Rohit Shetty, Murali Subramani, Ponnalagu Murugeswari, Venkata Ramana Anandula, Himanshu Matalia, Chaitra Jayadev, Arkasubhra Ghosh, Debashish Das
PURPOSE: Dry eye disease (DED) is a common ocular surface condition across age groups. Recently, vitamin D deficiency has gained importance as a causative factor, and its supplementation alleviates symptoms of DED. Resveratrol (RES) regulates vitamin D receptors (VDRs) and Notch signaling. We investigated the role of RES on vitamin D levels and Notch signaling under hyperosmolar conditions. METHODS: Human corneal epithelial (HCE-T) cells were treated with RES in hyperosmolar and normal conditions...
September 16, 2020: Cornea
Yanyan Wang, Tian Wang, Yan Huo, Liu Li, Suxin Liu, Xiaoqian Yin, Runfang Wang, Xingshuang Gao
OBJECTIVES AND METHODS: A total of 41 GDM and 40 normal glucose tolerance subjects were recruited. Through detecting the level of Serum vitamin D with electrochemical luminescence and vitamin D receptor (VDR) with Enzyme-linked immunosorbent assay (ELISA) in maternal and cord blood, the expression leves of CYP24A1, CYP27B1, VDR protein and mRNA in placenta and umbilical cord with western blotting and RT-PCR, and the DNA methylation levels of CYP24A1 and CYP27B1 gene in placenta with methylation-specific PCR (MSP) and direct bisulfite sequencing (BSP) analysis to explore the potential role of the vitamin D and its related genes in gestational diabetes mellitus (GDM)...
September 15, 2020: Journal of Steroid Biochemistry and Molecular Biology
Yang Gao, Wen Sun, Xushan Cha, Hailong Wang
Psoriasis is an immune‑mediated dermatosis characterized by T‑lymphocyte‑mediated epidermal hyperplasia, for which there are currently no effective clinical treatments. 'Psoriasis 1' is a Chinese herbal medicine formulation that has been recently used extensively in China for treating patients with psoriasis. However, the molecular mechanism of action of this potent formulation has not yet been fully elucidated. In the present study, the effects of 'Psoriasis 1' on T ymphocytes in patients with psoriasis were investigated and the underlying molecular mechanism was discussed...
August 6, 2020: International Journal of Molecular Medicine
Lauge Kellermann, Kim Bak Jensen, Fredrik Bergenheim, John Gubatan, Naomi D Chou, Alan Moss, Ole Haagen Nielsen
Epidemiological studies have identified vitamin D (25(OH)D) deficiency to be highly prevalent among patients with inflammatory bowel disease (IBD), and low serum levels correlate with a higher disease activity and a more complicated disease course. The link to IBD pathogenesis has been subject of investigations, primarily due to the distinct immunological functions of vitamin D signaling, including anti-inflammatory and anti-fibrotic actions. Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR)...
September 14, 2020: Autoimmunity Reviews
Ronald M Evans, Scott M Lippman
SARS-CoV-2 pneumonitis can quickly strike to incapacitate the lung, leading to severe disease and sometimes death. In this perspective, we suggest that vitamin D deficiency and the failure to activate the vitamin D receptor (VDR) can aggravate this respiratory syndrome by igniting a wounding response in stellate cells of the lung. The FDA-approved injectable vitamin D analog, paricalcitol, suppresses stellate cell-derived murine hepatic and pancreatic pro-inflammatory and pro-fibrotic changes. Therefore, we suggest a possible parallel program in the pulmonary stellate cells of COVID-19 patients and propose repurposing paricalcitol infusion therapy to restrain the COVID-19 cytokine storm...
September 11, 2020: Cell Metabolism
Narmada Ashok, Richard Kirubakaran, Radha Saraswathy
Introduction: The association of Vitamin D and children with asthma is known and there are several individual studies on Vitamin D polymorphisms. However, systematic reviews on all vitamin D associated gene polymorphisms have not been done in children with asthma. Objective: To investigate the association of Vitamin D associated gene polymorphisms and asthma in children (0-18 years) by systematic review and meta-analytic approach. Methods: Our search included 20 full text articles of which 15 were case control studies and 5 used family based linkage disequilibrium method...
September 2020: Heliyon
Merve Alaylıoğlu, Erdinç Dursun, Gençer Genç, Büşra Şengül, Başar Bilgiç, Ayşegül Gündüz, Hülya Apaydın, Güneş Kızıltan, Hakan Gürvit, Haşmet Hanağası, Özgür Öztop Çakmak, Sibel Ertan, Selma Yılmazer, Duygu Gezen-Ak
PURPOSE/AIM OF THE STUDY: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Vitamin D deficiency is suggested to be related to PD. A genome-wide association study indicated that genes involved in vitamin D metabolism affect vitamin D levels. Among these genes, single nucleotide polymorphisms (SNPs) of the vitamin D receptor ( VDR ) and vitamin D binding protein ( VDBP/GC ) genes have also been demonstrated to be associated with PD risk. Our aim was to investigate the relevance of SNPs within the 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1 ( DHCR7/NADSYN1 ) locus and vitamin D 25-hydroxylase ( CYP2R1 ) gene, which encode important enzymes that play a role in the vitamin D synthesis pathway, with PD and its clinical features...
