Silvia Paukovcekova, Dalibor Valik, Jaroslav Sterba, Renata Veselska
The main objective of this study was to analyze changes in the antiproliferative effect of vitamin D3, in the form of calcitriol and calcidiol, via its combined application with all- trans retinoic acid (ATRA) in osteosarcoma cell lines. The response to treatment with calcitriol and calcidiol alone was specific for each cell line. Nevertheless, we observed an enhanced effect of combined treatment with ATRA and calcitriol in the majority of the cell lines. Although the levels of respective nuclear receptors did not correlate with the sensitivity of cells to these drugs, vitamin D receptor (VDR) upregulation induced by ATRA was found in cell lines that were the most sensitive to the combined treatment...
September 9, 2020: International Journal of Molecular Sciences
Masahiro Tawada, Yuki Misao, Kengo Ichikawa, Hidenori Tanaka
INTRODUCTION: Vitelline duct remnant (VDR) is a rare abnormality of the primitive yolk sac, and Meckel's diverticulum (MD) is the most common type. MD is a congenital small intestinal diverticulum that leaves the ileal side of vitelline duct, and MD adenocarcinoma is extremely rare. PRESENTATION OF CASE: A 49 year-old-man with abdominal mass was diagnosed as a huge pelvic tumor. We resected this tumor together with the invading ileum and the ileocecum. On histopathological and immunohistochemical analysis, tumor was diagnosed as adenocarcinoma and originated from the digestive tract...
September 2, 2020: International Journal of Surgery Case Reports
Mahya Pourostadi, Simin Sattarpour, Behroz Mahdavi Poor, Mohammad Asgharzadeh, Hossein Samadi Kafil, Mehdi Farhoudi, Vahid Asgharzadeh, Ali Vegari, Nima Najafi-Ghalelou, Jalil Rashedi
BACKGROUND: Multiple sclerosis (MS), a disease of central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is way to exert its function. OBJECTIVE: Possible correlation between vitamin D receptor (VDR) gene and MS was evaluated in Azeri population of Iran. METHOD: Different genotypes of Bsml site were determined by using PCR-RFLP method in 148 MS patients and 220 nonrelative healthy controls...
September 10, 2020: Endocrine, Metabolic & Immune Disorders Drug Targets
Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong
Vitamin D modulates about 3% human gene transcription besides the classical action on calcium/phosphorus homeostasis. The blood pressure-lowing and other protective action on cardiovascular disease have been reported. The present study aims to examine whether COX-1 and COX-2 were implicated in endothelial dysfunction in hypertension and calcitriol, an active form of vitamin D preserved endothelial function through regulating COX expression. Isometric study demonstrated the impaired endothelium-dependent relaxation (EDR) in renal arteries from spontaneously hypertensive rats were reversed by 12 h-calcitriol treatment and COX-1 and COX-2 inhibitors...
September 10, 2020: Clinical and Experimental Hypertension: CHE
Xi Yang, Meiting Qin, Shanshan Cui, Qi Zhang
Some studies showed that the polymorphisms of vitamin D receptor ( VDR ) gene were associated with pulmonary diseases. However, the relationship between the VDR variations and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The study aimed to determine the associations between VDR polymorphisms and susceptibility to CWP in Chinese Han population. The study involved 340 CWP patients and 312 healthy controls. The VDR polymorphisms were determined by DNA sequencing, and serum 25(OH)2D levels were detected by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry...
July 2020: Toxicology Research
Emma Bishop, Aiten Ismailova, Sarah K Dimeloe, Martin Hewison, John H White
Regulation of immune function continues to be one of the most well recognised extra-skeletal actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells such as macrophages could actively metabolise precursor 25-hydroxyvitamin D (25D) to active 1,25-dihydroxyvitamin D (1,25D). Parallel observation that activated cells from the immune system expressed the intracellular vitamin D receptor (VDR) for 1,25D suggested a potential role for vitamin D as a localised endogenous modulator of immune function...
August 22, 2020: JBMR plus
Mariane C F Barbosa, Daniela C Lima, Caio L B Reis, Ana L M Reis, Darlan Rigo, Raquel A B Segato, Carmen L M Storrer, Erika C Küchler, Daniela S B de Oliveira
BACKGROUND & AIM: To investigate the association between the genetic polymorphisms FokI (rs2228570) and BglI (rs739837) in vitamin D receptor (VDR) with dental caries and gingivitis susceptibility. DESIGN: This study included 353 Brazilian children (8 to 11 years old). Dental caries was assessed using ICDAS (International System for Detection and Assessment of Carious Lesions) and gingival bleeding using Community Periodontal Index (CPI). The presence of visible biofilm was also evaluated...
