Shi Zou, Yanqin Du, Shunmei Huang, Mingfa Chen, Xiaoli Yang, Sumeng Li, Yingshan Chen, Meihong Han, Jia Li, Qing Yu, Elisabeth Littwitz-Salomon, Hongming Huang, Mirko Trilling, Shi Liu, Rongjuan Pei, Jia Liu, Baoju Wang, Xin Zheng, Mengji Lu, Ulf Dittmer, Shuilin Sun, Dongliang Yang, Jun Wu
It remains controversial how interferon (IFN) response contributes to hepatitis B virus (HBV) control and pathogenesis. A previous study identified that hydrodynamic injection (HI) of type I IFN (IFN-I) inducer polyinosinic-polycytidylic acid (poly(I:C)) leads to HBV clearance in a chronic HBV mouse model. However, recent studies have suggested that premature IFN-I activation in the liver may facilitate HBV persistence. In the present study, we investigated how the early IFN-I response induces an immunosuppressive signaling cascade and thus causes HBV persistence...
September 22, 2021: Journal of Virology