Abdullah Gunes, Murat B Yazicioglu, Cagri Tiryaki, Nihal Uren, Emel Ergul, Turgay Simesek, Anıl Cubukcu
BACKGROUND: The role of vitamin D has previously been determined in autoimmune and malignant thyroid diseases. We aimed to identify the haplotype distribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, which has been suggested to play a role in the pathogenesis of differentiated thyroid cancers and benign thyroid diseases. MATERIALS AND METHODS: Two hundred and sixteen patients, 113 with benign and 103 with differentiated thyroid cancers,together with the same number of healthy controls, were included in the study...
August 3, 2020: Minerva Endocrinologica
Reuben McGregor, Daniel Chauss, Tilo Freiwald, Bingyu Yan, Luopin Wang, Estefania Nova-Lamperti, Zonghao Zhang, Heather Teague, Erin E West, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F Freeman, Daniella Schwartz, Didier Portilla, Susan John, Paul Lavender, Michail S Lionakis, Nehal N Mehta, Claudia Kemper, Nichola Cooper, Giovanna Lombardi, Arian Laurence, Majid Kazemian, Behdad Afzali
Pro-inflammatory immune responses are necessary for effective pathogen clearance, but cause severe tissue damage if not shut down in a timely manner 1,2 . Excessive complement and IFN-γ-associated responses are known drivers of immunopathogenesis 3 and are among the most highly induced immune programs in hyper-inflammatory SARS-CoV2 lung infection 4 . The molecular mechanisms that govern orderly shutdown and retraction of these responses remain poorly understood. Here, we show that complement triggers contraction of IFN-γ producing CD4 + T helper (Th) 1 cell responses by inducing expression of the vitamin D (VitD) receptor (VDR) and CYP27B1, the enzyme that activates VitD, permitting T cells to both activate and respond to VitD...
July 19, 2020: the Preprint Server for Biology
Elham Kazemian, Mohammad Esmaeil Akbari, Nariman Moradi, Safoora Gharibzadeh, Atieh Amouzegar, Yasaman Jamshidi-Naeini, Alison M Mondul, Maryam Khademolmele, Nasim Ghodoosi, Katie R Zarins, Zahra Shateri, Sayed Hossein Davoodi, Laura S Rozek
We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by 'association' function in the R package 'SNPassoc'. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated that the aa genotype of the ApaI [codominant model (aa vs...
September 2020: European Journal of Cancer Prevention
Lijuan Fu, Jinhuan Ma, Sumei Yan, Qijun Si
BACKGROUND: Whether polymorphisms in VDR gene affect the risk of postmenopausal osteoporosis or not remain unclear. Thus, the authors performed a meta-analysis to more robustly assess associations between polymorphisms in VDR gene and the risk of postmenopausal osteoporosis by integrating the results of previous literature. METHODS: Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible literatures, and sixty-seven genetic association studies were finally selected to be included in this meta-analysis...
July 1, 2020: Endocrine Connections
Risako Mori, Takumi Yokokawa, Satoshi Fujita
The vitamin D pathway is related to the mass and function of skeletal muscles. Several studies have demonstrated the role of vitamin D receptor (VDR) and CYP27B1 in skeletal muscles, suggesting that these proteins may regulate skeletal muscles and their function. However, it remains unclear whether the expression of VDR and CYP27B1 is modified in skeletal muscle atrophy. We investigated whether denervation-induced muscle atrophy is associated with altered expression of VDR and CYP27B1 in murine skeletal muscles...
August 27, 2020: Biochemical and Biophysical Research Communications
Le Kuai, Jiankun Song, Ruoxi Zhang, Meng Xing, Ying Luo, Yi Ru, Xiao-Jie Ding, Liu Liu, Yi Lu, Xiaoying Sun, Hua Nian, Xin Li, Bin Li
ETHNOPHARMACOLOGICAL RELEVANCE: Our clinical practice demonstrated that Jueyin granules (JYG) benefit patients with mild to moderate psoriasis vulgaris without apparent adverse effects. JYG have been shown to inhibit epidermal proliferation in an imiquimod (IMQ)-induced psoriasis-like mouse model, as well as keratinocyte proliferation. Moreover, JYG causes no acute or chronic toxicity in animal models. However, its related molecular mechanism has still not been elucidated. AIM OF THE STUDY: To assess the mechanism of JYG against psoriasis...
