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JOURNAL ARTICLE
Chenhao Ye, Yuedong Fu, Xijie Zhou, Feiya Zhou, Xuwei Zhu, Yiheng Chen
BACKGROUND: The mechanism of Nicotinamide Adenine Dinucleotide (NAD+) metabolism-related genes (NMRGs) in diabetic peripheral neuropathy (DPN) is unclear. This study aimed to find new NMRGs biomarkers in DPN. METHODS: DPN related datasets GSE95849 and GSE185011 were acquired from the Gene Expression Omnibus (GEO) database. 51 NMRGs were collected from a previous article. To explore NMRGs expression in DPN and control samples, differential expression analysis was completed in GSE95849 to obtain differentially expressed genes (DEGs), and the intersection of DEGs and NMRGs was regarded as DE-NMRGs...
2024: Frontiers in Endocrinology
#42
JOURNAL ARTICLE
Bingjia Zhao, Qian Zhang, Yiqian He, Weifang Cao, Wei Song, Xiaochun Liang
Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies are currently lacking. Disturbed energy status plays a crucial role in DPN pathogenesis. However, the integrated profile of energy metabolism, especially the central carbohydrate metabolism, remains unclear in DPN. Here, we developed a metabolomics approach by targeting 56 metabolites using high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) to illustrate the integrative characteristics of central carbohydrate metabolism in patients with DPN and streptozotocin-induced DPN rats...
February 2024: Journal of Pharmaceutical Analysis
#43
REVIEW
Yiqian He, Ling Qu
Diabetic peripheral neuropathy (DPN) is a complication of diabetes with a high rate of disability. However, current clinical treatments for DPN are suboptimal. Non-coding RNAs (ncRNAs) are a type of RNAs that are not translated into proteins. NcRNAs perform functions that regulate epigenetic modifications, transcriptional or post-transcriptional regulators of proteins, and thus participate in the physiological and pathological processes of the body. NcRNAs play a role in the progress of DPN by affecting the processes of inflammation, oxidative stress, cellular autophagy or apoptosis...
March 8, 2024: Metabolism: Clinical and Experimental
#44
REVIEW
Zhang Ludi, Matthias Yi Quan Liau, Bryan Song Jun Yong, Amanda Sze Yen Auyong, Quah Hui Ting Lynette, Samuel Jianjie Yeo, Khin Swee Elizabeth Tan, Sreenivasulu Reddy Mogali, Ramya Chandrasekaran, Vivek Perumal, Ranganath Vallabhajosyula
PURPOSE: The aim of this systematic review is to evaluate the usefulness of sural nerve ultrasonography in diagnosing diabetes mellitus (DM) and diabetic polyneuropathy (DPN), the latter of which is a common long-term complication for diabetic patients that frequently involves the sural nerve. METHODOLOGY: A meta-analysis of the cross-sectional areas (CSAs) of sural nerves in healthy individuals and patients with diabetes mellitus based on a total of 32 ultrasonographic-based studies from 2015 to 2023 was performed...
March 8, 2024: Journal of Ultrasound
#45
REVIEW
Ercole Barsotti, Bailey Goodman, Riley Samuelson, Martha L Carvour
BACKGROUND: Individuals with intellectual disabilities (IDs) are at risk of diabetes mellitus (DM) and diabetic peripheral neuropathy (DPN), which can lead to foot ulcers and lower-extremity amputations. However, cognitive differences and communication barriers may impede some methods for screening and prevention of DPN. Wearable and mobile technologies-such as smartphone apps and pressure-sensitive insoles-could help to offset these barriers, yet little is known about the effectiveness of these technologies among individuals with ID...
March 4, 2024: Journal of Diabetes Science and Technology
#46
JOURNAL ARTICLE
Brooke K Coombes, Leanne M Bisset, Eva Sierra-Silvestre, Robert S Ware, Jeff S Coombes, Michel W Coppieters, Nicola W Burton, Gregore Iven Mielke
BACKGROUND AND OBJECTIVES: People with diabetic peripheral neuropathy (DPN) report fluctuating foot symptoms. This study used ecological momentary assessment to: (1) compare foot symptoms between days, time points and periods with/without preceding physical activity or pain medication; and (2) determine relationships between symptoms and endogenous pain modulation. METHOD: Ten low-active Australian adults with probable DPN underwent temporal summation of pain (TSP) and conditioned pain modulation (CPM) then completed mobile phone surveys five times daily for seven days, where they recorded the intensity of six foot symptoms and whether they performed physical activity or consumed pain medication in the preceding three hours...
