Kazuhiro Kurihara, Takanori Suganuma
Peutz-Jeghers syndrome is an autosomal dominant disorder characterized by hamartomatous polyposis, pigmentation, and malignant tumors. We report a case of ileocecal carcinoma that was incidentally detected during follow-up for Peutz-Jeghers syndrome. A 39-year-old man with solitary Peutz-Jeghers syndrome had undergone three abdominal surgeries. He had been followed up via upper and lower gastrointestinal endoscopy and small intestinal endoscopy. In the endoscopic examination of the lower gastrointestinal tract, a 35 mm large, bumpy, elevated lesion was observed in the cecum...
October 9, 2020: Clinical Journal of Gastroenterology
Eger R Mikaeel, Joanne P Young, Jenny E Hardingham, Gonzalo Tapia Rico, Peter J Hewett, Erin L Symonds, Suzanne Edwards, Eric Smith, Yoko Tomita, Wendy Uylaki, Mehgan Horsnell, Peter Gibbs
OBJECTIVES: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia. METHODS: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y)...
October 6, 2020: Expert Review of Gastroenterology & Hepatology
Junichi Kato, Akinori Maruta, Yohei Shirakami, Taku Mizutani, Noritaka Ozawa, Takayasu Ideta, Jun Takada, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu
A goblet cell carcinoid is quite rare and has features, wherein, a carcinoid-like image and an adenocarcinoma-like image coexist. We encountered two cases of rare goblet cell carcinoid originating in the appendix. Case 1 is that of a 48-year-old man with a chief complaint of abdominal distension and case 2 is that of a 64-year-old woman with a chief complaint of constipation. At the time of diagnosis, both cases had already metastasized to the peritoneum and other organs, and no radical surgical treatment could be administered in either case...
September 17, 2020: Clinical Journal of Gastroenterology
Ali Toffaha, Walid El Ansari, Ammar Aleter
INTRODUCTION: Adnexal masses include those affecting the ovary or fallopian tubes. We report a unique case with discrepancy between the pre-operative diagnosis (adnexal mass) and the post-operative definitive findings (appendicular tumor invading ovary). We also employ a literature review to provide four scenarios of uncertainty that are encountered between appendiceal and adnexal masses. PRESENTATION OF CASE: A 58 year old female with history of treated left colon cancer, referred to the gynecology clinic with intermittent vaginal bleeding for 5 days...
September 19, 2020: International Journal of Surgery Case Reports
Shimpei Matsui, Kohei Murata, Yosuke Fukunaga, Takashi Takeda, Makoto Fujii, Tatsuro Yamaguchi, Yoshinori Kagawa, Tsunekazu Mizushima, Yuko Ohno, Takashi Yao, Yuichiro Doki, Kenichi Sugihara
BACKGROUND: Appendiceal tumor has recently been treated differently from colorectal cancer. However, obtaining knowledge of this disease is difficult because of its rareness. OBJECTIVE: This study aimed to investigate the clinicopathological characteristics of appendiceal tumors in a Japanese cohort. DESIGN: This was a nationwide multi-institution retrospective observational study. SETTING: This study was conducted at the participating tertiary referral hospitals...
October 2020: Diseases of the Colon and Rectum
Tatsuya Suzuki, Yasuhiro Yamamoto, Toshihiko Torigoe, Shoichiro Mizukami, Kengo Shigehara
Primary appendiceal tumors are rare malignancies; some cases have been described to invade other organs, and this represents a very rare clinical condition. We report a case of appendiceal adenocarcinoma invading the sigmoid colon and a review of similar cases. A 69-year-old woman with complaints of hematochezia was admitted to the hospital. Colonoscopy revealed a tumor in the sigmoid colon, which was a well-differentiated tubular adenocarcinoma. A computed tomography scan showed an appendiceal mass that involved the sigmoid colon, suggesting an appendiceal cancer invading the sigmoid colon...
2020: Case Reports in Surgery
Hiroshi Yoshida, Hiroki Tanaka, Takafumi Tsukada, Naoko Abeto, Mayumi Kobayashi-Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
BACKGROUND: This study examined the accuracy and pitfalls associated with frozen section diagnosis of primary ovarian tumors and ovarian metastases based on the 2014 World Health Organization classification (WHO) criteria and proposed improvements from a pathologist's perspective. METHODS: We microscopically reviewed 871 cases of primary ovarian tumor (N = 802) and ovarian metastasis (N = 69) and compared the results of frozen sections with the final diagnosis. Malignant potential concordance (benign, borderline, or malignant) and specific discordant diagnosis rates were analyzed...
