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REVIEW
Kohei Chida, Hirofumi Kanazawa, Hirotaka Kinoshita, Arya Mariam Roy, Kenichi Hakamada, Kazuaki Takabe
Since its development in 1943, lidocaine has been one of the most commonly used local anesthesia agents for surgical procedures. Lidocaine alters neuronal signal transmission by prolonging the inactivation of fast voltage-gated sodium channels in the cell membrane of neurons, which are responsible for action potential propagation. Recently, it has attracted attention due to emerging evidence suggesting its potential antitumor properties, particularly in the in vitro setting. Further, local administration of lidocaine around the tumor immediately prior to surgical removal has been shown to improve overall survival in breast cancer patients...
May 1, 2024: Pharmacology & Therapeutics
#42
JOURNAL ARTICLE
Mikayla M Smith-Craven, Tahnee J Dening, Anil K Basra, Michael J Hageman
Amphotericin B (AmB) is the gold standard for antifungal therapy; however, its poor solubility limits its administration via intravenous infusion. A promising formulation strategy to achieve an oral formulation is the development of amorphous solid dispersions (ASDs) via spray-drying. Inclusion of surfactants into ASDs is a newer concept, yet it offers increased dissolution opportunities when combined with a polymer (HPMCAS 912). We developed both binary ASDs (AmB:HPMCAS 912 or AmB:surfactant) and ternary ASDs (AmB:HPMCAS 912:surfactant) using a variety of surfactants to determine the optimal surfactant carbon chain length and functional group for achieving maximal AmB concentration during in vitro dissolution...
May 1, 2024: Journal of Pharmaceutical Sciences
#43
JOURNAL ARTICLE
Tim Menzen
Long-lasting space missions as well as space tourism are technically possible today and economically in reach. It is a matter of time until the use of biopharmaceutical drug products in space will be common practice. Until drug product manufacturing in space is possible, the products need to be brought to space with rockets, which means that stable and light-weight products are preferred. Lyophilization is a promising approach to reduce weight during transportation and achieve storage stability at room temperature without cold-chain demands...
May 1, 2024: Journal of Pharmaceutical Sciences
#44
JOURNAL ARTICLE
Hyo Jin Gu, Do-Young Kim, Seung Hee Shin, Md Saidur Rahman, Hee-Seok Lee, Myung-Geol Pang, Jun-Mo Kim, Buom-Yong Ryu
Cumulative human exposure to the environmental toxin, bisphenol A (BPA), has raised important health concerns in recent decades. However, the direct genomic regulation of BPA in skeletal muscles and its clinical significance are poorly understood. Therefore, we conducted a genome-wide transcriptome analysis after daily oral administration of BPA at the lowest observed adverse-effect level (LOAEL, 50 mg/kg) in male mice for six weeks to explore the gene-expression regulations in skeletal muscle induced by BPA...
May 1, 2024: Environmental Research
#45
JOURNAL ARTICLE
Francisco J Pastor-Pérez, Iris P Garrido-Bravo, Pablo Peñafiel-Verdú, Noelia Fernández-Villa, Sergio Manzano-Fernández, María José Oliva-Sandoval, María Teresa Pérez-Martínez, César Caro-Martínez, Álvaro Hernández-Vicente, Domingo A Pascual-Figal
Introduction and objectives Cardiac resynchronization therapy (CRT) is an effective treatment for patients with nonischemic dilated cardiomyopathy associated with left bundle branch block (LBBB). In these patients, the device can normalize left ventricular ejection fraction (LVEF). Nevertheless, it remains unclear whether CRT responders still require neurohormonal blockers. The aim of this study is to determine the long-term safety of withdrawing drug therapy in these patients. Methods The REMOVE trial (NCT05151861) is a prospective, multicenter, open-label and randomized 1:1 study designed to assess the effect of withdrawing neurohormonal blockers in patients with nonischemic dilated cardiomyopathy associated with left bundle branch block who recovered LVEF after CRT...
