenteric border with microscopic features typical of a calcifying fibrous tumor. The tumor cells were positive for CD34 and negative for other markers, differentiating it from other neoplasms...
2024: Revista Española de Patología
#3
JOURNAL ARTICLE
Kaisheng Zhang, Xue Xiao, Xianfei Zhong, Yu Tang
A 58-year-old woman was found to have a submucosal bulging lesion in the anterior wall of the gastric fundus during a screening esophagogastroscopy. Endosonographic evaluation revealed it to be a 3.1×2.5cm, hypoechoic mass originating from muscularis propria (MP). Endoscopic full-thickness resection (EFR) was attempted. After submucosal injection, a four-fifth circumferential mucosal incision was made around the lesion. Submucosal dissection was performed to unroof the overlying mucosa, which was preserved via the remaining one-fifth circumferential mucosal edge...
March 12, 2024: Revista Española de Enfermedades Digestivas
#4
JOURNAL ARTICLE
Liliangzi Guo, Jie-Li Chen, Li-Sheng Wang, Jun Yao
NF1 is an autosomal dominant hereditary disease, with a prevalence of at least 1 in 4000-5000 population. The diagnosis criteria of NF1 included typical manifestations such as café-au-lait spots, frecking in the axilla or inguinal region, multiple neurofibromas, Lisch nodeules, and distinctive osseous lesions. Genetic testing shows NF1 mutation. It is essential for tumor surveillance in NF1 patients because their life expectancy is about 54 years due to malignancy. A case of NF-1 patient receive laparoscopic small bowel resection and finally diagnosed as adenocarcinoma and ganglioneuroma...
March 12, 2024: Revista Española de Enfermedades Digestivas
#5
Hui-Fei Lu, Jing-Jing Li, De-Bin Zhu, Li-Qi Mao, Li-Fen Xu, Jing Yu, Lin-Hua Yao
BACKGROUND: Gastric stromal tumors, originating from mesenchymal tissues, are one of the most common tumors of the digestive tract. For stromal tumors originating from the muscularis propria, compared with conventional endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR) can remove deep lesions and digestive tract wall tumors completely. However, this technique has major limitations such as perforation, postoperative bleeding, and post-polypectomy syndrome...
February 27, 2024: World Journal of Gastrointestinal Surgery
#6
JOURNAL ARTICLE
Felipe Silva, Miguel Bustamante, Gonzalo Latorre, Jorge Flandez, Isabella Montero, Eitan Dukes, Vicente Gandara, Camila Robles, Javier Uribe, Andrés Iglesias, Felipe Bellolio, María Elena Molina, Rodrigo Migueles, Gonzalo Urrejola, Tomás Larach, Nicolas Besser, Allan Sharp, Carlos Agüero, Arnoldo Riquelme, José Ignacio Vargas, Roberto Candia, Hugo Monrroy, Federico De Simone, Alberto Espino
BACKGROUND: Small bowel tumors (SBT) are infrequent and represent a small proportion of digestive neoplasms. There is scarce information about SBT in Latin America. AIM: To describe the epidemiology, clinical characteristics, diagnostic methods, and survival of malignant SBTs. METHODS: Retrospective observational study of adult patients with histopathological diagnosis of SBT between 2007-2021 in a university hospital in Chile. RESULTS: A total of 104 patients [51...
February 6, 2024: Gastroenterología y Hepatología
#7
JOURNAL ARTICLE
María de Las Nieves Sicilia Pozo, Laura García Zoghby, Aquilino López de la Osa García, Ricardo Sotillo Sánchez, Víctor Manuel Poblete García
A 69-year-old man with suspected gastrointestinal stromal tumor was referred to 18F-FDG PET/CT. Images showed increased metabolism in a jejunal wall thickening, 2 liver lesions, and hepatic lymph nodes. The patient underwent wedge biopsy of the liver, which revealed inflammatory pseudotumor. The patient was treated with 20 mg/d prednisone, with a gradual dose reduction. A partial metabolic response was achieved after 2 months of therapy, and a final PET/CT showed complete metabolic response after 9 months. This clinical case shows the potential role of PET/CT in the assessment of the response of the inflammatory pseudotumor to corticosteroid therapy...
January 16, 2024: Clinical Nuclear Medicine
#8
JOURNAL ARTICLE
J Y Blay, N Penel, T Valentin, Ph Anract, F Duffaud, A Dufresne, B Verret, A Cordoba, A Italiano, M Brahmi, C Henon, T Amouyel, I Ray-Coquard, G Ferron, P Boudou-Rouquette, C Tlemsani, S Salas, R Rochwerger, M Faron, E Bompas, A Ducassou, D Gangloff, F Gouin, N Firmin, S Piperno-Neumann, M Rios, M Ropars, J E Kurtz, L R Le Nail, F Bertucci, S Carrere, C Llacer, S Watson, S Bonvalot, A Leroux, C Perrin, J Gantzer, M Pracht, B Narciso, A Monneur, C Lebbe, A Hervieu, E Saada-Bouzid, P Dubray-Longeras, F Fiorenza, L Chaigneau, Z-M Nevieres, P Soibinet, O Bouché, C Guillemet, J P Spano, J C Ruzic, N Isambert, G Vaz, P Meeus, M Karanian, Carine Ngo, J M Coindre, G De Pinieux, F Le Loarer, F Ducimetiere, C Chemin, M Morelle, M Toulmonde, A Le Cesne
UNLABELLED: We investigated the impact of the implementation of a network of reference centers for sarcomas (NETSARC) on the care and survival of sarcoma patients in France since 2010. PATIENTS AND METHODS: NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor boards (MDTB), funded by the French INCA since 2010. Its aims are to improve the quality of diagnosis and care of sarcoma patients. Patients' characteristics, treatments and outcomes are collected in a nationwide database...
