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JOURNAL ARTICLE
Jie Chen, Xixian Ruan, Tian Fu, Shiyuan Lu, Dipender Gill, Zixuan He, Stephen Burgess, Edward L Giovannucci, Susanna C Larsson, Minzi Deng, Shuai Yuan, Xue Li
BACKGROUND: The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease are unclear. We performed a Mendelian randomization analysis to examine these associations. METHODS: Genetic instruments associated with leisure screen time (LST, an indicator of a sedentary lifestyle) and moderate-to-vigorous intensity physical activity (MVPA) at the genome-wide significance (P < 5 × 10-8 ) level were selected from a genome-wide association study...
April 6, 2024: EBioMedicine
#42
JOURNAL ARTICLE
Chalani Lasanthika, Ann-Christin Janlöv, Thamara Amarasekara, Helena Larsson
OBJECTIVE: The number of patients with end-stage kidney disease (ESKD) requiring renal replacement therapy in Sri Lanka is significantly rising. Most of these patients depend on haemodialysis, carrying a significant burden on their family caregivers. To develop care and support for both the patient and their family caregiver, it is crucial to understand how caregivers experience their caregiving situation. Therefore, this study aimed to explore family caregivers' experiences of burden and coping when caring for a family member receiving haemodialysis in the Sri Lankan context...
April 5, 2024: BMJ Open
#43
Jane Alrø Bøtkjær, Stine Gry Kristensen, Hanna Ørnes Olesen, Per Larsson, Bernadette Mannaerts, Claus Yding Andersen
[This corrects the article DOI: 10.3389/fendo.2022.1004596.].
2024: Frontiers in Endocrinology
#44
JOURNAL ARTICLE
Christopher Gillberg, Ylva Larsson, Eva Billstedt
No abstract text is available yet for this article.
March 27, 2024: Lancet Child & Adolescent Health
#45
JOURNAL ARTICLE
William Rosenbaum, Erik Bovinder Ylitalo, Guillaume Castel, Andreas Sjödin, Pär Larsson, Julia Wigren Byström, Mattias N E Forsell, Clas Ahlm, Lisa Pettersson, Anne Tuiskunen Bäck
Orthohantaviruses, transmitted primarily by rodents, cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome in the Americas. These viruses, with documented human-to-human transmission, exhibit a wide case-fatality rate, 0.5-40 %, depending on the virus species, and no vaccine or effective treatment for severe Orthohantavirus infections exists. In Europe, the Puumala virus (PUUV), carried by the bank vole Myodes glareolus, causes a milder form of HFRS. Despite the reliance on serology and PCR for diagnosis, the three genomic segments of Swedish wild-type PUUV have yet to be completely sequenced...
March 30, 2024: Journal of Clinical Virology
#46
JOURNAL ARTICLE
Ingegerd Öfverholm, Karin Wallander, Cecilia Haglund, Venkatesh Chellappa, Johan Wejde, Anna Gellerbring, Valtteri Wirta, Annick Renevey, Eva Caceres, Panagiotis Tsagkozis, Markus Mayrhofer, Andri Papakonstantinou, Christina Linder-Stragliotto, Robert Bränström, Olle Larsson, Johan Lindberg, Yingbo Lin, Felix Haglund de Flon
PURPOSE: Tumor classification is a key component in personalized cancer care. For soft tissue and bone tumors, this classification is currently based primarily on morphology assessment and immunohistochemical staining. However, these standard-of-care methods can pose challenges for pathologists. We therefore assessed how whole-genome and whole-transcriptome sequencing (WGTS) impacted tumor classification and clinical management when interpreted together with histomorphology. EXPERIMENTAL DESIGN: We prospectively evaluated WGTS in routine diagnostics of 200 soft tissue and bone tumors suspicious for malignancy, including DNA and RNA isolation from the tumor, and DNA isolation from a peripheral blood sample or any non-tumor tissue...
