Komaldeep Kaur, Aditi Gupta, Gagandeep Kaur, Vishal Chopra
Pleural effusion is rarely encountered in patients of allergic bronchopulmonary aspergillosis (ABPA). We report the case of a 17-year-old male who presented with complaints of fever, cough and increasing shortness of breath for 3 weeks. Patient had breathlessness with seasonal variation. Patient had right lower lobe consolidation with pleural effusion which did not respond to antibiotics. Pleural fluid was exudate with neutrophilic predominance and low ADA. Skin prick test for Aspergillus fumigatus was positive, both total IgE and specific IgE against Aspergillus fumigatus were raised...
September 9, 2020: Monaldi Archives for Chest Disease
Margherita Bertuzzi, Norman van Rhijn, Sven Krappmann, Paul Bowyer, Michael J Bromley, Elaine M Bignell
The origin of isolates routinely used by the community of Aspergillus fumigatus researchers is periodically a matter of intense discussion at our centre, as the construction of recombinant isolates have sometimes followed convoluted routes, the documentation describing their lineages is fragmented, and the nomenclature is confusing. As an aide memoir, not least for our own benefit, we submit the following account and tabulated list of strains (Table 1) in an effort to collate all of the relevant information in a single, easily accessible document...
September 17, 2020: Medical Mycology
Kevin S K Lau, Chantane Yeung, Chris Carlsten
Background: Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus . ABPA typically occurs in individuals with airway diseases such as asthma or cystic fibrosis and is associated with worse outcomes for individuals with these conditions. Each year, physicians across the province of British Columbia submit over 2600 diagnostic testing requests to a centralized location in Vancouver, requiring specimen collection, storage, and shipment from different clinics across the province...
2020: Allergy, Asthma, and Clinical Immunology
Veronika Volgger, Julia Louza, Donata Gellrich, Katharina Eder, Moritz Gröger
INTRODUCTION: Sensitization to Aspergillus fumigatus is a risk factor for severe asthma. However, little is known about its presence, appearance, and impact on allergic rhinitis. Herein, we investigated the usefulness of component resolved diagnostics in patients sensitized to Aspergillus fumigatus protein extract. METHODS: Seventy-eight patients with suspected allergic rhinitis and elevated IgE levels toward Aspergillus fumigatus protein extract were retrospectively evaluated regarding their total and Aspergillus-specific IgE levels and their skin prick test...
September 17, 2020: International Archives of Allergy and Immunology
Lilian Pereira Silva, Dean Frawley, Leandro José de Assis, Ciara Tierney, Alastair B Fleming, Ozgur Bayram, Gustavo Henrique Goldman
The high-osmolarity glycerol (HOG) response pathway is a multifunctional signal transduction pathway that specifically transmits ambient osmotic signals. Saccharomyces cerevisiae Hog1p has two upstream signaling branches, the sensor histidine kinase Sln1p and the receptor Sho1p. The Sho1p branch includes two other proteins, the Msb2p mucin and Opy2p. Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Here, we investigated the roles played by A. fumigatus SlnASln1p , ShoASho1p , MsbAMsb2p , and OpyAOpy2p putative homologues during the activation of the mitogen-activated protein kinase (MAPK) HOG pathway...
September 16, 2020: MSphere
Maxine A Höft, J Claire Hoving, Gordon D Brown
We are all exposed to fungal organisms daily, and although many of these organisms are not harmful, billions of people a year contract a fungal infection. Most of these infections are not fatal and can be cleared by the host immune response. However, due to an increase in high-risk populations, the global fungal burden has increased, with more than 1.5 million deaths per year caused by invasive fungal infections. The fungal cell wall is an important surface for interacting with the host immune system as it contains pathogen-associated molecular patterns (PAMPs) which are detected as being foreign by the host pattern recognition receptors (PRRs)...
September 17, 2020: Current Topics in Microbiology and Immunology
Subba Reddy Dodda, Nibedita Sarkar, Piyush Jain, Kaustav Aikat, Sudit S Mukhopadhyay
Cheap production of glucose is the current challenge for the production of cheap bioethanol. Ideal protein engineering approaches are required for improving the efficiency of the members of the cellulase, the enzyme complex involved in the saccharification process of cellulose. An attempt was made to improve the efficiency of the cellobiohydrolase (Cel6A), the important member of the cellulase isolated from Aspergillus fumigatus (AfCel6A). Structure-based variants of AfCel6A were designed. Amino acids surrounding the catalytic site and conserved residues in the cellulose-binding domain were targeted (N449V, N168G, Y50W and W24YW32Y)...
