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REVIEW
Laurent Souci, Caroline Denesvre
This article reviews the avian viruses that infect the skin of domestic farm birds of primary economic importance: chicken, duck, turkey, and goose. Many avian viruses (e.g., poxviruses, herpesviruses, Influenza viruses, retroviruses) leading to pathologies infect the skin and the appendages of these birds. Some of these viruses (e.g., Marek's disease virus, avian influenza viruses) have had and/or still have a devasting impact on the poultry economy. The skin tropism of these viruses is key to the pathology and virus life cycle, in particular for virus entry, shedding, and/or transmission...
April 26, 2024: Veterinary Research
#2
JOURNAL ARTICLE
Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Ilka Pinz, Calvin Vary, Larisa Ryzhova, Lucy Liaw
BACKGROUND: RAB27A, a modulator of secretion, is expressed within vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function. METHODS: Body weight of Rab27a ash mice was measured from 2 to 18 months of age, along with glucose resorption at 6 and 12 months of age and glucose sensitivity at 18 months of age. Body weight and cellular and molecular features of perivascular adipose tissue and aortic tissue were examined in a novel C57BL/6J Rab27a null strain...
April 25, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#3
RANDOMIZED CONTROLLED TRIAL
A Clairoux, A Moore, M Caron-Goudreault, M Soucy-Proulx, M Thibault, V Brulotte, M E Bélanger, J Raft, N Godin, M Idrissi, J Desroches, M Ruel, A Fortier, P Richebé
INTRODUCTION: There is a sizable niche for a minimally invasive analgesic technique that could facilitate ambulatory video-assisted thoracoscopic surgery (VATS). Our study aimed to determine the analgesic potential of a single-shot erector spinae plane (ESP) block for VATS. The primary objective was the total hydromorphone consumption with patient-controlled analgesia (PCA) 24 h after surgery. METHODS: We conducted a randomized, controlled, double-blind study with patients scheduled for VATS in two major university-affiliated hospital centres...
April 23, 2024: BMC Anesthesiology
#4
JOURNAL ARTICLE
Kristiana Xhima, Julie Ottoy, Erin Gibson, Katherine Zukotynski, Christopher Scott, Ginelle J Feliciano, Sabrina Adamo, Phillip H Kuo, Michael J Borrie, Howard Chertkow, Richard Frayne, Robert Laforce, Michael D Noseworthy, Frank S Prato, Demetrios J Sahlas, Eric E Smith, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Maged Goubran, Sandra E Black, Joel Ramirez
INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate-severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18 F-AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape...
April 4, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#5
JOURNAL ARTICLE
Ting Qiu, Zhen-Qi Liu, François Rheault, Jon Haitz Legarreta, Alex Valcourt Caron, Frédéric St-Onge, Cherie Strikwerda-Brown, Amelie Metz, Mahsa Dadar, Jean-Paul Soucy, Alexa Pichet Binette, R Nathan Spreng, Maxime Descoteaux, Sylvia Villeneuve
INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties...
April 1, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#6
Jonathan R Soucy, Emil Kriukov, Julia Oswald, John Masland, Chris Pernstich, Petr Baranov
Retinal ganglion cells (RGCs) lack regenerative capacity in mammals, and their degeneration in glaucoma leads to irreversible blindness. Traditional RGC transplantation has been limited by poor survival rates of transplanted cells in the hostile microenvironment of a diseased retina. Our research identifies brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) as key elements in retinal development and RGC survival through in silico analysis of the single-cell transcriptome of developing human retinas...
March 12, 2024: bioRxiv
#7
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington de Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel de la Hoya, Anna deFazio, Allison DePersia, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah
BACKGROUND: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS). METHODS: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed...
March 4, 2024: medRxiv
#8
JOURNAL ARTICLE
Camille Legault-Denis, Étienne Aumont, Kate M Onuska, Taylor W Schmitz, Aurélie Bussy, Mallar Chakravarty, Jean-Paul Soucy, Marc-André Bédard
Although brain cholinergic denervation has been largely associated with cognitive decline in patients with Parkinson's disease (PD), new evidence suggests that cholinergic upregulation occurs in the hippocampus of PD patients without cognitive deficits. The specific hippocampal sectors and potential mechanisms of this cholinergic compensatory process have been further studied here, using MRI volumetry and morphometry coupled with molecular imaging using the PET radiotracer [18 F]-Fluoroethoxybenzovesamicol ([18 F]-FEOBV)...