March 2024: Australian Journal of General Practice
#47
JOURNAL ARTICLE
Jingjing Zhou, Dongfeng Li, Youmin Wang
OBJECTIVE: Vitamin D deficiency is associated with patients with diabetic peripheral neuropathy (DPN), and low levels of vitamin D are common in patients with depression. Depression is common in DPN patients and the definite pathogenesis remains unclear. This study aimed to determine vitamin D deficiency in the onset of depression in DPN and evaluate the effect of vitamin D supplementation on depression. METHODS: A total of 192 patients with DPN were enrolled in this study...
2024: Neuropsychiatric Disease and Treatment
#48
REVIEW
Yulian Liu, Runyuan Yu, Xiaoyu Wang, Yuexia Chen, Tao Yin, Qiang Gao, Limin Sun, Zuncheng Zheng
Diabetic peripheral neuropathy (DPN) is one of the most prevalent consequences of diabetes, with a high incidence and disability rate. The DPN's pathogenesis is extremely complex and yet to be fully understood. Persistent high glucose metabolism, nerve growth factor deficiency, microvascular disease, oxidative stress, peripheral nerve cell apoptosis, immune factors, and other factors have been implicated in the pathogenesis of DPN. Astragalus mongholicus is a commonly used plant used to treat DPN in clinical settings...
March 1, 2024: Biomedicine & Pharmacotherapy
#49
JOURNAL ARTICLE
Yusuke Hayashi, Tatsuhito Himeno, Yuka Shibata, Nobuhiro Hirai, Yuriko Asada-Yamada, Sachiko Sasajima, Emi Asano-Hayami, Mikio Motegi, Saeko Asano, Makoto Kato, Hiromi Nakai-Shimoda, Hiroya Tani, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Takayuki Nakayama, Jiro Nakamura, Hideki Kamiya
AIMS/INTRODUCTION: This study aimed to investigate the diagnostic potential of two simplified tests, a point-of-care nerve conduction device (DPNCheck™) and a coefficient of variation of R-R intervals (CVR-R ), as an alternative to traditional nerve conduction studies for the diagnosis of diabetic polyneuropathy (DPN) in patients with diabetes. MATERIALS AND METHODS: Inpatients with type 1 or type 2 diabetes (n = 167) were enrolled...
February 29, 2024: Journal of Diabetes Investigation
#50
JOURNAL ARTICLE
Palani Selvam Mohanraj, Arani Das, Aniruddha Sen, Amit Ranjan, Vinoth Rajendran, Anupriya Velu, U Venkatesh
INTRODUCTION: Diabetic peripheral neuropathy (DPN) presents a formidable health challenge in type 2 diabetes mellitus (T2DM) patients. This study in eastern Uttar Pradesh aims to assess the roles of vascular endothelial growth factor (VEGF) and adiponectin in DPN, recognizing the crucial need for understanding its molecular underpinnings for enhanced diagnosis and management. METHODS: In a cross-sectional study analyzing clinical and biochemical data, 86 individuals aged 35 to 65 years were examined, including 43 with neuropathy and 43 without...
January 2024: Curēus
#51
JOURNAL ARTICLE
Ilenia D'Ippolito, Marika Menduni, Cinzia D'Amato, Aikaterini Andreadi, Davide Lauro, Vincenza Spallone
BACKGROUND: The aim was to investigate if autonomic symptoms questionnaire Composite Autonomic Symptom Score (COMPASS) 31 has different association with cardiovascular autonomic neuropathy (CAN) and diagnostic performance between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: Seventy-nine participants with T1DM and 140 with T2DM completed COMPASS 31 before cardiovascular reflex tests (CARTs) for CAN, and assessment of symptoms, signs, vibration, and thermal perception thresholds for diabetic polyneuropathy (DPN) diagnosis...
