Olga T Gupta, Rana K Gupta
Body fat distribution is a predictor of metabolic health in obesity. In this Classics in Diabetes article, we revisit a 1985 Diabetes article by Swedish investigators Ohlson et al. This work was one of the first prospective population-based studies that established a relationship between abdominal adiposity and the risk for developing diabetes. Here, we discuss evolving concepts regarding the link between regional adiposity and diabetes and other chronic disorders. Moreover, we highlight fundamental questions that remain unresolved...
May 1, 2024: Diabetes
Laia Peruchet-Noray, Anja M Sedlmeier, Niki Dimou, Hansjörg Baurecht, Béatrice Fervers, Emma Fontvieille, Julian Konzok, Kostas K Tsilidis, Sofia Christakoudi, Anna Jansana, Reynalda Cordova, Patricia Bohmann, Michael J Stein, Andrea Weber, Stéphane Bézieau, Hermann Brenner, Andrew T Chan, Iona Cheng, Jane C Figueiredo, Koldo Garcia-Etxebarria, Victor Moreno, Christina C Newton, Stephanie L Schmit, Mingyang Song, Cornelia M Ulrich, Pietro Ferrari, Vivian Viallon, Robert Carreras-Torres, Marc J Gunter, Heinz Freisling
It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with CRC risk in observational analyses in 329,828 UK Biobank participants (3728 cases)...
April 19, 2024: Science Advances
H F Mendez-Reyes, M Franco-Olaya, O Canon-Cubillos, J M Uribe-Lopez, M C Delgado-Alvarez, M Velasquez-Portilla, M Olaya-C
BACKGROUND: Exposure to toxins during pregnancy is the main modifiable behavior that affects the placenta and, consequently, the fetus. In particular, smoking is a recognized risk factor for negative outcomes. Our study pretended to examine gross and microscopic placental features in women who reported exposure to tobacco, alcohol, or other psychoactive substances. METHODS: In this observational case-control study, we collected 706 placentas to assess precise substance exposure histological-interaction features of in the placenta...
April 13, 2024: Journal of Neonatal-perinatal Medicine
Hiba Sh Ahmed, Hind Sh Ahmed, Haylim N Abud
BACKGROUND: The number of coronavirus disease-19 (COVID-19) positive patients and fatalities keeps rising. It is important to recognize risk factors for severe outcomes. Evidence linking vitamin D deficiency and the severity of COVID-19 is tangential but substantial - relating to race, obesity, and institutionalization. OBJECTIVE: This study aims to examine the function of vitamin D and nutritional defense against infections such as COVID-19, which is the goal of this research...
April 10, 2024: Human Antibodies
Behnam Bagherzadeh-Rahmani, Emanuele Marzetti, Esmail Karami, Bill I Campbell, Ali Fakourian, Amir Hossein Haghighi, Seyyed Hossein Mousavi, Katie M Heinrich, Luca Brazzi, Friedrich Jung, Julien S Baker, Darpan I Patel
OBJECTIVES: The purpose of this study was to investigate the effects of 6 weeks of resistance training (RT) combined with aerobic training (AT) and Tirzepatide supplementation on lipid profiles, insulin resistance, anthropometric characteristics and physical fitness in prediabetic obese soldiers. METHODS: 61 obese men were randomly divided into six groups: Placebo; Tirzepatide 5 mg (T5); Tirzepatide 2.5 mg (T2.5); Hypertrophy, Strength, Power-Circuit Training+Placebo (Ex+P); Hypertrophy, Strength, Power-Circuit Training+Tirzepatide 5 mg (Ex+T5); Hypertrophy, Strength, Power-Circuit Training+Tirzepatide 2...
April 12, 2024: Clinical Hemorheology and Microcirculation
Santhosh Kumar Pasupuleti, Reuben Kapur
PURPOSE OF REVIEW: This review meticulously delves into existing literature and recent findings to elucidate the intricate link between obesity and clonal hematopoiesis of indeterminate potential (CHIP) associated clonal hematopoiesis. It aims to enhance our comprehension of this multifaceted association, offering insights into potential avenues for future research and therapeutic interventions. RECENT FINDINGS: Recent insights reveal that mutations in CHIP-associated genes are not limited to symptomatic patients but are also present in asymptomatic individuals...
April 22, 2024: Current Opinion in Hematology
Guorui Fan, Xiaohai Guan, Bo Guan, Hongfei Zhu, Yongchao Pei, Chonghao Jiang, Yonggui Xiao, Zhiguo Li, Fenghong Cao
BACKGROUND: Recent studies have shown that obesity may contribute to the pathogenesis of benign prostatic hyperplasia (BPH). However, the mechanism of this pathogenesis is not fully understood. METHODS: A prospective case-control study was conducted with 30 obese and 30 nonobese patients with BPH. Prostate tissues were collected and analyzed using ultra performance liquid chromatography ion mobility coupled with quadrupole time-of-flight mass spectrometry (UPLC-IMS-Q-TOF)...