March 13, 2024: Brain Imaging and Behavior
#9
REVIEW
Freimut Juengling, Frank Wuest, Ralf Schirrmacher, Jonathan Abele, Alexander Thiel, Jean-Paul Soucy, Richard Camicioli, Valentina Garibotto
PET imaging is increasingly recognized as an important diagnostic tool to investigate patients with cognitive disturbances of possible neurodegenerative origin. PET with 2-[18 F]fluoro-2-deoxy-D-glucose ([18 F]FDG), assessing glucose metabolism, provides a measure of neurodegeneration and allows a precise differential diagnosis among the most common neurodegenerative diseases, such as Alzheimer's disease, frontotemporal dementia or dementia with Lewy bodies. PET tracers specific for the pathological deposits characteristic of different neurodegenerative processes, namely amyloid and tau deposits typical of Alzheimer's Disease, allow the visualization of these aggregates in vivo ...
March 4, 2024: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
#10
JOURNAL ARTICLE
Jean-Paul R Soucy, Marcelo Low, Kamal R Acharya, Moriah Ellen, Anette Hulth, Sonja Löfmark, Gary E Garber, William Watson, Jacob Moran-Gilad, Nadav Davidovitch, Tamar Amar, Janine McCready, Matthew Orava, John S Brownstein, Kevin A Brown, David N Fisman, Derek R MacFadden
Tools to advance antimicrobial stewardship in the primary health care setting, where most antimicrobials are prescribed, are urgently needed. The aim of this study was to evaluate OPEN Stewarship (Online Platform for Expanding aNtibiotic Stewardship), an automated feedback intervention, among a cohort of primary care physicians. We performed a controlled, interrupted time-series study of 32 intervention and 725 control participants, consisting of primary care physicians from Ontario, Canada and Southern Israel, from October 2020 to December 2021...
February 27, 2024: Microbiology Spectrum
#11
JOURNAL ARTICLE
Samik Roy Moulik, Yingming Lai, Aida Amini, Patrick Soucy, Kenneth R Beyerlein, Jinyang Liang
A long-standing motivation driving high-speed electron microscopy development is to capture phase transformations and material dynamics in real time with high spatial and temporal resolution. Current dynamic transmission electron microscopes (DTEMs) are limited to nanosecond temporal resolution and the ability to capture only a few frames of a transient event. With the motivation to overcome these limitations, we present our progress in developing a streak-mode DTEM (SM-DTEM) and demonstrate the recovery of picosecond images with high frame sequence depth...
January 2024: Structural Dynamics (Melville, N.Y.)
#12
Koichi Sudo, Amber Delmas-Eliason, Shannon Soucy, Kaitlyn E Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael James, Courtney L Hegner, Henry D Dionne, Alexander Rodriguez-Palacios, Henry Krause, George A O'Toole, Saul J Karpen, Paul A Dawson, Daniel Schultz, Mark S Sundrud
Bile acids (BAs) are gastrointestinal metabolites that serve dual functions in lipid absorption and cell signaling. BAs circulate actively between the liver and distal small intestine (i.e., ileum), yet the dynamics through which complex BA pools are absorbed in the ileum and interact with intestinal cells in vivo remain ill-defined. Through multi-site sampling of nearly 100 BA species in individual wild type mice, as well as mice lacking the ileal BA transporter, Asbt/Slc10a2, we calculate the ileal BA pool in fasting C57BL/6J mice to be ~0...
February 18, 2024: bioRxiv
#13
JOURNAL ARTICLE
Ashutosh Kumar, Jun Hatayama, Alex Soucy, Ethan Carpio, Nassim Rahmani, Constantine Anagnostopoulos, Mohammad Faghri
This study presents an integrated approach to understanding fluid dynamics in Microfluidic Paper-Based Analytical Devices (µPADs), combining empirical investigations with advanced numerical modeling. Paper-based devices are recognized for their low cost, portability, and simplicity and are increasingly applied in health, environmental monitoring, and food quality analysis. However, challenges such as lack of flow control and the need for advanced detection methods have limited their widespread adoption...
January 31, 2024: Micromachines
#14
JOURNAL ARTICLE
Kamal R Acharya, Adar Cohen, Gabrielle Brankston, Jean-Paul R Soucy, Anette Hulth, Sonja Löfmark, John S Brownstein, Nadav Davidovich, Moriah E Ellen, David N Fisman, Jacob Moran-Gilad, Amir Steinman, Derek R MacFadden, Amy L Greer
An interrupted time-series study design was implemented to evaluate the impact of antibiotic stewardship interventions on antibiotic prescribing among veterinarians. A total of 41 veterinarians were enrolled in Canada and Israel and their prescribing data between 2019 and 2021 were obtained. As an intervention, veterinarians periodically received three feedback reports comprising feedback on the participants' antibiotic prescribing and prescribing guidelines. A change in the level and trend of antibiotic prescribing after the administration of the intervention was compared using a multi-level generalized linear mixed-effect negative-binomial model...
