Alexander Borowsky, Alexa Glencer, Kirithiga Ramalingam, Nicole Schindler, Hidetoshi Mori, Parchi Ghule, Kyra Lee, Daniela Nachmanson, Adam Officer, Olivier Harismendy, Janet Stein, Gary Stein, Mark Evans, Donald Weaver, Christina Yau, Gillian Hirst, Michael Campbell, Laura Esserman
Ductal carcinoma in situ (DCIS) constitutes an array of morphologically recognized intraductal neoplasms in the mammary ductal tree defined by an increased risk for subsequent invasive carcinomas at or near the site of biopsy detection. However, only 15-45% of untreated DCIS cases progress to invasive cancer, so understanding mechanisms that prevent progression is key to avoid overtreatment and provides a basis for alternative therapies and prevention. This study was designed to characterize the tumor microenvironment and molecular profile of high-risk DCIS that grew to a large size but remained as DCIS...
May 9, 2024: Research Square