kidney or glomerulonephritis

Yohko Nagai, Fumito Yamabe, Yosuke Sasaki, Takamasa Ishii, Kazushige Nakanishi, Koichi Nakajima, Kazutoshi Shibuya, Tetsuo Mikami, Yoshikiyo Akasaka, Yoshihisa Urita, Nobuaki Yamanaka
BACKGROUND: Renin-angiotensin-aldosterone system blockers are known to reduce hypertrophy of vascular smooth muscle cells (SMCs) in hypertensive cases. However, we have reported marked proliferative changes of renal afferent arteriolar SMCs in rats induced by a long-term administration of angiotensin II type 1 receptor blockers (ARBs) and an angiotensin-converting enzyme inhibitor (ACEI). In this study, we examined the morphological changes of afferent arteriolar walls in human kidneys with or without ARBs/ACEIs...
January 16, 2020: Kidney & Blood Pressure Research
Julita Piasecka, Elzbieta Lenartowicz, Marta Soszynska-Jozwiak, Barbara Szutkowska, Ryszard Kierzek, Elzbieta Kierzek
The influenza A virus is a human pathogen that poses a serious public health threat due to rapid antigen changes and emergence of new, highly pathogenic strains with the potential to become easily transmitted in the human population. The viral genome is encoded by eight RNA segments, and all stages of the replication cycle are dependent on RNA. In this study, we designed small interfering RNA (siRNA) targeting influenza segment 5 nucleoprotein (NP) mRNA structural motifs that encode important functions. The new criterion for choosing the siRNA target was the prediction of accessible regions based on the secondary structure of segment 5 (+)RNA...
December 24, 2019: Molecular Therapy. Nucleic Acids
Temitope Isaac Adelusi, Lei Du, Meng Hao, Xueyan Zhou, Qian Xuan, Chowdhury Apu, Ying Sun, Qian Lu, Xiaoxing Yin
Hyperglycemia/oxidative stress has been implicated in the initiation and progression of diabetic complications while the components of Keap1/Nrf2/ARE signaling are being exploited as therapeutic targets for the treatment/management of these pathologies. Antioxidant agents like drugs, nutraceuticals and pure compounds that target the proteins of this pathway and their downstream genes hold the therapeutic strength to put the progression of this disease at bay. Here, we elucidate how the modulation of Keap1/Nrf2/ARE had been exploited for the treatment/management of end-stage diabetic kidney complication (diabetic nephropathy) by looking into (1) Nrf2 nuclear translocation and phosphorylation by some protein kinases at specific amino acid sequences and (2) Keap1 downregulation/Keap1-Nrf2 protein-protein inhibition (PPI) as potential therapeutic mechanisms exploited by Nrf2 activators for the modulation of diabetic nephropathy biomarkers (Collagen IV, Laminin, TGF-β1 and Fibronectin) that ultimately lead to the amelioration of this disease progression...
January 13, 2020: Biomedicine & Pharmacotherapy
Yasmina M Abd El-Hakim, Walaa El-Houseiny, Abd Elhakeem El-Murr, Lamiaa L M Ebraheim, Amr A Moustafa, Amany Abdel Rahman Mohamed
Currently, feed adulteration and contamination with melamine (MEL) are considered one of the serious issues in the aquatic industry. With the limited studies of MEL exposure alone in fish, its adverse impacts on fish cannot be evaluated well. Accordingly, this study aimed to investigate the effects of MEL containing diets on the immune response, disease resistance to Aeromonas hydrophila, growth performance, chemical composition, immune-related genes expression, and histopathology of both spleen and head kidneys...
January 10, 2020: Aquatic Toxicology
Kylee L Martens, Parisa R Khalighi, Shan Li, Andrew A White, Emily Silgard, Deborah Frieze, Eli Estey, David A Garcia, Sangeeta Hingorani, Ang Li
While rasburicase has shown efficacy to rapidly correct hyperuricemia compared with allopurinol, its overall impact in improving clinically significant outcomes, such as acute kidney injury (AKI), in tumor lysis syndrome (TLS) is unknown. In this retrospective cohort study, we included all hospitalized cancer patients with hyperuricemia and AKI who received rasburicase +/- allopurinol or allopurinol alone from 2009 to 2015. Inverse probability of treatment weighting using propensity score was used to account for potential confounders and to estimate the causal effect associated with differential drug treatment...
January 7, 2020: Leukemia Research
Mohammad Ali Ghaed, Maziar Daniali, Paniz Motaghi, Hamid Jalali Sohi
INTRODUCTION: Renal angiomyolipoma (also called renal hamartoma) is a benign Tumor, composed of adipose tissue, smooth muscle tissue, and blood vessels. Tumors more than 10 cm (referred to as "giant" AMLs) are infrequent and a very small number of reported cases were measured more than 20 cm. Epithelioid angiomyolipoma (EAML), is a rare variant of angiomyolipoma with malignant potential. There are less than 10 cases of huge EAML reported in English literature, that were all associated with recurrence and complications...
