Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Toxoplasma gondii in a Remote Subsistence Hunting-Based Indigenous Community of the Peruvian Amazon.
María Fernanda Menajovsky, Johan Espunyes, Gabriela Ulloa, Maritza Calderon, Andrea Diestra, Edith Malaga, Carmen Muñoz, Stephanie Montero, Andres G Lescano, Meddly L Santolalla, Oscar Cabezón, Pedro Mayor
Toxoplasma gondii is a ubiquitous zoonotic protozoan parasite that infects a wide variety range of warm-blooded animals. This study describes the epidemiological scenario of T. gondii in an indigenous community that relies on subsistence hunting in a well-conserved and isolated area of the Peruvian Amazon. The high seropositivity against T. gondii in humans (83.3% IgG and 6.1% IgM), wild mammals (30.45%, 17 species), peri-domestic rodents (10.0% Rattus sp.), and domestic animals (94.1% dogs and 100% cats) indicates the existence of a sylvatic cycle in the community under study...
April 26, 2024: Tropical Medicine and Infectious Disease
#42
JOURNAL ARTICLE
Stefano Gambarino, Ilaria Galliano, Anna Clemente, Cristina Calvi, Paola Montanari, Anna Pau, Maddalena Dini, Massimiliano Bergallo
Peripheral blood is the most practical tissue for human immune system gene expression profiling because it is easily accessible, whereas the site of primary infection in certain diseases may not be easily accessible. Due to the ex vivo instability of RNA transcripts, a key challenge in the gene expression analysis of blood samples is the rapid sample handling and stabilization of the mRNA by adding an RNA preservative (PAXgeneTM Blood RNA Tubes, TempusTM Blood RNA tubes, RNAlater Stabilization Reagent, RNAgard® Blood Tubes)...
May 7, 2024: Diagnostics
#43
JOURNAL ARTICLE
Colby A Redifer, Lindsey G Wichman, Abigail R Rathert-Williams, Allison M Meyer
Fall-calving primiparous beef females [body weight (BW): 451 ± 28 (SD) kg; body condition score (BCS): 5.4 ± 0.7] were individually-fed either 100% (control; CON; n = 13) or 70% (nutrient restricted; NR; n = 13) of metabolizable energy and metabolizable protein requirements for maintenance, pregnancy, and growth from day 160 of gestation to parturition. Doppler ultrasonography of both uterine arteries was conducted pre-treatment and every 21 d from days 181 to 265 of gestation. Expelled placentas were collected, and ipsilateral cotyledonary tissue was sampled to assess relative messenger ribonucleic acid (mRNA) expression...
May 24, 2024: Journal of Animal Science
#44
JOURNAL ARTICLE
Xiaolei Zhang, Yinan Zhao, Yagang Song, Mingsan Miao
BACKGROUND AND AIMS: Momordica charantia L. ( M. charantia ) has been traditionally utilized as a medicinal intervention for managing type 2 diabetes mellitus (T2DM). The current study was designed to offer a GRADE-assessed systematic review and meta-analysis of randomized controlled trials (RCTs) examining the impact of M. Charantia intake on glycemic indexes and the lipid profile of patients with T2DM. METHODS: A comprehensive search was conducted across several databases, including PubMed, EMBASE, Web of Science, and Cochrane Library, from the inception of each database until April 22, 2023...
May 30, 2024: Heliyon
#45
JOURNAL ARTICLE
Meng Sun, Fei Wu, Zhengmao Xu, Yanan Wang, Jie Cao, Yongzhi Zhou, Jinlin Zhou, Houshuang Zhang, Qianming Xu
Tick infestations transmit various infectious agents and result in significant socioeconomic consequences. Currently, the primary focus of tick control efforts is identifying potential targets for immune intervention. In a previous study, we identified a highly conserved protein abundant in tick haemolymph extracellular vesicles (EVs) known as translationally controlled tumour protein (TCTP). We have found that native TCTP is present in various tissues of the Rhipicephalus haemaphysaloides tick, including salivary glands, midgut, ovary, and fat body...
