Diogo V Fonsêca, Pablo R da Silva, Hugo F O Pires, Juliana S Rocha, Leandra Eugênia G de Oliveira, Flavia M S Reis, Erika B M Cavalho, Natalia D N Pazos, Natália F de Sousa, Erika C Guedes, Leandro R Ribeiro, Rita de Cassia S Sá, Mirian G S S Salvadori, Damião P Sousa, Marcus T Scotti, Cicero F B Felipe, Reinaldo N de Almeida, Luciana Scotti
Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3-mercapto-propionic acid...
April 30, 2024: ChemMedChem