April 4, 2024: Clinical Cancer Research
#47
JOURNAL ARTICLE
P W Crous, E R Osieck, R G Shivas, Y P Tan, S L Bishop-Hurley, F Esteve-Raventós, E Larsson, J J Luangsa-Ard, F Pancorbo, S Balashov, I G Baseia, T Boekhout, S Chandranayaka, D A Cowan, R H S F Cruz, P Czachura, S De la Peña-Lastra, F Dovana, B Drury, J Fell, A Flakus, R Fotedar, Ž Jurjević, A Kolecka, J Mack, G Maggs-Kölling, S Mahadevakumar, A Mateos, S Mongkolsamrit, W Noisripoom, M Plaza, D P Overy, M Piątek, M Sandoval-Denis, J Vauras, M J Wingfield, S E Abell, A Ahmadpour, A Akulov, F Alavi, Z Alavi, A Altés, P Alvarado, G Anand, N Ashtekar, B Assyov, G Banc-Prandi, K D Barbosa, G G Barreto, J-M Bellanger, J L Bezerra, D J Bhat, P Bilański, T Bose, F Bozok, J Chaves, D H Costa-Rezende, C Danteswari, V Darmostuk, G Delgado, S Denman, A Eichmeier, J Etayo, G Eyssartier, S Faulwetter, K G G Ganga, Y Ghosta, J Goh, J S Góis, D Gramaje, L Granit, M Groenewald, G Gulden, L F P Gusmão, A Hammerbacher, Z Heidarian, N Hywel-Jones, R Jankowiak, M Kaliyaperumal, O Kaygusuz, K Kezo, A Khonsanit, S Kumar, C H Kuo, T Læssøe, K P D Latha, M Loizides, S M Luo, J G Maciá-Vicente, P Manimohan, P A S Marbach, P Marinho, T S Marney, G Marques, M P Martín, A N Miller, F Mondello, G Moreno, K T Mufeeda, H Y Mun, T Nau, T Nkomo, A Okrasińska, J P A F Oliveira, R L Oliveira, D A Ortiz, J Pawłowska, M À Pérez-De-Gregorio, A R Podile, A Portugal, N Privitera, K C Rajeshkumar, I Rauf, B Rian, A Rigueiro-Rodríguez, G F Rivas-Torres, P Rodriguez-Flakus, M Romero-Gordillo, I Saar, M Saba, C D Santos, P V S R N Sarma, J L Siquier, S Sleiman, M Spetik, K R Sridhar, M Stryjak-Bogacka, K Szczepańska, H Taşkın, D S Tennakoon, D Thanakitpipattana, J Trovão, I Türkekul, A L van Iperen, P van 't Hof, G Vasquez, C M Visagie, B D Wingfield, P T W Wong, W X Yang, M Yarar, O Yarden, N Yilmaz, N Zhang, Y N Zhu, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Australia , Aschersonia mackerrasiae on whitefly, Cladosporium corticola on bark of Melaleuca quinquenervia , Penicillium nudgee from soil under Melaleuca quinquenervia , Pseudocercospora blackwoodiae on leaf spot of Persoonia falcata , and Pseudocercospora dalyelliae on leaf spot of Senna alata . Bolivia , Aspicilia lutzoniana on fully submersed siliceous schist in high-mountain streams, and Niesslia parviseta on the lower part and apothecial discs of Erioderma barbellatum on a twig...
June 2023: Persoonia
#48
JOURNAL ARTICLE
Linn Zettergren, Elin C Larsson, Lovisa Hellsten, Kyriaki Kosidou, Anna Maria Nielsen
BACKGROUND: Digital health care services have the potential to improve access to sexual and reproductive health care for youth but require substantial implementation efforts to translate into individual and public health gains. Health care providers are influential both regarding implementation and utilization of the services, and hence, their perceptions of digital health care services and the implementation process are essential to identify and address. The aim of this study was to explore midwives' perception of digital sexual and reproductive health care services for youth, and to identify perceived barriers and facilitators of the implementation of digital health care provision in youth clinics...
April 2, 2024: BMC Health Services Research
#49
JOURNAL ARTICLE
Elin Trägårdh, Johannes Ulén, Olof Enqvist, Lars Edenbrandt, Måns Larsson
BACKGROUND: We developed a fully automated artificial intelligence (AI)AI-based-based method for detecting suspected lymph node metastases in prostate-specific membrane antigen (PSMA)(PSMA) positron emission tomography-computed tomography (PET-CT)(PET-CT) images of prostate cancer patients by using data augmentation that adds synthetic lymph node metastases to the images to expand the training set. METHODS: Synthetic data were derived from original training images to which new synthetic lymph node metastases were added...