July 28, 2020: Journal of Ethnopharmacology
Srija Moulik, Joyshree Karmakar, Sumit Joshi, Anuradha Dube, Chitra Mandal, Mitali Chatterjee
AIM: Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates host monocytes-macrophages to ensure its survival. However, knowledge regarding the host-parasite interactions underpinning the disease remains limited. As disease progression is associated with polarization of monocytes/macrophages towards M2 which is regulated by cytokines IL-4/IL-13 and IL-10, this study evaluated the status of key IL-4 and IL-10 driven markers in experimental models of VL, as also evaluated their correlation, if any, with parasite load...
July 31, 2020: Parasite Immunology
Agnieszka Kempinska-Podhorodecka, Monika Adamowicz, Mateusz Chmielarz, Maciej K Janik, Piotr Milkiewicz, Malgorzata Milkiewicz
Vitamin D deficiency has been associated with depressive symptoms and reduced physical functioning. The aim of the study was to characterize the relationship between polymorphisms of the vitamin D receptor (VDR) gene and the quality of life in patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). Three polymorphisms of the VDR gene ( TaqI-rs731236 , BsmI-rs1544410 , and ApaI-rs7975232 ) were analyzed in patients with AIH ( n = 142) and PBC ( n = 230) and in healthy individuals ( n = 376)...
July 27, 2020: Nutrients
Maria Callejo, Gema Mondejar-Parreño, Daniel Morales-Cano, Bianca Barreira, Sergio Esquivel-Ruiz, Miguel Angel Olivencia, Grégoire Manaud, Frédéric Perros, Juan Duarte, Laura Moreno, Angel Cogolludo, Francisco Perez-Vizcaino
Vitamin D (vitD) receptor (VDR) regulates the expression of several genes involved in signaling pathways affected in pulmonary hypertension (PH). VitD deficiency is highly prevalent in PH, and low levels are associated with poor prognosis. We investigated if vitD deficiency may predispose to or exacerbate PH. Male Wistar rats were fed with a standard or a vitD-free diet for five weeks. Then, rats were further divided into controls or PH, which was induced by a single dose of Su5416 (20 mg/kg) and exposure to hypoxia (10% O2 ) for 2 weeks...
July 29, 2020: American Journal of Physiology. Lung Cellular and Molecular Physiology
Hossam M Shokri, Karim O Mohamed, Nagia A Fahmy, Ahmed O Mostafa, Ahmed Ghareeb
INTRODUCTION: Vitamin D works by binding to vitamin D receptor (VDR). The muscle involvement in hypovitaminosis D was broadly named osteomalacic myopathy. METHODS: A case control study involved 20 female patients diagnosed with osteomalacic myopathy compared with 15 age-matched healthy female controls. We assessed both for VDR genotype single-nucleotide polymorphisms (SNP) at 3 sites (ApaI, BsmI, and FokI). RESULTS: ApaI and BsmI genotypes distribution in both groups showed non-significant difference unlike FokI genotypes in which we found significantly higher percentages of single allele mutation in patients vs...
July 26, 2020: Neurological Sciences
Panpan Cui, Yan Wang, Yanzhong Li, Lei Ge
BACKGROUND This study aimed to investigate the mechanisms underlying the neuroprotective effects of vitamin D. MATERIAL AND METHODS Rat primary neuron cells were incubated under a hypoxia condition [a hypoxic chamber mixed with anaerobic gas (90% N₂, 5% CO₂) and 5% O₂] to induce cell injury. Cell transfection was performed to overexpress or suppress the expression of dual oxidase 1 (DUOX1). The malondialdehyde (MDA) and superoxide dismutase (SOD) levels were detected using a MDA (A003-2) or SOD (A001-1) kit...
July 26, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Gengfu Wang, Yingpei Li, Yun Li, Jiaxiang Zhang, Chengfan Zhou, Changhao Wu, Qixing Zhu, Tong Shen
Bisphenol A (BPA) exposure can increase the risk of immune-related diseases in later life. Vitamin D3 (Vit D3) has been shown to have multiple immunomodulatory actions and has been used to treat immune diseases. However, the potential beneficial effects of Vit D3 on BPA-induced adverse effects in the immune system have not explored. We hypothesize that VitD3 may ameliorate BPA-induced side effects in the immune system, even in offspring of VitD3-supplemented mothers. Here, we established our experimental model by exposing pregnant dams with 1000 nM BPA with or without VitD3 (0...
