Qian Zhang, Chen Zhao, Lei Zhang, Kai Sun, Linlin Yu, Xianming Wang, Lei Ren, Nan Zhang, Chengyu Chen, Ju Liu, Haimei Wang, Hu Tian
Acute pancreatitis (AP), an inflammatory disorder of the pancreas, can cause systemic inflammatory responses. Escin Sodium (ES), a natural mixture of triterpene saponins extracted from the dry ripe fruit of Fructus Aesculi or horse chestnut crude, has been demonstrated to have antiedematous, anti-inflammatory, and antiexudative effects. We here aim to investigate the effects of ES pretreatment on AP in vivo and in vitro and explore its potential molecular mechanism. In the present study, we demonstrated that ES pretreatment could apparently decrease amylase and lipase, downregulate inflammatory cytokines, and attenuate pancreatic damage...
2021: Oxidative Medicine and Cellular Longevity