April 2, 2024: Clinical Physiology and Functional Imaging
#50
JOURNAL ARTICLE
Elis Haan, Kristi Krebs, Urmo Võsa, Isabell Brikell, Henrik Larsson, Kelli Lehto
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is often comorbid with other medical conditions in adult patients. However, ADHD is extremely underdiagnosed in adults and little is known about the medical comorbidities in undiagnosed adult individuals with high ADHD liability. In this study we investigated associations between ADHD genetic liability and electronic health record (EHR)-based ICD-10 diagnoses across all diagnostic categories, in individuals without ADHD diagnosis history...
April 2, 2024: Psychological Medicine
#51
JOURNAL ARTICLE
Yu Tian, Yi Lin, Conghui Qu, Volker Arndt, James W Baurley, Sonja I Berndt, Stephanie A Bien, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Arif Budiarto, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Andrew T Chan, Rui Chen, Xuechen Chen, David V Conti, Virginia Díez-Obrero, Niki Dimou, David A Drew, Jane C Figueiredo, Steven Gallinger, Graham G Giles, Stephen B Gruber, Marc J Gunter, Sophia Harlid, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina M Jordahl, Amit D Joshi, Temitope O Keku, Eric Kawaguchi, Andre E Kim, Anshul Kundaje, Susanna C Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Victor Moreno, John Morrison, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A Newcomb, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, John D Potter, Ross L Prentice, Gad Rennert, Edward A Ruiz-Narvaez, Lori C Sakoda, Robert E Schoen, Anna Shcherbina, Mariana C Stern, Yu-Ru Su, Stephen N Thibodeau, Duncan C Thomas, Konstantinos K Tsilidis, Franzel J B van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Ulrike Peters, W James Gauderman, Li Hsu, Jenny Chang-Claude
BACKGROUND: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk. METHODS: We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles...
April 1, 2024: British Journal of Cancer
#52
Marie-Louis Wronski, Ralf Kuja-Halkola, Elin Hedlund, Miriam I Martini, Paul Lichtenstein, Sebastian Lundström, Henrik Larsson, Mark J Taylor, Nadia Micali, Cynthia M Bulik, Lisa Dinkler
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder, characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with a range of psychiatric and somatic symptoms, and therefore consult various pediatric subspecialties; large-scale studies mapping comorbidities are however lacking. To characterize health care needs of people with ARFID, we systematically investigated ARFID-related mental and somatic conditions in 616 children with ARFID and >30,000 children without ARFID...
March 15, 2024: medRxiv
#53
JOURNAL ARTICLE
C Björkelund, E-L Petersson, I Svenningsson, A Saxvik, L Wiegner, G Hensing, I H Jonsdottir, M Larsson, C Wikberg, N Ariai, S Nejati, D Hange
OBJECTIVES: To investigate whether intensified cooperation between general practitioner (GP), care manager and rehabilitation coordinator (RC) for patients sick-listed for stress-related mental disorder, combined with a person-centred dialogue meeting with employer, could reduce sick-leave days compared with usual care manager contact. DESIGN: Pragmatic cluster-randomised controlled trial, randomisation at primary care centre (PCC) level. SETTING: PCCs in Region Västra Götaland, Sweden, with care manager organisation...
March 31, 2024: Scandinavian Journal of Primary Health Care
#54
JOURNAL ARTICLE
Selma Curkic Kapidzic, Johan Gustafsson, Erik Larsson, Lovisa Jessen, Katarina Sjögreen Gleisner
PURPOSE: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [177 Lu]Lu-DOTA-TATE therapy. METHOD: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed to determine the average activity concentration (AC) in each kidney...
March 30, 2024: Physica Medica: PM
#55
JOURNAL ARTICLE
Elin Gahm, Magnus Peterson, Kjerstin Larsson
OBJECTIVE: To explore men's views on the causes and consequences of two common sexual dysfunctions - erectile dysfunction and premature ejaculation - and how this affects physical and mental health as well as social life and intimate or close relations. DESIGN: A qualitative design with semi-structured interviews using open-ended questions was employed. Individual interviews were conducted, audio recorded and transcribed, and a qualitative content analysis of the text was performed...