February 26, 2024: Diabetes & Metabolism Journal
#52
JOURNAL ARTICLE
Coral García-Gutiérrez, Ignacio Pérez-Victoria, Ignacio Montero, Jorge Fernández-De la Hoz, Mónica G Malmierca, Jesús Martín, José A Salas, Carlos Olano, Fernando Reyes, Carmen Méndez
Piperazic acid is a cyclic nonproteinogenic amino acid that contains a hydrazine N-N bond formed by a piperazate synthase (KtzT-like). This amino acid, found in bioactive natural products synthesized by non-ribosomal peptide synthetases (NRPSs), confers conformational constraint to peptides, an important feature for their biological activities. Genome mining of Streptomyces strains has been revealed as a strategy to identify biosynthetic gene clusters (BGCs) for potentially active compounds. Moreover, the isolation of new strains from underexplored habitats or associated with other organisms has allowed to uncover new BGCs for unknown compounds...
February 16, 2024: International Journal of Molecular Sciences
#53
JOURNAL ARTICLE
Animesh Hazari, Vinaytosh Mishra, Praveen Kumar, Arun Maiya
OBJECTIVE: The purpose of this study was to test the diagnostic accuracy of the 10g monofilament to screen for diabetic peripheral neuropathy (DPN) in India. The study further assessed the effect of physical activity, footwear use, and occupation on the outcome. METHODS: Non-probabilistic purposive sampling was used to recruit patients with T2DM to assess the diagnostic utility of the 10 g monofilament. 160 participants were recruited divided into 4 groups. Each group consisted of 40 participants with 20 under each category described as "Physical Worker Vs Non- physical worker" (n = 40), "Barefoot Vs Footwear" (n = 40), "Use of Slipper at Home Vs No-slippers use at home" (n = 40), "Agriculture Vs Non- agriculture" (n = 40)...
2024: PloS One
#54
JOURNAL ARTICLE
Faquan Hu, Jiaran Lin, Liyuan Xiong, Zhengpin Li, Wen-Ke Liu, Yu-Jiao Zheng
BACKGROUND: Xuebifang (XBF), a potent Chinese herbal formula, has been employed in managing diabetic peripheral neuropathy (DPN). Nevertheless, the precise mechanism of its action remains enigmatic. PURPOSE: The primary objective of this investigation is to employ a bioinformatics-driven approach combined with network pharmacology to comprehensively explore the therapeutic mechanism of XBF in the context of DPN. STUDY DESIGN AND METHODS: The active chemicals and their respective targets of XBF were sourced from the TCMSP and BATMAN databases...
2024: Frontiers in Endocrinology
#55
RANDOMIZED CONTROLLED TRIAL
Hao-Yue Huang, Yu-Ping Lin, Hua Wei, Yu Fu, Yue-Hong Zhou, Zhao-Hui Fang, Xiao-Tang Qiu, Mei Wang, Qing-Bo Li, Shan-Shan Li, Shi-Dong Wang, Fang Dai, Zhen-Jie Liu, Ling Zhao, Jian-Xuan Wen, Li-Yan Wu, Hui-Yan Zeng, Jin-Ming Zhang, Qi-Yun Lu, Liu He, Wei Song, Lu Sun, Lu-Lu Luo, Jia-Li He, Wen-Wen Xie, Qing-Shun Liang, Yuan Huang, Sheng-Ling Zhu, Jie-Er Long, Zhi-Juan Gao, Ze-Huai Wen, Chun-Ji Li, Wen-Wei Ouyang, Geng Li, Ming-Hui Wu, An-Xiang Li, Jin-Zhu Huang, Sanjoy K Paul, Xian-Yu Tang, Guan-Jie Fan
OBJECTIVE: To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN). METHODS: It is a multicenter double-blinded randomized controlled trial. Participants with DPN were recruited between November 18, 2016 and May 30, 2018 from 8 hospitals in China. All patients received basic treatments for glycemic management. Patients received foot baths with TW herbal granules either 66.9 g (intervention group) or 6...