2024: PloS One
Liam R Brunham
PURPOSE OF REVIEW: The purpose of this review article was to describe recent advances in our knowledge about how diabetes and metabolic syndrome are changing the face of familial hypercholesterolemia. RECENT FINDINGS: Heterozygous familial hypercholesterolemia, most commonly caused by disruption to LDL receptor function, leads to lifelong elevation of LDL cholesterol and increased risk of atherosclerotic cardiovascular disease. Familial hypercholesterolemia was originally described as a form of 'pure' hypercholesterolemia, in the sense that levels of LDL were uniquely affected...
April 22, 2024: Current Opinion in Lipidology
Emily Harris
No abstract text is available yet for this article.
April 19, 2024: JAMA
Abigail R Walker, Holly Ann Parkin, Sung Hye Kim, Vasso Terzidou, David F Woodward, Phillip R Bennett, Aylin C Hanyaloglu
The prostanoid G protein-coupled receptor (GPCR) EP2 is widely expressed and implicated in endometriosis, osteoporosis, obesity, pre-term labour, and cancer. Internalisation and intracellular trafficking are critical for shaping GPCR activity, yet little is known regarding spatial programming of EP2 signalling and whether this can be exploited pharmacologically. Using three EP2-selective ligands that favour activation of different EP2 pathways, we show that EP2 undergoes limited agonist-driven internalisation but is constitutively internalised via dynamin-dependent, β-arrestin-independent pathways...
April 1, 2024: Journal of Molecular Endocrinology
Tobias Kappenschneider, Günther Maderbacher, Matthias Meyer, Stefano Pagano, Jan Reinhard, Katrin Michalk, Joachim Grifka, Dominik Emanuel Holzapfel
BACKGROUND: The care of geriatric patients undergoing elective orthopedic surgery is becoming increasingly more important due to demographic trends. Compared to geriatric traumatology, however, there are still no established orthogeriatric care models in Germany and therefore hardly any scientific data. The aim of this study was to describe the risk and complication profiles in older patients with elective hip and knee replacements. METHODS: In a prospective study data were collected from orthogeriatric patients with indications for elective hip and knee replacement surgery who fulfilled defined inclusion and exclusion criteria between January 2021 and August 2023 in the orthopedic department of a German university hospital for the descriptive analysis of risk and complication profiles...
April 19, 2024: Zeitschrift Für Gerontologie und Geriatrie
Andie MacNeil, Susanna Abraham Cottagiri, Paul J Villeneuve, Ying Jiang, Margaret de Groh, Esme Fuller-Thomson
OBJECTIVES: The objectives of this study were: 1) to examine and compare changes in functional limitations during the COVID-19 pandemic among older adults with and without diabetes; and 2): to identify key risk factors associated with developing functional limitations among older adults with and without diabetes during the pandemic. METHODS: We analyzed data collected from the Canadian Longitudinal Study on Aging. The analysis was restricted to those with no functional limitations in the follow-up 1 wave (2015 to 2018) (final sample N=6,045)...
April 12, 2024: Canadian Journal of Diabetes
Anna Weir Johnson, Alisha H Redelfs, William Christensen, Lori Andersen Spruance
OBJECTIVE: This study aimed to discover the prevalence of school nutrition state legislation and to identify the correlates of enactment. DESIGN, SETTING, AND PARTICIPANTS: An online legislative database, Legiscan, was used to collect bills related to school nutrition from the US from 2010 to 2019. Bills were coded and compiled into a study database with state-level dietary variables (obesity prevalence, fruit, and vegetable intake, sugar-sweetened beverage consumption), community variables (percent White, poverty), and bill-characteristic variables (party affiliation in legislature, strength of language, party of governor, school gardens, vegetable intake, and other salient variables)...
April 19, 2024: Journal of Nutrition Education and Behavior
Pichamol Jirapinyo, Alia Hadefi, Christopher C Thompson, Árpád V Patai, Rahul Pannala, Stefan K Goelder, Vladimir Kushnir, Marc Barthet, Caroline M Apovian, Ivo Boskoski, Christopher G Chapman, Paul Davidson, Gianfranco Donatelli, Vivek Kumbhari, Bu Hayee, Janelle Esker, Tomas Hucl, Aurora D Pryor, Roberta Maselli, Allison R Schulman, Francois Pattou, Shira Zelber-Sagi, Paul A Bain, Valérie Durieux, Konstantinos Triantafyllou, Nirav Thosani, Vincent Huberty, Shelby Sullivan
This joint ASGE-ESGE guideline provides an evidence-based summary and recommendations regarding the role of endoscopic bariatric and metabolic therapies (EBMTs) in the management of obesity. The document was developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. It evaluates the efficacy and safety of EBMT devices and procedures that currently have CE mark or FDA-clearance/approval, or that had been approved within five years of document development. The guideline suggests the use of EBMTs plus lifestyle modification in patients with a BMI of ≥ 30 kg/m2 , or with a BMI of 27...
