Anderson Cargnin-Carvalho, Mariella Reinol Silva, Ana Beatriz Costa, Nicole Alessandra Engel, Bianca Xavier Farias, Joice Benedet Bressan, Kassiane Mathiola Backes, Francielly de Souza, Naiana da Rosa, Aloir Neri de Oliveira Junior, Mariana Pereira de Souza Goldim, Maria Eduarda Anastácio Borges Corrêa, Ligia Milanez Venturini, Jucélia Jeremias Fortunato, Josiane Somariva Prophiro, Fabricia Petronilho, Paulo Cesar Lock Silveira, Gabriela Kozuchovski Ferreira, Gislaine Tezza Rezin
Excessive fructose consumption is associated with the incidence of obesity and systemic inflammation, resulting in increased oxidative stress and damage to the function of brain structures. Thus, we hypothesized that fructose consumption will significantly increase inflammation, oxidative damage and mitochondrial dysfunction in the mouse brain and, consequently, memory damage. The effects of different fructose concentrations on inflammatory and biochemical parameters in the mouse brain were evaluated. Male Swiss mice were randomized into four groups: control, with exclusive water intake, 5%, 10% and 20% fructose group...
March 22, 2023: Biochemistry and Cell Biology
Andrew J Beamish, Elizabeth Ryan Harper, Kajsa Järvholm, Annika Janson, Torsten Olbers
Severe obesity in adolescence negatively impacts upon health and wellbeing. Lifestyle modifications do not usually achieve a sufficient degree or durability of weight loss to mitigate the risk of medical complications. In recent years, metabolic and bariatric surgery (MBS), already a well-established treatment for adults with severe obesity, has emerged as an option in adolescents. Controlled studies in this age group have demonstrated substantial and sustained weight loss, improvements in associated health parameters, and a safety profile surpassing that observed in adult patients...
March 22, 2023: Journal of Clinical Endocrinology and Metabolism
Erika Segawa, Keiichi Jingu, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Noriyuki Kadoya, Ken Takeda
Radiotherapy for breast cancer has attracted attention in Western countries because radiation to the heart can cause cardiac events. The purposes of this study were to evaluate the relationship between radiotherapy after breast-conserving surgery and the frequency of cardiac events in Japanese patients and to investigate the risk factors of cardiac events after postoperative radiotherapy in those patients. Female patients who received postoperative radiotherapy following breast-conserving surgery between 2007 and 2012 at our hospital were evaluated...
March 22, 2023: Journal of Radiation Research
Amina Khatun, Titli Panchali, Sukhamoy Gorai, Ananya Dutta, Tridip Kumar Das, Kuntal Ghosh, Shrabani Pradhan, Keshab Chandra Mondal, Sudipta Chakrabarti
OBJECTIVES: In this study mice were fed a high-fat diet for 12 weeks to establish diet-induced obesity and syringic acid (SA) was assessed for anti-obese, neuroprotective, and neurogenesis. METHOD: Animals were given HFD for 12 weeks to measure metabolic characteristics and then put through the Barns-maze and T-maze tests to measure memory. Additionally, the physiology of the blood-brain barrier, oxidative stress parameters, the expression of inflammatory genes, neurogenesis, and histopathology was evaluated in the brain...
March 22, 2023: Nutritional Neuroscience
Christina M Sanzari, Julia M Hormes
PURPOSE: This study examined U.S. health professionals' perspectives on the clinical utility, measurement, and etiology of orthorexia nervosa (ON). METHODS: Participants (n = 100) were U.S. health professionals with experience working clinically with eating disorders, including trainees, Ph.D. psychologists, social workers/mental health counselors, and medical health professionals. After reviewing the proposed ON criteria, participants responded to questions regarding the clinical utility, diagnosis, and measurement of ON, and sociocultural influence on the emergence of ON...
March 22, 2023: Eating and Weight Disorders: EWD
Luis C Bertot, Gary P Jeffrey, Bastiaan de Boer, Zhengyi Wang, Yi Huang, George Garas, Gerry MacQuillan, Michael Wallace, Briohny W Smith, Leon A Adams
BACKGROUND: Non-invasive tests are widely used to diagnose fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), however, the optimal method remains unclear. We compared the accuracy of simple serum models, a serum model incorporating direct measures of fibrogenesis (Hepascore), and Fibroscan®, for detecting fibrosis in NAFLD. METHODS: NAFLD patients undergoing liver biopsy were evaluated with Hepascore, NAFLD Fibrosis Score (NFS), FIB-4 and AST-platelet ratio index (APRI), with a subset (n = 131) undergoing Fibroscan®...
