Tae-Soo Noh, Jeong-Sug Kyong, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Myung-Whan Suh
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an alternative option for treating tinnitus. rTMS is a noninvasive method in which repetitive magnetic stimulation is applied to the cortex; it is considered a therapeutic strategy that modulates the loudness of tinnitus. In this study, we performed a double-blind randomized clinical trial to compare the outcome of tinnitus treatment among (1) dual-site (auditory + prefrontal) rTMS stimulation, (2) auditory cortex only rTMS stimulation (AC), and (3) sham stimulation...
September 17, 2020: Brain Topography
Jay F Piccirillo, Thomas L Rodebaugh, Eric J Lenze
No abstract text is available yet for this article.
September 15, 2020: JAMA
Gregory M Asnis
No abstract text is available yet for this article.
September 15, 2020: JAMA
Carl Christoph Schimanski, Stefan Kasper, Susanna Hegewisch-Becker, Jan Schröder, Friedrich Overkamp, Frank Kullmann, Wolf Otto Bechstein, Matthias Vöhringer, Robert Öllinger, Florian Lordick, Volker Heinemann, Michael Geißler, Armin Schulz-Abelius, Helga Bernhard, Michael R Schön, Richard Greil, Peter Galle, Hauke Lang, Irene Schmidtmann, Markus Moehler
Resection of colorectal liver metastases (CRLM) is a potential curative treatment for patients with metastatic colorectal cancer (mCRC) with liver-limited disease (LLD). Although long-term survival improved considerably within the last decades, high recurrence rates of 50-75% after resection remain a major challenge.Tecemotide (L-BLP25) is an antigen-specific cancer vaccine inducing immunity against mucin-1 (MUC1). The LICC trial aimed to improve survival in patients with mCRC after R0/R1 resection of CRLM...
August 23, 2020: Oncoimmunology
Ao-Fei Liu, Chen Li, Wengui Yu, Li-Mei Lin, Han-Cheng Qiu, Yi-Qun Zhang, Xian-Li Lv, Kai Wang, Ce Liu, Wei-Jian Jiang
Background: The development of carotid-cavernous fistulas (CCFs) during surgical recanalization of chronic internal carotid artery occlusion (ICAO) may be secondary to severe ICA dissection rather than a focal tear of the cavernous ICA seen in typical traumatic CCFs. The purpose of this study is to investigate the causal relationship between the CCFs and severe ICA dissections and to characterize technical outcomes after treatment with stenting. Methods: Five patients underwent treatment with self-expanding stents due to intraprocedural CCF and ICA dissection following surgical removal of ICAO plaque...
2020: Chinese Neurosurgical Journal
Jakko van Ingen, Stefano Aliberti, Claire Andrejak, James D Chalmers, Luigi R Codecasa, Charles L Daley, Naoki Hasegawa, David E Griffith, Wouter Hoefsloot, Gwen Huitt, Julie Jarand, Byung Woo Jhun, Michael R Loebinger, Theodore K Marras, Kozo Morimoto, Eva Polverino, Felix C Ringshausen, Miguel Santin, Rachel Thomson, Dirk Wagner, Richard J Wallace, Kevin L Winthrop, Jae-Joon Yim
Adverse events are frequent in NTM pulmonary disease treatment, but evidence to support their management is scarce. An expert panel survey on management of adverse events shows consistent opinions on management of hepatoxicity, ocular toxicity, ototoxicity, tinnitus and GI upset. These opinions can provide assistance in individual patient management decisions.
September 10, 2020: Clinical Infectious Diseases
Caitlin M Gray, Adejuyigbe Olusegun Adaralegbe, Sanjeev Kumar
Neuromodulation continues to grow in its scope and application in the relief of chronic and debilitating disorders. Both otalgia and tinnitus can be multifactorial in etiology, with diagnostic and treatment challenges. This is a case of spinal cord stimulator placement providing a patient with near total relief of otalgia, total relief of tinnitus, and mild improvement in sensorineural hearing loss. We believe that this is the first report showing benefit of high spinal cord stimulation in tinnitus, and we consider whether there are neuronal connections between upper cervical nerve roots and the auditory pathways...
July 2020: A&A Practice
Michaela Dedeciusova, Constantin Tuleasca, Steven David Hajdu, Luis Schiappacasse, David Patin, Marc Levivier
INTRODUCTION: Head and neck extracranial arteriovenous malformations (AVMs) are rare pathological conditions which pose diagnostic and reconstruction challenges. Stereotactic radiosurgery (SRS) is nowadays an established treatment method for brain AVMs, with high obliteration and low complication rates. Here we describe the first report of head extracranial AVMs successfully treated by Gamma Knife (GK) as a retrospective historical cohort. METHODS: Over a 9-year period, 2 cases of extracranial AVMs were treated by GK Perfexion (Elekta Instruments AB, Stockholm, Sweden) at a single institution...
