kidney or glomerulonephritis

Rita Cerejeira Matos, Helena Oliveira, Henrique M A C Fonseca, Simone Morais, Bechan Sharma, Conceição Santos, Maria de Lourdes Pereira
CCA (Chromium Copper Arsenate) treated wood, widely used in outdoor residential structures and playgrounds, poses considerable dangers of leaching of its components to the environment. In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3 ) and arsenic pentoxide (As2 O5 ) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 h of animal exposure. While Cr had no statistically significant cytostatic effects, As2 O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage...
November 6, 2019: Environmental Toxicology and Pharmacology
Mohini Guleria, Tapas Das, Jeyachitra Amirdhanayagam, Haladhar D Sarma, Ashutosh Dash
INTRODUCTION: [177 Lu]Lu-DOTA-Ahx-Lys40-Exendin-4 ([177 Lu]Lu-DOTA-Exendin-4) is a potential agent for radiotherapy of insulinomas owing to its specificity towards GLP-1 (Glucagon like peptide-1) receptors over-expressed on such cancers. The objective of the present study is to optimize the various radiochemistry parameters for the consistent formulation of the agent with high radiolabeling yield using carrier added [177 Lu]LuCl3 and also to evaluate its biological behaviour in small animal model...
November 9, 2019: Nuclear Medicine and Biology
Thomas Smol, Wassila Ribero-Karrouz, Patrick Edery, Daniela Brindusa Gorduza, Sophie Catteau-Jonard, Sylvie Manouvrier-Hanu, Jamal Ghoumid
Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a rare malformative disorder, characterized by congenital aplasia of the uterus and the upper two thirds of the vagina (MIM #277000). For a majority of patients, the disorder remained without identified genetic cause. However, four recurrent microdeletions, i.e. 1q21.1-16p11.2-17q12 and 22q11.21, as well as variants in genes contained in these loci, have been identified in a small number of cases. We describe an additional patient with 2q12.1q14.1 microdeletion, showing MRKH and congenital hypothyroidism due to thyroid gland hypoplasia...
November 12, 2019: European Journal of Medical Genetics
Justine M Abais-Battad, Hayley Lund, John Henry Dasinger, Daniel J Fehrenbach, Allen W Cowley, David L Mattson
Previous studies utilizing the SSp67phox-/- rat have demonstrated the importance of systemic NADPH oxidase NOX2-derived reactive oxygen species (ROS) production in the pathogenesis of Dahl Salt-Sensitive (SS) hypertension and renal damage. It is established that the immune system contributes to the development of SS hypertension and our laboratory has observed an enrichment of NOX2 subunits in infiltrating T cells. However, the contribution of immune cell-derived ROS in SS hypertension remains unknown. To assess the role of ROS in immune cells, SSp67phox-/- rats underwent total body irradiation and received bone marrow transfer from either SS (+SS) or SSp67phox-/- (+SSp67phox-/- ) donor rats...
November 12, 2019: Free Radical Biology & Medicine
Yinnan Mu, Wanru Li, Bin Wu, Jiong Chen, Xinhua Chen
Fish live in direct contact with aquatic environment, which exhibits much wider temporal and spatial variations in oxygen content. The molecular mechanisms underlying fish response to hypoxia have become a subject of great concern in recent years. In the present study, we performed transcriptome analysis of spleen and head kidney tissues from large yellow croaker (Larimichthys crocea) at 6 h, 24 h and 48 h after hypoxia challenge. A total of 2,499 and 3,685 differentially expressed genes (DEGs) were obtained in spleen and head kidney, respectively...
November 12, 2019: Fish & Shellfish Immunology
Nana Liang, Xuanyu Jiang, Lanlan Zeng, Zhuo Li, Desheng Liang, Lingqian Wu
BACKGROUND: Cilia play an important role in cellular signaling pathways. Defective ciliary function causes a variety of disorders involve retina, skeleton, liver, kidney or others. Cilia-related kidney disorders are characterized by cystic renal disease, nephronophthisis and renal failure in general. METHODS: In this study, we collected 33 families clinically suspected of cilia-related kidney disorders. Capture-based next-generation sequencing (NGS) of 88 related genes, Sanger sequencing, pedigree analysis and functional study were performed to analyze their genetic cause...
November 12, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Qian Wang, Zhe-Yi Dong, Wei-Guang Zhang, Xiao-Min Liu, Yi-Lun Qu, Shu-Wei Duan, Meng-Jie Huang, Jian-Hui Zhou, Pu Chen, Han-Yu Zhu, Li Zhang, Xue-Feng Sun, Guang-Yan Cai, Xiang-Mei Chen
AIM: Serum anti-phospholipase A2 receptor (anti-PLA2R) antibodies are highly accurate in diagnosing idiopathic membranous nephropathy (IMN) in populations with kidney disease. However, the diagnostic value of anti-PLA2R antibodies for IMN in diabetic kidney disease (DKD) is unclear. The objective of this study is to determine the diagnostic efficacy and the optimal cut-off value of this marker in populations with DKD. METHODS: This study included 227 patients with type 2 diabetes who were admitted to the Department of Nephrology of the Chinese People's Liberation Army General Hospital from May 2016 to January 2018 and underwent pathological diagnosis by renal biopsy...
