Youxiang Cao, Lin Zhu, Jingxin Liu
OBJECTIVES: Metabolic syndrome (MetS) is systemic metabolic disease that results from insulin resistance or obesity. Numerous meta-analyses have investigated the effect of exercise on different populations, but none were aimed at the effect of aerobic exercise alone on obese children. This review systematically assessed and performed a meta-analysis on the effect of aerobic exercise on obese children with MetS. CONTENT: MEDLINE via PubMed, Embase, SPORTDiscus, and the Cochrane library were searched and screened from inception to 20 October 2020 for randomized controlled trials...
July 21, 2021: Journal of Pediatric Endocrinology & Metabolism: JPEM
Katarzyna P Kaleta, Georgios Nikolakis, Amir M Hossini, Ottfried Balthasar, Daifallah Almansouri, Aristeidis Vaiopoulos, Jürgen Knolle, Anna Boguslawska, Anna Wojas-Pelc, Christos C Zouboulis
BACKGROUND: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results. OBJECTIVES: To assess the importance of metabolic disorders/obesity, smoking/environmental toxins, and inflammation in HS by utilizing the differential expression of major relevant protein markers in lesional skin of obese/smoking versus non-obese/non-smoking HS patients...
July 22, 2021: Dermatology: International Journal for Clinical and Investigative Dermatology
Feng Chen, Shuai Xu, Lu Cao, Yingfang Wang, Feng Chen, Huanlian Tian, Junwei Hu, Zheng Wang, Difei Wang
OBJECTIVES: The purpose of this study was to investigate the correlation between dietary patterns and the risk of sarcopenic obesity (SO) in community-dwelling elderly people. METHODS: SO was defined as the coexistence of sarcopenia and obesity. Participants with low skeletal muscle index, low muscle strength, or low physical performance were diagnosed with sarcopenia, whereas obesity was defined as waist circumference ≥85 cm in men and ≥80 cm in women. Dietary patterns were determined by principal component analysis...
June 7, 2021: Nutrition
Ankita Deb, Bhavana Deshmukh, Pranay Ramteke, Firoz Khan Bhati, Manoj Kumar Bhat
Resistin, a small secretory molecule, has been implicated to play an important role in the development of insulin resistance under obese condition. For the past few decades, it has been linked to various cellular and metabolic functions. It has been associated with diseases like metabolic disorders, cardiovascular diseases and cancers. Numerous clinical studies have indicated an increased serum resistin level in pathological disorders which have been reported to increase mortality rate in comparison to low resistin expressing subjects...
July 20, 2021: Translational Oncology
Tianshi David Wu, Ashraf Fawzy, Ayobami Akenroye, Corinne Keet, Nadia N Hansel, Meredith C McCormack
BACKGROUND: Diabetes is associated with worse asthma morbidity. Metformin, which treats diabetes, may have a role among patients with asthma and glycemic dysfunction. OBJECTIVE: To determine the association between metformin use and asthma exacerbations among patients with diabetes. METHODS: We queried the Johns Hopkins EHR from April 1, 2013 to May 31, 2018. Adults with asthma and diabetes were followed from first hemoglobin A1c (HbA1c) test to an asthma-related systemic corticosteroid prescription, emergency department (ED) visit, or hospitalization...
July 19, 2021: Journal of Allergy and Clinical Immunology in Practice
Luis A Rodriguez, Alka M Kanaya, Stephen C Shiboski, Alicia Fernandez, David Herrington, Jingzhong Ding, Patrick T Bradshaw
PURPOSE: To estimate the effect of obesity on type 2 diabetes (T2DM) risk and evaluate to what extent non-alcoholic fatty liver disease (NAFLD) mediates this association. METHODS: Data came from 4,522 adults ages 45-84 participating in the Multi-Ethnic Study of Atherosclerosis cohort. Baseline obesity was defined using established BMI categories. NAFLD was measured by CT scans at baseline and incident T2DM defined as fasting glucose ≥126 mg/dL or use of diabetes medications...
July 19, 2021: Annals of Epidemiology
Peng Zhou, Xiaodan Jiang, Xuemin Li
AIM: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as potent drug development target for treating diabetes and obesity. Here, we designed and evaluated novel long-acting GLP-1R G protein biased agonist with potent clinical application. MAIN METHODS: GLP-1R G-protein biased sequences were screened via a high-throughput autocrine-based strategy and then fused to Exendin (9-39). These fusion peptides were further performed with site-specific modification...
