Gabriela S Arcanjo, Mariana B Souza, Igor F Domingos, Diego A Pereira-Martins, Diego A Falcão, Jessica V Batista, Betania L Hatzlhofer, Madi V Diniz, Alexsandro P Silva, Werbson L Guaraná, Manuela F Hazin, Aderson S Araujo, Anderson F Cunha, Sara O Saad, Fernando F Costa, Antonio R Lucena-Araujo, Marcos André C Bezerra
The occurrence and severity of osteonecrosis in sickle cell anaemia (SCA) vary due to risk factors, including genetic modifiers. Bone morphogenetic proteins (BMPs), particularly BMP6, and the vitamin D receptor (VDR) play key roles in cartilage and bone metabolism, making them potential contributors to orthopaedic outcomes in SCA. Here, we evaluated the association of polymorphisms in BMP6 (rs3812163, rs270393 and rs449853) and VDR (FokI rs2228570 and Cdx2 rs11568820) genes with osteonecrosis risk in a Brazilian SCA cohort...
February 7, 2024: British Journal of Haematology