Parthipan Sivakumar, Deirdre B Fitzgerald, Hugh Ip, Deepak Rao, Alex West, Farinaz Noorzad, Deirdre Wallace, Mohamed Haris, Benjamin Prudon, Gihan Hettiarachchi, Deepak Jayaram, James Goldring, Nick Maskell, Jayne Holme, Neel Sharma, Iyad Ismail, Owais Kadwani, Sanchez Simpson, Catherine A Read, Xiaohui Sun, Abdel Douiri, Y C Gary Lee, Liju Ahmed
BACKGROUND: The principal aim of malignant pleural effusion (MPE) management is to improve health-related quality of life (HRQoL) and symptoms. METHODS: In this open-label randomised controlled trial, patients with symptomatic MPE were randomly assigned to either indwelling pleural catheter (IPC) insertion with the option of talc pleurodesis or chest drain and talc pleurodesis. The primary end-point was global health status, measured with the 30-item European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30) at 30 days post-intervention...
February 2024: European Respiratory Journal