Maria B Sokol, Veronika A Beganovskaya, Mariia R Mollaeva, Nikita G Yabbarov, Margarita V Chirkina, Dmitry V Belykh, Olga M Startseva, Anton E Egorov, Alexey A Kostyukov, Vladimir A Kuzmin, Sergei M Lomakin, Natalia G Shilkina, Alexey V Krivandin, Olga V Shatalova, Margarita A Gradova, Maxim A Abakumov, Aleksey A Nikitin, Varvara P Maksimova, Kirill I Kirsanov, Elena D Nikolskaya
In this study, we described physico-chemical properties of novel nanoformulation of photosensitizer-pyropheophorbide α 17-diethylene glycol ester (XL) (chlorophyll α derivative), revealing insights into antitumor activity and maintaining quality, meeting the pharmaceutical approach of new nanoformulation design. Our formulation, based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles, increased XL solubility and selective tumor-targeted accumulation. In our research, we revealed, for the first time, that XL binding to polyvinyl alcohol (PVA) enhances XL photophysical activity, providing the rationale for PVA application as a stabilizer for nanoformulations...
January 18, 2024: Pharmaceutics