December 28, 2019: International Journal of Surgery Case Reports
Jinglou Chen, Jianhua Liu, Yongfang Lei, Min Liu
The environmental pollution caused by cigarette smoke (CS) seriously endangers people's health. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. In this study, rats were exposed to CS for 90 days. Kidney function was evaluated by detecting the levels of serum creatinine and blood urea nitrogen. Liver function was evaluated by detecting the activities of alanine aminotransferase and aspartate transaminase. The renal and hepatic oxidative stress and inflammation were assessed by detecting the levels of malondialdehyde, reduced glutathione, antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and proinflammatory cytokines...
January 13, 2020: Ecotoxicology and Environmental Safety
Takahiro Kikuyama, Takao Susa, Mimi Tamamori-Adachi, Masayoshi Iizuka, Miho Akimoto, Hiroko Okinaga, Yoshihide Fujigaki, Shunya Uchida, Shigeru Shibata, Tomoki Okazaki
Recently, it was reported that 25(OH)D3 (25D3) has physiological bioactivity in certain tissues derived from Cyp27b1 knockout mice. To investigate the function of 25D3 in the kidney as an informational crossroad of various calciotropic substances, we employed the CRISPR-Cas9 system to knock out Cyp27b1 in the mouse renal distal tubular mDCT cell line. Unlike the previously reported mice in which Cyp27b1 was targeted systemically, Cyp27b1 knockout mDCT cells did not produce any measurable 1α,25(OH)2 D3 (1,25D3) after 25D3 administration...
January 13, 2020: Journal of Steroid Biochemistry and Molecular Biology
Anumita Kumari, Shivani A Muthu, Prem Prakash, Basir Ahmad
Lysozyme amyloidosis (ALys) is caused by the deposition of amyloid-like fibrils of lysozyme in the tissues of the gastrointestinal tract, liver and kidneys. The treatment/prevention of ALys is not known yet. Therefore, searching for therapeutic agents for amyloidosis is of great value. In this study, we have examined the ability of the aqueous extract of herbalome (thirty herbal components) Chandraprabha Vati (EHCV), a polyherbal Ayurvedic formulation, to prevent fibrillation of lysozyme. Transmission electron microscopy and multiple biophysical techniques were used to examine the processes...
January 13, 2020: International Journal of Biological Macromolecules
Rui-Bo Jia, Juan Wu, Zhao-Rong Li, Zhi-Rong Ou, Qiyuan Zhu, Baoguo Sun, Lianzhu Lin, Mouming Zhao
Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, molecular weight distribution, microstructure and rheological properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg·body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats...
January 13, 2020: International Journal of Biological Macromolecules
Ning Xu, Miao Li, Wei-Chun Chou, Zhoumeng Lin
The extensive use of doxycycline in aquaculture results in drug residue violations that negatively impact human food safety. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for doxycycline to predict drug residues and withdrawal times (WTs) in grass carp (Ctenopharyngodon idella) after daily oral administration for 3 days. Physiological parameters including cardiac output and organ weights were measured experimentally. Chemical-specific parameters were obtained from the literature or estimated by fitting to the observed data...
January 13, 2020: Food and Chemical Toxicology
Zhuoting Zhu, Huan Liao, Wei Wang, Jane Scheetz, Jian Zhang, Mingguang He
PURPOSE: To investigate the prevalence and associations of visual impairment (VI), major eye diseases with chronic kidney disease (CKD) in the US. DESIGN: Cross-sectional study. METHODS: We investigated the prevalence and associations of VI, major eye diseases with CKD among 5,518 participants aged 40 years or older in the 2005-2008 National Health and Nutrition Examination Survey. An estimated glomerular filtration rate of lower than 60 ml/min/1...
January 13, 2020: American Journal of Ophthalmology
Soo Jung Lee, Sabrina Blanchett-Anderson, Simon G Keep, Mitchell B Gasche, Michael M Wang
A large number of pre-clinical and developmental investigations involve experimental vertebrate animals, of which mice have emerged as a favored organism. Recognition of the differences between humans and mice is essential for assessment of the relevance of animal studies to humans. The primary purpose of this study was to gauge the conservation between human and mouse vascular smooth muscle cell (VSMC) proteins mined from an analysis of the Human Protein Atlas. Two comparison were made: a) immunohistochemistry for 16 proteins in brain, heart, esophagus, bladder, stomach, lung, kidney, and aorta enabled comparison between human and mouse of protein localization in VSMC and non-vascular SMC; and b) multi-species primary protein sequence analysis of an expanded set vascular molecules enabled comparison between VSMC sequences among vertebrate species...