September 14, 2020: Protein Engineering, Design & Selection: PEDS
Sarmad Waqas, Katie Dunne, Alida Fe Talento, Graham Wilson, Ignacio Martin-Loeches, Joseph Keane, Thomas R Rogers
Chronic obstructive pulmonary disease (COPD) patients have been recognized to be at increased risk of Aspergillus spp. colonization, which may progress to invasive pulmonary aspergillosis (IPA). The objective of this study was to determine the frequency of Aspergillus colonization, or disease, in a cohort of COPD patients. A prospective observational study was undertaken to determine Aspergillus colonization, or disease, in consecutive COPD patients undergoing bronchoscopy. Fungal culture as well as galactomannan antigen (GM) and Aspergillus nucleic acid detection (PCR) were performed on bronchoalveolar lavage fluid (BAL) samples...
September 14, 2020: Medical Mycology
Amirseena Tolebeyan, Oranus Mohammadi, Zahra Vaezi, Afshin Amini
Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic pulmonary disorder caused by a hypersensitivity reaction to Aspergillus fumigatus that manifests with uncontrolled asthma, peripheral blood eosinophilia, and radiological findings, such as mucus plugging. Early diagnosis and proper treatment of ABPA are essential to prevent irreversible lung damage such as pulmonary fibrosis and bronchiectasis and improve the quality of life of patients. Beside inhaled medication for asthma, anti-inflammatory agents (i...
August 12, 2020: Curēus
Hyoungjae Ahn, Jalil Ur Rehman, Taehyen Kim, Min Seung Oh, Ho Young Yoon, Changgyo Kim, Younki Lee, Seung Gu Shin, Jong-Rok Jeon
Filamentous fungi are believed to remove a wide range of environmental xenobiotics due to their characteristically non-specific catabolic metabolisms. Nonetheless, irregular hyphal spreading can lead to clogging problems in treatment facilities and the dependence of pollutant bioavailability on hyphal surface features severely limits their applicability in water treatment. Here, we propose a scalable and facile methodology to structurally modify fungal hyphae, allowing for both the maximization of pollutant sorption and fungal pellet morphology self-regulation...
September 1, 2020: Water Research
Chi-Ching Tsang, James Y M Tang, Haiyan Ye, Fanfan Xing, Simon K F Lo, Chenlu Xiao, Lizhong Han, Alan K L Wu, Antonio H Y Ngan, Kwok-Cheung Law, Ying-Nam To, Dorothy T T Sze, Oscar H Y Chim, Teresa W S Hui, Carl W H Leung, Tianrenzheng Zhu, Chunyan Yao, Brian P H Tse, Susanna K P Lau, Patrick C Y Woo
BACKGROUND: The number of patients infected with Aspergillus rose dramatically in recent years. However, studies on the clinical spectrum and antifungal susceptibilities of non-classical (non-fumigatus, non-flavus, non-niger and non-terreus) pathogenic Aspergillus species are very limited. OBJECTIVES: We examined the clinical spectrum and antifungal susceptibilities of 34 non-duplicated, non-classical Aspergillus isolates collected from Hong Kong, Shenzhen and Shanghai...
September 11, 2020: Mycoses
Yong Zhang, Xu Wu, Yang-Pan Hu
BACKGROUND: Aspergillosis infection of central nervous system (CNS) is rare and fatal. Diagnosis of invasive aspergillosis remains difficult. Aspergillosis of CNS can be an acute, subacute, or chronic onset, and the longest course of the disease was currently reported to be 4 years. Here, we report a case with recurrent headache over 20 years. CASE PRESENTATION: A 54-year-old man was admitted to our neurological disease ward due to intermittent throbbing headache lasting for more than 20 years that had grown notably worse over the past week...
September 11, 2020: BMC Neurology
Leyu Lyu, Liting Hu, Lin Han, Jie Zhang, Jintao Sun, Xiaomei Wan, Limei Wang, Haijing Yan, Chengye Che
AIM: To clarify the regulatory mechanisms of lacrimal androgen-binding proteins (ABPs) in mice with keratitis caused by Aspergillus fumigatus (A. fumigatus). METHODS: Mouse models of A. fumigatus keratitis were established. Lacrimal glands were removed after 24 h for general and histological comparison. Lacrimal ABPs were detected by qRT-PCR and quantitative proteomic analysis, or were detected by qRT-PCR after subconjunctival or lacrimal gland injection with dexamethasone...