May 17, 2024: Veterinary Parasitology
#46
JOURNAL ARTICLE
Markus Gabriel Manz, Francisco Caiado
Defense-oriented inflammatory reactivity supports survival at younger age, but might contribute to health impairments in modern, aging societies. The IL-1 cytokines are highly conserved and regulated, pleiotropic mediators of inflammation, essential to respond adequately to infection and tissue damage, but also with potential host damaging effects when left unresolved. In this review, we discuss how continuous low-level IL-1 signaling contributes to aging-associated hematopoietic stem and progenitor cell (HSPC) functional impairments and how this inflammatory selective pressure acts as a driver of more profound hematological alterations, such as clonal hematopoiesis of indeterminate potential (CHIP), and to overt HSPC diseases, like myeloproliferative and myelodysplastic neoplasia as well as acute myeloid leukemia...
May 23, 2024: Blood
#47
JOURNAL ARTICLE
Bernadette White, Jessica Curle, Lisa Gervais, David Wands, Ben Nichols, Richard Hansen, Richard K Russell, Konstantinos Gerasimidis, Simon Milling
The immunological effects of exclusive enteral nutrition (EEN) in the treatment of active Crohn's disease (CD) are yet to be unveiled. The present study investigated changes in peripheral blood mononuclear cell profiles in children with active CD following 8-week treatment with EEN. In nine children, EEN significantly decreased the number and frequency of circulating effector memory CD8+ T cells re-expressing CD45RA (TEMRA), with corresponding increases observed in the frequency of circulating central and effector memory CD8+ T cells...
May 23, 2024: Journal of Pediatric Gastroenterology and Nutrition
#48
JOURNAL ARTICLE
Daniel W Montgomery, Jennifer Finlay, Stephen D Simpson, Georg H Engelhard, Silvana N R Birchenough, Rod W Wilson
The mechanisms that determine the temperature tolerances of fish are poorly understood, creating barriers to disentangle how additional environmental challenges-such as CO2 -induced aquatic acidification and fluctuating oxygen availability-may exacerbate vulnerability to a warming climate and extreme heat events. Here, we explored whether two acute exposures (~0.5 hours or ~72 hours) to increased CO2 impact acute temperature tolerance limits in a freshwater fish, rainbow trout ( Oncorhynchus mykiss )...
2024: Conservation Physiology
#49
REVIEW
Luping Wang, Xi Zhong, Hao Yang, Jing Yang, Yan Zhang, Xia Zou, Lijie Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Qin Wu
Shock is a common critical illness characterized by microcirculatory disorders and insufficient tissue perfusion. Patients with shock and hemodynamic instability generally require vasopressors to maintain the target mean arterial pressure. Enteral nutrition (EN) is an important therapeutic intervention in critically ill patients and has unique benefits for intestinal recovery. However, the initiation of early EN in patients with shock receiving vasopressors remains controversial. Current guidelines make conservative and vague recommendations regarding early EN support in patients with shock...
June 2024: Clinical Nutrition ESPEN
#50
JOURNAL ARTICLE
Mizue Inumaru, Nana Matsumoto, Yoshiki Nakano, Tatsuo Sato, Yoshio Tsuda, Yukita Sato
Although wild bird rehabilitation facilities are important for the conservation of wild species, individuals may be kept within the facilities for long periods, consequently posing a risk for the bird to be infected with pathogens to which they are not naturally exposed. In turn, novel pathogens may be introduced through rescued migratory species. Avian malaria and West Nile fever are important avian diseases transmitted by mosquitoes. To understand the transmission dynamics of such diseases at rehabilitation facilities, the ecology of vector mosquitoes, including species composition, seasonality, and feeding behaviors, were explored...
May 21, 2024: Journal of Wildlife Diseases
#51
JOURNAL ARTICLE
Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang, Chuan Liu, Ting-Ting Gong, Qi-Jun Wu
BACKGROUND: Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking. METHODS: We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes...