2020: PloS One
Nobuhiko Miyatake, Hiroki Adachi, Kanae Nomura-Nakayama, Keiichiro Okada, Kazuaki Okino, Norifumi Hayashi, Keiji Fujimoto, Kengo Furuichi, Hitoshi Yokoyama
BACKGROUND: Cardiovascular disease (CVD) due to atherosclerosis is a major cause of death in renal allograft recipients. Recently, C1q/TNF-α related protein-9 (CTRP9), which is a paralog of adiponectin (ADPN), has been suggested to be related to the prevention of atherosclerosis and the occurrence of CVD, but this relationship has not been confirmed in renal allograft recipients. SUBJECTS AND METHODS: The relationships among the serum CTRP9 concentration, serum ADPN concentration, and vascular calcification were investigated in 50 kidney transplantation recipients at our hospital...
2020: PloS One
Wenkai Xiao, Yi Wen, Ping Ye, Fan Wang, Ruihua Cao, Yongyi Bai, Hongmei Wu
The purpose of this study was to investigate the prognostic properties of different BP measurements for renal function decrement and early chronic kidney disease (CKD) in community-dwelling populations with normal renal function at baseline. A total of 1426 participants were included and followed for a median of 4.8 years (interquartile range, 4.5-5.2), and central hemodynamic profile and estimated glomerular filtration rate (eGFR) were evaluated. One main outcome was the rapid eGFR decline defined as a decline in eGFR of greater than 3 mL/min per 1...
January 15, 2020: Journal of Clinical Hypertension
Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappa, Vanessa Esnault, Sabine Graf-Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L Dols
Cirrhosis is a complex disease that is associated with disturbances in different organs besides the liver, including kidneys, heart, arterial circulation, lungs, gut, and brain. As a consequence, patients develop a number of complications that result in frequent hospital admissions and high morbidity and mortality. Patients with cirrhosis require constant and rigorous monitoring both in and outside the hospital. In this context, the role of nurses in the care of patients with cirrhosis has not been sufficiently emphasized and there is very limited information about nursing care of patients with cirrhosis compared to other chronic diseases...
January 16, 2020: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Jun Matsuda, Atsushi Takahashi, Yoshitsugu Takabatake, Shinsuke Sakai, Satoshi Minami, Takeshi Yamamoto, Ryuta Fujimura, Tomoko Namba-Hamano, Hiroaki Yonishi, Jun Nakamura, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Tamotsu Yoshimori, Yoshitaka Isaka
Macroautophagy/autophagy is a lysosomal degradation system which plays a protective role against kidney injury. RUBCN/Rubicon (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein) inhibits the fusion of autophagosomes and lysosomes. However, its physiological role in kidney proximal tubular epithelial cells (PTECs) remains uncertain. In the current study, we analyzed the phenotype of newly generated PTEC-specific rubcn -deficient (KO) mice. Additionally, we investigated the role of RUBCN in lipid metabolism using isolated rubcn -deficient PTECs...
January 16, 2020: Autophagy
Huda A O Al-Jumayi, Hassan A Elhendy, Amira M G Darwish
BACKGROUND AND OBJECTIVE: The evidence for safe consumption of chili pepper to gain health benefits is insufficient as high doses reported to cause gastric erosion. The objective of this study was to investigate the contribution of red chili pepper ethanol extract (RCEE) to weight loss in high fat dieted female albino Wistar rats while monitoring adverse effects of high dose consumption. MATERIALS AND METHODS: Body weight gain, lipid profile, oxidative stress parameters, liver, kidney and thyroid biochemical functions were determined in addition to histopathological examination of liver and kidney to determine biological effects of 2 ingested concentrations of red chili pepper extract (5 and 10 mg)...
January 2020: Pakistan Journal of Biological Sciences: PJBS
Kathrine Sivertsen Åsrud, Ronja Bjørnstad, Reidun Kopperud, Line Pedersen, Barbara van der Hoeven, Tine Veronica Karlsen, Cecilie Brekke Rygh, Fitz-Roy Curry, Marit Bakke, Rolf K Reed, Olav Tenstad, Stein Ove Døskeland
AIM: The cAMP-mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1-/- mice. We hypothesized that Epac1 could restrict diuresis by promoting trans-cellular collecting duct water and urea transport or by stabilizing CD para-cellular junctions to reduce osmolyte loss from the renal papillary interstitium. METHODS: In Epac1-/- and Wt C57BL/6J mice, renal papillae, dissected from snap-frozen kidneys, were assayed for content of key osmolytes...
January 13, 2020: Acta Physiologica
Aijing Liu, Concetta Ferretti, Fu-Dong Shi, Irun R Cohen, Francisco J Quintana, Antonio La Cava
OBJECTIVE: To address whether a targeted modulation of the abnormal expression of heat shock protein (HSP)70 and autoantibodies against this molecule in systemic lupus erythematosus (SLE) can influence disease. METHODS: Lupus-prone (NZB x NZW)F1 mice that had been DNA-vaccinated with plasmids encoding HSP70 or controls were monitored for lupus disease parameters including anti-dsDNA autoantibodies and cytokines by enzyme-linked immunosorbent assay (ELISA), and for kidney function and pathology...
January 13, 2020: Arthritis & Rheumatology
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