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JOURNAL ARTICLE
Maggie S Chen, Rujie Sun, Richard Wang, Yuyang Zuo, Kun Zhou, Junyoung Kim, Molly M Stevens
Many cardiac diseases, such as arrhythmia or cardiogenic shock, cause irregular beating patterns that must be regulated to prevent disease progression towards heart failure. Treatments can include invasive surgery or high systemic drug dosages, which lack precision, localization, and control. Drug delivery systems (DDSs) that can deliver cargo to the cardiac injury site could address these unmet clinical challenges. Here, we present a microrobotic DDS that can be mobilized to specific sites via magnetic control...
May 15, 2024: Advanced Healthcare Materials
#2
Hiroshi Takagi, Nayoung Lee, Andrew K Hempton, Savita Purushwani, Michitaka Notaguchi, Kota Yamauchi, Kazumasa Shirai, Yaichi Kawakatsu, Susumu Uehara, William G Albers, Benjamin L R Downing, Shogo Ito, Takamasa Suzuki, Takakazu Matsuura, Izumi C Mori, Nobutaka Mitsuda, Daisuke Kurihara, Tomonao Matsushita, Young Hun Song, Yoshikatsu Sato, Mika Nomoto, Yasuomi Tada, Kousuke Hanada, Josh T Cuperus, Christine Queitsch, Takato Imaizumi
Seasonal changes in spring induce flowering by expressing the florigen, FLOWERING LOCUS T (FT), in Arabidopsis . FT is expressed in unique phloem companion cells with unknown characteristics. The question of which genes are co-expressed with FT and whether they have roles in flowering remains elusive. Through tissue-specific translatome analysis, we discovered that under long-day conditions with the natural sunlight red/far-red ratio, the FT -producing cells express a gene encoding FPF1-LIKE PROTEIN 1 (FLP1)...
April 29, 2024: bioRxiv
#3
JOURNAL ARTICLE
Wei Li, Lingzhen Chen, S Mohammad Sajadi, Sh Baghaei, Soheil Salahshour
Stem cells (SCs) play a crucial role in tissue repair, regeneration, and maintaining physiological homeostasis. Exercise mobilizes and enhances the function of SCs. This review examines the effects of acute and chronic aerobic and resistance exercise on the population of SCs in healthy and diseased individuals across different age groups. Both acute intense exercise and moderate regular training increase circulating precursor cells CD34+ and, in particular, the subset of angiogenic progenitor cells (APCs) CD34+/KDR+...
December 2024: Regenerative Therapy
#4
JOURNAL ARTICLE
Sangmin Lee, Jeongbok Lee, Soomi Choi, Eunhyung Kim, Hyunseok Kwon, Jinkyu Lee, Sung Min Kim, Heungsoo Shin
Reconstruction of large 3D tissues based on assembly of micro-sized multi-cellular spheroids has gained attention in tissue engineering. However, formation of 3D adipose tissue from spheroids has been challenging due to the limited adhesion capability and restricted cell mobility of adipocytes in culture media. In this study, we addressed this problem by developing adipo-inductive nanofibers enabling dual delivery of indomethacin and insulin. These nanofibers were introduced into composite spheroids comprising human adipose-derived stem cells (hADSCs)...
May 13, 2024: Biofabrication
#5
JOURNAL ARTICLE
Toru Nakamura, Atsutaka Masuda, Makoto Kako, Hirayuki Enomoto, Masaki Kaibori, Yasuyuki Fujita, Kyoko Tanizawa, Tetsuya Ioji, Yoshihiro Fujimori, Kei Fukami, Takuma Hazama, Hideki Iwamoto, Yasukazu Kako, Kaoru Kobayashi, Hironori Koga, Koji Nagafuji, Takayasu Ohtake, Hiroyuki Suzuki, Tomoyuki Takashima, Toshitaka Tsukiyama, Haruki Uojima, Kenichi Yamahara, Koichiro Yamakado, Hidekazu Yamamoto, Kazunori Yoh, Satoshi Yoshihara, Atsuhiko Kawamoto, Shuhei Nishiguchi, Shuzo Kobayashi, Takuji Torimura, Takumi Kawaguchi
INTRODUCTION: In this multicenter clinical study, we aimed to investigate the efficacy and safety of the transhepatic arterial administration of granulocyte-colony stimulating factor (G-CSF)-mobilized autologous peripheral blood (PB)-CD34+ cells compared with standard therapy in patients with decompensated cirrhosis type C. METHODS: Patients were randomly assigned (2:1) to the CD34+ cell transplant (CD34+ cell) or standard-of-care (SOC) group and followed up for 52 weeks...
