Mohammad K Khan, Tahseen H Nasti, Joshua Y Qian, Troy J Kleber, Jeffrey M Switchenko, Jonathan L Kaufman, Ajay J Nooka, Madhav V Dhodapkar, Zachary S Buchwald, Daby Obiekwe, Sagar Lonial, Rafi Ahmed
BACKGROUND: Currently, the use of radiotherapy alone for people with multiple myeloma is limited to palliation of pain, pending fracture, and control of spinal-cord compression. Single immune-checkpoint inhibitors, such as anti-programmed death-1 (anti-PD1), have not been successful. We aimed to evaluate the activity and safety of the combination of pembrolizumab and low-dose, single-fraction, hypofractionated radiotherapy to treat patients with relapsed or refractory multiple myeloma...
May 23, 2024: Lancet Haematology