January 19, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#9
JOURNAL ARTICLE
Deborah van de Wal, Dide den Hollander, Ingrid M E Desar, Hans Gelderblom, Astrid W Oosten, Anna K L Reyners, Neeltje Steeghs, Olga Husson, Winette T A van der Graaf
BACKGROUND: This study aims to (1) investigate the prevalence of anxiety, depression and severe fear of cancer recurrence or progression in gastrointestinal stromal tumor (GIST) patients treated in a curative or palliative setting, (2) compare their prevalence with a norm population, (3) identify factors associated with anxiety, depression and severe fear, and (4) study the impact of these psychological symptoms on health-related quality of life (HRQoL). METHODS: In a cross-sectional study, GIST patients completed the Hospital Anxiety and Depression Scale, Cancer Worry Scale, and EORTC QLQ-C30...
2024: International Journal of Clinical and Health Psychology: IJCHP
#10
JOURNAL ARTICLE
Maria Gómez Otero, Eduardo Valdivielso Cortázar, Carmen Cabezal Iglesias, Lucía Pérez Vior, Laura Pardeiro Mariño, Roque Nogueira Fariña, Sara Gamundi Barros, Pedro Alonso Aguirre
Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract and a rare cause of gastrointestinal bleeding. These tumors usually affect people over 50 years of age and they exhibit a wide range of clinical manifestations, including asymptomatic patients, nonspecific symptoms, obstruction or bleeding, which may delay diagnosis. Early diagnosis and treatment are crucial because GISTs can be aggressive and metastasize. This case highlights the importance of considering GISTs in the differential diagnosis of obscure gastrointestinal bleeding...
January 11, 2024: Revista Española de Enfermedades Digestivas
#11
JOURNAL ARTICLE
Roberto Martí-Obiol, Rosa Martí-Fernández, Maria Carmen Fernández-Moreno, Maria Eugenia Barrios-Carvajal, Fernando López-Mozos
INTRODUCTION: Our aim is to analyze the differences between sporadic gastrointestinal stromal tumors and those associated with other tumors. METHODS: Retrospective cohort study including patients with diagnosis of gastrointestinal stromal tumors operated at our center. Patients were divided into two groups, according to whether or not they had associated other tumors, both synchronously and metachronously. Disease free survival and overall survival were calculated for both groups...
December 20, 2023: Cirugia española
#12
JOURNAL ARTICLE
Roos F Bleckman, K Esther Broekman, Evelyne Roets, Mohammed Mohammadi, Ingrid M E Desar, Hans Gelderblom, Ron H J Mathijssen, Neeltje Steeghs, Pauline de Graeff, Anna K L Reyners
BACKGROUND: While the effectiveness of tyrosine kinase inhibitors (TKIs) seems similar in older patients with gastrointestinal stromal tumors (GIST) compared with younger patients, toxicities in older patients treated with TKIs more often lead to discontinuation of treatment. OBJECTIVE: To better understand the age-related pharmacology and pharmacodynamic differences in patients with GIST treated with TKIs, the primary aim of this study was to evaluate TKI dosing patterns in older patients with GIST, while the secondary aims were to evaluate differences in imatinib trough plasma concentrations between age groups and to compare the overall survival (OS) in patients with and without dose reductions in all treatment lines in a palliative setting...
December 20, 2023: Drugs & Aging
#13
JOURNAL ARTICLE
Lorenzo D'Ambrosio, Elena Fumagalli, Tommaso Martino De Pas, Margherita Nannini, Alexia Bertuzzi, Silvia Carpano, Antonella Boglione, Angela Buonadonna, Danila Comandini, Silvia Gasperoni, Bruno Vincenzi, Antonella Brunello, Giuseppe Badalamenti, Elena Maccaroni, Giacomo Giulio Baldi, Alessandra Merlini, Andrea Mogavero, Francesca Ligorio, Elisabetta Pennacchioli, Fabio Conforti, Giulia Manessi, Sandra Aliberti, Francesco Tolomeo, Marco Fiore, Marta Sbaraglia, Angelo Paolo Dei Tos, Silvia Stacchiotti, Maria Abbondanza Pantaleo, Alessandro Gronchi, Giovanni Grignani
IMPORTANCE: Gastrointestinal stromal tumor (GIST) follow-up is recommended by international guidelines, but data on the role of follow-up in patients with low relapse risk are missing. For these patients, the potential benefit of anticipating recurrence detection should be weighed against psychological burden and radiologic examination loads in terms of costs and radiation exposure. OBJECTIVE: To evaluate the outcomes of guideline-based follow-up in low-risk GIST...