November 12, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Xiaodong Liu, Yu Bai, Xiaoming Zhou, Xiu Gu, Li Zhao
WHAT IS KNOWN AND OBJECTIVE: Membranous nephrotic syndrome is one of the most commonly seen paraneoplastic nephropathies. CASE DESCRIPTION: We describe a 59-year-old man who was referred with massive unilateral pleural effusion and was subsequently diagnosed with lung adenocarcinoma. Routine physical and laboratory examinations revealed lower limb oedema, hypoproteinaemia and proteinuria. Examination of a kidney biopsy aspirate confirmed the diagnosis of membranous nephropathy...
November 15, 2019: Journal of Clinical Pharmacy and Therapeutics
Olivia D Lara, Ying Wang, Amma Asare, Tao Xu, Hau-Sheng Chiu, Yuexin Liu, Wei Hu, Pavel Sumazin, Shitanshu Uppal, Lin Zhang, J Alejandro Rauh-Hain, Anil K Sood
BACKGROUND: Racial disparities in cancer outcomes are increasingly recognized, but comprehensive analyses, including molecular studies, are limited. The objective of the current study was to perform a pan-cancer clinical and epigenetic molecular analysis of outcomes in African American (AA) and European American (EA) patients. METHODS: Cross-platform analyses using cancer databases (the Surveillance, Epidemiology, and End Results program database and the National Cancer Data Base) and a molecular database (The Cancer Genome Ancestry Atlas) were performed to evaluate clinical and epigenetic molecular differences between AA and EA patients based on genetic ancestry...
November 15, 2019: Cancer
Harmke J Groot, Flora E van Leeuwen, Sjoukje Lubberts, Simon Horenblas, Ronald de Wit, J Alfred Witjes, Gerard Groenewegen, Philip M Poortmans, Maarten C C M Hulshof, Otto W M Meijer, Igle J de Jong, Hetty A van den Berg, Tineke J Smilde, Ben G L Vanneste, Maureen J B Aarts, Katarzyna Jóźwiak, Alexandra W van den Belt-Dusebout, Jourik A Gietema, Michael Schaapveld
BACKGROUND: Although testicular cancer (TC) treatment has been associated with severe late morbidities, including second malignant neoplasms (SMNs) and ischemic heart disease (IHD), cause-specific excess mortality has been rarely studied among patients treated in the platinum era. METHODS: In a large, multicenter cohort including 6042 patients with TC treated between 1976 and 2006, cause-specific mortality was compared with general population mortality rates. Associations with treatment were assessed with proportional hazards analysis...
November 15, 2019: Cancer
Séverine Bézie, Béatrice Charreau, Nadège Vimond, Juliette Lasselin, Nathalie Gérard, Véronique Nerrière-Daguin, Frédérique Bellier-Waast, Franck Duteille, Ignacio Anegon, Carole Guillonneau
Polyclonal CD8+CD45RClow/- Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)-specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing acute as well as chronic rejection in rodent models. The difficulty of identifying disease-relevant antigens able to stimulate Tregs has reduced the possibility of obtaining antigen-specific Tregs. To bypass this requirement and gain the advantage of antigen specificity, and thus improve the therapeutic potential of CD8+ Tregs, we stably introduced a chimeric antigen receptor (CAR) derived from a HLA-A*02 antigen-specific antibody (A2-CAR) in human CD8+ Tregs and developed a clinically compatible protocol of transduction and expansion...
November 26, 2019: Blood Advances
Luke Kumar, Russell Greiner
Cancer is one of the leading cause of death, worldwide. Many believe that genomic data will enable us to better predict the survival time of these patients, which will lead to better, more personalized treatment options and patient care. As standard survival prediction models have a hard time coping with the high-dimensionality of such gene expression data, many projects use some dimensionality reduction techniques to overcome this hurdle. We introduce a novel methodology, inspired by topic modeling from the natural language domain, to derive expressive features from the high-dimensional gene expression data...
2019: PloS One
Roshni Sadashiv, Balappa Murgappa Bannur, Praveenkumar Shetty, Udupi Shastry Dinesh, Jamboor K Vishwanatha, Subhash Krishnarao Deshpande, Anil Bargale, Sarathkumar E, Komal Ruikar
Background The expression in the glomerular mesangial cells, papillary, and collecting duct cells demonstrated annexin A1 (AnxA1)'s role in specific renal functions. With varying concentrations of calcium (Ca2+), it is considered to regulate cellular processes such as cell proliferation, apoptosis, and clearance of apoptotic cells by forming ceramides, a key lipid mediator of apoptosis. It also participates in tumorigenesis based on its location. On account of these features, we investigated the expression of this apoptosis-associated protein in fetal kidneys at different gestational periods, mature kidneys and in kidney cancer tissues in order to localize and possibly characterize its role during nephrogenesis and renal tumors...
