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J Dove, B Kerns, R E McClellan, S Miyasaka, D H Morton, K Nagai, S Prasad, F Sanftl, M B C Scott, A S Tadepalli, C A Aidala, J Arrington, C Ayuso, C L Barker, C N Brown, W C Chang, A Chen, D C Christian, B P Dannowitz, M Daugherity, M Diefenthaler, L El Fassi, D F Geesaman, R Gilman, Y Goto, L Guo, R Guo, T J Hague, R J Holt, D Isenhower, E R Kinney, N Kitts, A Klein, D W Kleinjan, Y Kudo, C Leung, P-J Lin, K Liu, M X Liu, W Lorenzon, N C R Makins, M Mesquita de Medeiros, P L McGaughey, Y Miyachi, I Mooney, K Nakahara, K Nakano, S Nara, J-C Peng, A J Puckett, B J Ramson, P E Reimer, J G Rubin, S Sawada, T Sawada, T-A Shibata, D Su, M Teo, B G Tice, R S Towell, S Uemura, S Watson, S G Wang, A B Wickes, J Wu, Z Xi, Z Ye
No abstract text is available yet for this article.
April 8, 2022: Nature
#22
Murtaza Bharmal, Morton J Kern, Gautam Kumar, Arnold H Seto
No abstract text is available yet for this article.
April 8, 2022: Current Cardiology Reports
#23
Travis J Cohoon, Morton J Kern
Translesional coronary pressure measures the hemodynamic significance of epicardial coronary artery disease. Angiographic-physiologic mismatching is attributed mainly to imaging limitations. We present a patient with extreme visual-physiologic functional mismatch and a markedly elevated left ventricular end diastolic pressure (LVEDP) as a potential contributory mechanism.
January 4, 2022: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#24
REVIEW
Laurens J C van Zandvoort, Ziad Ali, Morton Kern, Nicolas M van Mieghem, Gary S Mintz, Joost Daemen
Although clinical outcomes after percutaneous coronary intervention (PCI) are improving, the long-term risk for target vessel failure remains concerning. Although the application of intravascular imaging and physiological indexes significantly improves outcomes, their routine use in practice remains limited. Nevertheless, merely using these modalities is not enough, and to truly improve patient outcomes, optimal intravascular dimensions with minimal vascular injury should be targeted. When assessing post-PCI results using either type of physiological or imaging technology, a broad spectrum of stent- and vessel-related anomalies can be expected...
November 22, 2021: JACC. Cardiovascular Interventions
#25
Maya Yabumoto, Murtaza Bharmal, Morton Kern
No abstract text is available yet for this article.
November 4, 2021: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#26
EDITORIAL
Morton J Kern
No abstract text is available yet for this article.
October 2021: Catheterization and Cardiovascular Interventions
#27
JOURNAL ARTICLE
Stephani C Wang, Mark Lee, Elvis Cami, Morton Kern
No abstract text is available yet for this article.
September 25, 2021: European Heart Journal Cardiovascular Imaging
#28
EDITORIAL
Morton J Kern
No abstract text is available yet for this article.
August 23, 2021: JACC. Cardiovascular Interventions
#29
REVIEW
Sripal Bangalore, Gregory W Barsness, George D Dangas, Morton J Kern, Sunil V Rao, Linda Shore-Lesserson, Jacqueline E Tamis-Holland
Cardiac catheterization procedures have rapidly evolved and expanded in scope and techniques over the past few decades. However, although some practices have emerged based on evidence, many traditions have persisted based on beliefs and theoretical concerns. The aim of this review is to highlight common preprocedure, intraprocedure, and postprocedure catheterization laboratory practices where evidence has accumulated over the past few decades to support or discount traditionally held practices.
August 3, 2021: Circulation
#30
EDITORIAL
Morton J Kern, Arnold H Seto
No abstract text is available yet for this article.
