Pornpan Chalermkitpanit, Oraluxna Rodanant, Winnie Thaveepunsan, Sireedhorn Assavanop
Background and Aims: Succinylcholine and high dose rocuronium are neuromuscular blocking agents commonly used for rapid sequence induction of anesthesia. Their usage is limited or contraindicated in some circumstances. The aim of this study is to determine the dosage and efficacy of atracurium without priming for rapid sequence induction of anesthesia. Material and Methods: One hundred fifteen surgical patients under general anesthesia were randomised into three groups...
January 2020: Journal of Anaesthesiology, Clinical Pharmacology
Alessandro Putzu, Martin R Tramèr, Maxim Giffa, Christoph Czarnetzki
BACKGROUND: The evidence base for the widely accepted standard regimen of succinylcholine for rapid sequence induction (1.0 mg kg- 1 ) remains unclear. METHODS: We performed a systematic review and meta-analysis of randomized trials comparing any succinylcholine regimen with the standard regimen (1.0 mg kg- 1 ) and reporting on intubating conditions and/or apnoea times. Results were expressed as absolute risk differences (ARD) for dichotomous data and mean differences (MD) for continuous data...
March 2, 2020: BMC Anesthesiology
Asitha D L Jayawardena, Sarah Bouhabel, Robert L Sheridan, Christopher J Hartnick
The management of laryngotracheal stenosis (LTS) in the pediatric burn patient is complex and requires a multi-disciplinary approach. The mainstay of treatment for LTS is laryngotracheal reconstruction (LTR), however, limited reports of burn-specific laryngotracheal reconstruction techniques exist. Here, we provide insight into the initial airway evaluation, surgical decision-making, anesthetic challenges, and incision modifications based on our experience in treating patients with this pathology. The initial airway evaluation can be complicated by microstomia, trismus and neck contractures - the authors recommend treatment of these complications prior to initial airway evaluation to optimize safety...
February 29, 2020: Journal of Burn Care & Research: Official Publication of the American Burn Association
Carlos Gustavo de Almeida, José Colleti Junior
OBJECTIVE: To report on a case of malignant hyperthermia in a child after a magnetic resonance imaging of the skull was performed using sevoflurane anesthesia. CASE DESCRIPTION: A 3-year-old boy admitted to the pediatric intensive care unit after presenting clinical and laboratory findings consistent with unspecified viral meningoencephalitis. While the patient was sedated, a magnetic resonance imaging of the skul was performed using propofol followed by the administration of sevoflurane through a laryngeal mask in order to continue anesthesia...
2020: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Audrey De Jong, Amélie Rollé, François-Régis Souche, Olfa Yengui, Daniel Verzilli, Gérald Chanques, David Nocca, Emmanuel Futier, Samir Jaber
The obese patient is at risk of perioperative complications including difficult airway access (intubation, difficult or impossible ventilation), and postextubation acute respiratory failure due to the formation of atelectases or to airway obstruction. The association of obstructive sleep apnoea syndrome (OSA) with obesity is very common, and induces a high risk of per and postoperative complications. Preoperative OSA screening is crucial in the obese patient, as well as its specific management: use of continuous positive pre-, per- and postoperative pressure...
February 14, 2020: Anaesthesia, Critical Care & Pain Medicine
Shahryar Sane, Mir Moussa Aghdashi, Behzad Kazemi Haki, Behzad Gholamveisi, Mina Rajabzadeh, Parang Golabi
PURPOSE: This study evaluates the effect of pregabalin on fasciculation and myalgia after using succinylcholine. DESIGN: This randomized double-blind prospective study was conducted among 100 patients aged 20 to 60 years old. METHODS: Pregabalin (300 mg) and placebo (in capsule form) were placed in similar containers. The results were analyzed by SPSS 23 software, and statistical analysis consisted of χ2 test and t test, and a P value less than ...
January 25, 2020: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Amy L Rutt, Elird Bojaxhi, Klaus D Torp
Laryngospasm has been well described in patients emerging from general anesthesia (GA) and is routinely managed with intermittent positive-pressure mask ventilation, a temporary increase in the depth of anesthesia, or small, titrated amounts of succinylcholine. Patients with severe laryngospasm require reintubation to maintain adequate oxygenation and ventilation. However, reintubation may be only a temporary solution because laryngospasm may recur during re-emergence and re-extubation; thus, anesthesiologists need a comprehensive plan that addresses potential causes of laryngospasm and incorporates continuous positive airway pressure (CPAP) for patients with difficulty emerging from GA...