September 2020: International Journal of Paediatric Dentistry
C Puangthong, P Sukhong, P Saengnual, R Srikuea, M Chanda
BACKGROUND: The expressions of vitamin D receptor (VDR) and vitamin D-metabolising enzymes (CYP27B1 and CYP24A1) in skeletal muscle have been reported. However, the regulation of this vitamin D system in horse skeletal muscle after high-intensity exercise has not yet been elucidated. OBJECTIVES: To investigate the effect of high-intensity exercise on the expression of vitamin D system-related proteins in horse skeletal muscle and its associations to skeletal muscle stem cell (SMSC) activity and serum 25(OH)D level...
September 9, 2020: Equine Veterinary Journal
Pei-Shan Hu, Ting Li, Jin-Fei Lin, Miao-Zhen Qiu, De-Shen Wang, Ze-Xian Liu, Zhan-Hong Chen, Lu-Ping Yang, Xiao-Long Zhang, Qi Zhao, Yan-Xing Chen, Yun-Xin Lu, Qi-Nian Wu, Heng-Ying Pu, Zhao-Lei Zeng, Dan Xie, Huai-Qiang Ju, Hui-Yan Luo, Rui-Hua Xu
The acidic tumor microenvironment provides an energy source driving malignant tumor progression. Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells. The expression of the vitamin D receptor (VDR) is closely related to the initiation and development of colorectal carcinoma (CRC), but its regulatory mechanism in CRC stem cells is still unclear. Our study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta (PPARD) expression...
September 9, 2020: Signal Transduction and Targeted Therapy
Nejla Latic, Reinhold G Erben
Vitamin D deficiency is the most common nutritional deficiency, affecting almost one billion people worldwide. Vitamin D is mostly known for its role in intestinal calcium absorption and bone mineralization. However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D receptor (VDR) and 1α-hydroxylase in cardiomyocytes, as well as endothelial and vascular smooth muscle cells, implicated a role of vitamin D in the cardiovascular system. Animal studies provided compelling evidence that vitamin D signaling is essential for cardiovascular integrity, especially for the regulation of vascular tone and as an antifibrotic and antihypertrophic signaling pathway in the heart...
September 4, 2020: International Journal of Molecular Sciences
Beatrice Arosio, Franca Rosa Guerini, Andrea Saul Costa, Alessandra Dicitore, Evelyn Ferri, Daniela Mari, Erminio Torresani, Mario Clerici, Matteo Cesari, Giovanni Vitale
The "male-female health-survival paradox" evidences that the survival advantage observed in women is linked to higher rates of disability and poor health status compared to men, a phenomenon also called the "sex-frailty paradox". The depletion of vitamin D seems to play a role in the fragilization of old persons, and genetic polymorphisms of the vitamin D receptor ( VDR ) gene seem to be involved in regulating the vitamin D pathway. This study correlated the VDR gene polymorphisms (FokI, ApaI, BsmiI, and TaqI) with frailty, computed by frailty index (FI), in 202 persons (127 women and 75 men, aged from 60 to 116 years), aiming to capture the involvement of vitamin D in the sex-frailty paradox...
September 5, 2020: Nutrients
Trailokyanath Panigrahi, Sharon D'Souza, Rohit Shetty, Archana Padmanabhan Nair, Anuprita Ghosh, Everette Jacob Remington Nelson, Arkasubhra Ghosh, Swaminathan Sethu
Dry eye disease (DED) signs and symptoms are causally associated with increased ocular surface (OS) inflammation. Modulation of key regulators of aberrant OS inflammation is of interest for clinical management. We investigated the status and the potential to harness key endogenous protective factors, such as cystic fibrosis transmembrane conductance regulator (CFTR) and vitamin D receptor (VDR) in hyperosmotic stress-associated inflammation in patients with DED and in vitro. Conjunctival impression cytology samples from control subjects (n = 11) and patients with DED (n = 15) were used to determine the status of hyperosmotic stress (TonEBP/NFAT5), inflammation (IL-6, IL-8, IL-17A/F, TNFα, MMP9, and MCP1), VDR, and intracellular chloride ion (GLRX5) by quantitative polymerase chain reaction and/or immunofluorescence...
August 16, 2020: Clinical and Translational Science
Ning Lyu, Jing Zhang, Yiqin Dai, Jun Xiang, Yue Li, Jianjiang Xu
BACKGROUND: Previously, calcitriol has been demonstrated as a potential therapeutic agent for dry eye, whilst its role on corneal epithelium death remains unclear. This study aims to investigate the relationship between apoptosis and autophagy on dry eye related scenario, as well as the effect of calcitriol and its potential mechanism. METHODS: In vitro, immortalized human corneal epithelial cells (iHCEC) were cultured in hyperosmotic medium with or without various concentrations of calcitriol and other reagents...