June 1, 2021: Catheterization and Cardiovascular Interventions
#31
EDITORIAL
Arnold H Seto, Morton J Kern
No abstract text is available yet for this article.
April 1, 2021: Catheterization and Cardiovascular Interventions
#32
EDITORIAL
Arnold H Seto, Morton J Kern
No abstract text is available yet for this article.
March 2021: Catheterization and Cardiovascular Interventions
#33
JOURNAL ARTICLE
J Dove, B Kerns, R E McClellan, S Miyasaka, D H Morton, K Nagai, S Prasad, F Sanftl, M B C Scott, A S Tadepalli, C A Aidala, J Arrington, C Ayuso, C L Barker, C N Brown, W C Chang, A Chen, D C Christian, B P Dannowitz, M Daugherity, M Diefenthaler, L El Fassi, D F Geesaman, R Gilman, Y Goto, L Guo, R Guo, T J Hague, R J Holt, D Isenhower, E R Kinney, N Kitts, A Klein, D W Kleinjan, Y Kudo, C Leung, P-J Lin, K Liu, M X Liu, W Lorenzon, N C R Makins, M Mesquita de Medeiros, P L McGaughey, Y Miyachi, I Mooney, K Nakahara, K Nakano, S Nara, J-C Peng, A J Puckett, B J Ramson, P E Reimer, J G Rubin, S Sawada, T Sawada, T-A Shibata, D Su, M Teo, B G Tice, R S Towell, S Uemura, S Watson, S G Wang, A B Wickes, J Wu, Z Xi, Z Ye
The fundamental building blocks of the proton-quarks and gluons-have been known for decades. However, we still have an incomplete theoretical and experimental understanding of how these particles and their dynamics give rise to the quantum bound state of the proton and its physical properties, such as its spin1 . The two up quarks and the single down quark that comprise the proton in the simplest picture account only for a few per cent of the proton mass, the bulk of which is in the form of quark kinetic and potential energy and gluon energy from the strong force2 ...
February 2021: Nature
#34
JOURNAL ARTICLE
Agustí Rodríguez-Palmero, Melissa Maria Boerrigter, David Gómez-Andrés, Kimberly A Aldinger, Íñigo Marcos-Alcalde, Bernt Popp, David B Everman, Alysia Kern Lovgren, Stephanie Arpin, Vahid Bahrambeigi, Gea Beunders, Anne-Marie Bisgaard, V A Bjerregaard, Ange-Line Bruel, Thomas D Challman, Benjamin Cogné, Christine Coubes, Stella A de Man, Anne-Sophie Denommé-Pichon, Thomas J Dye, Frances Elmslie, Lars Feuk, Sixto García-Miñaúr, Tracy Gertler, Elisa Giorgio, Nicolas Gruchy, Tobias B Haack, Chad R Haldeman-Englert, Bjørn Ivar Haukanes, Juliane Hoyer, Anna C E Hurst, Bertrand Isidor, Maria Johansson Soller, Sulagna Kushary, Malin Kvarnung, Yuval E Landau, Kathleen A Leppig, Anna Lindstrand, Lotte Kleinendorst, Alex MacKenzie, Giorgia Mandrile, Bryce A Mendelsohn, Setareh Moghadasi, Jenny E Morton, Sebastien Moutton, Amelie J Müller, Melanie O'Leary, Marta Pacio-Míguez, Maria Palomares-Bralo, Sumit Parikh, Rolph Pfundt, Ben Pode-Shakked, Anita Rauch, Elena Repnikova, Anya Revah-Politi, Meredith J Ross, Claudia A L Ruivenkamp, Elisabeth Sarrazin, Juliann M Savatt, Agatha Schlüter, Bitten Schönewolf-Greulich, Zohra Shad, Charles Shaw-Smith, Joseph T Shieh, Motti Shohat, Stephanie Spranger, Heidi Thiese, Frederic Tran Mau-Them, Bregje van Bon, Ineke van de Burgt, Ingrid M B H van de Laar, Esmée van Drie, Mieke M van Haelst, Conny M van Ravenswaaij-Arts, Edgard Verdura, Antonio Vitobello, Stephan Waldmüller, Sharon Whiting, Christiane Zweier, Carlos E Prada, Bert B A de Vries, William B Dobyns, Simone F Reiter, Paulino Gómez-Puertas, Aurora Pujol, Zeynep Tümer
PURPOSE: Postsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53 patients (42 previously unpublished) with DLG4 variants. METHODS: The clinical and genetic information were collected through GeneMatcher collaboration. All the individuals were investigated by local clinicians and the gene variants were identified by clinical exome/genome sequencing. RESULTS: The clinical picture was predominated by early onset global developmental delay, intellectual disability, autism spectrum disorder, and attention deficit-hyperactivity disorder, all of which point to a brain disorder...
