Shahab Aldin Sattari, Ali Reza Sattari, Christopher G Salib, Hytham S Salem, Daniel Hameed, Jeremy Dubin, Michael A Mont
BACKGROUND: Studies comparing the outcomes of bariatric surgery followed by total knee arthroplasty (TKA) versus TKA alone in obese patients have disparate results. This systematic review and meta-analysis sought to compare TKA with and without prior bariatric surgery in obese patients. METHODS: MEDLINE, PubMed, and Embase were searched from inception to April 9, 2023. There were twelve included studies that yielded 2,876,547 patients, of whom 62,818 and 2,813,729 underwent TKA with and without prior bariatric surgery, respectively...
May 16, 2024: Journal of Arthroplasty
Lucas Gabriel Vieira, Sylvana Izaura Salyba Rendeiro de Noronha, Máira Tereza Talma Chírico, Ana Beatriz de Souza, Natália Alves de Matos, Deoclécio Alves Chianca Júnior, Frank Silva Bezerra, Rodrigo Cunha Alvim de Menezes
BACKGROUND: Obesity is a worldwide public health problem associated with cognitive and mental health problems in both humans and rats. Studies assessing the effect of fiber supplementation on behavioral deficits and oxidative stress caused by high-fat diet (HFD) consumption in female rats are still scarce. We hypothesized that HFD consumption would lead to anxiety-related behavior and hepatic oxidative stress and that inulin would protect against these changes. We analyzed the impact of HFD-induced obesity combined with fiber supplementation (inulin) on anxiety-related defensive behavior and hepatic oxidative stress...
May 16, 2024: Behavioural Brain Research
Chengxia Huang, Yang Wang, Cunshan Zhou, Xingyu Fan, Qiaolan Sun, Jingyi Han, Chenhui Hua, Yao Li, Yunwei Niu, Clinton Emeka Okonkwo, Deyang Yao, Linglin Song, Phyllis Otu
For health and safety reasons, the search for green, healthy, and low-calorie sweeteners with good taste has become the demand of many consumers. Furthermore, the need for sugar substitutes of natural origin has increased dramatically. In this review, we briefly discussed the safety and health benefits of stevia sweeteners and enumerated some examples of physiological functions of steviol glycosides (SGs), such as anti-inflammatory, anti-obesity, antihypertensive, anti-diabetes, and anticaries, citing various evidence related to their application in the food industry...
May 17, 2024: Food Chemistry
Campbell Ince, Lucy Albertella, Chang Liu, Jeggan Tiego, Leonardo F Fontenelle, Samuel R Chamberlain, Murat Yücel, Kristian Rotaru
Modern internet pornography allows users to harness sexual novelty in numerous ways, which can be used to overcome desensitisation through increasing volume of use (quantitative tolerance), progressing to more stimulating genres (qualitative escalation), skipping between stimuli (tab-jumping), delaying orgasm ('edging'), and engaging in pornographic binges. However, existing research has not yet evaluated how these potentially reciprocal consumption patterns relate to problematic pornography use (PPU). To this end, we recruited two independent samples of male pornography users (N1  = 1,356, Mage  = 36...
May 2, 2024: Addictive Behaviors
Maya Vijayaraghavan, Holly Elser, Kevin Delucchi, Janice Y Tsoh, Kara Lynch, Sheri D Weiser, Elise D Riley
BACKGROUND: Recent insights into substance use cessation suggest that outcomes short of long-term abstinence are clinically meaningful and may offer more realistic incremental goals, particularly for highly vulnerable individuals. With the goal of informing tobacco treatment programs, we examined distinct patterns of cigarette smoking and their association with the ongoing use of other substances in women who experience housing instability. METHODS: We recruited participants from a longitudinal study of women experiencing housing instability...
May 16, 2024: Addictive Behaviors
Saurav Basu, Vansh Maheshwari, Debolina Roy, Mahira Saiyed, Rutul Gokalani
BACKGROUND: The Indian Diabetes Risk Score (IDRS) is a simple tool to assess the probability of an individual having type 2 diabetes (T2DM) but its applicability in community-dwelling older adults is lacking. This study aimed to estimate the risk of T2DM and its determinants among older adults without prior diabetes (DM) using the IDRS, while also assessing its sensitivity and specificity in individuals with a history of diabetes. METHODS: We analyzed cross-sectional data from the Longitudinal Ageing Study in India (LASI) wave-1 (2017-18)...