May 1, 2024: Revista Española de Cardiología
#46
JOURNAL ARTICLE
Sonia Ares-Gómez, Narmeen Mallah, María-Isolina Santiago-Pérez, Jacobo Pardo-Seco, Olaia Pérez-Martínez, María-Teresa Otero-Barrós, Nuria Suárez-Gaiche, Rolf Kramer, Jing Jin, Leticia Platero-Alonso, Rosa-María Alvárez-Gil, Olga-María Ces-Ozores, Victoria Nartallo-Penas, Susana Mirás-Carballal, Marta Piñeiro-Sotelo, Alberto Malvar-Pintos, Juan-Manuel González-Pérez, Carmen Rodríguez-Tenreiro-Sánchez, Irene Rivero-Calle, Antonio Salas, Carmen Durán-Parrondo, Federico Martinón-Torres
BACKGROUND: Galicia (Spain) was one of the first regions worldwide to incorporate nirsevimab for universal respiratory syncytial virus (RSV) prophylaxis in infants into its immunisation programme. The NIRSE-GAL longitudinal population-based study aimed to assess nirsevimab effectiveness in preventing hospitalisations (ie, admittance to hospital). METHODS: The 2023-24 immunisation campaign with nirsevimab in Galicia began on Sept 25, 2023, and concluded on March 31, 2024...
April 30, 2024: Lancet Infectious Diseases
#47
JOURNAL ARTICLE
Ilka Ute Emmerich
In 2023, 2 novel pharmaceutical agents for small animals were released on the German market: the structural but non-functional analog of the inhibitory neurotransmitter gamma-aminobutyric acid pregabalin with an anxiolytic active component and the dopamine agonist ropinirole in form of eye drops to induce vomiting. Two established active veterinary pharmaceutical ingredients became available for additional species: The phosphorus compound butafosfan was additionally approved for horses, dogs and cats and the mineral sodium chloride as an isotonic sodium chloride solution was also approved for rabbits and guinea pigs...
April 2024: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
#48
JOURNAL ARTICLE
Ilka Ute Emmerich
In 2023, no new active pharmaceutical ingredients were released on the German market for horses and food-producing animals. Two established veterinary active pharmaceutical ingredients became available for additional species: The phosphorus compound butafosfan was also approved for horses, dogs, and cats and the mineral sodium chloride as an isotonic sodium chloride solution was also approved for rabbits and guinea pigs. In addition, for small animals, there were new releases of an agent (pergolidmesilate) in a novel pharmaceutical formulation and a lower content of the active ingredient, one drug (fluralaner) in a smaller package size as well as one drug (oxalic acid dehydrate) with a new route of administration...
April 2024: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
#49
JOURNAL ARTICLE
Xuejun Wang, Jiahui Chen, Yihui Shen, Hui Zhang, Yuchen Xu, Jian Zhang, Leilei Cheng
PURPOSE: The emergence of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, but these drugs can also cause severe immune-related adverse effects (irAEs), including myocarditis. Researchers have become interested in exploring ways to mitigate this side effect, and one promising avenue is the use of baricitinib, a Janus kinase inhibitor known to have anti-inflammatory properties. This study aimed to examine the potential mechanism by which baricitinib in ICIs-related myocarditis...
May 2, 2024: Cytokine
#50
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
OBJECTIVES: This study aimed to identify clinical characteristics that could predict the response to perampanel (PER) and determine whether structural connectivity is a predictive factor. METHODS: We enrolled patients with epilepsy who received PER and were followed-up for a minimum of 12 months. Good PER responders, who were seizure-free or presented with more than 50 % seizure reduction, were classified separately from poor PER responders who had seizure reduction of less than 50 % or non-responders...
April 29, 2024: Seizure: the Journal of the British Epilepsy Association
#51
REVIEW
Philipp Steinbauer, Tamara Lisy, Francisco J Monje, Eva Chwala, Brigitte Wildner, Hannah Schned, Philipp Deindl, Angelika Berger, Vito Giordano, Monika Olischar
BACKGROUND AND AIM: Neonatal intensive care treatment, including frequently performed painful procedures and administration of analgesic drugs, can have different effects on the neurodevelopment. This systematic review and meta-analysis aimed to investigate the influence of pain, opiate administration, and pre-emptive opiate administration on pain threshold in animal studies in rodents, which had a brain development corresponding to preterm and term infants. METHODS: A systematic literature search of electronic data bases including CENTRAL (OVID), CINAHL (EBSCO), Embase...