September 16, 2020: International Journal of Neuroscience
Rosa Giannina Castillo-Avila, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, María Lilia López-Narváez, José Manuel Rodríguez-Pérez, Samuel Suárez-Méndez
OBJECTIVE: The aim of the present meta-analysis was to explore the association between FokI polymorphism of the VDR gene and lumbar spine disc degeneration. DESIGN: The search was performed in PubMed, Scopus and Web of Science databases up to January 2020. We selected nine studies that comprised a total of 1549 cases and 1672 controls. The association analysis included the allelic, dominant, recessive, homozygous and heterozygous genetic models. Odds ratios with 95% confidence intervals were used to evaluate the association...
September 14, 2020: American Journal of Physical Medicine & Rehabilitation
Marie Christine Martens, Steffen Emmert, Lars Boeckmann
Sunlight, in particular UV-B radiation, is an important factor for endogenous vitamin D production as 80-90% of the required vitamin D needs to be photosynthesized in the skin. The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Recently, calcitriol and analogs have been shown to have antiproliferative effects in mouse and human BCC and SCC cell lines in vitro. As UV radiation plays a critical role in the photosynthesis of vitamin D, stringent sun protection, as recommended for xeroderma pigmentosum (XP) patients, may impact their vitamin D levels...
2020: Advances in Experimental Medicine and Biology
Jörg Reichrath, Sandra Reichrath, Thomas Vogt, Klaus Römer
It has now been convincingly shown that vitamin D and p53 signaling protect against spontaneous or carcinogen-induced malignant transformation of cells. The vitamin D receptor (VDR) and the p53/p63/p73 proteins (the p53 family hereafter) exert their effects as receptors/sensors that turn into transcriptional regulators upon stimulus. While the p53 clan, mostly in the nucleoplasm, responds to a large and still growing number of alterations in cellular homeostasis commonly referred to as stress, the nuclear VDR is transcriptionally activated after binding its naturally occurring biologically active ligand 1,25-dihydroxyvitamin D with high affinity...
2020: Advances in Experimental Medicine and Biology
Daniel D Bikle
Cutaneous malignancies including melanomas and keratinocyte carcinomas (KC) are the most common types of cancer, occurring at a rate of over one million per year in the United States. KC, which include both basal cell carcinomas and squamous cell carcinomas, are substantially more common than melanomas and form the subject of this chapter. Ultraviolet radiation (UVR), both UVB and UVA, as occurs with sunlight exposure is generally regarded as causal for these malignancies, but UVB is also required for vitamin D synthesis in the skin...
2020: Advances in Experimental Medicine and Biology
Patrizia Gnagnarella, Sara Raimondi, Valentina Aristarco, Harriet Ann Johansson, Federica Bellerba, Federica Corso, Sara Gandini
Increasing scientific evidence supports the link between vitamin D and cancer risk. The active metabolite 1,25(OH)2D exerts its activity by binding to the vitamin D receptor (VDR), an intracellular receptor that mediates transcriptional activation and repression of target genes. The binding of 1,25(OH)2D to VDR is able to regulate hundreds of different genes. VDR is active in virtually all tissues including the colon, breast, lung, ovary, bone, kidney, parathyroid gland, pancreatic b-cells, monocytes, T lymphocytes, melanocytes, keratinocytes, and also cancer cells...
2020: Advances in Experimental Medicine and Biology
Sumit Kumar, Ravikanth Nanduri, Ella Bhagyaraj, Rashi Kalra, Nancy Ahuja, Anuja P Chacko, Drishti Tiwari, Kanupriya Sethi, Ankita Saini, Vemika Chandra, Monika Jain, Shalini Gupta, Deepak Bhatt, Pawan Gupta
Macrophage derived foam cells in atherosclerotic plaques are the major factor responsible for the pathogenesis of atherosclerosis (AS). During advanced AS, macrophage-specific macroautophagy/autophagy is dysfunctional. 1, 25-dihydroxy vitamin D3 (VitD3) and its receptor VDR (vitamin D receptor) are reported to inhibit foam cell formation and induce autophagy; however, the role of VitD3-VDR-induced autophagy and foam cell formation in AS has not been explored. Here we find that VitD3 significantly recovered oxidized low-density lipoprotein-impaired autophagy, as well as increased autophagy-mediated lipid breakdown in mouse bone marrow-derived macrophages and human monocyte-derived macrophages, thus inhibiting the conversion of macrophages into foam cells...