May 16, 2024: Diabetes & Metabolic Syndrome
Pingping Su, Yao Su, Xinrui Jia, Huan Han, Wenjiao Li, Hao Ying
OBJECTIVE: In singleton-pregnant women, abnormal maternal apolipoprotein levels have been confirmed as a risk factor for preterm birth. However, there are currently no studies on the relationship of the related research in twin-pregnant women. METHODS: This single-center retrospective study included 743 dichorionic twin-pregnant women who delivered between January 2019 and December 2020. Twins delivered before 37 weeks gestation were categorized as the preterm group, while those delivered at or after 37 weeks gestation were classified as the term group...
May 13, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Xue Xin Goh, Shiau Foon Tee, Pek Yee Tang, Kok Yoon Chee, Kenny Kien Woon Loh
Antipsychotics with weight gain as side effect and vitamin D receptor dysfunction associated with single nucleotide polymorphisms (VDR SNPs) may have different effects on vitamin D status. Hence, present study aimed to investigate the relationship between vitamin D with body mass index (BMI), antipsychotics and VDR SNPs (rs2228570, rs1544410, rs7975232 and rs731236) in Malaysian patients with schizophrenia. Serum vitamin D level was measured using competitive enzyme-linked immunosorbent assay kit. VDR SNPs were analyzed using polymerase chain reaction-restriction fragment length polymorphism...
May 7, 2024: Journal of Psychiatric Research
Lili Yu, Feifei Gao, Yaoxin Li, Dan Su, Liping Han, Yueming Li, Xuehan Zhang, Zhiwei Feng
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent liver diseases worldwide, and its occurrence is strongly associated with obesity, insulin resistance (IR), genetics, and metabolic stress. Ranging from simple fatty liver to metabolic dysfunction-associated steatohepatitis (MASH), even to severe complications such as liver fibrosis and advanced cirrhosis or hepatocellular carcinoma, the underlying mechanisms of MASLD progression are complex and involve multiple cellular mediators and related signaling pathways...
May 17, 2024: Biomedicine & Pharmacotherapy
Kai Wang, Jianing Liu
PURPOSE: α-Klotho has been linked to insulin resistance (IR) in basic research. However, experimental evidence is inconsistent, and there is a lack of data from human research. This study seeks to elucidate the association of α-Klotho with IR in a nationwide, multiracial population. METHODS: A total of 5289 participants aged 40-79 years were included in the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2016. Serum α-Klotho was measured using enzyme-linked immunosorbent assays (ELISA), and IR was evaluated by the homeostatic model assessment of insulin resistance (HOMA-IR)...
May 18, 2024: Endocrine
Neda Dolatkhah, Alireza Jafari, Fariba Eslamian, Vahideh Toopchizadeh, Parviz Saleh, Maryam Hashemian
PURPOSE: This study aimed to determine the effect of the probiotic Saccharomyces boulardii (S. boulardii) in patients with knee osteoarthritis (KOA). METHODS: In this study, 70 patients with KOA were recruited via outpatient clinics between 2020 and 2021 and randomly assigned to receive probiotics or placebo supplements for 12 weeks. The primary outcome was a change in pain intensity according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score...
May 18, 2024: European Journal of Nutrition
Evelien van Gelderen, Kevin J Psoter, Rafi Faria, Cozumel Pruette, Tammy M Brady
BACKGROUND: Ambulatory Blood Pressure Monitoring (ABPM) is recommended for diagnosis and management of hypertension. We aimed to identify characteristics associated with physician action after receipt of abnormal findings. METHODS: This was a retrospective cross-sectional analysis of patients 5-22 years old who underwent 24-h ABPM between 2003-2022, met criteria for masked or ambulatory hypertension, and had a pediatric nephrology clinic visit within 2 weeks of ABPM...
May 18, 2024: Pediatric Nephrology
Jonathan P Bennett, Carla M Prado, Steven B Heymsfield, John A Shepherd
Beyond obesity, excess levels of visceral adipose tissue (VAT) significantly contribute to the risk of developing metabolic syndrome (MetS), although thresholds for increased risk vary based on population, regions of interest, and units of measure employed. We sought to determine whether a common threshold exists that is indicative of heightened MetS risk across all populations, accounting for sex, age, BMI, and race/ethnicity. A systematic literature review was conducted in September 2023, presenting threshold values for elevated MetS risk...