November 14, 2019: Journal of Basic and Clinical Physiology and Pharmacology
Loreto Arias Fernández, Jacobo Pardo Seco, Miriam Cebey-López, Ruth Gil Prieto, Irene Rivero-Calle, Federico Martinon-Torres, Ángel Gil de Miguel, F Martinón-Torres, D Vargas, E Mascarós, E Redondo, J L Díaz-Maroto, M Linares-Rufo, A Gil, J Molina, D Ocaña, I Rivero-Calle
BACKGROUND: Diabetes is one of the underlying risk factors for developing community-acquired pneumonia (CAP). The high prevalence of diabetes among population and the rising incidence of this illness, converts it as an important disease to better control and manage, to prevent its secondary consequences as CAP. The objective of this research is to describe the characteristics of the patients with diabetes and the differences with the no diabetes who have had an episode of CAP in the context of the primary care field...
November 15, 2019: BMC Infectious Diseases
Ho-Ryun Won, Jae Yoon Kang, In Ho Lee, Jin-Man Kim, Jae Won Chang, Bon Seok Koo
BACKGROUND: Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease that requires vigilant treatment due to its high mortality rate. Pharmacologic therapy is recommended as an initial treatment; if there is no response, a total parathyroidectomy is performed. In some cases, surgery is accompanied by auto-transplantation of parathyroid tissue. CASE PRESENTATION: The patient was diagnosed with chronic kidney disease and received a kidney transplant...
November 15, 2019: BMC Nephrology
Ambarish Athavale, Hemant Kulkarni, Cagil D Arslan, Peter Hart
BACKGROUND: Desmopressin is used to reduce bleeding after kidney biopsy but evidence supporting its use is weak, especially in patients with elevated creatinine. The present study was undertaken to evaluate efficacy of desmopressin in reducing bleeding after percutaneous kidney biopsy. METHODS: Retrospective cohort study. 269 of 322 patients undergoing percutaneous kidney biopsy between January 1, 2014 and January 31, 2018 were included. Patients had normal bleeding time, platelet count and coagulation profile...
November 15, 2019: BMC Nephrology
Babak J Orandi, Jayme E Locke
The incidence rate of end-stage renal disease (ESRD) is projected to increase 11-18% by 2030, with the exact rate dependent on obesity trends.1 Nearly 40% of the adult U.S. population is obese, with class 3 obesity prevalence (body-mass index [BMI] ≥40)-a common upper limit for waitlisting at kidney transplant centers--of 5.5% for men and 9.9% for women.2 Obesity and ESRD are intricately linked, as the former contributes to the latter, mediated at least partly by obesity-related comorbidities (hypertension and diabetes) and hyperfiltration injury...
November 15, 2019: American Journal of Transplantation
J P Sheppard, K L Tucker, W J Davison, R Stevens, W Aekplakorn, H B Bosworth, A Bove, K Earle, M Godwin, B B Green, P Hebert, C Heneghan, N Hill, F D R Hobbs, I Kantola, S M Kerry, A Leiva, D J Magid, J Mant, K L Margolis, B McKinstry, M A McLaughlin, K McNamara, S Omboni, O Ogedegbe, G Parati, J Varis, W J Verberk, B J Wakefield, R J McManus
BACKGROUND: Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS: A systematic review was conducted of articles published in Medline, Embase and the Cochrane Library up to January 2018. Randomised controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested...
November 15, 2019: American Journal of Hypertension
Viren Ahluwalia, Faizel Osman, Jitendra Parmar, Jamal Nasir Khan
Despite 3D echocardiography (3DE) acquiring significantly greater data than standard 2D echocardiography (2DE), it is underutilized in assessing cardiac anatomy and physiology. A key advantage is the ability of a single 3DE acquisition to be post-processed to generate volume rendered 3D models and an unlimited number of multiplanar reconstruction (MPR) images. We describe the case of a highly anxious patient with life-threatening complex aortic valve endocarditis and aortic root abscess, refusing transesophageal echocardiography (TOE) under general anaesthesia with tachycardia, breathlessness and acute kidney injury precluding accurate or safe gated (computed tomography) CT, who was comprehensively assessed with a rapid 3DE-TOE under sedation...
October 1, 2019: Echo Research and Practice
Liz J Walker, Rhiannon L Wallace, James J Smith, Trudy Graham, Themy Saputra, Sally Symes, Anastasia Stylianopoulos, Benjamin G Polkinghorne, Martyn D Kirk, Kathryn Glass
The aim of this study was to investigate the prevalence and distribution of Campylobacter species in a variety of fresh and frozen meat and offal products collected from retail outlets in New South Wales (NSW), Queensland (Qld), and Victoria (Vic). A total of 1,490 chicken, beef, lamb, and pork samples were collected from Australian supermarkets and butcher shops over a 2-year sampling period (October 2016 to October 2018). Campylobacter spp. were detected in 90% of chicken meat and 73% of chicken offal products (giblet and liver), with significantly lower prevalence in lamb (38%), pork (31%), and beef (14%) offal (kidney and liver)...
November 15, 2019: Journal of Food Protection
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