September 8, 2020: International Immunopharmacology
Hailemariam Abrha Assress, Ramganesh Selvarajan, Hlengilizwe Nyoni, Henry Joseph Oduor Ogola, Bhekie B Mamba, Titus A M Msagati
Wastewater treatment plants (WWTPs) can be significant sources of antifungal resistant fungi, which can disseminate further in the environment by getting into rivers together with effluents discharged from WWTPs and pose a risk for human health. In this study, the presence of azole resistance was determined in fungal isolates from treated effluents of two WWTPs using the standard microdilution method from Clinical and Laboratory Standards Institute (CLSI). A total of 41 fungal isolates representing 23 fungal species and 16 fungal genera were obtained...
September 10, 2020: Environmental Science and Pollution Research International
Daisuke Hagiwara
Increasing numbers of azole-resistant Aspergillus fumigatus (AR Af ) in the environment have become a global public health issue. We surveyed tulip bulbs that were imported from the Netherlands and found that 6.3-15.8% of bulbs were contaminated by AR Af with a tandem-repeat mutation in the promoter region of the cyp51A gene. We also showed that fungicide treatment of the tulip bulbs by benomyl or prochloraz effectively reduced the rate of isolation. This is the first report demonstrating a method of eliminating human fungal pathogens from plant bulbs...
August 20, 2020: Journal of Pesticide Science
I M W Dewi, A Y Soeroto, G Putriyani, W Hanifah, A Permata, J Annisa, I Fithriyana, P E Verweij, A van Laarhoven, F L van de Veerdonk, B Alisjahbana, R van Crevel
No abstract text is available yet for this article.
August 1, 2020: International Journal of Tuberculosis and Lung Disease
Amin Tahoun, Helmy K Elnafarawy, Ehab Kotb Elmahallawy, Abdelhamed Abdelhady, Amira M Rizk, Hanem El-Sharkawy, Mohamed A Youssef, Sabry El-Khodery, Hussam M M Ibrahim
Diagnosis and treatment of ocular fungal infection in equine seems very challenging for owners and clinicians. The present study aimed to identify and characterize fungal species isolated from the eyes of clinically healthy and diseased equines (N = 100) from Dakahlia Governorate, Egypt. The work also involved morphological and molecular characterization of the major fungal species. In addition, correlations between the occurrence of isolated fungi and some of the potential risk factors were also investigated...
September 8, 2020: Veterinary Sciences
John E Moore, B Cherie Millar
A novel method is described for the laboratory storage of the filamentous fungi, Aspergillus fumigatus and Scedosporium apiospermum. These fungi were isolated directly from the sputum of patients with cystic fibrosis (CF) on previously described Medium B+ fungal selective agar. Medium B+ plates containing heavy growths of filamentous fungi were air dried to completeness and the resulting dehydrated agar containing fungi were hermetically sealed within A4 plastic lamination sheets using a domestic paper laminator...
September 7, 2020: Journal of Microbiological Methods
Selwyn Arlington Headley, Melissa Cristina Müller, Thalita Evani Silva de Oliveira, Caroline Ambiel Barros Gil Duarte, Priscilla Fajardo Valente Pereira, Marcos Vinícius Vieira, Cristina Wetzel Cunha, Eduardo Furtado Flores, Júlio Augusto Naylor Lisbôa, Lucienne Garcia Pretto-Giordano
Diphtheric aspergillosis tracheitis is an uncommon syndrome described in human pathology, usually associated with immunosuppression in the affected individuals. Interestingly, no comparative/equivalent cases were found in domestic animals. This report describes the pathological and mycological findings associated with diphtheric aspergillosis tracheitis in an immunocompromised calf. The main pathological findings were diphtheric tracheitis and rhinitis, and necrotizing ruminitis associated with intralesional septate, acute branching fungal hyphae consistent with Aspergillus spp...
September 7, 2020: Microbial Pathogenesis
Ying Jie Ma, Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Peter Garred
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, whether this observation is C3 dependent is unknown. By application of the C3-inhibitor Cp40, we found that properdin in normal human serum bound to Aspergillus fumigatus solely in a C3b dependent manner. Cp40 also prevented properdin binding when properdin-depleted serum reconstituted with purified properdin was applied, in analogy with the findings achieved by C3- depleted serum...
September 10, 2020: ELife
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