December 2024: Regenerative Therapy
#6
REVIEW
Attilio Olivieri, Francesco Saraceni, Amalia De Luca
No abstract text is available yet for this article.
April 23, 2024: Transfusion and Apheresis Science
#7
JOURNAL ARTICLE
Ying Ma, Xingguo She, Yang Liu, Xian Qin
MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. We explored the mechanism through which MSCs-exo influences cognitive impairment in sepsis-associated encephalopathy (SAE). Here, we show that miR-140-3p targeted Hmgb1. MSCs-exo plus miR-140-3p mimic (Exo) and antibiotic imipenem/cilastatin (ABX) improve survival, weight, and cognitive impairment in cecal ligation and puncture (CLP) mice. Exo and ABX inhibit high mobility group box 1 (HMGB1), IBA-1, interleukin (IL)-1β, IL-6, iNOS, TNF-α, p65/p-p65, NLRP3, Caspase 1, and GSDMD-N levels...
May 11, 2024: Communications Biology
#8
JOURNAL ARTICLE
Lin Liu, Ding-Song Zhang, Xue-Juan Zhang, Zhong-Zheng Zheng, San-Bin Wang
Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) has been introduced for the mobilization of peripheral blood stem cells (PBSCs). However, no cases of acute lung injury (ALI) in healthy donors have been reported, and the underlying mechanisms remain poorly understood. We first reported a case of ALI caused by PEG-rhG-CSF in a healthy Chinese donor, characterized by hemoptysis, hypoxemia, and patchy shadows. Ultimately, hormone administration, planned PBSC collection, leukocyte debridement, and planned PBSC collection resulted in active control of the donor's ALI...
May 10, 2024: International Journal of Hematology
#9
JOURNAL ARTICLE
Daiki Hokkoku, Kazuki Sasaki, Shogo Kobayashi, Takashi Shimbo, Tomomi Kitayama, Sho Yamazaki, Yukari Yamamoto, Yuya Ouchi, Hiroki Imamura, Takeshi Kado, Keisuke Toya, Wataru Fujii, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Katsuto Tamai, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND: Chronic pancreatitis (CP) is a progressive disease characterized by pancreatic fibrosis for which effective treatment options are lacking. Mesenchymal stem cells (MSCs) have shown potential for fibrosis treatment but face limitations in clinical application. The high-mobility group box 1 (HMGB1) fragment mobilizes MSCs from bone marrow into the blood and has emerged as a promising therapeutic agent for tissue regeneration in various pathological conditions. The aim of this study was to investigate the potential therapeutic effects of systemic administration of the HMGB1 fragment in a mouse model of CP...
May 10, 2024: Journal of Gastroenterology
#10
JOURNAL ARTICLE
Lou Soret, Coralie L Guerin, Guillaume Goudot, Léa Guyonnet, Jean-Luc Diehl, Aurélien Philippe, Pascale Gaussem, David M Smadja
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The SARS-CoV-2 pandemic has unveiled complex pathophysiological mechanisms underpinning COVID-19, notably inducing a systemic acquired vascular hemopathy characterized by endothelial dysfunction and intussusceptive angiogenesis, a rapid vascular remodeling process identified as a hallmark in severe COVID-19 cases affecting pulmonary and cardiac tissues. Stem cell migration have been proposed as significant regulators of this neoangiogenic process...