January 24, 2020: Journal of Voice
Stefani A Vande Lune, James H Lantry, Phillip E Mason, Richard Skupski, Arthur Toth, Donald Zimmer, John Mulligan, Michael T McCurdy, Emilee E Larson, Fletcher Preuss, Quincy K Tran
INTRODUCTION: In austere environments, the safe administration of anesthesia becomes challenging because of unreliable electrical sources, limited amounts of compressed gas, and insufficient machine maintenance capabilities. Such austere environments exist in battlefield medicine, in low- and middle-income countries (LMICs), and in areas struck by natural disasters. Whether in military operations or civilian settings, the Universal Anesthesia Machine (UAM) (Gradian Health Systems, New York, New York) is a draw-over device capable of providing safe and effective general anesthesia when external oxygen supplies or reliable electrical sources are limited...
December 31, 2019: Military Medicine
Senthil Packiasabapathy, Valluvan Rangasamy, Nicole Horn, Michele Hendrickson, Janelle Renschler, Senthilkumar Sadhasivam
Pharmacogenetics, the genetic influence on the interpersonal variability in drug response, has enabled tailored pharmacotherapy and emerging 'personalized medicine.' Although oncology spearheaded the clinical implementation of personalized medicine, other specialties are rapidly catching up. In anesthesia, classical examples of genetically mediated idiosyncratic reactions have been long known (e.g., malignant hyperthermia and prolonged apnea after succinylcholine). The last two decades have witnessed an expanding body of pharmacogenetic evidence in anesthesia...
January 2020: Pharmacogenomics
Bertrand Guihard, Charlotte Chollet-Xémard, Philippe Lakhnati, Benoit Vivien, Claire Broche, Dominique Savary, Agnes Ricard-Hibon, Pierre-Jean Marianne Dit Cassou, Frédéric Adnet, Eric Wiel, Juliette Deutsch, Cindy Tissier, Thomas Loeb, Vincent Bounes, Emmanuel Rousseau, Patricia Jabre, Laetitia Huiart, Cyril Ferdynus, Xavier Combes
Importance: Rocuronium and succinylcholine are often used for rapid sequence intubation, although the comparative efficacy of these paralytic agents for achieving successful intubation in an emergency setting has not been evaluated in clinical trials. Succinylcholine use has been associated with several adverse events not reported with rocuronium. Objective: To assess the noninferiority of rocuronium vs succinylcholine for tracheal intubation in out-of-hospital emergency situations...
December 17, 2019: JAMA: the Journal of the American Medical Association
Seok-Jin Lee, Tae-Yun Sung, Choon-Kyu Cho
BACKGROUND: Sugammadex allows rapid recovery from rocuronium-induced neuromuscular blockade. Succinylcholine is often used for brief surgeries but is associated with myalgia, headache, histamine release, and increased lactate levels. Thus, we hypothesized that succinylcholine may affect emergence agitation (EA) and compared the effects of succinylcholine and rocuronium-sugammadex on EA in patients undergoing closed reduction of a nasal bone fracture under general anesthesia. METHODS: Forty-two patients were prospectively enrolled and allocated randomly to the succinylcholine group (group SC) or the rocuronium-sugammadex group (group RS; each n = 21)...
December 16, 2019: BMC Anesthesiology
Judit Mari, Peter Franczia, Wojciech Margas, Jakub Rutkowski, Magdalena Bebrysz, Renata Bokiniec, Joanna Seliga-Siwecka
AIM: This study evaluated whether practitioners from 70 countries used premedication for non-emergency neonatal intubation and identified attitudes and experience regarding the safety, side effects and efficiency of neonatal intubation. METHODS: Invitations to take part in the survey were issued between 18 December 2018 and 4 February 2019 to users of neonatal-based websites and Facebook groups, members of professional societies and the authors of relevant publications in the last five years...
