Maha S Lokman, Rami Kassab, Fatma A M Salem, Gehad E Elshopakey, Akram Hussein, Ahmed A Aldarmahi, Abdulrahman Theyab, Khalid J Alzahrani, Khalid E Hassan, Khalaf F Alsharif, Ashraf Albrakati, Jehad Z Tayyeb, Manal F El-Khadragy, Mariam A Alkhateeb, Ali O Al-Ghamdy, Hussam A Althagafi, Ahmed Abdel Moneim, Rehab E El-Hennamy
Asiatic acid (AA) is a polyphenolic compound with potent antioxidative and anti-inflammatory activities that make it a potential choice to attenuate inflammation and oxidative insults associated with ulcerative colitis (UC). Hence, the present study aimed to evaluate if AA can attenuate molecular, biochemical, and histological alterations in the acetic acid-induced UC model in rats. To perform the study, five groups were applied, including the control, acetic acid-induced UC, UC-treated with 40 mg/kg aminosalicylate (5-ASA), UC-treated with 20 mg/kg AA, and UC-treated with 40 mg/kg AA...
May 5, 2024: Bioscience Reports