March 31, 2024: Scandinavian Journal of Primary Health Care
#56
JOURNAL ARTICLE
Julián Bobis Camacho, Johanna Nilsson, D G Joakim Larsson, Carl-Fredrik Flach
BACKGROUND: Recent studies have shown promise in predicting clinical antibiotic resistance rates from sewage data. Few have focused on Klebsiella pneumoniae, despite its virulence and importance as carrier of antibiotic resistance. Several media have been suggested for the isolation of K. pneumoniae from complex samples. However, comprehensive evaluations of culture protocols for isolation of K. pneumoniae from sewage are lacking. METHODS: Here, influent samples from a major Swedish sewage treatment plant were used to evaluate ten culture conditions in parallel: cultivation on Brilliant green containing Inositol-Nitrate-Deoxycholate agar (BIND), Bruce agar, Klebsiella ChromoSelect Selective agar®, MacConkey-Inositol-Carbenicillin, or Simmons Citrate Agar with Inositol (SCAI) incubated at either 37˚C or 42˚C for 44 h...
March 27, 2024: Journal of Global Antimicrobial Resistance
#57
JOURNAL ARTICLE
Alex B Addinsall, Nicola Cacciani, Noah Moruzzi, Hazem Akkad, Alice Maestri, Per-Olof Berggren, Anna Widegren, Jonas Bergquist, Tamara Tchkonia, James L Kirkland, Lars Larsson
AIM: Mechanical ventilation (MV) results in diminished diaphragm size and strength, termed ventilator-induced diaphragm dysfunction (VIDD). VID increases dependence, prolongs weaning, and increases discharge mortality rates. The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is implicated in VIDD, upregulated following MV. JAK/STAT inhibition alleviates chronic muscle wasting conditions. This study aimed to explore the therapeutic potential of Ruxolitinib, an FDA approved JAK1/2 inhibitor (JI) for the treatment of VIDD...
March 29, 2024: Acta Physiologica
#58
JOURNAL ARTICLE
Nora I Strom, Christie L Burton, Conrad Iyegbe, Talisa Silzer, Lilit Antonyan, René Pool, Mathieu Lemire, James J Crowley, Jouke-Jan Hottenga, Volen Z Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Danielle Cath, Jennifer Crosbie, David Mataix-Cols, Dorret I Boomsma, Manuel Mattheisen, Sandra M Meier, Dirk J A Smit, Paul D Arnold
While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13-38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date (N = 33,943 with complete phenotypic and genome-wide data), combining the results from seven large-scale population-based cohorts from Sweden, the Netherlands, England, and Canada (including six twin cohorts and one cohort of unrelated individuals)...
March 28, 2024: Molecular Psychiatry
#59
JOURNAL ARTICLE
Jaisheela Vimali, Yean K Yong, Amudhan Murugesan, Hong Y Tan, Ying Zhang, Rajeev Ashwin, Sivadoss Raju, Pachamuthu Balakrishnan, Marie Larsson, Vijayakumar Velu, Esaki M Shankar
BACKGROUND: Chronic viral infection results in impaired immune responses rendering viral persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-infected individuals by examining the levels of expression of selected immune activation and exhaustion molecules on circulating MAIT cells and Tfh cells. METHODS: Cytokines were measured using a commercial Bio-plex Pro Human Cytokine Grp I Panel 17-plex kit (BioRad, Hercules, CA, USA)...
March 22, 2024: Frontiers in Bioscience (Landmark Edition)
#60
JOURNAL ARTICLE
Sofi Oskarsson, Anneli Andersson, Bridget M Bertoldi, Antti Latvala, Ralf Kuja-Halkola, Brittany Evans, Adrian Raine, Christopher J Patrick, Henrik Larsson, Catherine Tuvblad
BACKGROUND: Lower autonomic arousal is a well-known correlate of criminal offending and other risk-taking behaviors in men, but few studies have investigated this association in women. AIM: To test associations between autonomic arousal and criminal offending as well as unintentional injuries among female conscripts. METHODS: All women born 1958-1994 in Sweden who participated in voluntary military conscription (n = 12,499) were identified by linking Swedish population-based registers...
2024: PloS One
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