September 21, 2020: International Journal of Surgical Pathology
David S Hong, Marwan G Fakih, John H Strickler, Jayesh Desai, Gregory A Durm, Geoffrey I Shapiro, Gerald S Falchook, Timothy J Price, Adrian Sacher, Crystal S Denlinger, Yung-Jue Bang, Grace K Dy, John C Krauss, Yasutoshi Kuboki, James C Kuo, Andrew L Coveler, Keunchil Park, Tae Won Kim, Fabrice Barlesi, Pamela N Munster, Suresh S Ramalingam, Timothy F Burns, Funda Meric-Bernstam, Haby Henary, Jude Ngang, Gataree Ngarmchamnanrith, June Kim, Brett E Houk, Jude Canon, J Russell Lipford, Gregory Friberg, Piro Lito, Ramaswamy Govindan, Bob T Li
BACKGROUND: No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers. Sotorasib is a small molecule that selectively and irreversibly targets KRASG12C . METHODS: We conducted a phase 1 trial of sotorasib in patients with advanced solid tumors harboring the KRAS p.G12C mutation. Patients received sotorasib orally once daily...
September 20, 2020: New England Journal of Medicine
Mengzhen Zheng, Tong Li, Yan Li, Tengfei Zhang, Lianfeng Zhang, Wang Ma, Lin Zhou
Introduction: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neuroendocrine neoplasms (NENs). The purpose of this study was to investigate the characteristics and survival profile of appendiceal MiNENs, with a view of providing robust clinical features of this rare disease. Methods: Patients were selected from the Surveillance, Epidemiology, and End Results database (2004-2016). The prognosis of MiNEN ( n = 315) was compared with other histological subtypes including neuroendocrine tumor (NETs) ( n = 1734), neuroendocrine carcinoma (NECs) ( n = 375), goblet cell carcinoid (GCC) ( n = 968), signet ring cell carcinoma ( n = 463), mucinous adenocarcinoma (MAC) ( n = 2355), and non-mucinous adenocarcinoma (NMAC) ( n = 1187) in the appendix...
2020: Frontiers in Oncology
Yaniv Berger, Darryl Schuitevoerder, Charles C Vining, Lindsay Alpert, Emily Fenton, Enal Hindi, Chih-Yi Liao, Ardaman Shergill, Daniel V T Catenacci, Blase N Polite, Oliver S Eng, Kiran K Turaga
BACKGROUND: Peritoneal metastases (PMs) from appendiceal ex-goblet adenocarcinoma (AEGA) are associated with a poor prognosis. While cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to prolong survival, the majority of patients are ineligible for complete cytoreduction. We describe a novel approach to the management of such patients with iterative HIPEC (IHIPEC). METHODS: Patients with signet ring/poorly differentiated AEGA with high Peritoneal Cancer Index (PCI) and extensive bowel involvement underwent IHIPEC with mitomycin C at 6-week intervals for a total of three cycles...
September 5, 2020: Annals of Surgical Oncology
Joel Johansson, Roland E Andersson, Kalle Landerholm, Stefan Redéen
BACKGROUND: There is limited knowledge about the epidemiology of the major histological subtypes of appendiceal malignancy: adenocarcinoma and neuroendocrine neoplasm of the appendix (A-NEN). The aims of this national cohort study were to assess the prevalence, incidence and trends of appendiceal malignancies in Sweden. METHOD: All individuals who underwent appendicectomy and all diagnosed with appendiceal malignancy from 1970 to 2012 were identified from the National Patient Register and the Swedish Cancer Registry...
September 3, 2020: World Journal of Surgery
Y M Sun, D S Zhang, Y F Feng, Y Wang, Z W Xu
Objective: To investigate the clinical application of additional surgery after non-curative endoscopic resection for early colorectal cancer. Methods: A retrospectively descriptive cohort study was conducted. Inclusion criteria: (1) pathologically confirmed primary colorectal adenocarcinoma;(2) receiving additional surgery after endoscopic resection; (3) semi-elective operation. Exclusion criteria: familial adenomatous polyposis, appendiceal neoplasms, anal canal neoplasms, neuroendocrine tumors, and surgery because of perforation or bleeding after endoscopic resection...
May 25, 2020: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Yuka Yanai, Tsuyoshi Saito, Takuo Hayashi, Yoichi Akazawa, Noboru Yatagai, Sho Tsuyama, Shigeki Tomita, Shu Hirai, Kanako Ogura, Toshiharu Matsumoto, Ryo Wada, Takashi Yao
Appendiceal mucinous tumors (AMTs) include low-grade mucinous appendiceal neoplasms (LAMNs), high-grade mucinous appendiceal neoplasms (HAMNs), and mucinous adenocarcinomas (MACs). We collected 51 AMT samples (LAMN: 34, HAMN: 8, MAC: 9). Three of the eight HAMN cases contained LAMN components, and four out of nine MAC cases contained LAMN and/or HAMN components within the tumor. A next-generation sequencing (NGS) cancer hotspot panel was used to analyze 11 pure LAMN, 4 HAMN, and 3 MAC cases. The results revealed KRAS and GNAS as the most frequently mutated genes...