May 18, 2024: Obesity Reviews
Eric Tsz-Chun Poon, Hong-Yat Li, Martin J Gibala, Stephen Heung-Sang Wong, Robin Sze-Tak Ho
BACKGROUND: High-intensity interval training (HIIT) is characterized by repeated bouts of relatively intense exercise interspersed with recovery periods. Previous studies have evaluated this exercise strategy with various population subgroups, regimens, and comparator groups, limiting the generalizability of findings. We performed a novel umbrella review to generate an up-to-date synthesis of the available evidence regarding the effect of HIIT on cardiorespiratory fitness (CRF) in adults as compared to non-exercise control and traditional continuous forms of exercise such as moderate-intensity continuous training (MICT)...
May 2024: Scandinavian Journal of Medicine & Science in Sports
Giovanni Petralli, Francesco Raggi, Alice Del Zoppo, Chiara Rovera, Antonio Salvati, Maurizia Rossana Brunetto, Anna Solini
BACKGROUND: Metabolic dysfunction-associated Steatotic Liver Disease (MASLD) displays a worse prognosis in subjects with type 2 diabetes (T2D); effective treatments are, so far, scanty. Semaglutide showed efficacy in improving steatohepatitis. We longitudinally observed a MASLD cohort of T2D subjects starting semaglutide, to detect an improvement of non-invasive surrogates of steatosis and fibro-inflammatory liver involvement, evaluating the role of mild alcohol consumption. PATIENTS AND METHODS: In 62 overweight/obese T2D subjects with MASLD (36 non-drinker and 26 mild alcohol consumers), anthropometric, bio-humoral and transient elastography (TE) data were collected before (T0) and after an average time of 6...
May 17, 2024: Diabetology & Metabolic Syndrome
Qin Pei, Yuwei Song, Zhongwei Huang, Hongkun Yu, Hao Xu, Xunda Ye, Lvfen Gao, Jian Gong, Xiaoying Tian
BACKGROUND: There is insufficient research on how gender-affirming hormone therapy (GAHT) affects body fat modifications in transwomen from China. It is unclear whether hormone therapy affects the prevalence of obesity and blood lipid levels within this population. The current research aimed to assess how GAHT and treatment duration had an impact on the change in and redistribution of body fat in Chinese transwomen. METHODS: This study included 40 transwomen who had not received GAHT and 59 who had...
May 17, 2024: Lipids in Health and Disease
Kenneth Bao Ren Leong, Qin Xiang Ng, Wee Hoe Gan, Wee Tong Ng, John Wah Lim
BACKGROUND: Despite the relative importance, the prevalence of workplace safety and health issues in hospital food service workers is not well studied. This study describes the epidemiology of work-related injuries and occupational diseases among hospital food service workers (FSWs) in a tertiary hospital in Singapore. METHODS: Using a total population sampling approach, a cross-sectional self-administered questionnaire was distributed to all FSWs employed at a major tertiary hospital in Singapore...
May 17, 2024: Journal of Occupational Medicine and Toxicology
Eman A Hassan, Yassin Khalifa, Ahmed A Morsy
Monitoring of ingestive activities is critically important for managing the health and wellness of individuals with various health conditions, including the elderly, diabetics, and individuals seeking better weight control. Monitoring swallowing events can be an ideal surrogate for developing streamlined methods for effective monitoring and quantification of eating or drinking events. Swallowing is an essential process for maintaining life. This seemingly simple process is the result of coordinated actions of several muscles and nerves in a complex fashion...
May 17, 2024: Biomedical Engineering Online
Lin Wang, Han Du, Chao Sheng, Hongji Dai, Kexin Chen
BACKGROUND: Kidney cancer has become known as a metabolic disease. However, there is limited evidence linking metabolic syndrome (MetS) with kidney cancer risk. This study aimed to investigate the association between MetS and its components and the risk of kidney cancer. METHODS: UK Biobank data was used in this study. MetS was defined as having three or more metabolic abnormalities, while pre-MetS was defined as the presence of one or two metabolic abnormalities...
May 17, 2024: Lipids in Health and Disease
Froukje E Takens, Indira Indyk, Mai J M Chinapaw, Joanne K Ujčič-Voortman, Femke van Nassau, Vincent Busch
BACKGROUND: Comprehensive school-based programs applying the WHO Health Promoting School Model have the potential to initiate and sustain behavior change and impact health. However, since they often include intervention efforts on a school's policies, physical environment, curriculum, health care and involving parents and communities, they significantly 'intrude' on a complex system that is aimed primarily at education, not health promotion. More insights into and concrete strategies are therefore needed regarding their adoption, implementation, and sustainment processes to address the challenge to sustainable implementation of HPS initiatives in a primarily educational setting...
May 17, 2024: BMC Public Health
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