April 26, 2024: Early Human Development
#52
EDITORIAL
Clara Bermúdez-Tamayo, Miguel Negrín Hernández, Juan Alguacil, David Cantarero, Mercedes Carrasco-Portiño, Gonzalo Casino, Mar García Calvente, Mariano Hernán, Leila Posenato García, María Teresa Ruiz Cantero, Andreu Segura, Javier García Amez, Lucero A Juárez Herrera Y Cairo, Joan Carles March, Jorge Marcos-Marcos, Javier Mar, Rosana Peiró, Carlos Álvarez-Dardet
No abstract text is available yet for this article.
May 2, 2024: Gaceta Sanitaria
#53
JOURNAL ARTICLE
Yangyang Li, Yan Guo, Fengzhi Chen, Yuqing Cui, Xuesong Chen, Guangyue Shi
BACKGROUND: Male breast cancer (MBC) is a rare malignancy with a worse prognosis than female breast cancer (FBC). Current MBC treatment strategies are based on those for FBC. However, molecular differences between MBC and FBC with respect to prognosis and drug responses remain unclear. METHODS: After controlling for confounding factors with propensity score matching (PSM), differences between MBC and FBC were comprehensively analyzed using many types of data: survival, immune microenvironments, sex hormone responses, drug sensitivity, transcriptomes, genomes, epigenomes, and proteomes...
May 2, 2024: Translational Oncology
#54
JOURNAL ARTICLE
Maria V Shestovskaya, Anna L Luss, Olga A Bezborodova, Pavel P Kulikov, Daria A Antufrieva, Ekaterina A Plotnikova, Valentin V Makarov, Vladimir S Yudin, Andrey A Pankratov, Anton A Keskinov
The combination of radiation treatment and chemotherapy is currently the standard for management of cancer patients. However, safe doses do not often provide effective therapy, then pre-treated patients are forced to repeat treatment with often already increased tumor resistance to drugs and irradiation. One of the solutions we suggest is to improve primary course of radiation treatment via enhancing radiosensitivity of tumors by magnetic-guided iron oxide nanoparticles (magnetite). We obtained spherical heparinized iron oxide nanoparticles (hIONPs, ∼20 nm), characterized it by TEM, Infrared spectroscopy and DLS...
May 2, 2024: Biomedicine & Pharmacotherapy
#55
REVIEW
Yuhong Tang, Yujuan Fan, Yiming Wang, Dong Wang, Qingyu Huang, Tongqing Chen, Xinyue Cao, Cailing Wen, Xiaoyan Shen, Jian Li, Yan You
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has reached 30 %, with an annual increase. The incidence of NAFLD-induced cirrhosis is rapidly rising and has become the leading indicator for liver transplantation in the US. However, there are currently no US Food and Drug Administration-approved drugs for NAFLD. Increasing evidence underscores the close association between NAFLD and bile acid metabolism disorder, highlighting the feasibility of targeting the bile acid signaling pathway for NAFLD treatment...
May 2, 2024: Biomedicine & Pharmacotherapy
#56
JOURNAL ARTICLE
Wei Zhao, Shuang Zhao, Ran Wei, Ziqi Wang, Fang Zhang, Fangjiao Zong, Han-Ting Zhang
Chronic ethanol consumption is a prevalent condition in contemporary society and exacerbates anxiety symptoms in healthy individuals. The activation of microglia, leading to neuroinflammatory responses, may serve as a significant precipitating factor; however, the precise molecular mechanisms underlying this phenomenon remain elusive. In this study, we initially confirmed that chronic ethanol exposure (CEE) induces anxiety-like behaviors in mice through open field test and elevated plus maze test. The cGAS/STING signaling pathway has been confirmed to exhibits a significant association with inflammatory signaling responses in both peripheral and central systems...