September 9, 2020: Stereotactic and Functional Neurosurgery
Jasem Youssef Al-Hashel, Ismail Ibrahim Ismail, Mohamed Ibrahim, John K John, Fatemah Husain, Walaa Ahmed Kamel, Raed Behbehani, Samar Farouk Ahmed
Background: Idiopathic intracranial hypertension (IIH) affects predominantly obese females during their reproductive age period. The demographics of this condition has not been studied in Kuwait before. Objectives: To determine the demographics, clinical features, risk factors, and treatment modalities of IIH in the main neurology tertiary referral hospital in Kuwait and to compare our data with literature. Methods: A retrospective study was conducted to identify cases of IIH seen between January 1, 2018, and December 31, 2018...
2020: Frontiers in Neurology
Yeon Seok You, Sang Woo Park, Seok Kweon Yun, Eun Jung Lee
INTRODUCTION: Sweet syndrome (SS) is an idiopathic autoimmune disease which has been associated with various extracutaneous manifestations. Otologic symptoms secondary to SS are characterized by bilateral, progressive, sensorineural hearing loss, which requires auditory rehabilitation with, for example, cochlear implantation. PATIENT CONCERNS: A 43-year-old woman complaining of bilateral sudden hearing loss visited the Emergency Department of our University. Abrupt onset of fever peaking up to 40°C and vomiting accompanied the hearing loss and other associated symptoms were: tinnitus that sounded like a machine humming, mild dizziness, a painful rash (on the right upper eyelid, chest, back, forearms, and lower extremities), arthralgia in both the hip and knee joints, and vision loss in the right eye...
September 4, 2020: Medicine (Baltimore)
Jiemei Chen, Ping Zhong, Zhaoli Meng, Fan Pan, Leiyu Qi, Tiantian He, Jingzhe Lu, Peiyu He, Yun Zheng
PURPOSE: To improve the efficacy of music therapy on tinnitus relief, specific music that was not repetitively played and satisfies individualized preference was developed. The aim of this study was to investigate effects of combination of the specific music and educational counseling on tinnitus relief in short term. METHODS: Sixty patients suffering from chronic tinnitus were included. The non-randomized controlled study was designed with two intervention groups: educational counseling (EC, which included a 1-h individualized instruction) and preferred music therapy [PMT, which included EC plus 15, 30-min preferred music sessions (PMS)]...
September 5, 2020: European Archives of Oto-rhino-laryngology
Yume Suzuki, Naoki Toma, Yusuke Kuroda, Yoichi Miura, Masato Shiba, Ryuta Yasuda, Hidenori Suzuki
BACKGROUND: An elongated styloid process can less frequently lead to symptomatic compression of the internal jugular vein (IJV). We present the first case of dural arteriovenous fistula (DAVF) in association with compressed IJV by an elongated styloid process. CASE DESCRIPTION: A 77-year-old woman presented with pulsating tinnitus. She was diagnosed with DAVF at the right hypoglossal canal and underwent transvenous embolization (TVE). The shunt flow was reduced and the symptom disappeared after TVE...
September 3, 2020: World Neurosurgery
Denis Jacques, Thomas Dubois, Nicolas Zdanowicz, Pierre Garin, Chantal Gilain
BACKGROUND: The multidisciplinary management of disabling chronic tinnitus in the audiophonology centre demonstrates its relevance. The detection and treatment of overlapping psychiatric pathologies is a crucial issue in the work of liaison psychiatry. SUBJECTS AND METHODS: A 10-year retrospective review of the activities of a university audiophonology centre with 166 patients who consulted for disabling chronic tinnitus and who underwent a Mini International Neuropsychiatric Interview...
September 2020: Psychiatria Danubina
Miguel Muñoz-Ruiz, Janne Nordberg, Jaana Lähdetie, Satu K Jääskeläinen
Aims: A 13-year-old boy with symptomatic focal epilepsy due to a right parietal dysembryoplastic neuroepithelial tumor (DNET) presented pre- and post-operatively fluctuating tinnitus and sensory symptoms which became persistent after incomplete tumor resection. He received low-frequency rTMS treatment and cathodal tDCS treatment. Methods: Case report with clinical details and pictures from rTMS and tDCS stimulation targets. Results: The patient became symptom free with an initial low-frequency rTMS treatment series targeted to the EEG-verified epileptic zone followed by maintenance therapy at the same region with cathodal tDCS at home...