April 16, 2024: Gastrointestinal Endoscopy
Nisa M Maruthur, Scott J Pilla, Karen White, Beiwen Wu, May Thu Thu Maw, Daisy Duan, Ruth-Alma Turkson-Ocran, Di Zhao, Jeanne Charleston, Courtney M Peterson, Ryan J Dougherty, Jennifer A Schrack, Lawrence J Appel, Eliseo Guallar, Jeanne M Clark
BACKGROUND: Time-restricted eating (TRE) lowers body weight in many studies. Whether TRE induces weight loss independent of reductions in calorie intake, as seen in rodent studies, is unknown. OBJECTIVE: To determine the effect of TRE versus a usual eating pattern (UEP) on body weight in the setting of stable caloric intake. DESIGN: Randomized, isocaloric feeding study. ( NCT03527368). SETTING: Clinical research unit...
April 19, 2024: Annals of Internal Medicine
S Genc, B Evren, M N Aydın, I Sahin
OBJECTIVE: Prediabetes accompanied by metabolic syndrome accelerates the process leading to diabetes and causes an increase in complications. The current study aimed to investigate the clinical conditions accompanying prediabetes and the effect of the association of metabolic syndrome on clinical outcomes in prediabetics. SUBJECTS AND METHODS: This cross-sectional study was conducted with 88 prediabetic individuals between November 2022 and January 2023. Prediabetes was diagnosed using the American Diabetes Association (ADA) criteria, and metabolic syndrome was diagnosed using the International Diabetes Federation criteria...
April 2024: European Review for Medical and Pharmacological Sciences
Jingen Li, Jie Zhang, Virend K Somers, Naima Covassin, Lijing Zhang, Hao Xu
BACKGROUND: Although cardiovascular mortality continued declining from 2000 to 2019, the rate of this decrease decelerated. We aimed to assess the trends and disparities in risk factor control and treatment among US adults with atherosclerotic cardiovascular disease to find potential causes of the deceleration. METHODS AND RESULTS: A total of 55 ,021 participants, aged ≥20 years, from the 1999 to 2018 National Health and Nutrition Examination Survey were included, of which 5717 were with atherosclerotic cardiovascular disease...
April 19, 2024: Journal of the American Heart Association
Kanako Teramoto, Wan Ting Tay, Jasper Tromp, Wouter Ouwerkerk, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Oi Wah Liew, Jenny Chong, Katrina K Poppe, Mayanna Lund, Gerry Devlin, Richard W Troughton, Robert N Doughty, Arthur Mark Richards, Carolyn S P Lam
BACKGROUND: The relationship of serial NT-proBNP (N-terminal pro-B-type natriuretic peptide) measurements with changes in cardiac features and outcomes in heart failure (HF) remains incompletely understood. We determined whether common clinical covariates impact these relationships. METHODS AND RESULTS: In 2 nationwide observational populations with HF, the relationship of serial NT-proBNP measurements with serial echocardiographic parameters and outcomes was analyzed, further stratified by HF with reduced versus preserved left ventricular ejection fraction, inpatient versus outpatient enrollment, age, obesity, chronic kidney disease, atrial fibrillation, and attainment of ≥50% guideline-recommended doses of renin-angiotensin system inhibitors and β-blockers...
April 19, 2024: Journal of the American Heart Association
Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura
SCOPE: Obesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)-supplemented diet may ameliorate obesity and other metabolic disorders. Although accumulating evidence supports the notion of the developmental origins of health and disease, the underlying mechanisms remain obscure...
April 19, 2024: Molecular Nutrition & Food Research
Xing Zheng, Jun Zhang, Shun Liu, Yingzi Yu, Qingying Peng, Yaling Peng, Xu Yao, Xingxing Peng, Jing Zhou
As a beneficial natural flavonoid, genistein has demonstrated a wide range of biological functions via regulating a number of targets and signaling pathways, such as anti-cancer, antioxidant, antibacterial, antiinflammatory, antifungal, antiviral, iron chelation, anti-obesity, anti-diabetes, and anti-hypertension. PubMed/Medline and Web of Science were searched using appropriate keywords until the end of December 2023. Despite its many potential benefits, genistein's clinical application is limited by low hydrophilicity, poor solubility, and suboptimal bioavailability due to its structure...
April 18, 2024: Anti-cancer Agents in Medicinal Chemistry
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