March 22, 2023: Digestive Diseases and Sciences
Chiara Conti, Maria Di Nardo, Roberta Lanzara, Maria Teresa Guagnano, Valentina Cardi, Piero Porcelli
PURPOSE: The aim of this longitudinal study was to examine the extent to which improved levels of binge eating (BE) behaviors, alexithymia, self-esteem, and psychological distress would predict a reduction in body mass at 9-month follow-up, following a lifestyle modification program for weight loss in obese or overweight patients. METHODS: A convenience sample of 120 obese or overweight patients were recruited. Body mass index (BMI), binge eating (BES), levels of alexithymia (TAS-20), perceived stress (PSS), depressive symptoms (SDS), and self-esteem (RSE) were assessed during their first medical examination (T1), and after a weight-loss treatment period of 9 months (T2)...
March 22, 2023: Eating and Weight Disorders: EWD
Faridadin Ebrahimi Meimand, Abdolreza Pazouki, Seyed Amin Setaredan, Masoumeh Shahsavan, Mohammad Kermansaravi
PURPOSE: Sleeve gastrectomy (SG) has gained worldwide popularity by surgeons due to acceptable results in weight loss and obesity-associated medical problems. Distance from the pylorus during antral resection in SG may be effective in decreasing the occurrence of gastroesophageal reflux disease (GERD). The aim of this study was to evaluate GERD symptoms and weight loss outcomes in two groups of SG patients with different start points of antral resection. METHODS: This is a prospective cohort study on 220 patients who underwent SG between June 2019 and July 2021, aged 18 and above, BMI ≥ 40 kg/m2 , or BMI > 35 kg/m2 with at least one obesity-associated medical problem...
March 22, 2023: Surgical Endoscopy
Patchareya Nivatpumin, Tripop Lertbunnaphong, Siritorn Maneewan, Nutha Vittayaprechapon
OBJECTIVE: To compare the perioperative outcomes and anesthetic-related complications of morbidly obese and super-obese parturients delivering by cesarean section. METHODS: A retrospective analysis of 6 years of data was performed. Exclusions were cases with gestational ages <24 weeks, placenta accreta spectrum, polyhydramnios, or multiple gestations. RESULTS: The study included 494 patients whose body mass index (BMI) exceeded 40 kg/m2 at delivery...
December 2023: Annals of Medicine
Chad D Rethorst, Phrashiah Githinji, Rebecca A Seguin-Fowler, Alexandra L MacMillan Uribe, Jacob Szeszulski, Yue Liao
BACKGROUND: Glucose variability increases cardiometabolic disease risk. While many factors can influence glucose levels, postprandial glucose response is the primary driver of glucose variability. Furthermore, affect may directly and indirectly impact glucose variability through its effect on eating behavior. Continuous glucose monitors (CGMs) facilitate the real-time evaluation of blood glucose, and ecological momentary assessment (EMA) can be used to assess affect in real time. Together, data collected from these sources provide the opportunity to further understand the role of affect in glucose levels...
March 22, 2023: JMIR Research Protocols
Martta Kerkelä, Mika Gissler, Tanja Nordström, Olavi Ukkola, Juha Veijola
BACKGROUND: We studied the association between participation in the longitudinal follow-up study and cardiometabolic disorders in two longitudinal studies which started prospectively in the antenatal period: the Northern Finland Cohort 1966 (NFBC1966) and the Northern Finland Birth Cohort 1986 (NFBC1986). Both birth cohorts have been followed up since birth with multiple follow-ups including questionnaires, and clinical examinations. METHODS: The NFBC studies were compared to comparison cohorts of individuals who were born in the same area as the study cohorts, but in different years...
December 2023: Annals of Medicine
Dongjin Seo, Han Sang Kim, Joong Bae Ahn, Yu Rang Park
BACKGROUND: Skeletal muscle and BMI are essential prognostic factors for survival in colorectal cancer (CRC). However, there is a lack of understanding due to scarce studies on the continuous aspects of these variables. OBJECTIVE: This study aimed to evaluate the prognostic impact of the initial status and trajectories of muscle and BMI on overall survival (OS) and assess whether these 4 profiles within 1 year can represent the profiles 6 years later. METHODS: We analyzed 4056 newly diagnosed patients with CRC between 2010 to 2020...
March 22, 2023: JMIR Public Health and Surveillance
Muhammad Abdul-Ghani, Ralph A DeFronzo
No abstract text is available yet for this article.
March 22, 2023: Journal of Clinical Endocrinology and Metabolism
Alexey Surov, Franz Benkert, Wolfram Pönisch, Hans-Jonas Meyer
OBJECTIVES: Body composition assessment is comprised by skeletal muscle mass (SMM) and subcutaneous and visceral adipose tissue (SAT and VAT) and can be quantified by imaging. It can be predictive of several clinically outcomes in patients with hematological diseases. Our aim was to establish the effect of body composition parameters on overall survival (OS) and progression-free survival (PFS) in patients with multiple myeloma (MM). MATERIALS AND METHODS: All patients with MM were retrospectively analyzed between 2009 and 2019...