July 19, 2021: Life Sciences
Christina Chwyl, Michael P Berry, Stephanie M Manasse, Evan M Forman
Emotional eating (EE) has been proposed as a key weight loss barrier. However, most investigations of EE rely on retrospective self-reports, which may have poor construct validity. This study evaluated concordance between a common self-report EE measure and a novel method for assessing momentary EE using ecological momentary assessment (EMA). We further assessed the utility of both measures for predicting both BMI and weight outcomes. Participants with overweight or obesity enrolled in a weight loss trial (N = 163) completed a self-report measure of EE and underwent an EMA protocol that assessed momentary emotions and eating behaviors...
July 19, 2021: Appetite
Huinian Liu, Wenli Hu, Xin Li, Fangwen Hu, Yanni Xi, Zhu Su, Yicai Huang, Bo Liu, Chang Zhang
BACKGROUND: Since 2016, more and more studies have been conducted to explore the combination of obesity and perfluoroalkyl substances (PFASs) exposure, and the results indicate that PFASs may be connected with the occurrence of obesity-associated glucolipid metabolic disease (GLMD). OBJECTIVES: This article summarizes the epidemiological studies on PFASs and obesity-related GLMD, as well as relevant experimental evidence. RESULTS: (i) Both obesity and PFASs exposure can cause disorder of glucose and lipid metabolism (GLM)...
July 19, 2021: Environmental Research
Ye Jin Jeon, Ji Heon Lee, Hyeon Chang Kim, Sun Jae Jung
Background: Both cardiovascular health (CVH) and inflammation associated with cognition, and inflammation also associated with cardiovascular health. However, related information in the Korean population is limited. The objective of our study was to confirm the influence of inflammation on the association between CVH and cognition in cross-sectional design. Methods: Data were obtained from the Cardiovascular and Metabolic Diseases Etiology Research Center baseline study...
July 13, 2021: Epidemiology and Health
María Correa-Rodríguez, Mikel Izquierdo, Antonio García-Hermoso, Robinson Ramírez-Vélez
BACKGROUND: The aims of this study was to assess the potential of sixteen anthropometric, body composition and endocrine indexes as predictors of high liver fat and determine the most appropriate cutoff points in US adolescents. METHODS: A cross-sectional study was conducted on a population of 816 adolescents aged 12-17years. The FibroScan®502V2 device was used to estimate the controlled attenuation parameter (CAP). Body fat percentage, fat mass, trunk fat percentage and trunk fat mass were measured by dual-energy X-ray absorptiometry...
July 22, 2021: European Journal of Clinical Investigation
Samantha D Pauls, Lisa R Rodway, Karanbir K Sidhu, Tanja Winter, Nikhil Sidhu, Harold M Aukema, Peter Zahradka, Carla G Taylor
BACKGROUND: Omega-3 fatty acids, including DHA and α-linolenic acid (ALA), are proposed to improve metabolic health by reducing obesity-associated inflammation. Their effects are mediated in part by conversion to oxylipins. ALA is relatively understudied, and direct comparisons to other omega-3 fatty acids are limited. OBJECTIVES: We compared the effects of equal doses of ALA and DHA on plasma oxylipins and markers of metabolic health in women with obesity. METHODS: We carried out a randomized, double-blind, crossover clinical trial where women aged 20-51 with a BMI of 30-51 kg/m2 were supplemented with 4 g/day of ALA or DHA for 4 weeks in the form of ALA-rich flaxseed oil or DHA-rich fish oil...
July 22, 2021: Journal of Nutrition
Dirk De Bacquer, Felicity Astin, Kornelia Kotseva, Nana Pogosova, Delphine De Smedt, Guy De Backer, Lars Rydén, David Wood, Catriona Jennings
AIMS : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. METHODS AND RESULTS : In the EUROASPIRE IV and V surveys, 16 259 CHD patients were examined and interviewed during a study visit ≥6 months after hospital discharge...