May 20, 2024: BMC Medicine
#52
JOURNAL ARTICLE
Katarina Zmajkovicova, Sumit Pawar, Svetlana O Sharapova, Christoph Bruno Geier, Ivana Wiest, Chi Nguyen, Halenya Monticelli, Sabine Maier-Munsa, Kelly Chen, John W Sleasman, Svetlana Aleshkevich, Ekaterina Polyakova, Inga Sakovich, Klaus Warnatz, Bodo Grimbacher, Michele Proietti, Neal Sondheimer, Boglarka Ujhazi, Sumai Gordon, Maryssa Ellison, Melis Yilmaz, Jolan E Walter, Adriana Badarau, Arthur G Taveras, Jadee L Neff, Jacob R Bledsoe, Teresa K Tarrant
Warts, Hypogammglobulinemia, Infections, Myelokathexis (WHIM) syndrome is a rare immunodeficiency disease that results from impaired leukocyte trafficking (myelokathexis) predominately caused by gain-of-function variants in C-X-C chemokine receptor type 4 (CXCR4). Clinical manifestations of WHIM syndrome can differ in familial forms or in people harboring identical CXCR4 variants. All known pathogenic CXCR4 variants associated with WHIM syndrome (CXCR4WHIM) to date are localized in the intracellular C-terminus of CXCR4...
May 20, 2024: Blood Advances
#53
Ilinca I Ciubotariu, Bradley K Broyles, Shaojun Xie, Jyothi Thimmapuram, Mulenga C Mwenda, Brenda Mambwe, Conceptor Mulube, Japhet Matoba, Jessica L Schue, William J Moss, Daniel J Bridges, He Qixin, Giovanna Carpi
BACKGROUND: A highly effective vaccine for malaria remains an elusive target, at least in part due to the under-appreciated natural parasite variation. This study aimed to investigate genetic and structural variation, and immune selection of leading malaria vaccine candidates across the Plasmodium falciparum 's life cycle. METHODS: We analyzed 325 P. falciparum whole genome sequences from Zambia, in addition to 791 genomes from five other African countries available in the MalariaGEN Pf3k Rdatabase...
May 12, 2024: medRxiv
#54
JOURNAL ARTICLE
Madison Kucinick, Kate E Charles, Kenrith Carter, Jonnel Edwards, Catherine Costlow, Melinda Wilkerson, Dawn Seddon, David Marancik
Blood biochemistry represents a minimally invasive tool for monitoring sea turtle health, assessing injured sea turtles and supporting conservation strategies. In Grenada, West Indies, plasma biochemical variables were examined in 33 nesting leatherback ( Dermochelys coriacea ), 49 foraging green ( Chelonia mydas ), 49 foraging hawksbill ( Eretmochelys imbricata ) and 12 nesting hawksbill sea turtles sampled between 2017 and 2022. Plasma biochemistry reference intervals are described herein except for nesting hawksbills, which are represented by descriptive statistics due to the low sample size...
2024: Conservation Physiology
#55
Miyuki Hattori, Kazuya Kikutani, Shinichiro Ohshimo, Nobuaki Shime
Hypercalcemia is generally treated conservatively, including massive fluid administration. However, in cases of acute respiratory distress syndrome (ARDS) associated with drowning, excessive fluid administration may worsen respiratory status. An 81-year-old female was found drowned in a hot spring at an accommodation facility and urgently transported to our hospital. On arrival, the patient exhibited severe respiratory failure, impaired consciousness, and bilateral lung infiltrates on computed tomography (CT), suggesting ARDS...
April 2024: Curēus
#56
JOURNAL ARTICLE
Shashi Kumar, Qasif Qavi, Nida Bashir, Firas Alkistawi, Omotara Lesi, Praveen Sekaran, Jafer Hamdani, Abdalla Saad Abdalla Al-Zawi
Introduction Gallstone ileus is an uncommon cause of small bowel obstruction; it is a rare complication of calculus chronic cholecystitis which leads to cholecystoenteric fistula and impaction of gallstone in the gastrointestinal tract leading to mechanical bowel obstruction. Our aim is to report the natural history and management of this rare condition in a teaching hospital. Materials and methods It is a retrospective study, where 10 years of data related to the management of intestinal obstruction secondary to gallstone ileus was collected...
