Piotr Soczewka, Déborah Tribouillard-Tanvier, Jean-Paul di Rago, Teresa Zoladek, Joanna Kaminska
Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes and Wilson's diseases, respectively, and iron imbalance is observed in Parkinson's and Alzheimer's diseases. To better understand human diseases, Saccharomyces cerevisiae yeast are used as a model organism. In our studies, we used the vps13 Δ yeast strain as a model of rare neurological diseases caused by mutations in VPS13A - D genes. In this work, we show that overexpression of genes encoding copper transporters, CTR1 , CTR3, and CCC2 , or the addition of copper salt to the medium, improved functioning of the vps13 Δ mutant...
February 24, 2021: International Journal of Molecular Sciences