July 19, 2021: European Journal of Preventive Cardiology
Miguel A Vences, Juan J Pareja-Ramos, Paula Otero, Liz E Veramendi-Espinoza, Melissa Vega-Villafana, Julissa Mogollón-Lavi, Eduardo Morales-Romero, Josseline Olivera-Vera, Carol Meza, Lucía J Salas-Lazo, Andy Triveño, Renzo Marín-Dávalos, Ricardo Carpio Rodriguez, Jessica H Zafra-Tanaka
Objectives: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru. Methods: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded...
July 5, 2021: Medwave
María-Elisa Fernández-Rubio, José-Luis Urcelay-Segura, José-María Bellón-Cano, Teresa Cuesta-Rodríguez
PURPOSE: To identify characteristics of patients undergoing cataract surgery associated with pathogenic and antibiotic-resistant conjunctival bacteria. SETTING: Spanish tertiary hospital. DESIGN: Retrospective cross-sectional study. METHODS: Records of consecutive patients undergoing cataract surgery between July 2005 and September 2014, contained data on patient characteristics and conjunctival bacteria systematically identified with preoperative tests and anesthetic evaluation...
August 1, 2021: Journal of Cataract and Refractive Surgery
Najiao Hong, Zhirong Ye, Yongjun Lin, Wensen Liu, Na Xu, Yan Wang
Agomelatine is a non-selective melatonin receptor agonist and an atypical antidepressant with anti-inflammatory, neuroprotective, and cardioprotective effects. The renin-angiotensin system modulates blood pressure and vascular homeostasis. Angiotensin II (Ang II) and its receptor Ang II type I receptor (AT1 R) are recognized as contributors to the pathogenesis of cardiovascular and cardiometabolic diseases, including diabetes, obesity, and atherosclerosis. The recruitment and attachment of monocytes to the vascular endothelium is a major event in the early stages of atherosclerosis and other cardiovascular diseases...
July 22, 2021: Aging
Braden J Passias, Greg Grenier, John Buchan, Daniel R Buchan, Joseph Scheschuk, Benjamin C Taylor
Unstable pelvic ring disruption is most commonly treated with closed reduction and percutaneous screw fixation. Traditional methods involve screw placement under fluoroscopic imaging, but with recent technologic advances, intraoperative 3D navigation can now be used to help with the insertion of sacroiliac screws. Various cadaver studies have shown that placement of sacroiliac screws under 3D navigation is more accurate than placement under traditional fluoroscopic guidance. This retrospective review of 134 patients evaluated the clinical use of 3D navigation vs traditional fluoroscopy for sacroiliac screw insertion at an urban level I trauma center...
July 2021: Orthopedics
José Carugno, Adriana Wong
Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence among younger, nulliparous patients. These epidemiological shifts are attributed to increasing rates of obesity, in combination with delayed childbearing. This highlights a need for fertility-sparing options for individuals who wish to delay standard surgical management with hysterectomy, bilateral salpingoophorectomy, and assessment of pelvic/para-aortic lymph nodes. Careful consideration should be taken to select which patients are suitable candidates for fertility-sparing methods...
July 22, 2021: Minimally Invasive Therapy & Allied Technologies: MITAT
Laura Tabacof, Jamie Wood, Nicki Mohammadi, Katherine E Link, Jenna Tosto-Mancuso, Sophie Dewil, Erica Breyman, Leila Nasr, Christopher Kellner, David Putrino
Background: Telehealth was frequently used in the provision of care and remote patient monitoring (RPM) during the COVID-19 pandemic. The Precision Recovery Program (PRP) remotely monitored and supported patients with COVID-19 in their home environment. Methods: This was a single-center retrospective cohort study reviewing data acquired from the PRP clinical initiative. Results: Of the 679 patients enrolled in the PRP, 156 patients were screened by a clinician following a deterioration in symptoms and vital signs on a total of 240 occasions, and included in the analyses...
July 22, 2021: Telemedicine Journal and E-health
Anna Konstantellou, Lot Sternheim, Lucy Hale, Mima Simic, Ivan Eisler
PURPOSE: This study aimed to explore how parents of young people with a restrictive eating disorder (ED) experience and manage uncertainty. METHODS: Seventeen parents of young people with a restrictive ED were recruited from multi-family therapy groups run within a specialised ED clinic. Five focus groups were conducted asking parents about their experience of uncertainty both prior and after the onset of their child's illness. RESULTS: Data were analysed using interpretative phenomenological analysis which yielded seven superordinate themes...
July 22, 2021: Eating and Weight Disorders: EWD
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"