Xiaoqian Li, Jie Zhang, Yingying Li, Yue Dai, Hui Zhu, Huimin Jiang, Yiran Han, Xiang Chu, Yueyue Sun, Wen Ju, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao
INTRODUCTION: Celastrol is an active pentacyclic triterpenoid extracted from Tripterygium wilfordii and has anti-inflammatory and anti-tumor properties. Whether Celastrol modulates platelet function remains unknown. Our study investigated its role in platelet function and thrombosis. METHODS: Human platelets were isolated and incubated with Celastrol (0, 1, 3 and 5 μM) at 37 °C for 1 h to measure platelet aggregation, granules release, spreading, thrombin-induced clot retraction and intracellular calcium mobilization...
December 10, 2023: Biochemical and Biophysical Research Communications