Jim C Hu, Melissa Assel, Mohamad E Allaf, Behfar Ehdaie, Andrew J Vickers, Andrew J Cohen, Benjamin T Ristau, David A Green, Misop Han, Michael E Rezaee, Christian P Pavlovich, Jeffrey S Montgomery, Keith J Kowalczyk, Ashley E Ross, Shilajit D Kundu, Hiten D Patel, Gerald J Wang, John N Graham, Jonathan E Shoag, Ahmed Ghazi, Nirmish Singla, Michael A Gorin, Anthony J Schaeffer, Edward M Schaeffer
BACKGROUND AND OBJECTIVE: The transrectal biopsy approach is traditionally used to detect prostate cancer. An alternative transperineal approach is historically performed under general anesthesia, but recent advances enable transperineal biopsy to be performed under local anesthesia. We sought to compare infectious complications of transperineal biopsy without antibiotic prophylaxis versus transrectal biopsy with targeted prophylaxis. METHODS: We assigned biopsy-naïve participants to undergo transperineal biopsy without antibiotic prophylaxis versus transrectal biopsy with targeted prophylaxis (rectal culture screening for fluoroquinolone-resistant bacteria and antibiotic targeting to culture and sensitivity results) through a multicenter, randomized trial...
January 11, 2024: European Urology