May 2021: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#35
EDITORIAL
Morton J Kern, Arnold H Seto
Outcomes of deferred PCI based on negative FFR are generally good. This study demonstrated deferred target lesion failure with FFR >0.80 in 7% and related it to coexistent risk factors, such as multivessel disease, diabetes, and SVG lesions. A negative FFR is only one variable on the continuum of ischemic risk, but in general provides an excellent prognostic tool.
February 1, 2021: Catheterization and Cardiovascular Interventions
#36
EDITORIAL
Morton J Kern
Post-coronary artery bypass graft surgery (CABG) angina has been attributed unligated thoracic side branches competing with LIMA-LAD flow. Case reports suggest thoracic branch occlusion can relieve angina. Phasic arterial blood flow and direct measurements argue against the existence of LIMA steal.
January 1, 2021: Catheterization and Cardiovascular Interventions
#37
EDITORIAL
Morton J Kern, Arnold H Seto
This study compared virtual (residual) post-PCI QFR and actual post-PCI QFR from pre- and post-stent angiograms in predicting post-PCI FFR. While there was no difference in mean values, compared with post-PCI FFR, the post-PCI QFR correlated better than residual QFR. As the CFD algorithms improve, post-PCI QFR can potentially serve as a quality control after PCI to reduce post-PCI angina and adverse outcomes.
November 2020: Catheterization and Cardiovascular Interventions
#38
EDITORIAL
Morton J Kern, Arnold H Seto
No abstract text is available yet for this article.
October 1, 2020: Catheterization and Cardiovascular Interventions
#39
JOURNAL ARTICLE
Melissa A Richard, Austin L Brown, John W Belmont, Michael E Scheurer, Vidal M Arroyo, Kayla L Foster, Kathleen D Kern, Melissa M Hudson, Wendy M Leisenring, M Fatih Okcu, Yadav Sapkota, Yutaka Yasui, Lindsay M Morton, Stephen J Chanock, Leslie L Robison, Gregory T Armstrong, Smita Bhatia, Kevin C Oeffinger, Philip J Lupo, Kala Y Kamdar
BACKGROUND: Treatment characteristics such as cranial radiation therapy (CRT) do not fully explain adiposity risk in childhood acute lymphoblastic leukemia (ALL) survivors. This study was aimed at characterizing genetic variation related to adult body mass index (BMI) among survivors of childhood ALL. METHODS: Genetic associations of BMI among 1458 adult survivors of childhood ALL (median time from diagnosis, 20 years) were analyzed by multiple approaches. A 2-stage genome-wide association study in the Childhood Cancer Survivor Study (CCSS) and the St...
October 13, 2020: Cancer
#40
EDITORIAL
Morton J Kern, Arnold H Seto
Angiographically visible collaterals are seen in a minority of STEMI patients, predominantly to the RCA and in patients with delays to reperfusion. Patients with visible collaterals were less likely to have cardiogenic shock and tended to have a longer survival. Further studies will determine the mechanisms of collateral formation and their protective associations.
September 1, 2020: Catheterization and Cardiovascular Interventions
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