Wei Zheng, Yujie Zhang, Puyang Zhang, Tengda Chen, Xin Yan, Lin Li, Lijun Shao, Zhiru Song, Weiling Han, Jia Wang, Junhua Huang, Kaiwen Ma, Ruihua Yang, Yuru Ma, Lili Xu, Kexin Zhang, Xianxian Yuan, Guanghui Li
AIMS: This study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, and the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genotype. MATERIALS AND METHODS: A prospective pregnancy cohort study was conducted in Beijing, China, from 2022 to 2023. Circulating folate metabolites, including red blood cell (RBC) 5-methyltetrahydrofolate (5-MTHF), 5, 10-methylene-tetrahydrofolate (5,10-CH2-THF), 5- formyltetrahydrofolate (5-CHO-THF), and unmetabolised folic acid (UMFA), and plasma homocysteine (HCY), 5-MTHF, and methylmalonic acid (MMA), were determined at 6-17 weeks and 20-26 weeks of gestation...
May 2024: Diabetes/metabolism Research and Reviews