Zhongyin Ji, Jie Li, Siyue Tao, Hui Li, Xiangxi Kong, Bao Huang, Zhenhua Feng, Xiaoan Wei, Zeyu Zheng, Jian Chen, Binhui Chen, Junhui Liu, Fengdong Zhao
Modic changes are radiographic features associated with microfracture, low-virulence organism infection and chronic inflammation with inflammatory cell infiltration in the vertebral endplate region. Mast cells, as innate immune cells similar to macrophages, are present in painful degenerated intervertebral discs. However, the involvement and mechanisms of mast cells in the development of Modic changes remain unclear. Herein, we found increased mast cell infiltration in samples from patients with Modic changes and in mouse models of Modic changes...
May 1, 2024: Experimental & Molecular Medicine