March 2024: Chinese Journal of Integrative Medicine
#56
JOURNAL ARTICLE
Yitong Zhang, Chenxuan Wu, Wenqi Jiang, Yan Cao, Dongtai Chen
Diabetic Peripheral Neuropathy (DPN) poses an escalating threat to public health, profoundly impacting well-being and quality of life. Despite its rising prevalence, the pathogenesis of DPN remains enigmatic, and existing clinical interventions fall short of achieving meaningful reversals of the condition. Notably, neurostimulation techniques have shown promising efficacy in alleviating DPN symptoms, underscoring the imperative to elucidate the neurobiochemical mechanisms underlying DPN. This study employs an integrated multi-omics approach to explore DPN and its response to neurostimulation therapy...
2024: Frontiers in Endocrinology
#57
JOURNAL ARTICLE
Roshan Dhanapalaratnam, Tushar Issar, Ann M Poynten, Kerry-Lee Milner, Natalie C G Kwai, Arun V Krishnan
OBJECTIVE: Diabetic peripheral neuropathy (DPN) is a frequent complication for persons with type 2 diabetes. Previous studies have failed to demonstrate any significant impact of treatment for DPN. The present study assessed the role of axonal ion channel dysfunction in DPN and explored the hypothesis that there may be a progressive change in ion channel abnormalities that varied with disease stage. METHODS: Neurophysiological studies were conducted using axonal excitability techniques, a clinical method of assessing ion channel dysfunction...
February 9, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#58
JOURNAL ARTICLE
Junli Zhang, Zhenghui Xu, Yu Fu, Lu Chen
BACKGROUND: Diabetic peripheral neuropathy (DPN), the very prevalent microvascular complication of type 2 diabetes mellitus (T2DM), severely threatens the quality of life of diabetic patients. Thus, prevention of DPN is extremely important for public health, and the identification of potential biomarkers may help with early prevention. Our work determined the association between phase angles (PhAs) and the risk of DPN in T2DM patients. MATERIALS AND METHODS: This cross-sectional study recruited 697 T2DM patients from the Third Affiliated Hospital of Soochow University...
February 17, 2024: Endocrine
#59
JOURNAL ARTICLE
Sijia Fei, Jingwen Fan, Jiaming Cao, Huan Chen, Xiaoxia Wang, Qi Pan
AIMS: This study explores the link between Vitamin D deficiency (VDD) and diabetic peripheral neuropathy (DPN) in elderly type 2 diabetes mellitus (T2DM) patients. METHODS: Involving 257 elderly T2DM patients, the study utilized propensity score matching to balance age, sex, and diabetes duration. VDD was defined as serum 25-hydroxyvitamin D [25(OH)D] levels below 20 ng/ml. Large nerve fiber lesions were evaluated by electromyogram, while small nerve fiber lesions were assessed by measuring skin conductance...
February 14, 2024: Diabetes Research and Clinical Practice
#60
JOURNAL ARTICLE
María Fernanda Pérez Hernández, Alejandra Calderón Vallejo, Sergio de Jesús Aguilar Castillo, Daniel Cuauhtémoc Gómez Jiménez, Eduardo Rodríguez Guerrero, Fátima Aguilar Morales, Macedonia Guadalupe Moreno Tovar, Miguel Alfredo Zurita Muñóz, Antonio Eduardo Bautista Cortéz, Claudia Camelia Calzada Mendoza, Mónica Ascención De Nova Ocampo, Juan Manuel Ordóñez Rodríguez, Mónica Luz Gómez Esquivel, Alberto García Méndez, Octavio Flores Gil, Víctor Manuel Macías Zaragoza, Gabriela Yanet Cortés Moreno, Citlaltepetl Salinas Lara, Germán Velázquez García, Héctor Iván Saldivar Cerón, Lucia Monserrat Pérez Navarro, Laura Ávila Jiménez, Jaime Héctor Gómez Zamudio, Margarita Díaz Flores, Miguel Cruz López, María Esther Ocharan Hernández, José de Jesús Peralta Romero
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM); its diagnosis and treatment are based on symptomatic improvement. However, as pharmacological therapy causes multiple adverse effects, the implementation of acupunctural techniques, such as electroacupuncture (EA) has been suggested as an alternative treatment. Nonetheless, there is a lack of scientific evidence, and its mechanisms are still unclear. We present the design and methodology of a new clinical randomized trial, that investigates the effectiveness of EA for the treatment of DPN...
February 15, 2024: BMC complementary medicine and therapies
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