May 9, 2024: Stem cell reviews and reports
#11
JOURNAL ARTICLE
Paula Renata Machado Passos Pederzoli, Karen de Lima Prata, Nathália Gomide Cruz, Pedro Victorio de Almeida Marzano, Maurício Colombini Martins, Luciana de Almeida Costa, Roberta Kelly de Andrade, Marcia Regina Issa Salomão Libânio, Brian Custer, André Rolim Belisário
BACKGROUND: Autologous stem cell transplantation is a treatment modality for several diseases. Prediction of successful mobilization may be useful to optimize hematopoietic stem cell collection. STUDY DESIGN AND METHODS: This was a retrospective study with data from transplantation candidates between September 2015 and December 2021 being analyzed. The medical record of each patient was reviewed to mine mobilization information. The laboratory data analyzed were CD34+ cell enumeration and pre-collection peripheral blood cell count...
April 29, 2024: Hematology, Transfusion and Cell Therapy
#12
JOURNAL ARTICLE
Tao Song, Fengxin Zhao, Ling Yan, Puxin Liu, Jirong Yang, Changshun Ruan, Dongxiao Li, Yumei Xiao, Xingdong Zhang
Injectable hydrogels are promising for treatment of bone defects in clinic owing to their minimally invasive procedure. Currently, there is limited emphasis on how to utilize injectable hydrogels to mobilize body's regenerative potential for enhancing bone regeneration. Herein, an injectable bone-mimicking hydrogel (BMH) scaffold assembled from nanocomposite microgel building blocks was developed, in which a highly interconnected microporous structure and an inorganic/organic (methacrylated hydroxyapatite and methacrylated gelatin) interweaved nano structure were well-designed...
May 2, 2024: Biomaterials
#13
REVIEW
Inbar Cohen, Iuliana Vaxman, Morie A Gertz
BACKGROUND: High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) has become part of standard of care (SOC) in newly diagnosed multiple myeloma (MM). In this review we provide a historical perspective on ASCT since its introduction in the 1990s. SUMMARY: Overall Survival (OS) benefit for HDT followed by ASCT was demonstrated in studies comparing HDT with ASCT to standard-dose therapy (SDT) before the era of novel agents. Conditioning is done with melphalan 200 mg/m2 (MEL200)...
May 6, 2024: Acta Haematologica
#14
JOURNAL ARTICLE
Yinfeng Guo, Meng Wang, Jiaxin Zhu, Qiaoming Li, Haitao Liu, Yang Wang, Steven X Hou
In Drosophila , long noncoding RNA Hsrω rapidly assembles membraneless organelle omega speckles under heat shock with unknown biological function. Here, we identified the distribution of omega speckles in multiple tissues of adult Drosophila melanogaster and found that they were selectively distributed in differentiated enterocytes but not in the intestinal stem cells of the midgut. We mimicked the high expression level of Hsrω via overexpression or intense heat shock and demonstrated that the assembly of omega speckles nucleates TBPH for the induction of ISC differentiation...
May 17, 2024: IScience
#15
REVIEW
Jessica Pérez-Sancho, Lisa Van den Broeck, Pedro García-Caparros, Rosangela Sozzani
All differentiated root cells derive from stem cells spatially organized within the stem cell niche (SCN), a microenvironment located within the root tip. Here, we compiled recent advances in the understanding of how the SCN drives the establishment and maintenance of cell types. The quiescent center (QC) is widely recognized as the primary driver of cell fate determination, but it is recently considered a convergence center of multiple signals. Cell identity of the cortex endodermis initials is mainly driven by the regulatory feedback loops between transcription factors (TFs), acting as mobile signals between neighboring cells, including the QC...
May 4, 2024: Current Opinion in Genetics & Development
#16
JOURNAL ARTICLE
Barbora Orlikova-Boyer, Anne Lorant, Sruthi Reddy Gajulapalli, Claudia Cerella, Michael Schnekenburger, Jin-Young Lee, Ji Yeon Paik, Yejin Lee, David Siegel, David Ross, Byung Woo Han, Thi Kim Yen Nguyen, Christo Christov, Hyoung Jin Kang, Mario Dicato, Marc Diederich
BACKGROUND: Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cells rely on altered mitochondrial metabolism and oxidative phosphorylation. Targeting rewired energy metabolism and inducing non-apoptotic cell death, along with the release of damage-associated molecular patterns (DAMPs), can enhance therapeutic strategies and immunogenic therapies against CML and prevent the emergence of TKI-resistant cells and LSC persistence...