September 11, 2020: Autophagy
Silvia Paukovcekova, Dalibor Valik, Jaroslav Sterba, Renata Veselska
The main objective of this study was to analyze changes in the antiproliferative effect of vitamin D3, in the form of calcitriol and calcidiol, via its combined application with all- trans retinoic acid (ATRA) in osteosarcoma cell lines. The response to treatment with calcitriol and calcidiol alone was specific for each cell line. Nevertheless, we observed an enhanced effect of combined treatment with ATRA and calcitriol in the majority of the cell lines. Although the levels of respective nuclear receptors did not correlate with the sensitivity of cells to these drugs, vitamin D receptor (VDR) upregulation induced by ATRA was found in cell lines that were the most sensitive to the combined treatment...
September 9, 2020: International Journal of Molecular Sciences
Masahiro Tawada, Yuki Misao, Kengo Ichikawa, Hidenori Tanaka
INTRODUCTION: Vitelline duct remnant (VDR) is a rare abnormality of the primitive yolk sac, and Meckel's diverticulum (MD) is the most common type. MD is a congenital small intestinal diverticulum that leaves the ileal side of vitelline duct, and MD adenocarcinoma is extremely rare. PRESENTATION OF CASE: A 49 year-old-man with abdominal mass was diagnosed as a huge pelvic tumor. We resected this tumor together with the invading ileum and the ileocecum. On histopathological and immunohistochemical analysis, tumor was diagnosed as adenocarcinoma and originated from the digestive tract...
September 2, 2020: International Journal of Surgery Case Reports
Mahya Pourostadi, Simin Sattarpour, Behroz Mahdavi Poor, Mohammad Asgharzadeh, Hossein Samadi Kafil, Mehdi Farhoudi, Vahid Asgharzadeh, Ali Vegari, Nima Najafi-Ghalelou, Jalil Rashedi
BACKGROUND: Multiple sclerosis (MS), a disease of central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is way to exert its function. OBJECTIVE: Possible correlation between vitamin D receptor (VDR) gene and MS was evaluated in Azeri population of Iran. METHOD: Different genotypes of Bsml site were determined by using PCR-RFLP method in 148 MS patients and 220 nonrelative healthy controls...
September 10, 2020: Endocrine, Metabolic & Immune Disorders Drug Targets
Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong
Vitamin D modulates about 3% human gene transcription besides the classical action on calcium/phosphorus homeostasis. The blood pressure-lowing and other protective action on cardiovascular disease have been reported. The present study aims to examine whether COX-1 and COX-2 were implicated in endothelial dysfunction in hypertension and calcitriol, an active form of vitamin D preserved endothelial function through regulating COX expression. Isometric study demonstrated the impaired endothelium-dependent relaxation (EDR) in renal arteries from spontaneously hypertensive rats were reversed by 12 h-calcitriol treatment and COX-1 and COX-2 inhibitors...
September 10, 2020: Clinical and Experimental Hypertension: CHE
Xi Yang, Meiting Qin, Shanshan Cui, Qi Zhang
Some studies showed that the polymorphisms of vitamin D receptor ( VDR ) gene were associated with pulmonary diseases. However, the relationship between the VDR variations and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The study aimed to determine the associations between VDR polymorphisms and susceptibility to CWP in Chinese Han population. The study involved 340 CWP patients and 312 healthy controls. The VDR polymorphisms were determined by DNA sequencing, and serum 25(OH)2D levels were detected by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry...
July 2020: Toxicology Research
Emma Bishop, Aiten Ismailova, Sarah K Dimeloe, Martin Hewison, John H White
Regulation of immune function continues to be one of the most well recognised extra-skeletal actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells such as macrophages could actively metabolise precursor 25-hydroxyvitamin D (25D) to active 1,25-dihydroxyvitamin D (1,25D). Parallel observation that activated cells from the immune system expressed the intracellular vitamin D receptor (VDR) for 1,25D suggested a potential role for vitamin D as a localised endogenous modulator of immune function...
August 22, 2020: JBMR plus
Mariane C F Barbosa, Daniela C Lima, Caio L B Reis, Ana L M Reis, Darlan Rigo, Raquel A B Segato, Carmen L M Storrer, Erika C Küchler, Daniela S B de Oliveira
BACKGROUND & AIM: To investigate the association between the genetic polymorphisms FokI (rs2228570) and BglI (rs739837) in vitamin D receptor (VDR) with dental caries and gingivitis susceptibility. DESIGN: This study included 353 Brazilian children (8 to 11 years old). Dental caries was assessed using ICDAS (International System for Detection and Assessment of Carious Lesions) and gingival bleeding using Community Periodontal Index (CPI). The presence of visible biofilm was also evaluated...
September 2020: International Journal of Paediatric Dentistry
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