Ângela Inácio, Laura Aguiar, Beatriz Rodrigues, Patrícia Pires, Joana Ferreira, Andreia Matos, Inês Mendonça, Raquel Rosa, Manuel Bicho, Rui Medeiros, Maria Clara Bicho
Human papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-related genes: CβS , MTHFR , NOS3 , ACE1 , CYBA , HAP , ACP1 , GSTT1 , GSTM1 , and CYP1A1 . Notably, the ACE1 gene emerges as a prominent factor with the presence of the I allele offering protection against HPV infection...
September 27, 2023: Antioxidants (Basel, Switzerland)