August 21, 2020: Virchows Archiv: An International Journal of Pathology
S K Li, C Q Li, Y B Li, L Ning, Z P Yu, P G Wang, X B Zhou, J A Ren
Objective: To analyze clinical characteristics of recurrent appendicitis. Methods: A retrospective cohort study was carried out. Clinical data of patients who underwent appendectomy due to acute appendicitis confirmed by pathology in the Affiliated Hospital of Qingdao University from January 2011 to December 2015 were analyzed retrospectively. Exclusion criteria: (1) age of less than 18 years;(2) chronic appendicitis; (3) periappendiceal abscess; (4) appendiceal mucocele or mucinous neoplasms; (5) appendiceal neuroendocrine tumors or cancers; (6) appendicitis during pregnancy; (7) concurrent AIDS, hematological disease, autoimmune disease, inflammatory bowel disease or advanced cancer; (8) other simultaneous surgery...
August 25, 2020: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Mackenzie C Morris, Jordan M Cloyd, John Hays, Sameer H Patel
BACKGROUND: Peritoneal carcinomatosis, from a variety of gastrointestinal and gynecological malignancies, has been historically challenging to treat and there remains a wide range of biologic aggressiveness in these patients. Malignancies commonly associated with PC include those of colorectal, appendiceal, gastric, ovarian, sarcoma, small intestinal, and primary peritoneal origin among others. Advances in our understanding of this unique disease process have led to significant interest in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) as an emerging treatment option...
August 17, 2020: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Phoenix D Bell, Aaron R Huber, Michael G Drage, Samuel L Barron, Jennifer J Findeis-Hosey, Raul S Gonzalez
Low-grade appendiceal mucinous neoplasm (LAMN) is an enigmatic tumor that lacks the capacity for classic invasion but can dissect through the appendiceal wall, causing pseudomyxoma peritonei (PMP). Most large studies of the histologic spectrum of LAMN and its rate of associated PMP include cases submitted from outside institutions, potentially skewing their findings. We identified 117 cases of LAMN at our institution. Hematoxylin and eosin-stained slides from each were reviewed, and clinical and pathologic parameters were noted...
August 12, 2020: American Journal of Surgical Pathology
Yutaka Yonemura, Haruaki Iahibashi, Shouzou Sako, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Shunsuke Motoi, Yang Liu, Satoshi Wakama, Yasuyuki Kamada, Kazurou Nishihara
INTRODUCTION: A new treatment strategy involving cytoreductive surgery (CRS) combined with perioperative intraperitoneal (IP) chemotherapy was proposed in 1999 by the Peritoneal Surface Oncology Group International, and the strategy is now justified as a state-of-the-art treatment to improve the long-term survival of patients with peritoneal metastasis (PM). To achieve cure in the patients with PM, complete removal of macroscopic tumors and eradication of micrometastasis on the peritoneum, left after CRS are essential...
August 12, 2020: Expert Opinion on Pharmacotherapy
Mikael L Soucisse, Joshua Lansom, Mohammad S Alshahrani, David L Morris
Mucinous appendiceal neoplasms (MANs) are rare tumours and the primary cause of pseudomyxoma peritonei. These tumours have a much more benign course than typical colorectal cancers, generally growing for many years before giving any clinical signs. The spectrum of presentations, tumour stages and the underlying cytology is very wide, warranting from the simplest operation like an appendicectomy to the most complicated operation like a complete cytoreduction surgery and hyperthermic intraperitoneal chemotherapy...
August 5, 2020: ANZ Journal of Surgery
Benjamin D Powers, Seth I Felder, Iman Imanirad, Sophie Dessureault, Sean P Dineen
BACKGROUND: The impact of adjuvant chemotherapy (AT) on resected colon adenocarcinoma based on histologic subtype is poorly defined and extrapolated from patients with advanced disease. We evaluated the receipt and effect of AT on overall survival stratified by histologic subtype-mucinous, non-mucinous, and signet ring adenocarcinomas. METHODS: A retrospective cohort study from 2004 to 2015 was conducted using the National Cancer Database. Patients with colon adenocarcinoma who underwent curative resection with pathologic stage III were included...
August 3, 2020: Journal of Gastrointestinal Cancer
Kanwal Raghav, John P Shen, Alexandre A Jácome, Jennifer L Guerra, Christopher P Scally, Melissa W Taggart, Wai C Foo, Aurelio Matamoros, Kenna R Shaw, Keith Fournier, Michael J Overman, Cathy Eng
BACKGROUND: Appendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key molecular differences between AA and CRC is critical. METHODS: We performed retrospective analyses of AA patients (N = 266) with tumour and/or blood next-generation sequencing (NGS) (2013-2018) with in-depth clinicopathological annotation. Overall survival (OS) was examined. For comparison, CRC cohorts annotated for sidedness, consensus molecular subtypes (CMS) and mutations (N = 3283) were used...
July 31, 2020: British Journal of Cancer
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