kidney or glomerulonephritis

Yue Zhou, Liyan Shen, Bingzi Dong, Chuanfeng Liu, Lv Wenshan, Jingwei Chi, Kui Che, Yanyan Gao, Yunyang Wang, Yangang Wang
BACKGROUD: Associations between sex hormones and diabetic vascular complications was recently studied, but the role luteinizing hormone (LH), playing in diabetic kidney disease (DKD) remains uncertain. We aimed to investigate the relationship of LH and DKD in Chinese men and postmenopausal women with type 2 diabetes mellitus (T2DM). METHODS: Data were collected from 1775 T2DM men and postmenopausal women in hospital. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to LH quartiles were obtained by multiple logistic regression analysis...
May 31, 2020: Journal of Diabetes
Malini Mukherjee, Ishara Ratnayake, Madhusudhana Janga, Eric Fogarty, Shania Scheidt, Justin Grassmeyer, Jennifer deRiso, Indra Chandrasekar, Phil Ahrenkiel, Raphael Kopan, Kameswaran Surendran
Alagille syndrome patients present with loss of function mutations in either JAG1 or NOTCH2. About 40%-50% of patients have kidney abnormalities, and frequently display multicystic, dysplastic kidneys. Additionally, gain-of-function mutations in NOTCH2 are associated with cystic kidneys in Hajdu-Cheney syndrome patients. How perturbations in Notch signaling cause renal tubular cysts remains unclear. Here, we have determined that reduced Notch signaling mediated transcription by ectopic expression of dominant-negative mastermind-like (dnMaml) peptide in the nephrogenic epithelia from after the s-shaped body formation and in the developing collecting ducts results in proximal tubular and collecting duct cysts, respectively...
May 31, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Ting Liu, Jialing Yuan, Caihong Dai, Jinxian Xu, Shude Li, Benjamin D Humphreys, Daniel T Kleven, Jian-Kang Chen
Nephron loss stimulates residual functioning nephrons to undergo compensatory growth. Excessive nephron growth may be a maladaptive response that sets the stage for progressive nephron damage, leading to kidney failure. To date, however, the mechanism of nephron growth remains incompletely understood. Our previous study revealed that class III phosphatidylinositol-3-kinase (Pik3c3) is activated in the remaining kidney after unilateral nephrectomy (UNX)-induced nephron loss, but previous studies failed to generate a Pik3c3 gene knockout animal model...
May 31, 2020: Journal of Cellular Physiology
Sara E Howden, Melissa H Little
The ultimate goal of regenerative medicine is to have access to an unlimited supply of specific cell types on demand, which can be used as effective therapies for a wide range of intractable disorders. With the availability of human pluripotent stem cells (hPSCs) and greatly improved protocols for their directed differentiation into specific cell types, including kidney, this prospect could soon become a reality. We have previously described the generation of kidney organoids from hPSCs. This chapter describes our latest differentiation protocol for generating kidney tissue, which uses a cost-effective and completely defined, xeno-free medium...
2020: Methods in Molecular Biology
Nete Tofte, Frederik Persson, Peter Rossing
The use of "omics" is increasing in research areas looking to identify biomarkers or early preclinical signs of disease or to increase understanding of complex pathological processes that determines prognosis of the disease. Diabetic kidney disease is no exception as it is an area in need of further improvement of both understanding and prognosis. In addition, there is a notion that pretreatment investigations using techniques like proteomics, lipidomics and metabolomics can help individualize therapy thus fulfilling the wish for personalized medicine...
May 30, 2020: Journal of Nephrology
Virginie Blanchard, Claire Courtellemont, Eve Cariou, Pauline Fournier, Yoan Lavie-Badie, Pierre Pascal, Michel Galinier, Nassim Kamar, Didier Carrié, Olivier Lairez
The relationship between arteriovenous access flow (Qa) and cardiovascular changes is complex. Several studies have shown cardiac remodeling and symptoms of heart failure for high-flow arteriovenous fistulas (AVF). To evaluate the early cardiovascular impact of AVF. Forty-seven patients with an AVF, hospitalized for the evaluation of high-flow AVF or a pre-kidney transplant assessment were included. We collected clinical and biological data. We also collected data of the assessment by transthoracic echocardiography, functional evaluation by 6-min-walk test and peak oxygen consumption, and measurement of coronary flow reserve by dynamic myocardial perfusion imaging...
May 30, 2020: Heart and Vessels
Jan M Hughes-Austin, Ronit Katz, Richard D Semba, Stephen Kritchevsky, Douglas C Bauer, Mark J Sarnak, Charles Ginsberg, Michael G Shlipak, Florence Lima, Hartmut H Malluche, Joachim H Ix
BACKGROUND: We sought to identify biomarkers that indicate low turnover on bone histomorphometry in CKD patients, and subsequently determined if this panel identified differential risk for fractures in community-living older adults. METHODS: Among CKD patients who underwent iliac crest bone biopsies and histomorphometry, we evaluated candidate biomarkers to differentiate low turnover from other bone disease. We applied this biomarker panel to 641 participants in the Health ABC study with eGFR<60 mL/min/1...