2020: Clinical Neurophysiology Practice
Nadera Ahmadzai, Wei Cheng, Shaun Kilty, Leila Esmaeilisaraji, Dianna Wolfe, James Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Becky Skidmore, Brian Hutton
BACKGROUND: Meniere's disease (MD) is a chronic condition of the inner ear consisting of symptoms that include vertigo attacks, fluctuating sensorineural hearing loss, tinnitus and aural fullness. Despite availability of various interventions, there is uncertainty surrounding their relative efficacy, thus making it difficult to select the appropriate treatments for MD. The objective of this systematic review was to assess the relative effects of the available pharmacologic and surgical interventions in patients with MD with regard to vertigo and other key patient outcomes based on data from randomized clinical trials (RCTs)...
2020: PloS One
Diyan Chen, Zhujian Wang, Gaogan Jia, Huanyu Mao, Yusu Ni
OBJECTIVE: Immunity is associated with acute low tone hearing loss. However, the exact pathophysiology of immunity-mediated acute low tone hearing loss remains unknown. In this study, we evaluated the presence, therapeutic effectiveness, and immunopathological mechanisms of anti-endothelial cell autoantibodies (AECEs) in patients with acute low-frequency hearing loss. MATERIAL AND METHODS: Forty-nine patients who were treated as inpatients having acute low-frequency hearing loss and additional symptoms, such as ear fullness, tinnitus, dizziness, or hyperacusis, were enrolled in this study...
August 31, 2020: Ear, Nose, & Throat Journal
Dayse da Silva Souza, Alexandre Alex Almeida, Suellen Marinho Dos Santos Andrade, Daniel Gomes da Silva Machado, Márcio Leitão, Tanit Ganz Sanchez, Marine Raquel Diniz da Rosa
OBJECTIVES: This study aims to determine whether transcranial direct current stimulation (tDCS): a) is effective in the treatment of tinnitus by decreasing its annoyance and severity; b) modulates the cortical electrical activity of such individuals. METHODS: A double-blind, placebo-controlled clinical trial was conducted with 24 patients with tinnitus, randomized into two groups: Group 1 (n = 12) received anodal tDCS over the left temporoparietal area (LTA) and cathodal tDCS over the right dorsolateral prefrontal cortex (DLPFC) and Group 2 (n = 12) received placebo intervention...
August 28, 2020: Neurophysiologie Clinique, Clinical Neurophysiology
S Vijayasundaram, Padmanabhan Karthikeyan, Shashwat Datt Mehta
AIM: The aim of this study was to assess the efficacy and feasibility of virtual follow-up in patients who have undergone intratympanic steroid injection for treatment of tinnitus during COVID-19 pandemic. MATERIALS & METHODS: Twenty-five patients having long-term tinnitus undergoing intratympanic steroid course, were followed up virtually via video calling & telephonic methods and evaluated using Tinnitus handicap inventory scoring over the period of 68 days...
August 15, 2020: American Journal of Otolaryngology
Nurdoğan Ata, Necat Alataş, Mustafa Güllüev, Esra Yılmaz
OBJECTIVE: Patients may be afraid when they receive knowledge that medications are injected into the middle ear through the tympanic membrane using a fine needle during intratympanic treatment. The aim of this study was to evaluate the effect of video-assisted information prior to intratympanic steroid injection on patient anxiety. STUDY DESIGN: Prospective, Non-randomized, controlled trial. SETTING: Tertiary academic medical center. METHODS: A total of 85 patients who had an indication for intratympanic treatment due to idiopathic sudden sensorineural hearing loss and tinnitus were included in this prospective study...
August 19, 2020: American Journal of Otolaryngology
Neila L Kline, Kristen Angster, Erica Archer, Prashant Raghavan, Robert E Morales, Michaela K Mathews, David J Eisenman
PURPOSE: Pulse synchronous tinnitus (PT) is common in patients with idiopathic intracranial hypertension (IIH) and in those with sigmoid sinus wall abnormalities (SSWAs). Although patients with SSWAs and IIH share many clinical features, the incidence of SSWAs in patients with IIH and its relationship to PT in this cohort is less well established. The purpose of this study is to assess the incidence of SSWAs in patients with IIH and PT, and to determine if there is an association between SSWAs and PT in this population...
August 13, 2020: American Journal of Otolaryngology
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