September 4, 2020: Experimental Eye Research
Oliver Robak, Marie-Theres Kastner, Carmen Stecher, Martina Schneider, Martin Andreas, Hildegard Greinix, Enikö Kallay, Claudia Honsig, Christoph Steininger
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for patients with hematological diseases but associated with high mortality and morbidity. Cytomegalovirus (CMV) infection is common in HSCT patients and modulates vitamin D metabolism in vitro. We aimed at validating CMV-associated vitamin D metabolism in vivo in HSCT. METHODS: Patients treated for significant CMV viremia after HSCT were evaluated for CMV load before, during and after antiviral treatment...
September 2, 2020: Transplantation
Wei Zhang, Yu Xu
Background: Vitamin D receptor (VDR) gene polymorphisms are involved in a variety of immune-related diseases, and VDR is associated with allergic rhinitis. The present study explored the associations between VDR gene polymorphisms and allergic rhinitis in the Chinese population. Methods: The study population consisted of 400 patients with allergic rhinitis and 400 healthy controls. General characteristics were determined by interview. Blood DNA was extracted and genotyping was performed via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
2020: Pharmacogenomics and Personalized Medicine
Yunxuan Xu, Lingyun Liang
Elucidation of the pathogenic mechanisms underlying post-stroke depression (PSD) could aid in the development of effective treatments. The present study explored whether Vitamin D3 (VitD3) can function as an antidepressant in PSD model mice and whether the effect is mediated by upregulation of brain-derived neurotrophic factor (BDNF). Mice were subjected to middle cerebral artery occlusion (MCAO) combined with chronic unpredicted mild stress (CUMS) to established the PSD model. For the mice in each group, Longa and Berderson behavioral tests were performed to evaluate motor function, sucrose preference and forced swimming tests were conducted to assess the cardinal depression-like behaviors anhedonia and helplessness, and western blot and immunohistochemistry were conducted to measure the levels of vitamin D receptor (VDR) and BDNF expression levels in mouse hippocampus...
August 31, 2020: Neuroscience Research
Milena Gašparović Krpina, Anita Barišić, Ana Peterlin, Nataša Tul, Saša Ostojić, Borut Peterlin, Nina Pereza
AIM: To evaluate the association between the FokI (rs2228570), ApaI (rs7975232), Bsml (rs1544410), TaqI (rs 731236), and Cdx2 (rs11568820) single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and spontaneous preterm birth (SPTB), as well as their effect on clinical characteristics of women with SPTB and their newborns. METHODS: This case-control study enrolled women who gave birth at the Department of Obstetrics and Gynecology, University Medical Center Ljubljana between 2010 to 2019...
August 31, 2020: Croatian Medical Journal
Maria Eduarda de Albuquerque Borborema, Jorge José de Souza Pereira, Aline Dos Santos Peixoto, Sergio Crovella, Haiana Charifker Schindler, Michelle Christiane da Silva Rabello, Jaqueline de Azevêdo Silva
Tuberculosis is an infectious disease with variable outcomes. This variability is due to host immune capacity in containing the infection process initiated by the Mycobacterium tuberculosis (MTB). Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding. Altered VDR forms may compromise vitamin D pathway and proper immune response after MTB infection. Herein we assessed the relationship of five potentially functional polymorphisms from VDR: rs2228570 FokI, rs11568820 Cdx-2, rs2248098, rs1540339 and rs4760648, with tuberculosis susceptibility...
September 3, 2020: Molecular Biology Reports
M Monrose, L Thirouard, M Garcia, H Holota, A De Haze, F Caira, C Beaudoin, D H Volle
The incidence of reproductive disorders is constantly increasing and affects 15% of couples, with male's abnormalities diagnosed in almost half of the cases. The male gonads exert two major functions of the testis with the productions of gametes (exocrine function) and of sexual hormones (endocrine function). In the last decades, next to steroid receptors such as estrogen and androgen receptors, the involvement of other members of the nuclear receptor superfamily have been described such as Steroidogenic factor-1 (SF-1), Nerve growth factor IB (NGFIB), Liver-X-Receptorα (LXRα) and Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1)...
August 31, 2020: Molecular Aspects of Medicine
Urszula Nowak, Sylwia Janik, Aleksandra Marchwicka, Agnieszka Łaszkiewicz, Agnieszka Jakuszak, Małgorzata Cebrat, Ewa Marcinkowska
(1) Background : Vitamin D receptor (VDR) is present in multiple types of blood cells, and its ligand, 1,25-dihydroxyvitamin D (1,25D), is important for the proper functioning of the immune system. Activity of VDR is higher in hematopoietic stem and progenitor cells than in fully differentiated blood cells of mice and humans. In some human acute myeloid leukemia (AML) blasts, the expression of the VDR gene is also high. The mechanism of silencing the VDR gene expression during differentiation of blood cells has been addressed in this work...
August 29, 2020: Cells
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