April 2024: Curēus
#57
JOURNAL ARTICLE
Kristianna L Felch, Jonathan D Crider, Debduti Bhattacharjee, Cameron Huhn, Melanie Wilson, Eva Bengtén
Toll-like receptors (TLRs) are pivotal pattern recognition receptors (PRRs) and key mediators of innate immunity. Despite the significance of channel catfish (Ictalurus punctatus) in comparative immunology and aquaculture, its 20 TLR genes remain largely functionally uncharacterized. In this study, our aim was to determine the catfish TLR7 agonists, signaling potential, and cellular localization. Using a mammalian reporter system, we identified imiquimod and resiquimod, typical ssRNA analogs, as potent catfish TLR7 agonists...
May 17, 2024: Developmental and Comparative Immunology
#58
JOURNAL ARTICLE
Thomas P Zonneveld, Sarah E Vermeer, Erik W van Zwet, Adrien E D Groot, Ale Algra, Leo A M Aerden, Kees C L Alblas, Frank de Beer, Paul J A M Brouwers, Koen de Gans, H Maarten A van Gemert, Bart C A M van Ginneken, Gerke S Grooters, Patricia H A Halkes, Tonny A M H G van der Heijden-Montfroy, Korné Jellema, Sonja W de Jong, Harry Lövenich-Ciccarello, Willem D M van der Meulen, Edwin W Peters, Taco C van der Ree, Michel J M Remmers, Edo Richard, Jörgen M P Rovers, Ritu Saxena, Sander M van Schaik, Wouter J Schonewille, Tobien A H C M L Schreuder, Els L L M de Schryver, Wouter J Schuiling, Fianne H Spaander, Julia H van Tuijl, Marieke C Visser, Sanne M Zinkstok, Elles Zock, Diederik W J Dippel, L Jaap Kappelle, Robert J van Oostenbrugge, Yvo B W E M Roos, Frederique H Vermeij, Marieke J H Wermer, H Bart van der Worp, Paul J Nederkoorn, Nyika D Kruyt
BACKGROUND: Intravenous thrombolysis is contraindicated in patients with ischaemic stroke with blood pressure higher than 185/110 mm Hg. Prevailing guidelines recommend to actively lower blood pressure with intravenous antihypertensive agents to allow for thrombolysis; however, there is no robust evidence for this strategy. Because rapid declines in blood pressure can also adversely affect clinical outcomes, several Dutch stroke centres use a conservative strategy that does not involve the reduction of blood pressure...
May 15, 2024: Lancet Neurology
#59
REVIEW
Li Ma, Zhengguo Cao
The periodontium is a highly organized ecosystem, and the imbalance between oral microorganisms and host defense leads to periodontal diseases. The periodontal pathogens, mainly Gram-negative anaerobic bacteria, colonize the periodontal niches or enter the blood circulation, resulting in periodontal tissue destruction and distal organ damage. This phenomenon links periodontitis with various systemic conditions, including cardiovascular diseases, malignant tumors, steatohepatitis, and Alzheimer's disease. Autophagy is an evolutionarily conserved cellular self-degradation process essential for eliminating internalized pathogens...
May 19, 2024: Inflammation
#60
JOURNAL ARTICLE
Aabha Divya, Alicia Chia, David Jenkins
Spontaneous retroperitoneal hematoma (SRH) is a rare complication of anticoagulation therapy. Presentation may vary from limb paresis to hypovolemic shock due to blood loss. The optimal treatment is controversial. It can be managed conservatively or surgically. We report a case of a 73-year-old man presenting with progressively worsening abdominal pain and severe pain radiating to his left lower limb twenty-five days after his pulmonary endarterectomy (PEA) surgery. He was on anticoagulation per our institutional protocol for PEA patients...
May 18, 2024: Journal of Cardiothoracic Surgery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
