Leonardo Iaccarino, Jorge J Llibre-Guerra, Eric McDade, Lauren Edwards, Brian Gordon, Tammie Benzinger, Jason Hassenstab, Joel H Kramer, Yan Li, Bruce L Miller, Zachary Miller, John C Morris, Nidhi Mundada, Richard J Perrin, Howard J Rosen, David Soleimani-Meigooni, Amelia Strom, Elena Tsoy, Guoqiao Wang, Chengjie Xiong, Ricardo Allegri, Patricio Chrem, Silvia Vazquez, Sarah B Berman, Jasmeer Chhatwal, Colin L Masters, Martin R Farlow, Mathias Jucker, Johannes Levin, Stephen Salloway, Nick C Fox, Gregory S Day, Maria Luisa Gorno-Tempini, Adam L Boxer, Renaud La Joie, Randall Bateman, Gil D Rabinovici
Approximately 5% of Alzheimer's disease patients develop symptoms before age 65 (early-onset Alzheimer's disease), with either sporadic (sporadic early-onset Alzheimer's disease) or dominantly inherited (dominantly inherited Alzheimer's disease) presentations. Both sporadic early-onset Alzheimer's disease and dominantly inherited Alzheimer's disease are characterized by brain amyloid-β accumulation, tau tangles, hypometabolism and neurodegeneration, but differences in topography and magnitude of these pathological changes are not fully elucidated...
2024: Brain communications