Keshan Wang, Fen Ma, Seiji Arai, Yun Wang, Andreas Varkaris, Larysa Poluben, Olga Voznesensky, Fang Xie, Xiaoping Zhang, Xin Yuan, Steven P Balk
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established. In a subset of prostate cancer organoid culture and xenograft models, inhibition of Wnt synthesis stimulated growth, while WNT5a or a WNT5a mimetic peptide (Foxy5) markedly suppressed tumor growth. WNT5a caused a ROR2-dependent decrease in YAP1 activity that was associated with increased phosphorylation of MST1/2, LATS1, MOB1, and YAP1, indicating Hippo pathway activation...
January 9, 2023: Cancer Research