November 1, 2023: JAMA Network Open
#14
JOURNAL ARTICLE
Min Li, Haina Chai, Xiufan Ni, Sujun Gao, Lei Chen, Denghao Deng, Zhen Zhu
We reported a patient diagnosed as Gastrointestinal stromal tumor according to the patient's age, past medical history, and CT images, but interestingly, SGIH was diagnosed on the basis of postoperative pathology after surgery.
October 26, 2023: Revista Española de Enfermedades Digestivas
#15
JOURNAL ARTICLE
Stijn J C van der Burg, Deborah van de Wal, Evelyne Roets, Neeltje Steeghs, Johanna W van Sandick, Martijn Kerst, Frits van Coevorden, Koen J Hartemink, Xander A A F A Veenhof, Anne Miek Koenen, Nikki Ijzerman, Winette T A van der Graaf, Yvonne M Schrage, Winan J van Houdt
BACKGROUND: Neoadjuvant imatinib is considered for gastrointestinal stromal tumors (GISTs) when decreased tumor size provides less extensive surgery and higher R0 resection rates. This study evaluates the effectivity and safety of neoadjuvant imatinib for large or locally advanced GIST. PATIENTS AND METHODS: From the prospective database of the Dutch GIST Consortium, all patients who underwent surgery after neoadjuvant imatinib at our center between 2009 and 2022 were selected...
October 9, 2023: Annals of Surgical Oncology
#16
Qi-Xing Gong, Ying Ding, Wei-Ming Zhang, Jia-Wen Zhang, Zhi-Hong Zhang
The dedifferentiation of the gastrointestinal stromal tumors (GISTs) has been reported in a small number of cases, usually under the pressure of the tyrosine kinase inhibitor (TKI) treatment. Herein, we described a de novo dedifferentiated GIST with the SDH deficiency in a 32-year-old Chinese woman. The tumor was located on the lesser curvature of the gastric antrum, measuring 4.1x9.1 cm2 . Microscopically, the tumor was composed of 2 distinct morphological populations, mild epithelioid cells arranged in the multinodular growth pattern and hyperchromatic spindle cells arranged in the fascicular or sheet-like architecture...
2023: Frontiers in Oncology
#17
JOURNAL ARTICLE
Maria Manuela Estevinho, João Varanda, Rolando Pinho, Fernando Viveiros, Susana Graça, Carlos Soares, Antónia Póvoa, Manuel Oliveira
We describe a case of coexistence of multiple gastrointestinal stromal tumors (GIST) and pheochromocytoma in a 32-year-old patient with neurofibromatosis type 1. The coexistence of these two conditions in patients with this syndrome is extremely rare.
December 2023: Revista Española de Enfermedades Digestivas
#18
JOURNAL ARTICLE
Chen Yuan, Youhong Cao
A 45-year-old male visited our hospital for a medical examination without any clinical complaints. The patient had an gastroscopy, which revealed a 30mm*30mm hemispherical submucosal tumor arising from the lesser curvature of the gastric body , suggesting a gastrointestinal stromal tumor (GIST) as a preoperative diagnosis;Endoscopic resection was determined to be the best choice and the patient underwent a endoscopic full-thickness resection and endoscopic purse-string suture. Except for a slight low fever, the patient was well recovered and was discharged on his 7th post-operation...
October 2023: Revista Española de Enfermedades Digestivas
#19
JOURNAL ARTICLE
Yazhuo Zhao, Liangrong Shi
Neurofibromatosis type I is a relatively rare inherited disorder. Simultaneous occurrence of abdominal tumors of three types in NF-I and causing intussusception is rare. We report a synchronous case of small bowel gastrointestinal stromal tumor, small bowel adenocarcinoma, and ganglioneuroma complicated by intussusception in an old woman with NF-I. The patient presented with a 2-month history of abdominal pain and multiple neurofibromas and café au lait macules was found all over the patient's body. The enhanced computed tomography revealed a terminal ileal tumor which was significantly enhanced with secondary intussusception...
September 21, 2023: Revista Española de Enfermedades Digestivas
#20
Daniela Martins, Pedro Costa, Gonçalo Guidi, Pedro Pinheiro, João A Pinto-de-Sousa
Jejunal gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal (GI) tract and a rare cause of massive GI bleeding. Due to this rarity and non-specific presentation, diagnosis and treatment may be difficult and often delayed. Urgent surgical intervention is crucial for controlling the source of bleeding and total tumor excision. Herein, we present the case of a 40-year-old male who presented to the emergency room (ER) with features of upper GI bleeding. He referred astheny and black stools, and was pale, sweaty, and tachycardic despite normal blood pressure...
August 2023: Curēus
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