July 20, 2020: Food and Chemical Toxicology
Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Yosuke Kaneko, Eri Ito, Tomoya Soma, Hiroyuki Okada, Kana Miyamoto, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice...
July 22, 2020: Scientific Reports
Xuemei Yao, Lei Yang, Meiyan Li, Hui Xiao
BACKGROUND: Vitamin D receptor (VDR) gene polymorphism is reported to be associated with muscle mass and muscle strength. Loss of skeletal muscle mass and decreased muscle strength are the main characteristics of sarcopenia. In this study, the relationship of VDR gene polymorphism with muscle traits (muscle mass, muscle strength, and physical performance) and sarcopenia were studied in Xinjiang, China. METHODS: Totally, 205 sarcopenia patients were enrolled. Propensity score method was used to match control group...
July 22, 2020: Journal of Clinical Laboratory Analysis
Abeer A Banjabi, Ayat B Al-Ghafari, Taha A Kumosani, Kurunthachalam Kannan, Salah M Fallatah
Objective: Osteoporosis is the most common type of bone disorder characterized by low bone mineral density (BMD). It is a multifactorial disease and caused by the interaction of environmental and genetic factors. It has been reported that mutations in the vitamin D receptor ( VDR ) gene highly affect the metabolism of minerals, which reduces bone density. Therefore, this study aimed to determine the association of VDR gene polymorphisms TaqI (rs731236) and ApaI (rs7975232) with osteoporosis risk in the Saudi population...
July 2020: International Journal of Health Sciences
Jeane Franco Pires Medeiros, Michelle Vasconcelos de Oliveira Borges, Aline Alves Soares, Jessica Cavalcante Dos Santos, Ana Beatriz Bezerra de Oliveira, Conceição Horrana Belo da Costa, Marina Sampaio Cruz, Raul Hernandes Bortolin, Renata Caroline Costa de Freitas, Paulo Moreira Silva Dantas, Mario Hiroyuki Hirata, Vivian Nogueira Silbiger, André Ducati Luchessi
Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA...
July 20, 2020: Scientific Reports
Courtney B Martin, Bryan T Oshiro, LeeAnna D Sands, Salma Kabir, Donna Thorpe, Tatiana C Clark, Ruofan Yao, Eugenia Mata-Greenwood
Vitamin D deficiency has been associated with preeclampsia, however, vitamin D supplementation studies have shown equivocal data on amelioration of this disease. We hypothesize that women with preeclampsia have an altered endogenous vitamin D homeostasis that counteracts the beneficial effects of vitamin D supplementation. Our study population consisted of 66 maternal/neonate dyads: 16 early-onset (<34 weeks) preeclampsia (EOP), 16 early-onset controls (EOC), 17 late-onset (≥34 weeks) preeclampsia (LOP), and 17 late-onset controls (LOC)...
July 15, 2020: Journal of Steroid Biochemistry and Molecular Biology
Ahmed El-Sharkawy, Ahmed Malki
Vitamin D and its active metabolites are important nutrients for human skeletal health. UV irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the liver and kidneys into its active form, 1α,25-dihydroxyvitamin D3. Apart from its classical role in calcium and phosphate regulation, scientists have shown that the vitamin D receptor is expressed in almost all tissues of the body, hence it has numerous biological effects. These includes fetal and adult homeostatic functions in development and differentiation of metabolic, epidermal, endocrine, neurological and immunological systems of the body...
July 15, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shaimaa Sahmoud, Mostafa S Ibrahim, Eman A Toraih, Noha Kamel, Manal S Fawzy, Samar Elfiky
Background: The reduced rate of bone formation despite the availability of vitamin D has been reported in β-thalassemia. Genetic factors, together with environmental ones, could be implicated in this condition. Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia...
2020: Mediterranean Journal of Hematology and Infectious Diseases
Mariya Zh Miteva, Boyan I Nonchev, Maria M Orbetzova, Snejana D Stoencheva
The essential biological action of vitamin D is regulation of calcium and phosphorus metabolism and preserving bone health. In recent years there have been reports about the extraskeletal actions of vitamin D and its role in the regulation of immune system. Vitamin D supplementation appears to reduce the incidence of cardiovascular diseases, cancer, and infections and be able to reduce all-cause mortality. Deficiency of vitamin D has been found to correlate with the increased incidence of autoimmune diseases, including type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis...
June 30, 2020: Folia Medica
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