May 31, 2020: Journal of Clinical Endocrinology and Metabolism
Miyang Luo, Linda Wei Lin Tan, Xueling Sim, Milly Khiam Hoon Ng, Rob Van Dam, E Shyong Tai, Kee Seng Chia, Wern Ee Tang, Darren Ej Seah, Kavita Venkataraman
PURPOSE: The diabetic cohort (DC) was set up to study the determinants of complications in individuals with type 2 diabetes and examine the role of genetic, physiological and lifestyle factors in the development of complications in these individuals. PARTICIPANTS: A total of 14 033 adult participants with type 2 diabetes were recruited from multiple public sector polyclinics and hospital outpatient clinics in Singapore between November 2004 and November 2010. The first round of follow-up was conducted for 4131 participants between 2012 and 2016; the second round of follow-up started in 2016 and is expected to end in 2021...
May 30, 2020: BMJ Open
Sameh El Kribi-Boukhris, Iteb Boughattas, Nesrine Zitouni, Sondes Helaoui, Valérie Sappin-Didier, Cécile Coriou, Sylvie Bussiere, Mohamed Banni
Mining activity may cause heavy metal accumulation, which threatens human and animal health by their long-term persistence in the environment. This study aims to assess the impact of polymetallic pollution on chicken (Gallus domesticus) from old lead mining sites in northeast of Tunisia: Jebel Ressas (JR). Samples of soil and chickens were collected from five sites being ranked along a gradient of heavy metal contamination. Heavy metal loads were evaluated in soil samples and in chicken liver and kidney. Biochemical evaluation of oxidative stress parameters termed as Catalase (CAT), Glutathione-S-Transferase (GST), and Malondialdehydes (MDA) accumulation was monitored...
May 20, 2020: Environmental Pollution
Michael P Whyte, Nina S Ma, Steven Mumm, Gary S Gottesman, William H McAlister, Angela R Nenninger, Vinieth N Bijanki, Karen L Ericson, Per Magnusson
Alkaline phosphatase (ALP) in humans comprises a family of four cell-surface phosphomonoester phosphohydrolase isozymes. Three genes separately encode the "tissue-specific" ALPs whereas the fourth gene encodes ubiquitous homodimeric "tissue-nonspecific" ALP (TNSALP) richly expressed in bone, liver, kidney, and developing teeth. TNSALP monomers have five putative N-linked glycosylation sites where different post-translational modifications account for this isozyme's distinctive physicochemical properties in different organs...
May 28, 2020: Bone
Jeff Ehresman, Andrew Schilling, Xinghai Yang, Zach Pennington, A Karim Ahmed, Ethan Cottrill, Daniel Lubelski, Majid Khan, Kendall F Moseley, Daniel M Sciubba
BACKGROUND: Current evidence suggests that dual-energy X-ray absorptiometry (DXA) scans, the conventional method defining osteoporosis, is underutilized and, when used, may underestimate patient risk for skeletal fragility. It has recently been suggested that other imaging modalities may better estimate bone quality, such as the magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score which also may assess vertebral compression fracture risk in patients with spine metastases...
May 28, 2020: Spine Journal: Official Journal of the North American Spine Society
James B Wetmore, Charles A Herzog, Anne Sexter, David T Gilbertson, Jiannong Liu, Scott E Kasner
RATIONALE & OBJECTIVE: The associations between ischemic stroke and time to dialysis initiation and/or death in adults with late-stage chronic kidney disease (CKD) have not been explored. We sought to measure the rate and factors associated with stroke in CKD stages 4 and 5 and to assess the association of stroke with initiation of dialysis and death. STUDY DESIGN: Retrospective cohort SETTING & PARTICIPANTS: Patients with CKD4-5 in Medicare, 2007-2014 EXPOSURE OR PREDICTOR: Ischemic stroke in CKD4-5...
May 28, 2020: American Journal of Kidney Diseases
Aline Bayerle, Christian Marsching, Mariona Rabionet, Shaalee Dworski, Mustafa A Kamani, Chandramohan Chitraju, Nina L Gluchowski, Katlyn R Gabriel, Silke Herzer, Richard Jennemann, Thierry Levade, Jeffrey A Medin, Roger Sandhoff
Except for epidermis and liver, little is known about endogenous expression of 1-O-acylceramides (1-OACs) in mammalian tissue. Therefore, we screened several organs (brain, lung, liver, spleen, lymph nodes, heart, kidney, thymus, small intestine, and colon) from mice for the presence of 1-OACs by LC-MS2 . In most organs, low levels of about 0.25-1.3 pmol 1-OACs/mg wet weight were recorded. Higher levels were detected in liver, small and large intestines, with about 4-13 pmol 1-OACs/mg wet weight. 1-OACs were esterified mainly with palmitic, stearic, or oleic acids...