February 16, 2024: Animals: An Open Access Journal From MDPI
#15
JOURNAL ARTICLE
Tanguy Demaret, Karine Bédard, Jean-François Soucy, David Watkins, Pierre Allard, Alina Levtova, Alan O'Brien, Catherine Brunel-Guitton, David S Rosenblatt, Grant A Mitchell
Mutations in MMACHC cause cobalamin C disease (cblC, OMIM 277400), the commonest inborn error of vitamin B12 metabolism. In cblC, deficient activation of cobalamin results in methylcobalamin and adenosylcobalamin deficiency, elevating methylmalonic acid (MMA) and total plasma homocysteine (tHcy). We retrospectively reviewed the medical files of seven cblC patients: three compound heterozygotes for the MMACHC (NM_015506.3) missense variant c.158T>C p.(Leu53Pro) in trans with the common pathogenic mutation c...
February 10, 2024: Molecular Genetics and Metabolism
#16
JOURNAL ARTICLE
Michele LeBlanc, Michael Soucy, Moustafa Moustafa-Bayoumi, Dalziel Soto, Jeff Nessler
Osteoporosis and loss of muscle mass are secondary issues with spinal cord injury. Robotic gait training has provided evidence of increasing bone density and muscle mass, but its effect on bone strength is undetermined. The purpose of this study was to determine the effect of a 6-week robotic locomotion training program on skeletal muscle mass and bone characteristics. Twelve female Sprague-Dawley rats received a mid-thoracic spinal cord transection at 5 days old and at 3 weeks old were assigned to a Control or Trained Group...
February 20, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#17
JOURNAL ARTICLE
Maxim Soucy-Proulx, Hiromi Kato, Sean Coeckelenbergh, Salima Naili Kortaia, Laurence Herboulier, Gabriella Pittau, Patrick Pham, Antoinette Lemoine, Jacques Duranteau, Stéphanie Roullet
BACKGROUND: Liver transplantation (LT) remains a potentially haemorrhagic procedure whose perioperative bleeding and transfusion could be better monitored using point-of-care devices. Quantra® is a device based on sonorheometry to assess whole blood clot formation. Our aims were to describe Quantra® parameters during LT and to study their correlations with standard laboratory parameters, and to determine Quantra® cut-off values for thrombocytopenia, hypofibrinogenemia and coagulation factors' deficit...
January 25, 2024: Journal of Clinical Medicine
#18
JOURNAL ARTICLE
Shady Rahayel, Ronald Postuma, Andrée-Ann Baril, Bratislav Misic, Amélie Pelletier, Jean-Paul Soucy, Jacques Montplaisir, Alain Dagher, Jean-François Gagnon
BACKGROUND AND OBJECTIVES: Idiopathic/isolated REM sleep behavior disorder (iRBD) is associated with dementia with Lewy bodies and Parkinson disease. Despite evidence of abnormal cerebral perfusion in iRBD, there is currently no pattern that can predict whether an individual will develop dementia with Lewy bodies or Parkinson disease. The objective was to identify a perfusion signature associated with conversion to dementia with Lewy bodies in iRBD. METHODS: Patients with iRBD underwent video-polysomnography, neurologic and neuropsychological assessments, and baseline 99m Tc-HMPAO SPECT to assess relative cerebral blood flow...
February 2024: Neurology
#19
JOURNAL ARTICLE
Janel Soucie, Beth Roland, Sierra Parsons, Teresa M Cavanaugh
Creating a welcoming and supportive environment for learners with disabilities needs to be a focus within pharmacy education. Including students with disabilities enhances program diversity and contributes to awareness and understanding of disability. Barriers to embracing disability include stigma toward disability, insufficient resource allocation, and misunderstanding of accommodations. Steps that need to be taken to embrace disability include evaluation of current programmatic culture, provision of education, and collaboration with external stakeholders...
January 6, 2024: American Journal of Pharmaceutical Education
#20
JOURNAL ARTICLE
Joseph Therriault, Marcel S Woo, Gemma Salvadó, Johan Gobom, Thomas K Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C Macedo, Firoza Z Lussier, Jenna Stevenson, Paolo Vitali, Manuel A Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
BACKGROUND: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau181 , p-tau217 and p-tau231 with established immunoassay techniques. METHODS: We measured p-tau181 , p-tau217 and p-tau231 concentrations in CSF from 173 participants from the TRIAD cohort and 394 participants from the BioFINDER-2 cohort using both mass spectrometry and immunoassay methods...
January 7, 2024: Molecular Neurodegeneration
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