Yang Bu, Qian Liu, Yongjie Shang, Zhenzhen Zhao, Haonan Sun, Feifei Chen, Qian Ma, Jie Song, Li Cui, E Sun, Yi Luo, Luan Shu, Haibo Jing, Xiaobin Tan
Granular β-1,3-glucan extracted from the wall of Ganoderma lucidum spores, named GPG, is a bioregulator. In this study, we investigated the structural, thermal, and other physical properties of GPG. We determined whether GPG ameliorated immunosuppression caused by Gemcitabine (GEM) chemotherapy. Triple-negative breast cancer mice with GPG combined with GEM treatment had reduced tumor burdens. In addition, GEM treatment alone altered the tumor microenvironment(TME), including a reduction in antitumor T cells and a rise in myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs)...
May 3, 2024: International Journal of Biological Macromolecules