Yan-Fei Cheng, Cui-Lian Zhang, Yun Liu, Jian-Ping Ou, Lei Chen, Gui-Feng Cai, Zu Yang, Tian-Min Ye, Jun Wang, Juan-Ke Xie, Ping Xiong, Xi-Ya Zhang, Min Li, Wei-Biao Xu, Xiao-Qing Wang, Ling-Yin Kong, Bo Liang, Xiao-Hong Wang, Yue-Qiang Wang, Yuan-Qing Yao
BACKGROUND: Preimplantation genetic testing for aneuploidy (PGT-A) was demonstrated to be superior to conventional IVF in reducing the incidence of miscarriage and abnormal offspring after the first embryo transfer (ET). PGT-A requires several embryo trophectoderm cells, but its negative impacts on embryo development and long-term influence on the health conditions of conceived children have always been a concern. As an alternative, noninvasive PGT-A (niPGT-A) approaches using spent blastocyst culture medium (SBCM) achieved comparable accuracy with PGT-A in several pilot studies...
September 6, 2023: BMC Pregnancy and Childbirth