May 2, 2024: International Immunopharmacology
#57
JOURNAL ARTICLE
Jose Danilo Bengzon Diestro, Nimer Adeeb, Basel Musmar, Hamza Salim, Assala Aslan, Nicole M Cancelliere, Rachel M McLellan, Oktay Algin, Sherief Ghozy, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Kevin Premat, Markus Möhlenbruch, Michael Kral, Joshua D Bernstock, Omer Doron, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Mohamed K Ibrahim, Marwa A Mohammed, Cetin Imamoglu, Ahmet Bayrak, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer E Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A Sheth, Gary Spiegel, Rabih G Tawk, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Erez Nossek, Eytan Raz, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Allan L Brook, David Altschul, Julian Spears, Thomas R Marotta, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Stavropoula I Tjoumakaris, Pascal M Jabbour, Frédéric Clarençon, Nicola Limbucci, Hugo H Cuellar-Saenz, Vitor Mendes Pereira, Aman B Patel, Adam A Dmytriw
OBJECTIVE: This study was conducted to investigate the impact of antiplatelet administration in the periprocedural period on the occurrence of thromboembolic complications (TECs) in patients undergoing treatment using the Woven EndoBridge (WEB) device for intracranial wide-necked bifurcation aneurysms. The primary objective was to assess whether the use of antiplatelets in the pre- and postprocedural phases reduces the likelihood of developing TECs, considering various covariates. METHODS: A retrospective multicenter observational study was conducted within the WorldWideWEB Consortium and comprised 38 academic centers with endovascular treatment capabilities...
May 3, 2024: Journal of Neurosurgery
#58
JOURNAL ARTICLE
Yuming Sun, Yongjia Liu, Yating Dian, Furong Zeng, Guangtong Deng, Shaorong Lei
BACKGROUND: Glucagon-like peptide-1 receptor (GLP1R) agonists have been approved by Food and Drug Administration for management of obesity. However, the causal relationship of GLP1R agonists (GLP1RA) with cancers still unclear. METHODS: The available cis-eQTLs for drugs target genes (GLP1R) were used as proxies for exposure to GLP1RA. Mendelian randomizations (MR) were performed to reveal the association of genetically-proxied GLP1RA with 14 common types cancer from large-scale consortia...
May 3, 2024: International Journal of Surgery
#59
JOURNAL ARTICLE
Vijith Vijayan, Hao Yan, Juliane K Lohmeyer, Kaylin A Prentiss, Rachana V Patil, Giulia Barbarito, Ivan Lopez, Aly Elezaby, Kolten Peterson, Jeanette Baker, Nicolai P Ostberg, Alice Bertaina, Robert S Negrin, Daria Mochly-Rosen, Kenneth I Weinberg, Bereketeab Haileselassie
Despite therapeutic advancements, GVHD is a major complication of HSCT. In current models of GVHD, tissue injury induced by cytotoxic conditioning regimens, along with translocation of microbes expressing Pathogen Associated Molecular Patterns (PAMPs), result in activation of host antigen-presenting cells (APC) to stimulate alloreactive donor T lymphocytes. Recent studies have demonstrated that in many pathologic states, tissue injury results in the release of mitochondria from the cytoplasm to the extracellular space...
May 3, 2024: Blood Advances
#60
JOURNAL ARTICLE
Tamar Tadmor, Guy Melamed, Hillel Alapi, Sivan Gazit, Tal Patalon, Lior Rokach
Low levels of vitamin D are associated with a shorter time to first treatment (TTFT) and inferior overall survival in patients with Chronic Lymphocytic leukemia. But whether vitamin D supplement affects the clinical course of CLL patients, remains an open question. In the current study, we aimed to retrospectively explore the clinical benefit of Vitamin D supplement, or one of its analogues, on TTFT and treatment-free survival (TFS) in a large cohort of patients with asymptomatic CLL, who were under watch and wait approach...
May 3, 2024: Blood Advances
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