Tsurugi Tanaka, Yoko Urata, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Zixin Xu, Nanoka Sakaguchi, Chihiro Tsuchida, Airi Komura, Ayaka Teshima, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, but its pathology has not been fully characterized and the optimal treatment strategy remains unclear. Cellular senescence is a permanent state of cell-cycle arrest that can be induced by multiple stresses. Senescent cells contribute to the pathogenesis of various diseases, owing to an alteration in secretory profile, termed 'senescence-associated secretory phenotype' (SASP), including with respect to pro-inflammatory cytokines...
April 11, 2024: Molecular Human Reproduction