May 28, 2020: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
Hany M R Abdel-Latif, Mohsen Abdel-Tawwab, Asmaa F Khafaga, Mahmoud A O Dawood
The use of herbal essential oils in aquafeeds is an important approach to maintain the fish health status. The oregano essential oil (OEO), extracted from Origanum vulgare, was included at levels of 0, 5, 10, 15, and 20 g per kg diet to evaluate its beneficial effects on antioxidant, immunity status, and expression of immune-related genes of common carp, Cyprinus carpio L. After 8 weeks, dietary inclusion of OEO significantly increased the activities of hepatic superoxide dismutase and catalase (P < 0...
May 28, 2020: Fish & Shellfish Immunology
Maoliang Su, Ran Zhang, Nanxi Liu, Junbin Zhang
Salinity changes on renal osmoregulation have often been investigated while the immune response of the kidney under osmotic stress is poorly understood in teleosts. Acute stress is generally associated with enhancement of circulating cortisol. The effects of osmotic stress on renal immune response and its regulation by cortisol deserve more attention. In the present study, the effects of exogenous cortisol treatment on the lipopolysaccharide (LPS)-induced immune response were analyzed in renal masses of Scatophagus argus under different osmotic stresses in vitro...
May 28, 2020: Fish & Shellfish Immunology
Heba A Sahyon, Sami A Al-Harbi
This study aimed to present a new heart of P. dactylifera (HP) extract loaded chitosan nanoparticles and estimate its anticancer, antimicrobial, antioxidant activity and free radical scavenger effect (in vitro). This nano-supplement may prevent doxorubicin cardiotoxicity and nephrotoxicity in rat model. The HP extract was loaded on chitosan nanoparticles producing HP-ChNPs, then characterized. The antioxidant properties of the HP-ChNPs was assessed in vitro. The antibacterial activity against three-gram positive bacteria and two gram-negative bacteria were done...
May 28, 2020: International Journal of Biological Macromolecules
Niels Hadrup, Anoop K Sharma, Katrin Loeschner, Nicklas R Jacobsen
Silver is used in a wide range of products, and during their production and use, humans may be exposed through inhalation. Therefore, it is critical to know the concentration levels at which adverse effects may occur. In rodents, inhalation of silver nanoparticles has resulted in increased silver in the lungs, lymph nodes, liver, kidney, spleen, ovaries, and testes. Reported excretion pathways of pulmonary silver are urinary and faecal excretion. Acute effects in humans of the inhalation of silver include lung failure that involved increased heart rate and decreased arterial blood oxygen pressure...
May 28, 2020: Regulatory Toxicology and Pharmacology: RTP
Katharina Schultrich, Colin J Henderson, Thorsten Buhrke, Albert Braeuning
2-Monochloropropane-1,3-diol (2-MCPD) and its isomer 3-monochloropropane-1,2-diol (3-MCPD) are widespread food contaminants. 3-MCPD has been classified as a non-genotoxic carcinogen, whereas very limited toxicological data are available for 2-MCPD. Animal studies indicate that heart and skeletal muscle are target organs of 2-MCPD. Oxidative stress may play a role in this process, and the potential of 3-MCPD to induce oxidative stress in vivo has already been demonstrated. To investigate the potential of 2-MCPD to induce oxidative stress in vivo, a 28-day oral feeding study in male HOTT reporter mice was conducted...
May 28, 2020: Food and Chemical Toxicology
Xiaojun Hu, Chenguang Ding, Xiaoming Ding, Ping Fan, Jin Zheng, Heli Xiang, Xiao Li, Yuxi Qiao, Wujun Xue, Yang Li
As a major risk factor of acute kidney injury, renal ischemia/reperfusion (I/R) has a high mortality rate. Myeloid differentiation protein 2 (MD-2) is a secretory glycoprotein that plays an important role in inflammation. Our study aimed to explore the roles of MD-2 in I/R-induced inflammation and oxidative stress in vivo and in vitro. For the in vivo studies, male C57BL/6 mice were randomly divided into one of for treatments groups: 1) sham, 2) I/R, 3) negative control for siRNA and I/R treatment, or 4) MD-2 siRNA and I/R...
May 28, 2020: Life Sciences
Ahmed Abdelhalim, Ashraf T Hafez, Mohamed Dawaba
Ureteral extension of childhood renal tumors is exceedingly rare. Hematuria, hydronephrosis, poorly or non-functioning kidney should raise suspicion for ureteral tumor extension. Identifying ureteral extension on preoperative imaging or intraoperatively before ureteral transection is crucial to obtain good oncological outcome without unnecessary exposure to radiation therapy or more intensive chemotherapy. In this report, we present three children with cystic renal tumors extending into the ureter and review the relevant literature...
May 28, 2020: Urology
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