December 2023: Hematology (Amsterdam, Netherlands)
Elizabet Saes-Silva, Mirelle de Oliveira Saes, Rodrigo Dalke Meucci, Fernanda de Oliveira Meller, Antônio Augusto Schäfer, Samuel Carvalho Dumith
This article aims to investigate the association between remote work and Back Pain during the COVID-19 pandemic, and to analyze this relationship according to the body mass index. Population-based, cross-sectional study carried in two cities in southern Brazil, in individuals aged 18 years and over. Data were collected through household interviews from October to January 2020/21. Outcomes: back pain (cervical, thoracic, lumbar/acute, chronic) and pain intensity. Exposure variable: remote work. For the analyses, Poisson regression with robust adjustment for variance was used, stratified by BMI (eutrophic vs overweight/obese), and restricted to those who had worked in the past month...
March 2023: Ciência & Saúde Coletiva
João Evangelista Neto, José Henrique Cardoso Ferreira da Costa, Johnnes Henrique Vieira Silva, Murilo Pimentel Leite Carrijo Filho, Pedro Castor Batista Timóteo da Silva, Daniel Felipe Morais Vasconcelos, E Pedro Cavalcanti de Albuquerque
BACKGROUND: Although bariatric surgery is highly effective for the treatment of obesity and its comorbidities, preoperative weight loss has an impact on its results. AIMS: The aim of this study was to correlate preoperative weight loss with the outcome of bariatric surgery using the Bariatric Analysis and Reporting Outcome System scores. METHODS: This is a cross-sectional, observational study with 43 patients undergoing bariatric surgery that compared a group of 25 patients with a percentage of preoperative excess weight loss ³8% with a group of 18 patients with a percentage of preoperative excess weight loss <8% or with weight gain...
2023: Brazilian Archives of Digestive Surgery: ABCD
Thiago de Almeida Furtado, Marcelo Gomes Girundi, Cláudio de Oliveira Chiari Campolina, Sofia Cunha Mafra, Alice Marina Osório de Oliveira, Maria Luiza Patrão Dias Dos Santos, Sarah Ferreira Lopes, Mariana Alvarenga Freire
BACKGROUND: Although bariatric surgery is today's gold standard treatment for obesity, weight regain affects the success rate of the procedure. Recent studies have identified psychiatric and neurological factors as possible causes. AIMS: The aim of this study was to evaluate the influence of psychiatric diseases on the outcome and long-term success of bariatric surgeries and find a weight regain threshold that has an acceptable sensibility to mental health-related issues to be used in research and clinical studies...
2023: Brazilian Archives of Digestive Surgery: ABCD
Mahmud Mahamid, Bashar Fteiha, Eran Goldin, William Nseir
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver disorders. Acute cholangitis (AC) is a life-threatening illness. OBJECTIVES: To determine whether NAFLD is a risk factor for the severity of AC. METHODS: We retrospectively studied hospitalized patients with a diagnosis of AC over 5 years. Patients were divided into a NAFLD group and a non-NAFLD group. We compared the two groups with regard to demographic characteristics, co-morbidities, laboratory data, and severity of AC (including Charlson Comorbidity Index [CCI] and Tokyo Consensus meeting criteria)...
March 2023: Israel Medical Association Journal: IMAJ
Neill Y Li, Daniel S Yang, Shashank Dwivedi, Joseph A Gil, Alan H Daniels
BACKGROUND: Patients with carpal tunnel syndrome (CTS) may also have cervical radiculopathy (CR) or vice versa, potentially requiring carpal tunnel release (CTR) and anterior cervical discectomy and fusion (ACDF). This study evaluates whether there is an increased risk of complications following CTR or ACDF in patients with concurrent CTS and CR (CTS-CR) compared with those with only CTS or CR. METHODS: A multipayer database was used to identify patients with CTS-CR...
March 22, 2023: Hand: Official Journal of the American Association for Hand Surgery
Joni K Evans, Chinenye O Usoh, Felicia R Simpson, Sara Espinoza, Helen Hazuda, Ambarish Pandey, Tara Beckner, Mark A Espeland
BACKGROUND: Multidomain lifestyle interventions may slow aging as captured by deficit accumulation frailty indices; however, it is unknown whether benefits extend beyond intervention delivery. METHODS: We developed a deficit accumulation frailty index (FI-E) to span the ten years that the Action for Health in Diabetes (Look AHEAD) randomized controlled clinical trial delivered interventions (a multidomain lifestyle intervention focused on caloric restriction, increased physical activity, and diet compared to a control condition) and to extend across an additional eight years post-delivery...
March 22, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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