Evan L Brittain, Lide Han, Jeffrey Annis, Hiral Master, Andrew Hughes, Dan M Roden, Paul A Harris, Douglas M Ruderfer
IMPORTANCE: Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity. OBJECTIVE: To use activity, clinical, and genetic data from the All of Us Research Program (AoURP) to explore the association of genetic risk of higher body mass index (BMI) with the level of physical activity needed to reduce incident obesity. DESIGN, SETTING, AND PARTICIPANTS: In this US population-based retrospective cohort study, participants were enrolled in the AoURP between May 1, 2018, and July 1, 2022...
March 4, 2024: JAMA Network Open