May 4, 2024: Biomarker Research
#17
REVIEW
Sucharita Patra, Pritam Kumar Roy, Ankita Dey, Mahitosh Mandal
The present study explores the complex roles of High Mobility Group Box 1 (HMGB1) in the context of cancer development, emphasizing glioblastoma (GBM) and other central nervous system (CNS) cancers. HMGB1, primarily known for its involvement in inflammation and angiogenesis, emerges as a multifaceted player in the tumorigenesis of GBM. The overexpression of HMGB1 correlates with glioma malignancy, influencing key pathways like RAGE/MEK/ERK and RAGE/Rac1. Additionally, HMGB1 secretion is linked to the maintenance of glioma stem cells (GSCs) and contributes to the tumor microenvironment's (TME) vascular leakiness...
May 1, 2024: Biochimica et Biophysica Acta. Reviews on Cancer
#18
JOURNAL ARTICLE
Eri Sasabe, Ayumi Tomomura, Tetsuya Yamamoto
BACKGROUND: Various antigen-presenting cells and tumor cells-expressing PD-L1 inhibits antitumor immune responses in the tumor microenvironment. Recently, numerous studies have shown that tumor cell intrinsic PD-L1 also plays important roles in tumor growth and progression. On the other hand, oral squamous cell carcinoma (OSCC) cells overexpress epidermal growth factor receptor (EGFR) and EGFR signal pathway exacerbates tumor progression. Therefore, this study assessed whether tumor-intrinsic PD-L1 facilitates malignant potential of OSCC cells through regulation of EGFR signaling...
May 1, 2024: Journal of Oral Pathology & Medicine
#19
REVIEW
Michael C Jin, Ian D Connolly, Karthik Ravi, Daniel G Tobert, Shannon M MacDonald, John H Shin
Chordomas are tumors thought to originate from notochordal remnants that occur in midline structures from the cloves of the skull base to the sacrum. In adults, the most common location is the sacrum, followed by the clivus and then mobile spine, while in children a clival origin is most common. Most chordomas are slow growing. Clinical presentation of chordomas tend to occur late, with local invasion and large size often complicating surgical intervention. Radiation therapy with protons has been proven to be an effective adjuvant therapy...
May 2024: Neurosurgical Focus
#20
JOURNAL ARTICLE
Giulia Consiglieri, Francesca Tucci, Maurizio De Pellegrin, Barbara Guerrini, Alessandro Cattoni, Giulia Risca, Stefano Scarparo, Marina Sarzana, Silvia Pontesilli, Renata Mellone, Serena Gasperini, Stefania Galimberti, Paolo Silvani, Chiara Filisetti, Silvia Darin, Giulia Forni, Simona Miglietta, Ludovica Santi, Marcella Facchini, Ambra Corti, Francesca Fumagalli, Maria Pia Cicalese, Valeria Calbi, Maddalena Migliavacca, Federica Barzaghi, Francesca Ferrua, Vera Gallo, Salvatore Recupero, Daniele Canarutto, Matteo Doglio, Lucia Tedesco, Nicola Volpi, Attilio Rovelli, Giancarlo la Marca, Maria Grazia Valsecchi, Stefano Zancan, Fabio Ciceri, Luigi Naldini, Cristina Baldoli, Rossella Parini, Bernhard Gentner, Alessandro Aiuti, Maria Ester Bernardo
Mucopolysaccharidosis type I Hurler (MPSIH) is characterized by severe and progressive skeletal dysplasia that is not fully addressed by allogeneic hematopoietic stem cell transplantation (HSCT). Autologous hematopoietic stem progenitor cell-gene therapy (HSPC-GT) provides superior metabolic correction in patients with MPSIH compared with HSCT; however, its ability to affect skeletal manifestations is unknown. Eight patients with MPSIH (mean age at treatment: 1.9 years) received lentiviral-based HSPC-GT in a phase 1/2 clinical trial (NCT03488394)...
May 2024: Science Translational Medicine
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