Elza Rechtman, Esmeralda Navarro, Erik de Water, Cheuk Y Tang, Paul Curtin, Demetrios M Papazaharias, Claudia Ambrosi, Lorella Mascaro, Giuseppa Cagna, Roberto Gasparotti, Azzurra Invernizzi, Abraham Reichenberg, Christine Austin, Manish Arora, Donald R Smith, Roberto G Lucchini, Robert O Wright, Donatella Placidi, Megan K Horton
BACKGROUND: Early-life environmental exposures during critical windows (CWs) of development can impact life course health. Exposure to neuroactive metals such as manganese (Mn) during prenatal and early postnatal CWs may disrupt typical brain development, leading to persistent behavioral changes. Males and females may be differentially vulnerable to Mn, presenting distinctive CWs to Mn exposure. METHODS: We used magnetic resonance imaging to investigate sex-specific associations between early-life Mn uptake and intrinsic functional connectivity in adolescence...
July 2023: Biol Psychiatry Glob Open Sci