December 3, 2019: Acta Paediatrica
Marcus M de Wolf, Nellie M Rus, Guus H Beljaars, Hanno L Tan
We describe a patient with a major depression and a newly discovered Brugada syndrome, who was successfully treated with 35 electroconvulsive therapy sessions using succinylcholine as muscle relaxant. We discuss the use of succinylcholine in patients with Brugada syndrome.
2019: Case Reports in Anesthesiology
Chul Park
Background: Peri-intubation cardiac arrest (PICA) following emergent endotracheal intubation (ETI) is a rare, however, potentially preventable type of cardiac arrest. Limited published data have described factors associated with inpatient PICA and patient outcomes. The aim of this study was to identify risk factors associated with PICA among hospitalized patients emergently intubated at a general ward as compared to non-PICA inpatients. In addition, we identified a difference of clinical outcomes in patients between PICA and other types of inpatient cardiac arrest (OTICA)...
August 2019: Acute and critical care
I-Cheng Lu, Sheng-Hua Wu, Che-Wei Wu
This article reviews the literature on development of neuromuscular blockade management in thyroid surgery with intraoperative neural monitoring (IONM) in the past decade. Neuromuscular blockade management includes the choice of neuromuscular blocking agents (NMBAs) and reversal of neuromuscular blockade by sugammadex. A series of animal study and clinical trials showed NMBAs effect on IONM in thyroid surgery. We summarized five NMBA regimens for IONM: (a) relaxant-free regimen, (b) depolarizing NMBA-succinylcholine, (c) titration of nondepolarizing NMBA, and (d) rocuronium combined with sugammadex...
November 12, 2019: Kaohsiung Journal of Medical Sciences
(no author information available yet)
No abstract text is available yet for this article.
December 2019: Clinical Pharmacology and Therapeutics
Zhuolin Qiu, Shaoli Zhou, Ming Zhang, Na Guo, Pinjie Huang, Ping Xiang, Ziqing Hei, Xiang Li
BACKGROUND: Postictal delirium (PID) is a relatively common complication following electroconvulsive therapy (ECT). OBJECTIVE: We investigated whether prophylactic dexmedetomidine administration would safely decrease the incidence of PID in psychiatric patients after ECT. DESIGN: A randomised, double-blind, placebo-controlled trial. PATIENTS: A total of 223 patients undergoing ECT were randomly allocated to two groups...
November 4, 2019: European Journal of Anaesthesiology
Arnaud Chaumeron, Jeremie Castanie, Louis Philippe Fortier, Patrick Basset, Sophie Bastide, Sandrine Alonso, Jean-Yves Lefrant, Philippe Cuvillon
BACKGROUND: Rapid sequence induction (RSI) is recommended in patients at risk of aspiration, but induced hemodynamic adverse events, including tachycardia. In elderly patients, this trial aimed to assess the impact of the addition of remifentanil during RSI on the occurrence of: tachycardia (primary outcome), hypertension (due to intubation) nor hypotension (remifentanil). METHODS: In this three-arm parallel, double blind, multicentre controlled study, elderly patients (65 to 90 years old) hospitalised in three centres and requiring RSI were randomly allocated to three groups, where anaesthesia was induced with etomidate (0...
October 12, 2019: Anaesthesia, Critical Care & Pain Medicine
Pei-Yu Li, Yong Chen, Chang-Hui Chen, Yu Liu
A series of supramolecular assemblies based on multi-charged calixarene (SC4A), bis(p-calixarene) (BSC4A) and pillararene (CP5A) modified gold nanoparticles (AuNP) was constructed to realize colorimetric sensing of both succinylcholine (SuCh) and butyrylcholinesterase (BChE). With the high binding affinity of BSC4A and CP5A towards SuCh, BSC4A-AuNPs and CP5A-AuNPs could assemble with micromolar level SuCh as SuCh-BSC4A/CP5A-AuNPs. More interestingly, the enzymatic hydrolysis of SuCh by BChE could lead to the disassembly of SuCh-BSC4A/CP5A-AuNPs and provide a sensitive time-dependent color change from blue to red which could be observed by the naked eye and used to monitor BChE activity...
October 15, 2019: Soft Matter
Vlad Suparschi, Stéphanie Sigaut, Catherine Paugam-Burtz
No abstract text is available yet for this article.
November 2019: European Journal of Anaesthesiology
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